Motif ID: SPIC
Z-value: 3.295
Transcription factors associated with SPIC:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| SPIC | ENSG00000166211.6 | SPIC |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 5.5 | GO:0001845 | phagolysosome assembly(GO:0001845) phagosome maturation(GO:0090382) |
| 1.8 | 12.6 | GO:0015755 | fructose transport(GO:0015755) |
| 1.8 | 5.3 | GO:0042097 | interleukin-4 biosynthetic process(GO:0042097) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404) |
| 1.4 | 7.0 | GO:0032959 | inositol trisphosphate biosynthetic process(GO:0032959) positive regulation of calcium ion transmembrane transporter activity(GO:1901021) positive regulation of cation channel activity(GO:2001259) |
| 1.3 | 10.4 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 1.0 | 3.1 | GO:0002538 | arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540) |
| 1.0 | 6.9 | GO:0036037 | maintenance of cell polarity(GO:0030011) positive regulation of cell adhesion mediated by integrin(GO:0033630) CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.9 | 6.5 | GO:0034616 | response to laminar fluid shear stress(GO:0034616) |
| 0.8 | 15.2 | GO:0006906 | vesicle fusion(GO:0006906) |
| 0.7 | 3.4 | GO:0010447 | response to acidic pH(GO:0010447) |
| 0.6 | 3.2 | GO:0003093 | regulation of glomerular filtration(GO:0003093) glomerular filtration(GO:0003094) renal filtration(GO:0097205) regulation of renal system process(GO:0098801) |
| 0.6 | 2.5 | GO:0051709 | regulation of killing of cells of other organism(GO:0051709) positive regulation of killing of cells of other organism(GO:0051712) |
| 0.6 | 1.9 | GO:0033578 | protein glycosylation in Golgi(GO:0033578) |
| 0.6 | 1.7 | GO:0019441 | tryptophan catabolic process to kynurenine(GO:0019441) |
| 0.6 | 1.7 | GO:0050983 | spermidine catabolic process(GO:0046203) deoxyhypusine biosynthetic process from spermidine(GO:0050983) |
| 0.6 | 2.2 | GO:0070527 | integrin activation(GO:0033622) regulation of integrin activation(GO:0033623) positive regulation of integrin activation(GO:0033625) platelet aggregation(GO:0070527) |
| 0.5 | 2.3 | GO:0043402 | glucocorticoid mediated signaling pathway(GO:0043402) |
| 0.4 | 3.1 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.4 | 1.3 | GO:0030205 | dermatan sulfate metabolic process(GO:0030205) dermatan sulfate biosynthetic process(GO:0030208) |
| 0.4 | 3.3 | GO:0032713 | negative regulation of interleukin-4 production(GO:0032713) |
| 0.4 | 2.0 | GO:0006857 | oligopeptide transport(GO:0006857) |
| 0.4 | 28.7 | GO:0030183 | B cell differentiation(GO:0030183) |
| 0.4 | 1.2 | GO:0071848 | regulation of fever generation by regulation of prostaglandin secretion(GO:0071810) positive regulation of fever generation by positive regulation of prostaglandin secretion(GO:0071812) TNFSF11-mediated signaling pathway(GO:0071847) positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling(GO:0071848) regulation of fever generation by prostaglandin secretion(GO:0100009) |
| 0.4 | 8.8 | GO:0050732 | negative regulation of peptidyl-tyrosine phosphorylation(GO:0050732) |
| 0.3 | 1.3 | GO:0002360 | T cell lineage commitment(GO:0002360) |
| 0.3 | 3.0 | GO:0015074 | DNA integration(GO:0015074) |
| 0.3 | 1.2 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.3 | 1.4 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.3 | 6.3 | GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504) |
| 0.2 | 1.4 | GO:0032472 | cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) Golgi calcium ion transport(GO:0032472) manganese ion homeostasis(GO:0055071) |
| 0.2 | 3.2 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
| 0.2 | 6.4 | GO:0002286 | T cell activation involved in immune response(GO:0002286) |
| 0.2 | 1.8 | GO:0006975 | DNA damage induced protein phosphorylation(GO:0006975) |
| 0.2 | 3.7 | GO:0002920 | regulation of humoral immune response(GO:0002920) |
| 0.2 | 2.8 | GO:0071230 | cellular response to amino acid stimulus(GO:0071230) |
| 0.2 | 1.5 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.2 | 0.5 | GO:0046586 | regulation of calcium-dependent cell-cell adhesion(GO:0046586) |
