Motif ID: STAT5A
Z-value: 1.709
Transcription factors associated with STAT5A:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| STAT5A | ENSG00000126561.12 | STAT5A |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.2 | GO:0002901 | mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906) purine nucleotide salvage(GO:0032261) nucleotide salvage(GO:0043173) inosine metabolic process(GO:0046102) xanthine metabolic process(GO:0046110) |
| 0.6 | 1.1 | GO:0002478 | antigen processing and presentation of exogenous peptide antigen(GO:0002478) |
| 0.5 | 1.5 | GO:0002431 | Fc receptor mediated stimulatory signaling pathway(GO:0002431) regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060368) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369) |
| 0.5 | 0.9 | GO:0002678 | positive regulation of chronic inflammatory response(GO:0002678) regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) |
| 0.5 | 1.8 | GO:0002313 | mature B cell differentiation involved in immune response(GO:0002313) |
| 0.4 | 1.2 | GO:0045062 | extrathymic T cell differentiation(GO:0033078) extrathymic T cell selection(GO:0045062) |
| 0.4 | 0.4 | GO:0002439 | chronic inflammatory response to antigenic stimulus(GO:0002439) |
| 0.4 | 1.2 | GO:0070340 | detection of bacterial lipoprotein(GO:0042494) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340) response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727) |
| 0.4 | 1.2 | GO:0035608 | protein deglutamylation(GO:0035608) |
| 0.4 | 1.1 | GO:0030205 | dermatan sulfate metabolic process(GO:0030205) dermatan sulfate biosynthetic process(GO:0030208) |
| 0.4 | 1.8 | GO:0006927 | obsolete transformed cell apoptotic process(GO:0006927) |
| 0.4 | 9.0 | GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504) |
| 0.3 | 1.6 | GO:0035455 | response to interferon-alpha(GO:0035455) |
| 0.3 | 1.2 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 0.3 | 0.6 | GO:0002693 | positive regulation of cellular extravasation(GO:0002693) |
| 0.3 | 0.9 | GO:0033632 | regulation of cell-cell adhesion mediated by integrin(GO:0033632) |
| 0.2 | 0.7 | GO:0021836 | chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923) |
| 0.2 | 0.6 | GO:0034135 | innate immune response in mucosa(GO:0002227) mucosal immune response(GO:0002385) antimicrobial humoral response(GO:0019730) antibacterial humoral response(GO:0019731) interleukin-18 production(GO:0032621) regulation of interleukin-18 production(GO:0032661) regulation of toll-like receptor 2 signaling pathway(GO:0034135) activation of MAPK activity involved in innate immune response(GO:0035419) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585) cellular response to peptidoglycan(GO:0071224) |
| 0.2 | 1.2 | GO:0060263 | regulation of respiratory burst(GO:0060263) |
| 0.2 | 1.9 | GO:0009404 | toxin metabolic process(GO:0009404) |
| 0.2 | 0.6 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780) stem cell fate commitment(GO:0048865) stem cell fate determination(GO:0048867) |
| 0.2 | 0.5 | GO:0002035 | brain renin-angiotensin system(GO:0002035) |
| 0.2 | 0.5 | GO:0071603 | negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) endothelial cell-cell adhesion(GO:0071603) |
| 0.2 | 0.8 | GO:0060292 | long term synaptic depression(GO:0060292) |
| 0.2 | 0.7 | GO:0060259 | regulation of feeding behavior(GO:0060259) |
| 0.2 | 4.7 | GO:0030224 | monocyte differentiation(GO:0030224) |
| 0.2 | 0.5 | GO:0032328 | alanine transport(GO:0032328) |
| 0.2 | 0.3 | GO:0010248 | establishment or maintenance of transmembrane electrochemical gradient(GO:0010248) |
| 0.2 | 0.5 | GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002) |
| 0.1 | 0.4 | GO:0006435 | threonyl-tRNA aminoacylation(GO:0006435) |
| 0.1 | 0.4 | GO:0045198 | establishment of epithelial cell apical/basal polarity(GO:0045198) |
