Motif ID: STAT1_STAT3_BCL6
Z-value: 3.056
Transcription factors associated with STAT1_STAT3_BCL6:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| BCL6 | ENSG00000113916.13 | BCL6 |
| STAT1 | ENSG00000115415.14 | STAT1 |
| STAT3 | ENSG00000168610.10 | STAT3 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 18.8 | GO:0032460 | negative regulation of protein oligomerization(GO:0032460) negative regulation of protein homooligomerization(GO:0032463) |
| 1.1 | 4.3 | GO:0031340 | positive regulation of vesicle fusion(GO:0031340) |
| 0.7 | 6.2 | GO:0051770 | positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770) |
| 0.7 | 5.3 | GO:0003065 | regulation of heart rate by chemical signal(GO:0003062) positive regulation of heart rate by epinephrine(GO:0003065) |
| 0.5 | 1.6 | GO:0014874 | renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure(GO:0001999) response to stimulus involved in regulation of muscle adaptation(GO:0014874) astrocyte activation(GO:0048143) |
| 0.5 | 8.6 | GO:0060638 | mesenchymal-epithelial cell signaling(GO:0060638) |
| 0.4 | 7.2 | GO:0018214 | peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214) |
| 0.4 | 1.3 | GO:2000121 | regulation of removal of superoxide radicals(GO:2000121) |
| 0.4 | 3.5 | GO:0060666 | dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666) |
| 0.3 | 2.3 | GO:0060414 | aorta development(GO:0035904) aorta morphogenesis(GO:0035909) aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.3 | 1.9 | GO:0002036 | regulation of L-glutamate transport(GO:0002036) |
| 0.3 | 0.9 | GO:1901142 | insulin processing(GO:0030070) insulin metabolic process(GO:1901142) |
| 0.3 | 0.9 | GO:0046341 | CDP-diacylglycerol metabolic process(GO:0046341) |
| 0.3 | 1.2 | GO:0050928 | negative regulation of positive chemotaxis(GO:0050928) |
| 0.3 | 0.9 | GO:0001544 | initiation of primordial ovarian follicle growth(GO:0001544) |
| 0.3 | 8.1 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.3 | 3.1 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.3 | 6.4 | GO:0030199 | collagen fibril organization(GO:0030199) |
| 0.3 | 1.1 | GO:0051409 | response to nitrosative stress(GO:0051409) |
| 0.3 | 1.3 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) |
| 0.3 | 0.8 | GO:0007412 | axon target recognition(GO:0007412) |
| 0.2 | 1.5 | GO:0007500 | mesodermal cell fate determination(GO:0007500) |
| 0.2 | 2.3 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.2 | 0.7 | GO:0003176 | aortic valve development(GO:0003176) aortic valve morphogenesis(GO:0003180) notochord formation(GO:0014028) |
| 0.2 | 1.8 | GO:0006069 | ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069) |
| 0.2 | 0.4 | GO:0097300 | necroptotic process(GO:0070266) programmed necrotic cell death(GO:0097300) |
| 0.2 | 1.2 | GO:0045916 | negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258) |
| 0.2 | 0.6 | GO:0002124 | territorial aggressive behavior(GO:0002124) brainstem development(GO:0003360) vocalization behavior(GO:0071625) |
| 0.2 | 0.6 | GO:0006041 | glucosamine metabolic process(GO:0006041) |
| 0.2 | 0.8 | GO:0045162 | clustering of voltage-gated sodium channels(GO:0045162) |
| 0.2 | 1.9 | GO:0060391 | positive regulation of SMAD protein import into nucleus(GO:0060391) |
| 0.2 | 0.4 | GO:1901031 | regulation of cellular response to oxidative stress(GO:1900407) regulation of response to reactive oxygen species(GO:1901031) regulation of response to oxidative stress(GO:1902882) |
| 0.2 | 1.6 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
| 0.2 | 0.6 | GO:0001807 | type IV hypersensitivity(GO:0001806) regulation of type IV hypersensitivity(GO:0001807) regulation of phosphatidylinositol biosynthetic process(GO:0010511) obsolete regulation of calcium ion transport via store-operated calcium channel activity(GO:0032234) regulation of phospholipid biosynthetic process(GO:0071071) |