| 0.2 | 5.3 | GO:0042531 | regulation of tyrosine phosphorylation of STAT protein(GO:0042509) positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531) |
| 0.2 | 0.5 | GO:0044314 | protein K27-linked ubiquitination(GO:0044314) |
| 0.2 | 1.2 | GO:0006477 | protein sulfation(GO:0006477) |
| 0.2 | 0.8 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
| 0.2 | 1.0 | GO:0032527 | retrograde protein transport, ER to cytosol(GO:0030970) protein exit from endoplasmic reticulum(GO:0032527) |
| 0.2 | 0.5 | GO:0045085 | negative regulation of interleukin-2 biosynthetic process(GO:0045085) |
| 0.2 | 1.8 | GO:0019228 | neuronal action potential(GO:0019228) |
| 0.2 | 1.7 | GO:0034260 | negative regulation of GTPase activity(GO:0034260) |
| 0.2 | 0.9 | GO:0019985 | translesion synthesis(GO:0019985) |
| 0.2 | 2.6 | GO:0045730 | respiratory burst(GO:0045730) |
| 0.1 | 6.5 | GO:0045576 | mast cell activation(GO:0045576) |
| 0.1 | 0.4 | GO:0006273 | lagging strand elongation(GO:0006273) |
| 0.1 | 1.3 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.1 | 0.7 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.1 | 0.7 | GO:0051299 | centrosome separation(GO:0051299) |
| 0.1 | 2.0 | GO:0001893 | maternal placenta development(GO:0001893) |
| 0.1 | 1.4 | GO:0032647 | interferon-alpha production(GO:0032607) regulation of interferon-alpha production(GO:0032647) positive regulation of interferon-alpha production(GO:0032727) |
| 0.1 | 0.3 | GO:0003351 | epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287) |
| 0.1 | 0.2 | GO:0001300 | chronological cell aging(GO:0001300) negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394) detection of hypoxia(GO:0070483) |
| 0.1 | 0.7 | GO:0045722 | positive regulation of gluconeogenesis(GO:0045722) |
| 0.1 | 5.2 | GO:0019079 | viral genome replication(GO:0019079) |
| 0.1 | 10.6 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.1 | 2.2 | GO:0030224 | monocyte differentiation(GO:0030224) |
| 0.1 | 0.7 | GO:0047496 | vesicle transport along microtubule(GO:0047496) vesicle cytoskeletal trafficking(GO:0099518) |
| 0.1 | 0.9 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
| 0.1 | 0.5 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
| 0.1 | 1.5 | GO:0051480 | regulation of cytosolic calcium ion concentration(GO:0051480) |
| 0.1 | 1.0 | GO:0001706 | endoderm formation(GO:0001706) |
| 0.1 | 0.2 | GO:0006269 | DNA replication, synthesis of RNA primer(GO:0006269) |
| 0.1 | 0.6 | GO:0051383 | kinetochore assembly(GO:0051382) kinetochore organization(GO:0051383) |
| 0.1 | 0.5 | GO:0051103 | DNA ligation involved in DNA repair(GO:0051103) |
| 0.1 | 0.6 | GO:0051294 | establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294) |
| 0.1 | 0.6 | GO:0016557 | peroxisome membrane biogenesis(GO:0016557) |
| 0.1 | 2.7 | GO:0032024 | positive regulation of insulin secretion(GO:0032024) |
| 0.1 | 1.0 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.1 | 1.3 | GO:0051319 | mitotic G2 phase(GO:0000085) G2 phase(GO:0051319) |
| 0.1 | 0.2 | GO:0006679 | glucosylceramide biosynthetic process(GO:0006679) |
| 0.1 | 1.5 | GO:0000722 | telomere maintenance via recombination(GO:0000722) |
| 0.1 | 0.6 | GO:0006072 | glycerol-3-phosphate metabolic process(GO:0006072) |
| 0.1 | 0.2 | GO:0009405 | pathogenesis(GO:0009405) |
| 0.1 | 0.4 | GO:0032933 | response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501) |
| 0.1 | 0.5 | GO:0042989 | sequestering of actin monomers(GO:0042989) |
| 0.1 | 1.4 | GO:0070206 | protein trimerization(GO:0070206) |
| 0.1 | 0.3 | GO:0090042 | tubulin deacetylation(GO:0090042) |
| 0.1 | 0.2 | GO:0060684 | epithelial-mesenchymal cell signaling(GO:0060684) |
| 0.1 | 1.6 | GO:0036503 | ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) ERAD pathway(GO:0036503) |
| 0.1 | 0.2 | GO:0070816 | phosphorylation of RNA polymerase II C-terminal domain(GO:0070816) |
| 0.1 | 1.0 | GO:0045123 | cellular extravasation(GO:0045123) |
| 0.1 | 0.8 | GO:0045540 | regulation of cholesterol biosynthetic process(GO:0045540) |
| 0.1 | 0.3 | GO:0045010 | actin nucleation(GO:0045010) |
| 0.1 | 7.1 | GO:0007162 | negative regulation of cell adhesion(GO:0007162) |
| 0.1 | 0.2 | GO:0045601 | regulation of endothelial cell differentiation(GO:0045601) |