| 0.1 | 0.5 | GO:0046121 | deoxyribonucleoside catabolic process(GO:0046121) |
| 0.1 | 0.5 | GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process(GO:0042535) |
| 0.1 | 0.7 | GO:0099515 | nuclear migration along microfilament(GO:0031022) actin filament-based transport(GO:0099515) |
| 0.1 | 1.1 | GO:0015074 | DNA integration(GO:0015074) |
| 0.1 | 0.3 | GO:0043550 | regulation of lipid kinase activity(GO:0043550) |
| 0.1 | 0.2 | GO:0051365 | cellular response to potassium ion starvation(GO:0051365) |
| 0.1 | 0.5 | GO:0010447 | response to acidic pH(GO:0010447) |
| 0.1 | 0.3 | GO:0033622 | integrin activation(GO:0033622) regulation of integrin activation(GO:0033623) positive regulation of integrin activation(GO:0033625) |
| 0.1 | 0.3 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 0.1 | 0.2 | GO:0010701 | positive regulation of norepinephrine secretion(GO:0010701) |
| 0.1 | 1.0 | GO:0046827 | positive regulation of protein export from nucleus(GO:0046827) |
| 0.1 | 2.4 | GO:0060334 | regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334) |
| 0.1 | 0.2 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
| 0.1 | 0.3 | GO:0060649 | nipple development(GO:0060618) mammary gland bud elongation(GO:0060649) nipple morphogenesis(GO:0060658) nipple sheath formation(GO:0060659) |
| 0.1 | 0.4 | GO:0042905 | retinal metabolic process(GO:0042574) 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.1 | 0.4 | GO:0046677 | response to antibiotic(GO:0046677) |
| 0.1 | 0.5 | GO:0051323 | chiasma assembly(GO:0051026) metaphase(GO:0051323) |
| 0.1 | 0.1 | GO:0006104 | succinyl-CoA metabolic process(GO:0006104) |
| 0.1 | 0.5 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064) |
| 0.1 | 0.2 | GO:0018243 | protein O-linked glycosylation via serine(GO:0018242) protein O-linked glycosylation via threonine(GO:0018243) |
| 0.1 | 0.2 | GO:0006273 | DNA replication, synthesis of RNA primer(GO:0006269) lagging strand elongation(GO:0006273) |
| 0.1 | 1.2 | GO:0030889 | negative regulation of B cell proliferation(GO:0030889) |
| 0.1 | 0.6 | GO:0051973 | positive regulation of telomerase activity(GO:0051973) |
| 0.1 | 0.3 | GO:0006848 | pyruvate transport(GO:0006848) |
| 0.1 | 0.3 | GO:0022614 | membrane to membrane docking(GO:0022614) |
| 0.1 | 0.2 | GO:0043461 | proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272) |
| 0.1 | 0.5 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
| 0.1 | 0.5 | GO:0015705 | iodide transport(GO:0015705) |
| 0.1 | 4.5 | GO:0071357 | response to type I interferon(GO:0034340) type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 0.1 | 0.3 | GO:0018106 | peptidyl-histidine phosphorylation(GO:0018106) |
| 0.1 | 0.3 | GO:0045654 | positive regulation of megakaryocyte differentiation(GO:0045654) positive regulation of hematopoietic progenitor cell differentiation(GO:1901534) |
| 0.1 | 0.2 | GO:0002689 | negative regulation of leukocyte chemotaxis(GO:0002689) |
| 0.1 | 0.3 | GO:0032516 | positive regulation of phosphoprotein phosphatase activity(GO:0032516) |
| 0.1 | 0.1 | GO:0060291 | long-term synaptic potentiation(GO:0060291) |
| 0.0 | 0.1 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.0 | 0.1 | GO:0090162 | establishment of epithelial cell polarity(GO:0090162) |
| 0.0 | 0.1 | GO:0046080 | dUTP metabolic process(GO:0046080) |
| 0.0 | 0.1 | GO:0045475 | locomotor rhythm(GO:0045475) |
| 0.0 | 0.2 | GO:0071418 | uroporphyrinogen III biosynthetic process(GO:0006780) cellular response to amine stimulus(GO:0071418) |
| 0.0 | 0.3 | GO:0000012 | single strand break repair(GO:0000012) |
| 0.0 | 0.4 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.0 | 0.3 | GO:0042989 | sequestering of actin monomers(GO:0042989) |
| 0.0 | 0.1 | GO:0019853 | L-ascorbic acid biosynthetic process(GO:0019853) |
| 0.0 | 0.1 | GO:0010586 | miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587) |
| 0.0 | 0.1 | GO:0031034 | skeletal muscle myosin thick filament assembly(GO:0030241) myosin filament assembly(GO:0031034) striated muscle myosin thick filament assembly(GO:0071688) |
| 0.0 | 0.1 | GO:0021896 | forebrain astrocyte differentiation(GO:0021896) forebrain astrocyte development(GO:0021897) |
| 0.0 | 0.2 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.0 | 0.3 | GO:0006893 | Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876) |
| 0.0 | 0.2 | GO:0060632 | regulation of microtubule-based movement(GO:0060632) |
| 0.0 | 0.3 | GO:0046618 | tetracycline transport(GO:0015904) antibiotic transport(GO:0042891) drug export(GO:0046618) toxin transport(GO:1901998) |
| 0.0 | 0.6 | GO:0045730 | respiratory burst(GO:0045730) |
| 0.0 | 0.5 | GO:0032876 | regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023) |
| 0.0 | 0.9 | GO:0006911 | phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324) |
| 0.0 | 0.1 | GO:0032416 | negative regulation of sodium:proton antiporter activity(GO:0032416) musculoskeletal movement, spinal reflex action(GO:0050883) negative regulation of sodium ion transmembrane transport(GO:1902306) negative regulation of sodium ion transmembrane transporter activity(GO:2000650) |
| 0.0 | 0.1 | GO:0001552 | ovarian follicle atresia(GO:0001552) |
| 0.0 | 0.3 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.0 | 0.1 | GO:0000389 | mRNA 3'-splice site recognition(GO:0000389) |
| 0.0 | 0.9 | GO:0051925 | obsolete regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051925) |
| 0.0 | 0.4 | GO:0019228 | neuronal action potential(GO:0019228) |
| 0.0 | 0.1 | GO:0070935 | positive regulation of interleukin-23 production(GO:0032747) 3'-UTR-mediated mRNA stabilization(GO:0070935) |
| 0.0 | 0.4 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.0 | 0.0 | GO:0034014 | response to triglyceride(GO:0034014) |
| 0.0 | 0.1 | GO:0016074 | snoRNA metabolic process(GO:0016074) |
| 0.0 | 0.3 | GO:0042269 | regulation of natural killer cell mediated immunity(GO:0002715) positive regulation of natural killer cell mediated immunity(GO:0002717) regulation of natural killer cell mediated cytotoxicity(GO:0042269) positive regulation of natural killer cell mediated cytotoxicity(GO:0045954) |
| 0.0 | 0.1 | GO:0051534 | negative regulation of NFAT protein import into nucleus(GO:0051534) |
| 0.0 | 0.2 | GO:0045945 | positive regulation of transcription from RNA polymerase III promoter(GO:0045945) |
| 0.0 | 0.1 | GO:0070092 | regulation of glucagon secretion(GO:0070092) |
| 0.0 | 0.2 | GO:0003032 | detection of oxygen(GO:0003032) |
| 0.0 | 0.1 | GO:0052805 | histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805) |
| 0.0 | 0.6 | GO:0006349 | regulation of gene expression by genetic imprinting(GO:0006349) |
| 0.0 | 0.2 | GO:0032957 | inositol trisphosphate metabolic process(GO:0032957) |
| 0.0 | 0.4 | GO:0075713 | establishment of viral latency(GO:0019043) establishment of integrated proviral latency(GO:0075713) |
| 0.0 | 0.1 | GO:0043353 | enucleate erythrocyte differentiation(GO:0043353) |
| 0.0 | 0.1 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.0 | 0.2 | GO:0005984 | disaccharide metabolic process(GO:0005984) |
| 0.0 | 0.2 | GO:0051898 | negative regulation of protein kinase B signaling(GO:0051898) |
| 0.0 | 0.1 | GO:0009450 | gamma-aminobutyric acid catabolic process(GO:0009450) |
| 0.0 | 0.5 | GO:0014046 | dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059) |
| 0.0 | 0.3 | GO:0014009 | response to lithium ion(GO:0010226) glial cell proliferation(GO:0014009) |
| 0.0 | 0.1 | GO:0071400 | cellular response to oleic acid(GO:0071400) |
| 0.0 | 0.2 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.0 | 0.9 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
| 0.0 | 0.2 | GO:0002031 | G-protein coupled receptor internalization(GO:0002031) |
| 0.0 | 0.9 | GO:0007205 | protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205) |
| 0.0 | 0.0 | GO:0002833 | positive regulation of response to biotic stimulus(GO:0002833) |
| 0.0 | 0.1 | GO:0032878 | regulation of establishment or maintenance of cell polarity(GO:0032878) |
| 0.0 | 0.8 | GO:0045576 | mast cell activation(GO:0045576) |
| 0.0 | 0.6 | GO:0030101 | natural killer cell activation(GO:0030101) |
| 0.0 | 0.2 | GO:0035019 | somatic stem cell population maintenance(GO:0035019) |
| 0.0 | 0.1 | GO:0060068 | vagina development(GO:0060068) |
| 0.0 | 1.2 | GO:1904018 | positive regulation of angiogenesis(GO:0045766) positive regulation of vasculature development(GO:1904018) |
| 0.0 | 0.5 | GO:1904894 | positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894) |
| 0.0 | 0.1 | GO:0010508 | positive regulation of autophagy(GO:0010508) |
| 0.0 | 0.1 | GO:0015742 | alpha-ketoglutarate transport(GO:0015742) |
| 0.0 | 0.0 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.0 | 0.1 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
| 0.0 | 0.0 | GO:0055005 | optic placode formation involved in camera-type eye formation(GO:0046619) venous blood vessel morphogenesis(GO:0048845) ventricular cardiac myofibril assembly(GO:0055005) embryonic retina morphogenesis in camera-type eye(GO:0060059) regulation of sarcomere organization(GO:0060297) positive regulation of sarcomere organization(GO:0060298) regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251) |
| 0.0 | 0.0 | GO:0042369 | vitamin D catabolic process(GO:0042369) |
| 0.0 | 0.0 | GO:0071109 | superior temporal gyrus development(GO:0071109) |
| 0.0 | 0.6 | GO:0009451 | RNA modification(GO:0009451) |
| 0.0 | 0.0 | GO:0010430 | ethanol catabolic process(GO:0006068) fatty acid omega-oxidation(GO:0010430) |
| 0.0 | 0.2 | GO:0032703 | negative regulation of interleukin-2 production(GO:0032703) |
| 0.0 | 0.0 | GO:0006471 | protein ADP-ribosylation(GO:0006471) |
| 0.0 | 0.1 | GO:0000090 | mitotic anaphase(GO:0000090) |
| 0.0 | 0.1 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.0 | 0.2 | GO:0008635 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635) |
| 0.0 | 1.3 | GO:0006401 | RNA catabolic process(GO:0006401) |
| 0.0 | 0.6 | GO:0006953 | acute-phase response(GO:0006953) |
| 0.0 | 0.1 | GO:0008653 | lipopolysaccharide metabolic process(GO:0008653) |
| 0.0 | 0.1 | GO:0000266 | mitochondrial fission(GO:0000266) |
| 0.0 | 0.1 | GO:0007512 | adult heart development(GO:0007512) |
| 0.0 | 0.2 | GO:0035024 | negative regulation of Rho protein signal transduction(GO:0035024) |
| 0.0 | 0.2 | GO:0071260 | cellular response to mechanical stimulus(GO:0071260) |
| 0.0 | 0.3 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.0 | 0.3 | GO:0050892 | intestinal absorption(GO:0050892) |
| 0.0 | 0.1 | GO:0015722 | canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782) |
| 0.0 | 1.3 | GO:0006898 | receptor-mediated endocytosis(GO:0006898) |
| 0.0 | 0.2 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) muscle cell cellular homeostasis(GO:0046716) |
| 0.0 | 0.9 | GO:0031295 | lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295) |
| 0.0 | 1.3 | GO:0034134 | toll-like receptor 1 signaling pathway(GO:0034130) toll-like receptor 2 signaling pathway(GO:0034134) |
| 0.0 | 0.1 | GO:0034643 | establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497) |
| 0.0 | 0.1 | GO:0060707 | trophoblast giant cell differentiation(GO:0060707) |
| 0.0 | 0.1 | GO:0040023 | establishment of nucleus localization(GO:0040023) |
| 0.0 | 0.2 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.0 | 0.0 | GO:0001821 | histamine secretion(GO:0001821) |
| 0.0 | 0.1 | GO:0035329 | hippo signaling(GO:0035329) |
| 0.0 | 0.1 | GO:0035964 | COPI-coated vesicle budding(GO:0035964) Golgi vesicle budding(GO:0048194) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205) |
| 0.0 | 0.5 | GO:0051017 | actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 9.0 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.4 | 1.2 | GO:0035354 | Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354) |
| 0.2 | 2.2 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.2 | 1.2 | GO:0042825 | TAP complex(GO:0042825) |
| 0.2 | 1.9 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.1 | 1.9 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.1 | 1.3 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.1 | 0.6 | GO:0045179 | apical cortex(GO:0045179) |
| 0.1 | 0.5 | GO:0031205 | endoplasmic reticulum Sec complex(GO:0031205) |
| 0.1 | 1.5 | GO:0001527 | microfibril(GO:0001527) |
| 0.1 | 0.3 | GO:0030895 | apolipoprotein B mRNA editing enzyme complex(GO:0030895) |
| 0.1 | 0.2 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.1 | 1.5 | GO:0034362 | low-density lipoprotein particle(GO:0034362) |
| 0.1 | 0.5 | GO:0001739 | sex chromatin(GO:0001739) |
| 0.1 | 0.9 | GO:0005922 | connexon complex(GO:0005922) |
| 0.1 | 0.7 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.1 | 0.3 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.0 | 0.5 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 1.1 | GO:0000299 | obsolete integral to membrane of membrane fraction(GO:0000299) |
| 0.0 | 0.6 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 0.2 | GO:0071062 | alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 0.0 | 0.1 | GO:0000800 | lateral element(GO:0000800) |
| 0.0 | 0.2 | GO:0045298 | tubulin complex(GO:0045298) |
| 0.0 | 0.5 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.0 | 0.2 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 0.0 | 0.4 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.0 | 0.3 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 0.0 | 0.1 | GO:0032144 | 4-aminobutyrate transaminase complex(GO:0032144) |
| 0.0 | 0.2 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
| 0.0 | 0.6 | GO:0019861 | obsolete flagellum(GO:0019861) |
| 0.0 | 0.9 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.0 | 0.2 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.0 | 0.4 | GO:0005606 | laminin-1 complex(GO:0005606) |
| 0.0 | 0.2 | GO:0005587 | collagen type IV trimer(GO:0005587) |
| 0.0 | 0.3 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.0 | 0.1 | GO:0030062 | mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062) |
| 0.0 | 0.1 | GO:0001652 | granular component(GO:0001652) |
| 0.0 | 0.2 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.0 | 0.1 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 0.0 | 0.2 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.0 | 0.4 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.0 | 0.1 | GO:0030868 | smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425) |
| 0.0 | 0.4 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.0 | 0.1 | GO:0005899 | insulin receptor complex(GO:0005899) |
| 0.0 | 0.5 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.0 | 0.2 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 0.1 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.0 | 0.4 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.0 | 0.7 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 0.2 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.0 | 1.9 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.0 | 0.1 | GO:0031430 | M band(GO:0031430) |
| 0.0 | 0.1 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.0 | 0.2 | GO:0030137 | COPI-coated vesicle(GO:0030137) |