| 0.2 | 0.5 | GO:1904358 | positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358) |
| 0.1 | 0.4 | GO:0035234 | ectopic germ cell programmed cell death(GO:0035234) |
| 0.1 | 7.2 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.1 | 0.8 | GO:0006295 | nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295) |
| 0.1 | 0.8 | GO:0035020 | regulation of Rac protein signal transduction(GO:0035020) |
| 0.1 | 0.5 | GO:0015825 | L-serine transport(GO:0015825) |
| 0.1 | 7.0 | GO:0071377 | cellular response to glucagon stimulus(GO:0071377) |
| 0.1 | 1.8 | GO:0007567 | parturition(GO:0007567) |
| 0.1 | 0.9 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.1 | 3.2 | GO:0015813 | L-glutamate transport(GO:0015813) |
| 0.1 | 0.3 | GO:0008356 | asymmetric cell division(GO:0008356) |
| 0.1 | 4.2 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.1 | 2.2 | GO:0007520 | myoblast fusion(GO:0007520) |
| 0.1 | 3.6 | GO:0010633 | negative regulation of epithelial cell migration(GO:0010633) |
| 0.1 | 1.5 | GO:0070670 | response to interleukin-4(GO:0070670) |
| 0.1 | 1.9 | GO:0071378 | growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378) |
| 0.1 | 0.9 | GO:0045880 | positive regulation of smoothened signaling pathway(GO:0045880) |
| 0.1 | 0.4 | GO:0045218 | zonula adherens maintenance(GO:0045218) |
| 0.1 | 0.5 | GO:0032801 | receptor catabolic process(GO:0032801) |
| 0.1 | 0.9 | GO:0051014 | actin filament severing(GO:0051014) |
| 0.1 | 1.7 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.1 | 1.0 | GO:0048488 | synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583) |
| 0.1 | 0.2 | GO:0002374 | cytokine secretion involved in immune response(GO:0002374) regulation of cytokine secretion involved in immune response(GO:0002739) negative regulation of cytokine secretion involved in immune response(GO:0002740) |
| 0.1 | 0.1 | GO:0072677 | eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677) |
| 0.1 | 0.8 | GO:1901072 | chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072) |
| 0.1 | 0.6 | GO:0006013 | mannose metabolic process(GO:0006013) |
| 0.1 | 3.0 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
| 0.1 | 0.5 | GO:0060046 | regulation of acrosome reaction(GO:0060046) |
| 0.1 | 0.3 | GO:1902414 | protein localization to adherens junction(GO:0071896) protein localization to cell junction(GO:1902414) |
| 0.1 | 0.2 | GO:0046521 | sphingoid catabolic process(GO:0046521) |
| 0.1 | 1.8 | GO:0007176 | regulation of epidermal growth factor-activated receptor activity(GO:0007176) |
| 0.1 | 0.3 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.1 | 0.3 | GO:0051895 | negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392) |
| 0.1 | 0.3 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 0.1 | 0.3 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
| 0.1 | 0.2 | GO:0007538 | primary sex determination(GO:0007538) |
| 0.1 | 1.3 | GO:0006656 | phosphatidylcholine biosynthetic process(GO:0006656) |
| 0.1 | 0.4 | GO:0006883 | cellular sodium ion homeostasis(GO:0006883) |
| 0.1 | 0.3 | GO:0006651 | diacylglycerol biosynthetic process(GO:0006651) |
| 0.1 | 0.2 | GO:0046984 | regulation of hemoglobin biosynthetic process(GO:0046984) |
| 0.1 | 0.2 | GO:0045760 | operant conditioning(GO:0035106) positive regulation of action potential(GO:0045760) |
| 0.1 | 0.9 | GO:0090630 | activation of GTPase activity(GO:0090630) |
| 0.1 | 0.5 | GO:0031017 | exocrine pancreas development(GO:0031017) |
| 0.1 | 1.1 | GO:0007172 | signal complex assembly(GO:0007172) |
| 0.1 | 0.6 | GO:0071223 | response to lipoteichoic acid(GO:0070391) cellular response to lipoteichoic acid(GO:0071223) |
| 0.1 | 0.1 | GO:0032611 | interleukin-1 beta production(GO:0032611) |
| 0.1 | 0.2 | GO:0045872 | positive regulation of rhodopsin gene expression(GO:0045872) |