| 0.1 | 0.9 | GO:0007076 | mitotic chromosome condensation(GO:0007076) |
| 0.1 | 7.9 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 0.1 | 1.2 | GO:0045104 | intermediate filament cytoskeleton organization(GO:0045104) |
| 0.1 | 0.8 | GO:0043984 | histone H4-K16 acetylation(GO:0043984) |
| 0.1 | 0.2 | GO:0032786 | positive regulation of DNA-templated transcription, elongation(GO:0032786) |
| 0.1 | 0.8 | GO:0006271 | DNA strand elongation involved in DNA replication(GO:0006271) |
| 0.1 | 1.2 | GO:0000291 | nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
| 0.0 | 1.4 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
| 0.0 | 1.3 | GO:0014046 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
| 0.0 | 2.3 | GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193) |
| 0.0 | 6.1 | GO:0006865 | amino acid transport(GO:0006865) |
| 0.0 | 0.3 | GO:0006422 | aspartyl-tRNA aminoacylation(GO:0006422) |
| 0.0 | 0.2 | GO:0045872 | positive regulation of rhodopsin gene expression(GO:0045872) |
| 0.0 | 0.4 | GO:0008535 | respiratory chain complex IV assembly(GO:0008535) |
| 0.0 | 0.2 | GO:1901503 | ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503) |
| 0.0 | 0.5 | GO:0001522 | pseudouridine synthesis(GO:0001522) |
| 0.0 | 0.4 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 0.0 | 0.4 | GO:0035964 | pancreatic juice secretion(GO:0030157) COPI-coated vesicle budding(GO:0035964) Golgi vesicle budding(GO:0048194) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205) |
| 0.0 | 2.1 | GO:0061025 | membrane fusion(GO:0061025) |
| 0.0 | 0.2 | GO:0021522 | spinal cord motor neuron differentiation(GO:0021522) |
| 0.0 | 2.9 | GO:0051258 | protein polymerization(GO:0051258) |
| 0.0 | 0.6 | GO:0051568 | histone H3-K4 methylation(GO:0051568) |
| 0.0 | 0.5 | GO:0032456 | endocytic recycling(GO:0032456) |
| 0.0 | 0.1 | GO:0001865 | NK T cell differentiation(GO:0001865) regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138) |
| 0.0 | 1.4 | GO:0046320 | regulation of fatty acid oxidation(GO:0046320) |
| 0.0 | 0.2 | GO:0021516 | dorsal spinal cord development(GO:0021516) |
| 0.0 | 0.4 | GO:0045648 | positive regulation of erythrocyte differentiation(GO:0045648) |
| 0.0 | 0.4 | GO:0046627 | negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077) |
| 0.0 | 1.5 | GO:0097696 | JAK-STAT cascade(GO:0007259) STAT cascade(GO:0097696) |
| 0.0 | 0.6 | GO:0032392 | DNA geometric change(GO:0032392) |
| 0.0 | 0.4 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
| 0.0 | 2.5 | GO:0050680 | negative regulation of epithelial cell proliferation(GO:0050680) |
| 0.0 | 1.9 | GO:0031295 | lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295) |
| 0.0 | 0.6 | GO:0001709 | cell fate determination(GO:0001709) |
| 0.0 | 0.4 | GO:0010212 | response to ionizing radiation(GO:0010212) |
| 0.0 | 0.3 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.0 | 0.3 | GO:0071157 | negative regulation of cell cycle arrest(GO:0071157) |
| 0.0 | 0.6 | GO:0000245 | spliceosomal complex assembly(GO:0000245) |
| 0.0 | 0.1 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.0 | 0.4 | GO:1902583 | multi-organism transport(GO:0044766) transport of virus(GO:0046794) intracellular transport of virus(GO:0075733) multi-organism localization(GO:1902579) multi-organism intracellular transport(GO:1902583) |
| 0.0 | 0.0 | GO:0031034 | skeletal muscle myosin thick filament assembly(GO:0030241) myosin filament assembly(GO:0031034) striated muscle myosin thick filament assembly(GO:0071688) |
| 0.0 | 1.2 | GO:0032480 | negative regulation of type I interferon production(GO:0032480) |
| 0.0 | 2.3 | GO:0008154 | actin polymerization or depolymerization(GO:0008154) |
| 0.0 | 1.3 | GO:0043473 | pigmentation(GO:0043473) |
| 0.0 | 1.5 | GO:0030178 | negative regulation of Wnt signaling pathway(GO:0030178) |
| 0.0 | 0.3 | GO:0048278 | vesicle docking(GO:0048278) |
| 0.0 | 0.5 | GO:0030307 | positive regulation of cell growth(GO:0030307) |
| 0.0 | 0.2 | GO:0014003 | oligodendrocyte development(GO:0014003) |
| 0.0 | 0.2 | GO:0006448 | regulation of translational elongation(GO:0006448) |