| 0.0 | 0.6 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 0.1 | GO:0046930 | pore complex(GO:0046930) |
| 0.0 | 0.2 | GO:0005675 | holo TFIIH complex(GO:0005675) |
| 0.0 | 0.3 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.5 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 0.4 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.0 | 0.3 | GO:0005640 | nuclear outer membrane(GO:0005640) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 7.7 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.5 | 1.6 | GO:0019962 | type I interferon binding(GO:0019962) |
| 0.3 | 0.8 | GO:0003953 | NAD+ nucleosidase activity(GO:0003953) |
| 0.3 | 1.1 | GO:0008907 | integrase activity(GO:0008907) |
| 0.2 | 1.2 | GO:0046980 | oligopeptide-transporting ATPase activity(GO:0015421) tapasin binding(GO:0046980) |
| 0.2 | 1.1 | GO:0004906 | interferon-gamma receptor activity(GO:0004906) |
| 0.2 | 2.2 | GO:0004000 | adenosine deaminase activity(GO:0004000) |
| 0.2 | 0.6 | GO:0004618 | phosphoglycerate kinase activity(GO:0004618) |
| 0.2 | 0.5 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
| 0.2 | 0.5 | GO:0004139 | deoxyribose-phosphate aldolase activity(GO:0004139) |
| 0.2 | 0.5 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.2 | 1.7 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.2 | 0.5 | GO:0005224 | ATP-binding and phosphorylation-dependent chloride channel activity(GO:0005224) channel-conductance-controlling ATPase activity(GO:0005260) |
| 0.2 | 0.5 | GO:0004796 | thromboxane-A synthase activity(GO:0004796) |
| 0.2 | 0.2 | GO:0004461 | lactose synthase activity(GO:0004461) |
| 0.2 | 0.5 | GO:0015193 | L-proline transmembrane transporter activity(GO:0015193) |
| 0.1 | 0.4 | GO:0004829 | threonine-tRNA ligase activity(GO:0004829) |
| 0.1 | 0.9 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.1 | 2.3 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) |
| 0.1 | 0.4 | GO:0071723 | lipopeptide binding(GO:0071723) |
| 0.1 | 0.3 | GO:0008545 | JUN kinase kinase activity(GO:0008545) |
| 0.1 | 1.1 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
| 0.1 | 0.4 | GO:0010698 | acetyltransferase activator activity(GO:0010698) |
| 0.1 | 0.6 | GO:0050700 | CARD domain binding(GO:0050700) |
| 0.1 | 0.6 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.1 | 0.3 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.1 | 1.0 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.1 | 0.3 | GO:0070259 | tyrosyl-DNA phosphodiesterase activity(GO:0070259) |
| 0.1 | 0.2 | GO:0010485 | H4 histone acetyltransferase activity(GO:0010485) |
| 0.1 | 0.2 | GO:0051765 | obsolete inositol-1,3,4-trisphosphate 5/6-kinase activity(GO:0035300) inositol tetrakisphosphate 1-kinase activity(GO:0047325) inositol tetrakisphosphate kinase activity(GO:0051765) |
| 0.1 | 1.9 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.1 | 1.7 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.1 | 0.9 | GO:0030547 | receptor inhibitor activity(GO:0030547) receptor antagonist activity(GO:0048019) |
| 0.1 | 1.7 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.1 | 0.3 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
| 0.1 | 0.9 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.1 | 0.2 | GO:0003896 | DNA primase activity(GO:0003896) |
| 0.1 | 0.3 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.1 | 0.3 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
| 0.1 | 0.3 | GO:0050833 | pyruvate secondary active transmembrane transporter activity(GO:0005477) pyruvate transmembrane transporter activity(GO:0050833) |
| 0.1 | 0.4 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.1 | 0.4 | GO:0003945 | N-acetyllactosamine synthase activity(GO:0003945) |
| 0.1 | 0.8 | GO:0003840 | gamma-glutamyltransferase activity(GO:0003840) |