| 0.0 | 0.4 | GO:0018126 | protein hydroxylation(GO:0018126) |
| 0.0 | 0.2 | GO:0014850 | response to muscle activity(GO:0014850) |
| 0.0 | 0.1 | GO:0019521 | aldonic acid metabolic process(GO:0019520) D-gluconate metabolic process(GO:0019521) |
| 0.0 | 4.4 | GO:0006665 | sphingolipid metabolic process(GO:0006665) |
| 0.0 | 0.2 | GO:0048388 | endosomal lumen acidification(GO:0048388) |
| 0.0 | 0.3 | GO:0014049 | positive regulation of glutamate secretion(GO:0014049) |
| 0.0 | 0.2 | GO:0042159 | lipoprotein catabolic process(GO:0042159) |
| 0.0 | 0.2 | GO:0071318 | cellular response to ATP(GO:0071318) |
| 0.0 | 0.4 | GO:0015780 | nucleotide-sugar transport(GO:0015780) |
| 0.0 | 0.1 | GO:0007341 | penetration of zona pellucida(GO:0007341) |
| 0.0 | 3.1 | GO:0030521 | androgen receptor signaling pathway(GO:0030521) |
| 0.0 | 0.3 | GO:0021516 | dorsal spinal cord development(GO:0021516) |
| 0.0 | 12.8 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.0 | 0.8 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.0 | 0.2 | GO:0045350 | interferon-beta biosynthetic process(GO:0045350) regulation of interferon-beta biosynthetic process(GO:0045357) positive regulation of interferon-beta biosynthetic process(GO:0045359) |
| 0.0 | 1.4 | GO:0015914 | phospholipid transport(GO:0015914) |
| 0.0 | 0.2 | GO:0008535 | respiratory chain complex IV assembly(GO:0008535) |
| 0.0 | 1.1 | GO:0008633 | obsolete activation of pro-apoptotic gene products(GO:0008633) |
| 0.0 | 2.4 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.0 | 0.2 | GO:0045047 | protein targeting to ER(GO:0045047) establishment of protein localization to endoplasmic reticulum(GO:0072599) |
| 0.0 | 1.1 | GO:0030520 | intracellular estrogen receptor signaling pathway(GO:0030520) |
| 0.0 | 1.6 | GO:0006914 | autophagy(GO:0006914) |
| 0.0 | 0.2 | GO:0016601 | Rac protein signal transduction(GO:0016601) |
| 0.0 | 0.2 | GO:0033119 | negative regulation of RNA splicing(GO:0033119) |
| 0.0 | 0.9 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.0 | 2.2 | GO:0002576 | platelet degranulation(GO:0002576) |
| 0.0 | 0.1 | GO:0007217 | tachykinin receptor signaling pathway(GO:0007217) |
| 0.0 | 0.1 | GO:0006848 | pyruvate transport(GO:0006848) |
| 0.0 | 0.4 | GO:0030838 | positive regulation of actin filament polymerization(GO:0030838) |
| 0.0 | 0.1 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.0 | 0.3 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
| 0.0 | 0.1 | GO:0021615 | glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615) |
| 0.0 | 0.3 | GO:0071285 | cellular response to lithium ion(GO:0071285) |
| 0.0 | 1.5 | GO:0034249 | negative regulation of translation(GO:0017148) negative regulation of cellular amide metabolic process(GO:0034249) |
| 0.0 | 0.1 | GO:0051546 | keratinocyte migration(GO:0051546) |
| 0.0 | 0.2 | GO:0008272 | sulfate transport(GO:0008272) |
| 0.0 | 0.3 | GO:0007628 | adult walking behavior(GO:0007628) walking behavior(GO:0090659) |
| 0.0 | 0.3 | GO:0009584 | detection of visible light(GO:0009584) |
| 0.0 | 0.7 | GO:0016567 | protein ubiquitination(GO:0016567) |
| 0.0 | 0.4 | GO:0006469 | negative regulation of protein kinase activity(GO:0006469) |
| 0.0 | 0.4 | GO:0021545 | cranial nerve development(GO:0021545) |
| 0.0 | 0.8 | GO:0030833 | regulation of actin filament polymerization(GO:0030833) |
| 0.0 | 3.2 | GO:0043623 | cellular protein complex assembly(GO:0043623) |
| 0.0 | 1.2 | GO:2000116 | regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043281) regulation of cysteine-type endopeptidase activity(GO:2000116) |
| 0.0 | 0.0 | GO:0034201 | response to oleic acid(GO:0034201) |
| 0.0 | 0.3 | GO:0009812 | flavonoid metabolic process(GO:0009812) |
| 0.0 | 0.5 | GO:0006362 | transcription elongation from RNA polymerase I promoter(GO:0006362) |