| 0.0 | 0.5 | GO:0008156 | negative regulation of DNA replication(GO:0008156) |
| 0.0 | 0.4 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 0.0 | 0.2 | GO:0016601 | Rac protein signal transduction(GO:0016601) |
| 0.0 | 0.1 | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846) |
| 0.0 | 0.2 | GO:0016458 | gene silencing(GO:0016458) |
| 0.0 | 0.1 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.0 | 0.1 | GO:0016045 | detection of bacterium(GO:0016045) |
| 0.0 | 0.7 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.0 | 1.1 | GO:0006413 | translational initiation(GO:0006413) |
| 0.0 | 0.1 | GO:0006379 | mRNA cleavage(GO:0006379) |
| 0.0 | 0.4 | GO:0000186 | activation of MAPKK activity(GO:0000186) |
| 0.0 | 1.0 | GO:0007498 | mesoderm development(GO:0007498) |
| 0.0 | 4.3 | GO:0043066 | negative regulation of apoptotic process(GO:0043066) |
| 0.0 | 0.3 | GO:0030262 | apoptotic nuclear changes(GO:0030262) |
| 0.0 | 0.1 | GO:0002281 | macrophage activation involved in immune response(GO:0002281) |
| 0.0 | 0.2 | GO:0035249 | synaptic transmission, glutamatergic(GO:0035249) |
| 0.0 | 0.7 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 0.0 | 0.1 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.0 | 0.3 | GO:0006493 | protein O-linked glycosylation(GO:0006493) |
| 0.0 | 0.4 | GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059) negative regulation of ERBB signaling pathway(GO:1901185) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 11.9 | GO:0001891 | phagocytic cup(GO:0001891) |
| 1.4 | 15.3 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 1.0 | 3.1 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.8 | 4.9 | GO:0019815 | immunoglobulin complex(GO:0019814) B cell receptor complex(GO:0019815) |
| 0.3 | 6.5 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.3 | 0.9 | GO:0035327 | transcriptionally active chromatin(GO:0035327) |
| 0.3 | 5.8 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.3 | 1.4 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
| 0.2 | 2.7 | GO:0098857 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.2 | 1.5 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 0.2 | 1.2 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
| 0.2 | 2.4 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.1 | 0.7 | GO:0005854 | nascent polypeptide-associated complex(GO:0005854) |
| 0.1 | 0.9 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.1 | 0.9 | GO:1990752 | microtubule plus-end(GO:0035371) microtubule end(GO:1990752) |
| 0.1 | 1.4 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.1 | 1.3 | GO:0016461 | unconventional myosin complex(GO:0016461) |
| 0.1 | 0.7 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
| 0.1 | 5.0 | GO:0098636 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.1 | 0.5 | GO:0032807 | DNA ligase IV complex(GO:0032807) |
| 0.1 | 0.6 | GO:0072487 | MSL complex(GO:0072487) |
| 0.1 | 0.3 | GO:0071001 | U4/U6 snRNP(GO:0071001) |
| 0.1 | 0.6 | GO:0009331 | glycerol-3-phosphate dehydrogenase complex(GO:0009331) |
| 0.1 | 0.9 | GO:0000796 | condensin complex(GO:0000796) |
| 0.1 | 0.1 | GO:0005921 | gap junction(GO:0005921) |
| 0.1 | 4.0 | GO:0005884 | actin filament(GO:0005884) |
| 0.1 | 0.4 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.1 | 0.8 | GO:0042555 | MCM complex(GO:0042555) |
| 0.1 | 3.1 | GO:0030175 | filopodium(GO:0030175) |
| 0.1 | 0.4 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.1 | 2.1 | GO:0030136 | clathrin-coated vesicle(GO:0030136) |
| 0.1 | 0.4 | GO:0042575 | DNA polymerase complex(GO:0042575) |
| 0.1 | 1.3 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.0 | 3.7 | GO:0098802 | plasma membrane receptor complex(GO:0098802) |
| 0.0 | 0.5 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.0 | 8.8 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 0.4 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.0 | 0.4 | GO:0030126 | COPI vesicle coat(GO:0030126) |
| 0.0 | 0.3 | GO:0005851 | eukaryotic translation initiation factor 2B complex(GO:0005851) |
