Motif ID: TBX2
Z-value: 1.033
Transcription factors associated with TBX2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
TBX2 | ENSG00000121068.9 | TBX2 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.3 | GO:0003308 | negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) |
0.2 | 1.4 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672) |
0.2 | 1.1 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
0.2 | 0.6 | GO:0002887 | negative regulation of myeloid leukocyte mediated immunity(GO:0002887) heme oxidation(GO:0006788) smooth muscle hyperplasia(GO:0014806) muscle hyperplasia(GO:0014900) negative regulation of leukocyte degranulation(GO:0043301) |
0.2 | 0.6 | GO:0051097 | negative regulation of helicase activity(GO:0051097) |
0.2 | 0.6 | GO:0048861 | leukemia inhibitory factor signaling pathway(GO:0048861) |
0.2 | 1.1 | GO:0032460 | negative regulation of protein oligomerization(GO:0032460) negative regulation of protein homooligomerization(GO:0032463) |
0.2 | 0.7 | GO:0015868 | purine ribonucleotide transport(GO:0015868) |
0.1 | 0.4 | GO:0030205 | dermatan sulfate metabolic process(GO:0030205) dermatan sulfate biosynthetic process(GO:0030208) |
0.1 | 0.7 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) |
0.1 | 1.5 | GO:0032727 | positive regulation of interferon-alpha production(GO:0032727) |
0.1 | 0.3 | GO:0016476 | regulation of embryonic cell shape(GO:0016476) |
0.1 | 0.8 | GO:0016255 | attachment of GPI anchor to protein(GO:0016255) |
0.1 | 0.3 | GO:0048143 | obsolete induction of apoptosis in response to chemical stimulus(GO:0031558) astrocyte activation(GO:0048143) |
0.1 | 1.2 | GO:0051497 | negative regulation of stress fiber assembly(GO:0051497) |
0.1 | 0.5 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
0.1 | 0.3 | GO:0021836 | chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923) |
0.1 | 0.5 | GO:0051387 | negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387) |
0.1 | 0.5 | GO:0046642 | negative regulation of alpha-beta T cell proliferation(GO:0046642) |
0.1 | 0.7 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
0.1 | 0.4 | GO:0033197 | response to vitamin E(GO:0033197) |
0.1 | 0.3 | GO:0042097 | interleukin-4 biosynthetic process(GO:0042097) positive regulation of interleukin-10 biosynthetic process(GO:0045082) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404) |
0.1 | 0.6 | GO:0050862 | positive regulation of T cell receptor signaling pathway(GO:0050862) |
0.1 | 0.2 | GO:1901522 | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522) |
0.1 | 0.2 | GO:0050758 | thymidylate synthase biosynthetic process(GO:0050757) regulation of thymidylate synthase biosynthetic process(GO:0050758) negative regulation of thymidylate synthase biosynthetic process(GO:0050760) |
0.1 | 0.7 | GO:0051014 | actin filament severing(GO:0051014) |
0.1 | 0.3 | GO:0022417 | protein maturation by protein folding(GO:0022417) |
0.1 | 0.2 | GO:0007079 | mitotic chromosome movement towards spindle pole(GO:0007079) chromosome movement towards spindle pole(GO:0051305) |
0.1 | 0.4 | GO:0030240 | skeletal muscle thin filament assembly(GO:0030240) |
0.1 | 0.2 | GO:1903961 | positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) positive regulation of anion transmembrane transport(GO:1903961) |
0.1 | 0.3 | GO:0015693 | magnesium ion transport(GO:0015693) |
0.1 | 0.6 | GO:0007130 | synaptonemal complex assembly(GO:0007130) |
0.0 | 0.1 | GO:0003171 | atrioventricular valve development(GO:0003171) aortic valve development(GO:0003176) aortic valve morphogenesis(GO:0003180) atrioventricular valve morphogenesis(GO:0003181) notochord formation(GO:0014028) |
0.0 | 0.5 | GO:0035024 | negative regulation of Rho protein signal transduction(GO:0035024) |
0.0 | 0.2 | GO:0050653 | UDP-N-acetylgalactosamine metabolic process(GO:0019276) chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653) |
0.0 | 0.3 | GO:0002710 | negative regulation of T cell mediated immunity(GO:0002710) |
0.0 | 1.4 | GO:0018208 | peptidyl-proline modification(GO:0018208) |