| 0.1 | 0.5 | GO:0042153 | obsolete RPTP-like protein binding(GO:0042153) alpha-catenin binding(GO:0045294) |
| 0.1 | 0.3 | GO:0015520 | tetracycline:proton antiporter activity(GO:0015520) |
| 0.1 | 1.6 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 0.2 | GO:0034481 | chondroitin sulfotransferase activity(GO:0034481) |
| 0.1 | 0.2 | GO:0070679 | inositol 1,4,5 trisphosphate binding(GO:0070679) |
| 0.1 | 0.2 | GO:0034190 | apolipoprotein receptor binding(GO:0034190) |
| 0.0 | 0.1 | GO:0004528 | phosphodiesterase I activity(GO:0004528) |
| 0.0 | 0.1 | GO:0004170 | dUTP diphosphatase activity(GO:0004170) |
| 0.0 | 0.4 | GO:0001758 | retinal dehydrogenase activity(GO:0001758) |
| 0.0 | 0.2 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.0 | 0.1 | GO:0003878 | ATP citrate synthase activity(GO:0003878) |
| 0.0 | 0.7 | GO:0032393 | MHC class I receptor activity(GO:0032393) |
| 0.0 | 0.2 | GO:0004852 | uroporphyrinogen-III synthase activity(GO:0004852) |
| 0.0 | 0.2 | GO:0003720 | telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964) |
| 0.0 | 1.0 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 1.1 | GO:0030169 | low-density lipoprotein particle binding(GO:0030169) |
| 0.0 | 0.1 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
| 0.0 | 0.1 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.0 | 0.3 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.0 | 0.4 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 0.0 | 0.6 | GO:0004908 | interleukin-1 receptor activity(GO:0004908) |
| 0.0 | 0.3 | GO:0030250 | cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250) |
| 0.0 | 0.2 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.0 | 0.3 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 0.4 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 0.0 | 0.1 | GO:0032145 | 4-aminobutyrate transaminase activity(GO:0003867) succinate-semialdehyde dehydrogenase binding(GO:0032145) (S)-3-amino-2-methylpropionate transaminase activity(GO:0047298) |
| 0.0 | 0.1 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 0.5 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.0 | 0.1 | GO:0015018 | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018) |
| 0.0 | 0.4 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.0 | 1.6 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 0.8 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.0 | 0.2 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.0 | 0.2 | GO:0004447 | iodide peroxidase activity(GO:0004447) |
| 0.0 | 0.6 | GO:0043498 | obsolete cell surface binding(GO:0043498) |
| 0.0 | 0.6 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.2 | GO:0003872 | 6-phosphofructokinase activity(GO:0003872) |
| 0.0 | 1.3 | GO:0003704 | obsolete specific RNA polymerase II transcription factor activity(GO:0003704) |
| 0.0 | 0.3 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.0 | 0.1 | GO:0005010 | insulin-like growth factor-activated receptor activity(GO:0005010) |
| 0.0 | 0.6 | GO:0043499 | obsolete eukaryotic cell surface binding(GO:0043499) |
| 0.0 | 0.0 | GO:0016251 | obsolete general RNA polymerase II transcription factor activity(GO:0016251) |
| 0.0 | 0.1 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.0 | 0.4 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 0.1 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.0 | 0.6 | GO:0008373 | sialyltransferase activity(GO:0008373) |
| 0.0 | 0.7 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.0 | 0.1 | GO:0033743 | peptide-methionine (R)-S-oxide reductase activity(GO:0033743) |
| 0.0 | 0.3 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.0 | 0.2 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.0 | 0.2 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.0 | 0.5 | GO:0015464 | acetylcholine receptor activity(GO:0015464) |