| 0.0 | 0.5 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.0 | 0.2 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 0.0 | 1.4 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 0.6 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 2.1 | GO:0005765 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 0.1 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.0 | 0.3 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
| 0.0 | 0.6 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.0 | 1.6 | GO:0031228 | intrinsic component of Golgi membrane(GO:0031228) |
| 0.0 | 40.8 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 0.2 | GO:0019908 | nuclear cyclin-dependent protein kinase holoenzyme complex(GO:0019908) |
| 0.0 | 1.0 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 0.4 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.0 | 1.1 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 2.0 | GO:0030496 | midbody(GO:0030496) |
| 0.0 | 0.3 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 0.2 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.0 | 0.3 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.0 | 0.2 | GO:1903561 | extracellular organelle(GO:0043230) extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561) |
| 0.0 | 0.3 | GO:0061200 | clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202) |
| 0.0 | 51.6 | GO:0005886 | plasma membrane(GO:0005886) |
| 0.0 | 1.1 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 1.0 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 2.4 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.0 | 0.8 | GO:0044815 | DNA packaging complex(GO:0044815) |
| 0.0 | 0.5 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.0 | 0.4 | GO:0005746 | mitochondrial respiratory chain(GO:0005746) |
| 0.0 | 0.7 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.0 | 0.1 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.0 | 0.2 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.0 | 0.2 | GO:0060076 | postsynaptic density(GO:0014069) excitatory synapse(GO:0060076) postsynaptic specialization(GO:0099572) |
| 0.0 | 0.1 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) histone pre-mRNA 3'end processing complex(GO:0071204) |
| 0.0 | 0.3 | GO:0005875 | microtubule associated complex(GO:0005875) |
| 0.0 | 0.1 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.0 | 0.4 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 0.1 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 0.1 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
| 0.0 | 0.3 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.0 | 0.2 | GO:0044665 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.0 | 0.2 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
| 0.0 | 0.2 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.0 | 0.2 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.0 | 0.4 | GO:0005626 | obsolete insoluble fraction(GO:0005626) |
| 0.0 | 0.3 | GO:0036064 | ciliary basal body(GO:0036064) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 10.4 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 1.8 | 12.6 | GO:0005353 | fructose transmembrane transporter activity(GO:0005353) |
| 1.6 | 19.0 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 1.2 | 3.6 | GO:0004914 | interleukin-5 receptor activity(GO:0004914) |
| 0.9 | 12.3 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.9 | 9.0 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.7 | 3.0 | GO:0008907 | integrase activity(GO:0008907) |
| 0.7 | 2.0 | GO:0022897 | peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897) |
| 0.6 | 1.9 | GO:0008424 | glycoprotein 6-alpha-L-fucosyltransferase activity(GO:0008424) alpha-(1->6)-fucosyltransferase activity(GO:0046921) |
| 0.6 | 4.0 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.6 | 1.7 | GO:0034038 | deoxyhypusine synthase activity(GO:0034038) |
| 0.5 | 7.0 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093) |
| 0.5 | 1.4 | GO:0003863 | alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863) |
| 0.5 | 2.3 | GO:0004883 | glucocorticoid receptor activity(GO:0004883) |
| 0.5 | 1.4 | GO:0042296 | ISG15 transferase activity(GO:0042296) |
| 0.4 | 2.5 | GO:0019863 | IgE binding(GO:0019863) |