0.0 | 0.3 | GO:0042149 | cellular response to glucose starvation(GO:0042149) |
0.0 | 3.1 | GO:0008360 | regulation of cell shape(GO:0008360) |
0.0 | 0.2 | GO:0006295 | nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295) |
0.0 | 0.0 | GO:0051589 | negative regulation of neurotransmitter transport(GO:0051589) |
0.0 | 0.1 | GO:0009642 | response to light intensity(GO:0009642) |
0.0 | 0.5 | GO:0007567 | parturition(GO:0007567) |
0.0 | 1.1 | GO:0010633 | negative regulation of epithelial cell migration(GO:0010633) |
0.0 | 0.2 | GO:0006880 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
0.0 | 0.1 | GO:0010002 | cardioblast differentiation(GO:0010002) |
0.0 | 0.3 | GO:0007076 | mitotic chromosome condensation(GO:0007076) |
0.0 | 0.1 | GO:0061084 | regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084) regulation of protein folding(GO:1903332) negative regulation of protein folding(GO:1903333) |
0.0 | 0.6 | GO:0030838 | positive regulation of actin filament polymerization(GO:0030838) |
0.0 | 0.3 | GO:0032288 | myelin assembly(GO:0032288) |
0.0 | 0.4 | GO:0034394 | protein localization to cell surface(GO:0034394) |
0.0 | 0.6 | GO:0006656 | phosphatidylcholine biosynthetic process(GO:0006656) |
0.0 | 1.0 | GO:0042384 | cilium assembly(GO:0042384) |
0.0 | 0.1 | GO:0009822 | alkaloid catabolic process(GO:0009822) |
0.0 | 0.2 | GO:0007379 | segment specification(GO:0007379) |
0.0 | 0.1 | GO:0033622 | integrin activation(GO:0033622) regulation of integrin activation(GO:0033623) positive regulation of integrin activation(GO:0033625) |
0.0 | 0.2 | GO:0009435 | NAD biosynthetic process(GO:0009435) |
0.0 | 0.1 | GO:0008653 | lipopolysaccharide metabolic process(GO:0008653) |
0.0 | 0.1 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
0.0 | 2.9 | GO:0006415 | translational termination(GO:0006415) |
0.0 | 0.1 | GO:0002829 | negative regulation of type 2 immune response(GO:0002829) |
0.0 | 0.1 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
0.0 | 1.6 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
0.0 | 0.0 | GO:0006275 | regulation of DNA replication(GO:0006275) |
0.0 | 0.1 | GO:0071731 | response to nitric oxide(GO:0071731) |
0.0 | 0.2 | GO:0090292 | nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292) |
0.0 | 0.1 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
0.0 | 0.7 | GO:0015914 | phospholipid transport(GO:0015914) |
0.0 | 0.0 | GO:0006740 | glyoxylate cycle(GO:0006097) NADPH regeneration(GO:0006740) |
0.0 | 0.0 | GO:0001955 | blood vessel maturation(GO:0001955) |
0.0 | 1.2 | GO:0071772 | BMP signaling pathway(GO:0030509) response to BMP(GO:0071772) cellular response to BMP stimulus(GO:0071773) |
0.0 | 0.1 | GO:0035520 | monoubiquitinated protein deubiquitination(GO:0035520) |
0.0 | 1.2 | GO:0050680 | negative regulation of epithelial cell proliferation(GO:0050680) |
0.0 | 0.3 | GO:0043968 | histone H2A acetylation(GO:0043968) |
0.0 | 0.4 | GO:0007257 | activation of JUN kinase activity(GO:0007257) |
0.0 | 0.4 | GO:0033209 | tumor necrosis factor-mediated signaling pathway(GO:0033209) |
0.0 | 0.1 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
0.0 | 0.1 | GO:0042987 | amyloid precursor protein catabolic process(GO:0042987) |
0.0 | 0.4 | GO:0060334 | regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334) |
0.0 | 0.4 | GO:0030262 | apoptotic nuclear changes(GO:0030262) |
0.0 | 0.1 | GO:0016045 | detection of bacterium(GO:0016045) |
0.0 | 1.4 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
0.0 | 0.4 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
0.0 | 1.9 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123) |
0.0 | 3.5 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
0.0 | 0.4 | GO:0045766 | positive regulation of angiogenesis(GO:0045766) |
0.0 | 0.0 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
0.0 | 0.1 | GO:0045650 | negative regulation of macrophage differentiation(GO:0045650) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 0.6 | GO:0005900 | oncostatin-M receptor complex(GO:0005900) |