| 0.0 | 0.2 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
| 0.0 | 0.0 | GO:0042511 | positive regulation of tyrosine phosphorylation of Stat1 protein(GO:0042511) |
| 0.0 | 0.1 | GO:0046470 | phosphatidylcholine metabolic process(GO:0046470) |
| 0.0 | 0.1 | GO:0090231 | regulation of spindle checkpoint(GO:0090231) |
| 0.0 | 0.1 | GO:0019321 | pentose metabolic process(GO:0019321) |
| 0.0 | 0.2 | GO:0002675 | positive regulation of acute inflammatory response(GO:0002675) |
| 0.0 | 0.7 | GO:0007202 | activation of phospholipase C activity(GO:0007202) positive regulation of phospholipase C activity(GO:0010863) regulation of phospholipase C activity(GO:1900274) |
| 0.0 | 0.1 | GO:2000124 | cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926) regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.0 | 0.2 | GO:0046415 | urate metabolic process(GO:0046415) |
| 0.0 | 0.1 | GO:0040016 | embryonic cleavage(GO:0040016) |
| 0.0 | 0.3 | GO:0051353 | positive regulation of oxidoreductase activity(GO:0051353) |
| 0.0 | 0.5 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.0 | 0.3 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.0 | 1.4 | GO:0006814 | sodium ion transport(GO:0006814) |
| 0.0 | 0.4 | GO:0007033 | vacuole organization(GO:0007033) |
| 0.0 | 0.4 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 0.0 | 0.1 | GO:0099515 | nuclear migration along microfilament(GO:0031022) actin filament-based transport(GO:0099515) |
| 0.0 | 1.3 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 5.3 | GO:0008285 | negative regulation of cell proliferation(GO:0008285) |
| 0.0 | 0.2 | GO:0045604 | regulation of epidermal cell differentiation(GO:0045604) |
| 0.0 | 0.1 | GO:0070207 | protein homotrimerization(GO:0070207) |
| 0.0 | 0.4 | GO:0001824 | blastocyst development(GO:0001824) |
| 0.0 | 0.1 | GO:0035964 | COPI-coated vesicle budding(GO:0035964) Golgi vesicle budding(GO:0048194) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 5.2 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 1.1 | 19.3 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.4 | 5.3 | GO:0032059 | bleb(GO:0032059) |
| 0.4 | 1.3 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.3 | 1.8 | GO:0070435 | Shc-EGFR complex(GO:0070435) |
| 0.3 | 2.5 | GO:0031430 | M band(GO:0031430) |
| 0.2 | 3.4 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
| 0.2 | 3.1 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.2 | 1.9 | GO:0000145 | exocyst(GO:0000145) |
| 0.2 | 14.0 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 0.7 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
| 0.1 | 4.0 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 2.2 | GO:0031105 | septin complex(GO:0031105) septin cytoskeleton(GO:0032156) |
| 0.1 | 6.8 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 0.6 | GO:0002080 | acrosomal membrane(GO:0002080) |
| 0.1 | 1.3 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 0.6 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.1 | 1.6 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 20.9 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 0.3 | GO:0034750 | Scrib-APC-beta-catenin complex(GO:0034750) |
| 0.1 | 0.3 | GO:0071062 | alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 0.1 | 0.8 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.1 | 0.8 | GO:0000109 | nucleotide-excision repair complex(GO:0000109) |
| 0.1 | 1.6 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 0.2 | GO:0005900 | oncostatin-M receptor complex(GO:0005900) |
| 0.1 | 0.4 | GO:0005602 | complement component C1 complex(GO:0005602) |
| 0.1 | 5.8 | GO:0030426 | growth cone(GO:0030426) |
| 0.1 | 0.2 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.1 | 0.5 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 0.5 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.0 | 0.8 | GO:0008091 | spectrin(GO:0008091) |
