Motif ID: STAT4
Z-value: 1.324
Transcription factors associated with STAT4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| STAT4 | ENSG00000138378.13 | STAT4 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 6.1 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 1.1 | 8.5 | GO:0003065 | regulation of heart rate by chemical signal(GO:0003062) positive regulation of heart rate by epinephrine(GO:0003065) |
| 0.8 | 2.4 | GO:0007412 | axon target recognition(GO:0007412) |
| 0.6 | 1.8 | GO:0060279 | progesterone secretion(GO:0042701) regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279) |
| 0.4 | 1.6 | GO:0031340 | positive regulation of vesicle fusion(GO:0031340) |
| 0.2 | 1.1 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
| 0.2 | 5.1 | GO:0030199 | collagen fibril organization(GO:0030199) |
| 0.2 | 1.8 | GO:0007351 | tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595) |
| 0.2 | 1.9 | GO:0055093 | response to increased oxygen levels(GO:0036296) response to hyperoxia(GO:0055093) |
| 0.2 | 1.0 | GO:0032460 | negative regulation of protein oligomerization(GO:0032460) negative regulation of protein homooligomerization(GO:0032463) |
| 0.1 | 2.0 | GO:0050872 | white fat cell differentiation(GO:0050872) |
| 0.1 | 0.9 | GO:0044413 | evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834) |
| 0.1 | 0.6 | GO:0070682 | proteasome regulatory particle assembly(GO:0070682) |
| 0.1 | 1.0 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
| 0.1 | 0.3 | GO:0007403 | glial cell fate determination(GO:0007403) |
| 0.1 | 0.8 | GO:0045898 | regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) |
| 0.1 | 0.2 | GO:0044314 | protein K27-linked ubiquitination(GO:0044314) |
| 0.1 | 0.3 | GO:0006848 | pyruvate transport(GO:0006848) |
| 0.1 | 0.3 | GO:0009296 | obsolete flagellum assembly(GO:0009296) |
| 0.1 | 3.5 | GO:0071377 | cellular response to glucagon stimulus(GO:0071377) |
| 0.1 | 1.5 | GO:0042554 | superoxide anion generation(GO:0042554) |
| 0.0 | 0.6 | GO:0033523 | histone monoubiquitination(GO:0010390) histone H2B ubiquitination(GO:0033523) |
| 0.0 | 0.6 | GO:0045351 | type I interferon biosynthetic process(GO:0045351) |
| 0.0 | 0.5 | GO:0048557 | embryonic digestive tract morphogenesis(GO:0048557) |
| 0.0 | 0.3 | GO:0006516 | glycoprotein catabolic process(GO:0006516) |
| 0.0 | 0.2 | GO:0045722 | positive regulation of gluconeogenesis(GO:0045722) |
| 0.0 | 0.3 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 0.0 | 0.3 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
| 0.0 | 0.2 | GO:0033119 | negative regulation of RNA splicing(GO:0033119) |
| 0.0 | 0.4 | GO:0045599 | negative regulation of fat cell differentiation(GO:0045599) |
| 0.0 | 0.2 | GO:0007598 | blood coagulation, extrinsic pathway(GO:0007598) |
| 0.0 | 0.1 | GO:0090281 | negative regulation of calcium ion import(GO:0090281) |
| 0.0 | 1.4 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.0 | 0.3 | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol(GO:0051281) |
| 0.0 | 1.3 | GO:0006665 | sphingolipid metabolic process(GO:0006665) |
| 0.0 | 1.0 | GO:0006826 | iron ion transport(GO:0006826) |
| 0.0 | 1.9 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 0.1 | GO:0032703 | negative regulation of interleukin-2 production(GO:0032703) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 3.6 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.7 | 8.5 | GO:0032059 | bleb(GO:0032059) |
| 0.6 | 1.9 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 0.6 | 1.8 | GO:0043512 | inhibin complex(GO:0043511) inhibin A complex(GO:0043512) |
| 0.2 | 0.6 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.1 | 0.6 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) |
| 0.1 | 3.5 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 5.8 | GO:0044853 | caveola(GO:0005901) plasma membrane raft(GO:0044853) |
| 0.1 | 1.0 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.0 | 0.3 | GO:0031512 | motile primary cilium(GO:0031512) |
| 0.0 | 1.4 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.0 | 1.5 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 2.0 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 1.6 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 0.9 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 0.1 | GO:0030315 | T-tubule(GO:0030315) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 1.8 | GO:0048184 | obsolete follistatin binding(GO:0048184) |
| 0.5 | 2.4 | GO:0031694 | alpha-2A adrenergic receptor binding(GO:0031694) |
| 0.3 | 1.0 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
| 0.3 | 3.5 | GO:0042301 | phosphate ion binding(GO:0042301) |
| 0.2 | 1.1 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
| 0.2 | 1.5 | GO:0019826 | oxygen sensor activity(GO:0019826) |
| 0.1 | 0.9 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.1 | 1.5 | GO:0016641 | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641) |
| 0.1 | 1.9 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) cyclin binding(GO:0030332) |
| 0.1 | 8.0 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 0.3 | GO:0004947 | bradykinin receptor activity(GO:0004947) |
| 0.1 | 0.7 | GO:0004522 | ribonuclease A activity(GO:0004522) |
| 0.1 | 1.6 | GO:0004859 | phospholipase inhibitor activity(GO:0004859) |
| 0.1 | 0.3 | GO:0050833 | pyruvate secondary active transmembrane transporter activity(GO:0005477) pyruvate transmembrane transporter activity(GO:0050833) |
| 0.1 | 1.0 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.1 | 3.6 | GO:0046332 | SMAD binding(GO:0046332) |
| 0.1 | 0.3 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.0 | 1.4 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 0.2 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.0 | 0.3 | GO:0030371 | translation repressor activity(GO:0030371) |
| 0.0 | 0.3 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
| 0.0 | 0.3 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.0 | 6.5 | GO:0005543 | phospholipid binding(GO:0005543) |
| 0.0 | 2.0 | GO:0051287 | NAD binding(GO:0051287) |
| 0.0 | 0.6 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.0 | 0.4 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.0 | 0.3 | GO:0005522 | profilin binding(GO:0005522) |
| 0.0 | 3.3 | GO:0030528 | obsolete transcription regulator activity(GO:0030528) |
| 0.0 | 0.1 | GO:0047498 | calcium-dependent phospholipase A2 activity(GO:0047498) |
| 0.0 | 0.0 | GO:0017057 | glucose-6-phosphate dehydrogenase activity(GO:0004345) 6-phosphogluconolactonase activity(GO:0017057) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.9 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