| 0.0 | 0.1 | GO:0016841 | ammonia-lyase activity(GO:0016841) |
| 0.0 | 0.2 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.0 | 0.2 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.0 | 0.4 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.0 | 0.2 | GO:0031072 | heat shock protein binding(GO:0031072) |
| 0.0 | 4.3 | GO:0003690 | double-stranded DNA binding(GO:0003690) |
| 0.0 | 0.2 | GO:0050664 | oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor(GO:0050664) |
| 0.0 | 0.1 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.0 | 3.0 | GO:0003702 | obsolete RNA polymerase II transcription factor activity(GO:0003702) |
| 0.0 | 0.1 | GO:0017110 | nucleoside-diphosphatase activity(GO:0017110) |
| 0.0 | 0.2 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.0 | 0.1 | GO:0008174 | mRNA methyltransferase activity(GO:0008174) |
| 0.0 | 0.4 | GO:0008186 | RNA-dependent ATPase activity(GO:0008186) |
| 0.0 | 0.0 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.0 | 0.0 | GO:0050528 | acyloxyacyl hydrolase activity(GO:0050528) |
| 0.0 | 0.1 | GO:0001591 | dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591) |
| 0.0 | 0.4 | GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656) |
| 0.0 | 4.6 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 0.0 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.0 | 1.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.4 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 0.1 | GO:0016681 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.0 | 0.0 | GO:0008480 | sarcosine dehydrogenase activity(GO:0008480) oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor(GO:0046997) |
| 0.0 | 0.1 | GO:0003711 | obsolete transcription elongation regulator activity(GO:0003711) |
| 0.0 | 0.1 | GO:0031369 | translation initiation factor binding(GO:0031369) |
| 0.0 | 1.4 | GO:0004896 | cytokine receptor activity(GO:0004896) |
| 0.0 | 0.5 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.0 | 0.2 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 0.1 | GO:0005105 | type 1 fibroblast growth factor receptor binding(GO:0005105) |
| 0.0 | 1.3 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 0.3 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 0.3 | GO:0019239 | deaminase activity(GO:0019239) |
| 0.0 | 0.0 | GO:0070576 | vitamin D 24-hydroxylase activity(GO:0070576) |
| 0.0 | 0.1 | GO:0034056 | estrogen response element binding(GO:0034056) |
| 0.0 | 0.9 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.0 | 0.2 | GO:0005522 | profilin binding(GO:0005522) |
| 0.0 | 0.1 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 0.1 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 0.0 | 0.1 | GO:0004311 | farnesyltranstransferase activity(GO:0004311) |
| 0.0 | 0.0 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) ATP-dependent microtubule motor activity(GO:1990939) |
| 0.0 | 0.2 | GO:0008237 | metallopeptidase activity(GO:0008237) |
| 0.0 | 0.1 | GO:0050998 | nitric-oxide synthase binding(GO:0050998) |
| 0.0 | 0.1 | GO:0004999 | vasoactive intestinal polypeptide receptor activity(GO:0004999) |
| 0.0 | 0.2 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.0 | 0.1 | GO:0016888 | endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888) |
| 0.0 | 0.1 | GO:0004982 | N-formyl peptide receptor activity(GO:0004982) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.6 | ST_INTERFERON_GAMMA_PATHWAY | Interferon gamma pathway. |
| 0.0 | 2.7 | ST_T_CELL_SIGNAL_TRANSDUCTION | T Cell Signal Transduction |
| 0.0 | 0.7 | SA_PTEN_PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 0.3 | ST_STAT3_PATHWAY | STAT3 Pathway |
| 0.0 | 0.3 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 0.4 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