| 0.4 | 5.8 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.3 | 11.0 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.3 | 3.1 | GO:1901567 | icosanoid binding(GO:0050542) arachidonic acid binding(GO:0050544) fatty acid derivative binding(GO:1901567) |
| 0.3 | 7.6 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.3 | 3.8 | GO:0019864 | IgG binding(GO:0019864) |
| 0.3 | 1.6 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.3 | 1.3 | GO:0000827 | inositol-1,3,4,5,6-pentakisphosphate kinase activity(GO:0000827) diphosphoinositol-pentakisphosphate kinase activity(GO:0033857) |
| 0.3 | 4.3 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.2 | 0.7 | GO:0015361 | low-affinity sodium:dicarboxylate symporter activity(GO:0015361) |
| 0.2 | 1.2 | GO:0001517 | N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) |
| 0.2 | 1.4 | GO:0015410 | manganese-transporting ATPase activity(GO:0015410) |
| 0.2 | 2.9 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.2 | 2.0 | GO:0016494 | C-X-C chemokine receptor activity(GO:0016494) |
| 0.2 | 2.2 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.2 | 1.5 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.2 | 8.5 | GO:0030295 | protein kinase activator activity(GO:0030295) |
| 0.2 | 2.2 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.2 | 3.0 | GO:0043548 | phosphatidylinositol 3-kinase binding(GO:0043548) |
| 0.2 | 0.5 | GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314) |
| 0.2 | 0.5 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.2 | 0.6 | GO:0052590 | sn-glycerol-3-phosphate:ubiquinone oxidoreductase activity(GO:0052590) sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity(GO:0052591) |
| 0.1 | 0.7 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
| 0.1 | 1.0 | GO:0001846 | opsonin binding(GO:0001846) |
| 0.1 | 1.8 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.1 | 6.9 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.1 | 1.7 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.1 | 9.3 | GO:0015171 | amino acid transmembrane transporter activity(GO:0015171) |
| 0.1 | 0.7 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.1 | 1.8 | GO:0004908 | interleukin-1 receptor activity(GO:0004908) |
| 0.1 | 1.8 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.1 | 0.4 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
| 0.1 | 0.3 | GO:0030611 | arsenate reductase activity(GO:0030611) |
| 0.1 | 0.3 | GO:0030156 | benzodiazepine receptor binding(GO:0030156) |
| 0.1 | 1.1 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
| 0.1 | 4.8 | GO:0003823 | antigen binding(GO:0003823) |
| 0.1 | 0.5 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
| 0.1 | 7.2 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.1 | 0.4 | GO:0004060 | arylamine N-acetyltransferase activity(GO:0004060) |
| 0.1 | 0.4 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.1 | 0.6 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
| 0.1 | 0.5 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.1 | 1.8 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.1 | 1.0 | GO:0042287 | MHC protein binding(GO:0042287) |
| 0.1 | 10.2 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.1 | 2.2 | GO:0015026 | coreceptor activity(GO:0015026) |
| 0.1 | 0.2 | GO:0042609 | CD4 receptor binding(GO:0042609) |
| 0.1 | 0.2 | GO:0004662 | CAAX-protein geranylgeranyltransferase activity(GO:0004662) |
| 0.1 | 0.4 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) |
| 0.1 | 0.6 | GO:0016004 | phospholipase activator activity(GO:0016004) |
| 0.1 | 0.9 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.1 | 0.2 | GO:0003896 | DNA primase activity(GO:0003896) |
| 0.1 | 0.8 | GO:0000339 | RNA cap binding(GO:0000339) |
| 0.1 | 0.2 | GO:0034235 | GPI anchor binding(GO:0034235) |
| 0.1 | 1.3 | GO:0015464 | acetylcholine receptor activity(GO:0015464) |
| 0.1 | 0.5 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.1 | 0.3 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.1 | 0.5 | GO:0016208 | AMP binding(GO:0016208) |
| 0.0 | 0.3 | GO:0008517 | folic acid transporter activity(GO:0008517) |
| 0.0 | 1.4 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 5.1 | GO:0003704 | obsolete specific RNA polymerase II transcription factor activity(GO:0003704) |