0.1 | 1.0 | GO:0034464 | BBSome(GO:0034464) |
0.1 | 1.4 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
0.1 | 0.3 | GO:0000788 | nuclear nucleosome(GO:0000788) |
0.1 | 0.3 | GO:0032009 | early phagosome(GO:0032009) |
0.1 | 2.8 | GO:0005844 | polysome(GO:0005844) |
0.1 | 0.9 | GO:0005916 | fascia adherens(GO:0005916) |
0.1 | 1.1 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
0.1 | 0.7 | GO:0005858 | axonemal dynein complex(GO:0005858) axoneme part(GO:0044447) |
0.1 | 0.8 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
0.1 | 0.3 | GO:0098984 | asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984) |
0.0 | 0.2 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
0.0 | 0.6 | GO:0000242 | pericentriolar material(GO:0000242) |
0.0 | 0.3 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
0.0 | 0.3 | GO:0030125 | clathrin vesicle coat(GO:0030125) |
0.0 | 0.1 | GO:0035145 | exon-exon junction complex(GO:0035145) |
0.0 | 0.5 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
0.0 | 1.5 | GO:0030532 | small nuclear ribonucleoprotein complex(GO:0030532) |
0.0 | 0.3 | GO:0000796 | condensin complex(GO:0000796) |
0.0 | 0.3 | GO:0043218 | compact myelin(GO:0043218) |
0.0 | 0.2 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
0.0 | 0.5 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
0.0 | 0.4 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
0.0 | 0.7 | GO:0000795 | synaptonemal complex(GO:0000795) |
0.0 | 0.1 | GO:0036125 | mitochondrial fatty acid beta-oxidation multienzyme complex(GO:0016507) fatty acid beta-oxidation multienzyme complex(GO:0036125) |
0.0 | 0.2 | GO:0060199 | clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203) |
0.0 | 0.4 | GO:0000421 | autophagosome membrane(GO:0000421) |
0.0 | 0.2 | GO:0031616 | spindle pole centrosome(GO:0031616) |
0.0 | 0.2 | GO:0042589 | zymogen granule membrane(GO:0042589) |
0.0 | 0.2 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
0.0 | 0.5 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
0.0 | 0.2 | GO:0000109 | nucleotide-excision repair complex(GO:0000109) |
0.0 | 0.9 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
0.0 | 0.3 | GO:0031105 | septin complex(GO:0031105) septin cytoskeleton(GO:0032156) |
0.0 | 0.2 | GO:0071778 | obsolete WINAC complex(GO:0071778) |
0.0 | 0.2 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
0.0 | 0.3 | GO:0035267 | NuA4 histone acetyltransferase complex(GO:0035267) |
0.0 | 0.3 | GO:0030660 | Golgi-associated vesicle membrane(GO:0030660) |
0.0 | 0.4 | GO:0005814 | centriole(GO:0005814) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 0.8 | GO:0030377 | urokinase plasminogen activator receptor activity(GO:0030377) |
0.2 | 0.7 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
0.2 | 0.6 | GO:0004392 | heme oxygenase (decyclizing) activity(GO:0004392) |
0.2 | 0.6 | GO:0042610 | CD8 receptor binding(GO:0042610) |
0.2 | 0.6 | GO:0019981 | interleukin-6 receptor activity(GO:0004915) oncostatin-M receptor activity(GO:0004924) ciliary neurotrophic factor receptor binding(GO:0005127) interleukin-6 binding(GO:0019981) interleukin-17 receptor activity(GO:0030368) |
0.1 | 0.6 | GO:0000739 | obsolete DNA strand annealing activity(GO:0000739) |
0.1 | 0.5 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
0.1 | 1.1 | GO:0031419 | cobalamin binding(GO:0031419) |
0.1 | 1.3 | GO:0030547 | receptor inhibitor activity(GO:0030547) receptor antagonist activity(GO:0048019) |
0.1 | 0.4 | GO:0050698 | proteoglycan sulfotransferase activity(GO:0050698) |
0.1 | 0.7 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
0.1 | 0.3 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
0.1 | 0.3 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
0.1 | 1.2 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093) |
0.1 | 1.2 | GO:0046625 | obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619) sphingolipid binding(GO:0046625) |
0.1 | 0.3 | GO:0004917 | interleukin-7 receptor activity(GO:0004917) |