| 0.0 | 1.2 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 0.2 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.0 | 0.4 | GO:0005915 | zonula adherens(GO:0005915) |
| 0.0 | 0.7 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 1.1 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 1.2 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 10.7 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 0.5 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.0 | 0.1 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.0 | 0.4 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.0 | 1.6 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 1.3 | GO:0016528 | sarcoplasm(GO:0016528) |
| 0.0 | 4.5 | GO:0030016 | myofibril(GO:0030016) |
| 0.0 | 0.5 | GO:0030132 | clathrin coat of coated pit(GO:0030132) |
| 0.0 | 1.3 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 0.4 | GO:0005849 | mRNA cleavage factor complex(GO:0005849) |
| 0.0 | 0.5 | GO:0031264 | death-inducing signaling complex(GO:0031264) |
| 0.0 | 0.2 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.0 | 0.8 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 1.3 | GO:0005626 | obsolete insoluble fraction(GO:0005626) |
| 0.0 | 1.3 | GO:0042383 | sarcolemma(GO:0042383) |
| 0.0 | 1.1 | GO:0043679 | axon terminus(GO:0043679) |
| 0.0 | 0.6 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 0.7 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 0.1 | GO:0000806 | Y chromosome(GO:0000806) |
| 0.0 | 0.3 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 0.1 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.0 | 1.6 | GO:0099568 | cytoplasmic region(GO:0099568) |
| 0.0 | 2.6 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.0 | 0.1 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.0 | 0.3 | GO:0043235 | receptor complex(GO:0043235) |
| 0.0 | 0.1 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.0 | 0.1 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.0 | 0.1 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.0 | 0.4 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.0 | 0.3 | GO:0001750 | photoreceptor outer segment(GO:0001750) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 8.6 | GO:0045545 | syndecan binding(GO:0045545) |
| 1.3 | 5.1 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 1.2 | 18.8 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.5 | 6.8 | GO:0042301 | phosphate ion binding(GO:0042301) |
| 0.5 | 2.3 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.4 | 1.6 | GO:0010698 | acetyltransferase activator activity(GO:0010698) |
| 0.4 | 12.5 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.4 | 1.1 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
| 0.4 | 2.2 | GO:0008269 | JAK pathway signal transduction adaptor activity(GO:0008269) |
| 0.3 | 3.5 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.3 | 2.1 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.3 | 1.3 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
| 0.3 | 0.9 | GO:0003881 | CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity(GO:0003881) |
| 0.3 | 2.3 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.3 | 2.1 | GO:0001758 | retinal dehydrogenase activity(GO:0001758) |
| 0.2 | 2.0 | GO:0004522 | ribonuclease A activity(GO:0004522) |
| 0.2 | 2.3 | GO:0004157 | dihydropyrimidinase activity(GO:0004157) |
| 0.2 | 1.5 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.2 | 4.3 | GO:0004859 | phospholipase inhibitor activity(GO:0004859) |
| 0.2 | 0.6 | GO:0070891 | peptidoglycan receptor activity(GO:0016019) lipoteichoic acid binding(GO:0070891) |
| 0.2 | 1.5 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.2 | 1.8 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.2 | 0.5 | GO:0050816 | beta-2 adrenergic receptor binding(GO:0031698) phosphothreonine binding(GO:0050816) |
| 0.2 | 0.8 | GO:0031694 | alpha-2A adrenergic receptor binding(GO:0031694) |
| 0.1 | 0.5 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.1 | 0.6 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.1 | 3.1 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.1 | 0.8 | GO:0042731 | PH domain binding(GO:0042731) |
| 0.1 | 0.8 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.1 | 0.6 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.1 | 0.4 | GO:0004505 | phenylalanine 4-monooxygenase activity(GO:0004505) |
| 0.1 | 0.4 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 0.1 | 1.3 | GO:0016493 | C-C chemokine receptor activity(GO:0016493) |
| 0.1 | 1.2 | GO:0016641 | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641) |
| 0.1 | 1.6 | GO:1905030 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.1 | 1.8 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.1 | 1.9 | GO:0008430 | selenium binding(GO:0008430) |
| 0.1 | 1.3 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.1 | 0.8 | GO:0070053 | thrombospondin receptor activity(GO:0070053) |
| 0.1 | 1.7 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.1 | 1.8 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.1 | 0.8 | GO:0004568 | chitinase activity(GO:0004568) |
| 0.1 | 3.1 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 0.8 | GO:0045309 | protein phosphorylated amino acid binding(GO:0045309) |
| 0.1 | 0.2 | GO:0004924 | oncostatin-M receptor activity(GO:0004924) |
| 0.1 | 8.1 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 0.2 | GO:0003796 | lysozyme activity(GO:0003796) |
| 0.1 | 0.1 | GO:0004476 | mannose-6-phosphate isomerase activity(GO:0004476) |
| 0.1 | 5.2 | GO:0046332 | SMAD binding(GO:0046332) |
| 0.1 | 1.4 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.1 | 3.1 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.1 | 0.7 | GO:0004117 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) |
| 0.1 | 0.3 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
| 0.1 | 0.7 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.1 | 1.1 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.1 | 5.3 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 0.9 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.1 | 0.2 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
| 0.1 | 5.5 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.1 | 0.2 | GO:0033867 | Fas-activated serine/threonine kinase activity(GO:0033867) |
| 0.1 | 0.2 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.1 | 0.2 | GO:0000033 | alpha-1,3-mannosyltransferase activity(GO:0000033) |
| 0.1 | 0.5 | GO:0030169 | low-density lipoprotein particle binding(GO:0030169) |
| 0.1 | 0.4 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.1 | 0.2 | GO:0005402 | sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) |
| 0.0 | 2.8 | GO:0050681 | androgen receptor binding(GO:0050681) |
| 0.0 | 0.3 | GO:0004703 | G-protein coupled receptor kinase activity(GO:0004703) |
| 0.0 | 1.0 | GO:0043499 | obsolete eukaryotic cell surface binding(GO:0043499) |
| 0.0 | 0.3 | GO:0008020 | G-protein coupled photoreceptor activity(GO:0008020) |
| 0.0 | 1.2 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 1.3 | GO:1990782 | receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782) |
| 0.0 | 0.3 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 0.3 | GO:0047045 | testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045) |
| 0.0 | 1.4 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 0.4 | GO:0070513 | death domain binding(GO:0070513) |
| 0.0 | 7.8 | GO:0005516 | calmodulin binding(GO:0005516) |
| 0.0 | 0.4 | GO:0005338 | nucleotide-sugar transmembrane transporter activity(GO:0005338) |
| 0.0 | 0.4 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.0 | 0.3 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.0 | 0.1 | GO:0004797 | thymidine kinase activity(GO:0004797) |
| 0.0 | 1.1 | GO:0043028 | cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028) |
| 0.0 | 1.9 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.0 | 0.6 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.0 | 0.2 | GO:0004995 | tachykinin receptor activity(GO:0004995) |
| 0.0 | 0.2 | GO:0008271 | secondary active sulfate transmembrane transporter activity(GO:0008271) |
| 0.0 | 5.6 | GO:0004866 | endopeptidase inhibitor activity(GO:0004866) |
| 0.0 | 0.1 | GO:0034713 | type I transforming growth factor beta receptor binding(GO:0034713) |
| 0.0 | 0.2 | GO:0030229 | very-low-density lipoprotein particle receptor activity(GO:0030229) |
| 0.0 | 3.2 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389) |
| 0.0 | 0.5 | GO:0042809 | vitamin D receptor binding(GO:0042809) |
| 0.0 | 0.1 | GO:0001632 | leukotriene B4 receptor activity(GO:0001632) |
| 0.0 | 0.4 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 0.0 | 0.3 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.0 | 0.5 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.0 | 0.2 | GO:0046790 | virion binding(GO:0046790) |
| 0.0 | 0.9 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 0.1 | GO:0034594 | phosphatidylinositol trisphosphate phosphatase activity(GO:0034594) |
| 0.0 | 0.1 | GO:0050833 | pyruvate secondary active transmembrane transporter activity(GO:0005477) pyruvate transmembrane transporter activity(GO:0050833) |
| 0.0 | 0.3 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.0 | 0.7 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 0.1 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) |
| 0.0 | 0.2 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.0 | 0.1 | GO:0004985 | opioid receptor activity(GO:0004985) |
| 0.0 | 0.2 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) |
| 0.0 | 0.2 | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450) |
| 0.0 | 0.7 | GO:0008601 | protein phosphatase type 2A regulator activity(GO:0008601) |
| 0.0 | 0.1 | GO:0061505 | DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505) |
| 0.0 | 0.2 | GO:0019826 | oxygen sensor activity(GO:0019826) |
| 0.0 | 3.3 | GO:0004721 | phosphoprotein phosphatase activity(GO:0004721) |
| 0.0 | 0.2 | GO:0004559 | alpha-mannosidase activity(GO:0004559) |
| 0.0 | 0.8 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.0 | 0.1 | GO:0019789 | SUMO transferase activity(GO:0019789) |
| 0.0 | 0.2 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.0 | 0.2 | GO:0004065 | arylsulfatase activity(GO:0004065) |
| 0.0 | 0.0 | GO:0008599 | protein phosphatase type 1 regulator activity(GO:0008599) |
| 0.0 | 0.4 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 0.3 | GO:0004622 | lysophospholipase activity(GO:0004622) |
| 0.0 | 0.1 | GO:0000268 | peroxisome targeting sequence binding(GO:0000268) |
| 0.0 | 0.1 | GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616) |
| 0.0 | 0.3 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.0 | 1.1 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.0 | 0.2 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 0.1 | GO:0051378 | serotonin binding(GO:0051378) |
| 0.0 | 0.2 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.0 | 2.0 | GO:0008022 | protein C-terminus binding(GO:0008022) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 2.6 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 0.8 | ST_GA12_PATHWAY | G alpha 12 Pathway |
| 0.0 | 1.6 | SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.0 | 0.5 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.5 | ST_TUMOR_NECROSIS_FACTOR_PATHWAY | Tumor Necrosis Factor Pathway. |
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