| 0.0 | 0.2 | GO:0005534 | galactose binding(GO:0005534) |
| 0.0 | 0.4 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) |
| 0.0 | 2.3 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.0 | 3.0 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 0.3 | GO:0004815 | aspartate-tRNA ligase activity(GO:0004815) |
| 0.0 | 0.5 | GO:0004993 | G-protein coupled serotonin receptor activity(GO:0004993) serotonin receptor activity(GO:0099589) |
| 0.0 | 0.2 | GO:0000268 | peroxisome targeting sequence binding(GO:0000268) |
| 0.0 | 1.1 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 0.3 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.0 | 2.4 | GO:0001948 | glycoprotein binding(GO:0001948) |
| 0.0 | 0.5 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 10.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 0.9 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 2.1 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 0.1 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.0 | 0.3 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.0 | 1.1 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.0 | 2.1 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 1.3 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.0 | 0.1 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
| 0.0 | 3.8 | GO:0017124 | SH3 domain binding(GO:0017124) |
| 0.0 | 0.6 | GO:0008320 | protein transmembrane transporter activity(GO:0008320) |
| 0.0 | 0.2 | GO:0004522 | ribonuclease A activity(GO:0004522) |
| 0.0 | 0.3 | GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499) |
| 0.0 | 0.2 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.0 | 0.7 | GO:0051721 | protein phosphatase 2A binding(GO:0051721) |
| 0.0 | 1.0 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.0 | 1.1 | GO:0004527 | exonuclease activity(GO:0004527) |
| 0.0 | 1.0 | GO:0004221 | obsolete ubiquitin thiolesterase activity(GO:0004221) |
| 0.0 | 2.1 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 0.8 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.0 | 0.2 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.0 | 1.1 | GO:0050136 | NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.6 | GO:0051539 | 4 iron, 4 sulfur cluster binding(GO:0051539) |
| 0.0 | 0.1 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
| 0.0 | 7.8 | GO:0005525 | GTP binding(GO:0005525) |
| 0.0 | 2.3 | GO:0016564 | obsolete transcription repressor activity(GO:0016564) |
| 0.0 | 0.2 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.0 | 0.3 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 0.2 | GO:0003711 | obsolete transcription elongation regulator activity(GO:0003711) |
| 0.0 | 0.1 | GO:0004974 | leukotriene receptor activity(GO:0004974) |
| 0.0 | 0.3 | GO:0005057 | receptor signaling protein activity(GO:0005057) |
| 0.0 | 0.2 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 0.0 | 0.5 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 0.4 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.1 | GO:0061733 | peptide-lysine-N-acetyltransferase activity(GO:0061733) |
| 0.0 | 1.1 | GO:0008565 | protein transporter activity(GO:0008565) |
| 0.0 | 0.9 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 0.8 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 0.7 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.0 | 0.1 | GO:0004518 | nuclease activity(GO:0004518) |
| 0.0 | 1.3 | GO:0005179 | hormone activity(GO:0005179) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 21.1 | SA_B_CELL_RECEPTOR_COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.3 | 10.4 | SIG_IL4RECEPTOR_IN_B_LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.2 | 7.0 | ST_B_CELL_ANTIGEN_RECEPTOR | B Cell Antigen Receptor |
| 0.2 | 1.2 | ST_P38_MAPK_PATHWAY | p38 MAPK Pathway |
| 0.1 | 2.4 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.1 | 4.3 | ST_T_CELL_SIGNAL_TRANSDUCTION | T Cell Signal Transduction |
| 0.1 | 1.6 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 0.5 | ST_INTERLEUKIN_4_PATHWAY | Interleukin 4 (IL-4) Pathway |
| 0.0 | 0.8 | SA_G1_AND_S_PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