0.1 | 0.2 | GO:0003863 | alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863) |
0.1 | 2.5 | GO:0019843 | rRNA binding(GO:0019843) |
0.1 | 0.4 | GO:0004064 | arylesterase activity(GO:0004064) |
0.1 | 1.1 | GO:0051787 | misfolded protein binding(GO:0051787) |
0.1 | 0.2 | GO:0008955 | peptidoglycan glycosyltransferase activity(GO:0008955) |
0.1 | 0.3 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) |
0.1 | 0.3 | GO:0005534 | galactose binding(GO:0005534) |
0.1 | 0.4 | GO:0031685 | adenosine receptor binding(GO:0031685) |
0.1 | 0.5 | GO:0017049 | GTP-Rho binding(GO:0017049) |
0.1 | 0.3 | GO:0035197 | siRNA binding(GO:0035197) |
0.1 | 0.3 | GO:0004169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169) |
0.1 | 0.9 | GO:0019992 | diacylglycerol binding(GO:0019992) |
0.0 | 1.4 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
0.0 | 0.1 | GO:0031877 | somatostatin receptor binding(GO:0031877) |
0.0 | 0.4 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
0.0 | 0.1 | GO:0050528 | acyloxyacyl hydrolase activity(GO:0050528) |
0.0 | 0.4 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
0.0 | 0.2 | GO:0004522 | ribonuclease A activity(GO:0004522) |
0.0 | 0.7 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
0.0 | 0.1 | GO:0004909 | interleukin-1, Type I, activating receptor activity(GO:0004909) |
0.0 | 0.4 | GO:0030332 | cyclin binding(GO:0030332) |
0.0 | 0.2 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
0.0 | 0.3 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
0.0 | 0.1 | GO:0000150 | recombinase activity(GO:0000150) |
0.0 | 0.1 | GO:0016509 | long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509) |
0.0 | 0.1 | GO:0001846 | opsonin binding(GO:0001846) |
0.0 | 0.1 | GO:0070643 | vitamin D3 25-hydroxylase activity(GO:0030343) vitamin D 25-hydroxylase activity(GO:0070643) |
0.0 | 0.4 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) |
0.0 | 0.1 | GO:0016019 | peptidoglycan receptor activity(GO:0016019) |
0.0 | 0.1 | GO:0003845 | 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845) |
0.0 | 0.1 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
0.0 | 1.9 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
0.0 | 0.3 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
0.0 | 0.3 | GO:0000155 | phosphorelay sensor kinase activity(GO:0000155) |
0.0 | 0.1 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
0.0 | 0.4 | GO:0017022 | myosin binding(GO:0017022) |
0.0 | 0.7 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
0.0 | 0.3 | GO:0042809 | vitamin D receptor binding(GO:0042809) |
0.0 | 0.6 | GO:0005504 | fatty acid binding(GO:0005504) |
0.0 | 0.4 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
0.0 | 0.2 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
0.0 | 0.2 | GO:0005243 | gap junction channel activity(GO:0005243) |
0.0 | 0.2 | GO:0030899 | calcium-dependent ATPase activity(GO:0030899) |
0.0 | 0.0 | GO:0004450 | isocitrate dehydrogenase (NADP+) activity(GO:0004450) |
0.0 | 0.1 | GO:0015185 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185) |
0.0 | 0.1 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
0.0 | 1.4 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
0.0 | 0.1 | GO:0046875 | ephrin receptor binding(GO:0046875) |
0.0 | 0.2 | GO:0070064 | proline-rich region binding(GO:0070064) |
0.0 | 1.4 | GO:0003704 | obsolete specific RNA polymerase II transcription factor activity(GO:0003704) |
0.0 | 0.2 | GO:0016303 | 1-phosphatidylinositol-3-kinase activity(GO:0016303) |
0.0 | 0.2 | GO:0070566 | adenylyltransferase activity(GO:0070566) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 2.5 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
0.1 | 1.4 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
0.0 | 1.4 | SA_G1_AND_S_PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
0.0 | 0.8 | SIG_IL4RECEPTOR_IN_B_LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
0.0 | 0.4 | ST_TYPE_I_INTERFERON_PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |