Motif ID: TBX21_TBR1
Z-value: 0.950
Transcription factors associated with TBX21_TBR1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
TBR1 | ENSG00000136535.10 | TBR1 |
TBX21 | ENSG00000073861.2 | TBX21 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.4 | 1.7 | GO:0051503 | adenine nucleotide transport(GO:0051503) |
0.3 | 1.2 | GO:0010944 | negative regulation of transcription by competitive promoter binding(GO:0010944) |
0.2 | 0.7 | GO:0010586 | miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587) |
0.2 | 1.8 | GO:0045647 | negative regulation of erythrocyte differentiation(GO:0045647) |
0.2 | 1.1 | GO:0003093 | regulation of glomerular filtration(GO:0003093) glomerular filtration(GO:0003094) renal filtration(GO:0097205) regulation of renal system process(GO:0098801) |
0.2 | 1.1 | GO:0006880 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
0.2 | 0.5 | GO:0090467 | L-arginine import(GO:0043091) arginine import(GO:0090467) L-arginine transport(GO:1902023) |
0.2 | 0.8 | GO:0001955 | blood vessel maturation(GO:0001955) |
0.1 | 0.9 | GO:0050862 | positive regulation of T cell receptor signaling pathway(GO:0050862) |
0.1 | 0.5 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
0.1 | 0.6 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
0.1 | 0.7 | GO:0019227 | neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870) |
0.1 | 0.3 | GO:0031297 | replication fork processing(GO:0031297) |
0.1 | 0.7 | GO:0070584 | mitochondrion morphogenesis(GO:0070584) |
0.1 | 0.3 | GO:0060708 | spongiotrophoblast differentiation(GO:0060708) |
0.1 | 0.2 | GO:0042097 | interleukin-4 biosynthetic process(GO:0042097) positive regulation of interleukin-10 biosynthetic process(GO:0045082) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404) |
0.1 | 0.4 | GO:0003070 | age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) |
0.1 | 0.5 | GO:0016265 | obsolete death(GO:0016265) dopamine biosynthetic process(GO:0042416) dopaminergic neuron differentiation(GO:0071542) |
0.1 | 0.2 | GO:0010273 | regulation of oxidative phosphorylation(GO:0002082) detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169) |
0.1 | 0.3 | GO:0071436 | sodium ion export(GO:0071436) |
0.1 | 0.4 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672) |
0.1 | 0.6 | GO:0006474 | N-terminal protein amino acid acetylation(GO:0006474) |
0.1 | 2.1 | GO:0033209 | tumor necrosis factor-mediated signaling pathway(GO:0033209) |
0.1 | 0.3 | GO:0070537 | histone H2A K63-linked deubiquitination(GO:0070537) |
0.1 | 0.3 | GO:0009143 | nucleoside triphosphate catabolic process(GO:0009143) |
0.1 | 1.5 | GO:0030199 | collagen fibril organization(GO:0030199) |
0.1 | 0.9 | GO:0048268 | negative regulation of receptor-mediated endocytosis(GO:0048261) clathrin coat assembly(GO:0048268) |
0.1 | 0.6 | GO:0033327 | Leydig cell differentiation(GO:0033327) |
0.1 | 0.8 | GO:0001522 | pseudouridine synthesis(GO:0001522) |
0.1 | 0.2 | GO:0061030 | axon target recognition(GO:0007412) epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) |
0.1 | 0.2 | GO:1904036 | negative regulation of epithelial cell apoptotic process(GO:1904036) regulation of establishment of cell polarity(GO:2000114) negative regulation of endothelial cell apoptotic process(GO:2000352) |
0.1 | 0.4 | GO:0032516 | positive regulation of phosphoprotein phosphatase activity(GO:0032516) |
0.1 | 0.1 | GO:0014874 | response to stimulus involved in regulation of muscle adaptation(GO:0014874) |
0.1 | 0.3 | GO:1901503 | ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503) |
0.1 | 0.6 | GO:1901984 | negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757) |
0.0 | 0.2 | GO:0021938 | smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938) |
0.0 | 0.2 | GO:0042118 | endothelial cell activation(GO:0042118) |
0.0 | 0.0 | GO:0051589 | negative regulation of neurotransmitter transport(GO:0051589) |
0.0 | 0.3 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
0.0 | 0.4 | GO:0045779 | negative regulation of bone resorption(GO:0045779) |
0.0 | 0.4 | GO:0019359 | nicotinamide nucleotide biosynthetic process(GO:0019359) |
0.0 | 0.2 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
0.0 | 0.9 | GO:0002076 | osteoblast development(GO:0002076) |
0.0 | 0.1 | GO:0042501 | serine phosphorylation of STAT protein(GO:0042501) |
0.0 | 0.1 | GO:0000338 | protein deneddylation(GO:0000338) |
0.0 | 0.4 | GO:0007080 | mitotic metaphase plate congression(GO:0007080) |
0.0 | 0.1 | GO:0072677 | eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677) |
0.0 | 0.1 | GO:0045715 | negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715) |
0.0 | 0.4 | GO:0045070 | positive regulation of viral genome replication(GO:0045070) |
0.0 | 0.3 | GO:0060351 | cartilage development involved in endochondral bone morphogenesis(GO:0060351) |
0.0 | 0.1 | GO:0043276 | anoikis(GO:0043276) |
0.0 | 0.5 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
0.0 | 0.4 | GO:0007220 | Notch receptor processing(GO:0007220) |
0.0 | 0.1 | GO:0045046 | protein import into peroxisome membrane(GO:0045046) |
0.0 | 0.3 | GO:0032817 | regulation of natural killer cell proliferation(GO:0032817) |
0.0 | 0.6 | GO:0019079 | viral genome replication(GO:0019079) |
0.0 | 0.6 | GO:0006110 | regulation of glycolytic process(GO:0006110) regulation of nucleoside metabolic process(GO:0009118) regulation of ATP metabolic process(GO:1903578) |
0.0 | 0.2 | GO:0007168 | receptor guanylyl cyclase signaling pathway(GO:0007168) |
0.0 | 1.7 | GO:0097696 | JAK-STAT cascade(GO:0007259) STAT cascade(GO:0097696) |
0.0 | 0.3 | GO:0051927 | obsolete negative regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051927) |
0.0 | 0.1 | GO:0090274 | positive regulation of somatostatin secretion(GO:0090274) |
0.0 | 0.8 | GO:0051899 | membrane depolarization(GO:0051899) |
0.0 | 0.2 | GO:0007096 | regulation of exit from mitosis(GO:0007096) |
0.0 | 0.2 | GO:0022027 | interkinetic nuclear migration(GO:0022027) |
0.0 | 0.3 | GO:0050872 | white fat cell differentiation(GO:0050872) |
0.0 | 0.0 | GO:0014742 | positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742) |
0.0 | 0.1 | GO:0055009 | atrial cardiac muscle tissue development(GO:0003228) cardiac muscle fiber development(GO:0048739) atrial cardiac muscle tissue morphogenesis(GO:0055009) |
0.0 | 0.1 | GO:0007196 | adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196) negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
0.0 | 0.1 | GO:0008612 | peptidyl-lysine modification to peptidyl-hypusine(GO:0008612) |
0.0 | 0.2 | GO:0032727 | positive regulation of interferon-alpha production(GO:0032727) |
0.0 | 0.2 | GO:0030157 | pancreatic juice secretion(GO:0030157) |
0.0 | 0.3 | GO:0045730 | respiratory burst(GO:0045730) |
0.0 | 0.2 | GO:0032288 | myelin assembly(GO:0032288) |
0.0 | 0.5 | GO:0007398 | ectoderm development(GO:0007398) |
0.0 | 0.1 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
0.0 | 0.0 | GO:0018874 | benzoate metabolic process(GO:0018874) |
0.0 | 0.2 | GO:0032259 | methylation(GO:0032259) |
0.0 | 0.6 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
0.0 | 0.3 | GO:0000380 | alternative mRNA splicing, via spliceosome(GO:0000380) |
0.0 | 1.2 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
0.0 | 0.2 | GO:0033169 | histone H3-K9 demethylation(GO:0033169) |
0.0 | 0.1 | GO:0001867 | complement activation, lectin pathway(GO:0001867) |
0.0 | 0.2 | GO:0002021 | response to dietary excess(GO:0002021) |
0.0 | 0.3 | GO:0030101 | natural killer cell activation(GO:0030101) |
0.0 | 0.5 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
0.0 | 0.2 | GO:0051568 | histone H3-K4 methylation(GO:0051568) |
0.0 | 0.1 | GO:0035246 | peptidyl-arginine N-methylation(GO:0035246) |
0.0 | 0.2 | GO:0032098 | regulation of appetite(GO:0032098) |
0.0 | 0.0 | GO:0070483 | detection of hypoxia(GO:0070483) |
0.0 | 0.3 | GO:0045814 | negative regulation of gene expression, epigenetic(GO:0045814) |
0.0 | 0.0 | GO:0001833 | inner cell mass cell proliferation(GO:0001833) |
0.0 | 0.2 | GO:0071479 | cellular response to ionizing radiation(GO:0071479) |
0.0 | 0.2 | GO:0040023 | establishment of nucleus localization(GO:0040023) nucleus localization(GO:0051647) |
0.0 | 0.1 | GO:0007076 | mitotic chromosome condensation(GO:0007076) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 0.5 | GO:0009279 | cell outer membrane(GO:0009279) |
0.1 | 1.3 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
0.1 | 0.2 | GO:0042629 | mast cell granule(GO:0042629) |
0.1 | 2.9 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
0.1 | 0.2 | GO:0000788 | nuclear nucleosome(GO:0000788) |
0.1 | 0.9 | GO:0030122 | AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) |
0.1 | 0.9 | GO:0000242 | pericentriolar material(GO:0000242) |
0.1 | 0.8 | GO:0005838 | proteasome regulatory particle(GO:0005838) |
0.1 | 0.8 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
0.0 | 1.1 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
0.0 | 0.4 | GO:0005828 | kinetochore microtubule(GO:0005828) |
0.0 | 0.3 | GO:0032389 | MutLalpha complex(GO:0032389) |
0.0 | 2.1 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
0.0 | 0.6 | GO:0032982 | myosin filament(GO:0032982) |
0.0 | 0.2 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
0.0 | 0.3 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
0.0 | 0.4 | GO:0030315 | T-tubule(GO:0030315) |
0.0 | 0.3 | GO:0070531 | BRCA1-A complex(GO:0070531) |
0.0 | 0.2 | GO:0043218 | compact myelin(GO:0043218) |
0.0 | 0.2 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
0.0 | 0.6 | GO:0030119 | AP-type membrane coat adaptor complex(GO:0030119) |
0.0 | 0.2 | GO:0030126 | COPI vesicle coat(GO:0030126) |
0.0 | 0.4 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
0.0 | 0.1 | GO:0000796 | condensin complex(GO:0000796) |
0.0 | 0.1 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
0.0 | 0.3 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
0.0 | 0.1 | GO:0071062 | alphav-beta3 integrin-vitronectin complex(GO:0071062) |
0.0 | 1.1 | GO:0034707 | chloride channel complex(GO:0034707) |
0.0 | 0.1 | GO:0060199 | clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203) |
0.0 | 1.2 | GO:0032993 | protein-DNA complex(GO:0032993) |
0.0 | 0.2 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
0.0 | 0.8 | GO:0000118 | histone deacetylase complex(GO:0000118) |
0.0 | 0.1 | GO:0042597 | NMDA selective glutamate receptor complex(GO:0017146) outer membrane-bounded periplasmic space(GO:0030288) periplasmic space(GO:0042597) |
0.0 | 0.6 | GO:0015030 | Cajal body(GO:0015030) |
0.0 | 0.1 | GO:0001739 | sex chromatin(GO:0001739) |
0.0 | 0.9 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 1.7 | GO:0015216 | adenine nucleotide transmembrane transporter activity(GO:0000295) purine nucleotide transmembrane transporter activity(GO:0015216) |
0.3 | 0.9 | GO:0042610 | CD8 receptor binding(GO:0042610) |
0.3 | 1.2 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
0.3 | 0.8 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
0.2 | 0.9 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
0.2 | 1.5 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
0.1 | 0.6 | GO:0016833 | oxo-acid-lyase activity(GO:0016833) |
0.1 | 0.5 | GO:0004473 | malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) |
0.1 | 2.1 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) |
0.1 | 1.3 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
0.1 | 0.4 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) ATP-dependent microtubule motor activity(GO:1990939) |
0.1 | 0.3 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
0.1 | 0.7 | GO:0031369 | translation initiation factor binding(GO:0031369) |
0.1 | 0.4 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
0.1 | 0.8 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
0.1 | 0.4 | GO:0005534 | galactose binding(GO:0005534) |
0.1 | 0.2 | GO:0000150 | recombinase activity(GO:0000150) |
0.1 | 0.3 | GO:0043140 | bubble DNA binding(GO:0000405) ATP-dependent 3'-5' DNA helicase activity(GO:0043140) |
0.1 | 0.3 | GO:0019103 | pyrimidine nucleotide binding(GO:0019103) |
0.1 | 0.9 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
0.1 | 0.5 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
0.1 | 0.6 | GO:0070053 | thrombospondin receptor activity(GO:0070053) |
0.1 | 0.4 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
0.1 | 0.2 | GO:0016531 | copper chaperone activity(GO:0016531) |
0.1 | 0.3 | GO:0043008 | ATP-dependent protein binding(GO:0043008) |
0.1 | 0.5 | GO:0031419 | cobalamin binding(GO:0031419) |
0.0 | 0.2 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
0.0 | 0.1 | GO:0000156 | phosphorelay response regulator activity(GO:0000156) |
0.0 | 0.4 | GO:0046935 | 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935) |
0.0 | 0.2 | GO:0070996 | type 1 melanocortin receptor binding(GO:0070996) |
0.0 | 1.2 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
0.0 | 0.2 | GO:0004663 | Rab geranylgeranyltransferase activity(GO:0004663) |
0.0 | 0.3 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
0.0 | 0.7 | GO:0005251 | delayed rectifier potassium channel activity(GO:0005251) |
0.0 | 0.2 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
0.0 | 0.2 | GO:0004169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169) |
0.0 | 0.5 | GO:0005384 | manganese ion transmembrane transporter activity(GO:0005384) |
0.0 | 0.1 | GO:0004142 | diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307) |
0.0 | 0.6 | GO:0003857 | 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857) |
0.0 | 0.5 | GO:0046625 | sphingolipid binding(GO:0046625) |
0.0 | 0.8 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
0.0 | 0.3 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
0.0 | 0.2 | GO:0004703 | G-protein coupled receptor kinase activity(GO:0004703) |
0.0 | 0.2 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
0.0 | 0.2 | GO:0030506 | ankyrin binding(GO:0030506) |
0.0 | 0.1 | GO:0035242 | protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242) |
0.0 | 0.5 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
0.0 | 2.8 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
0.0 | 0.2 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
0.0 | 0.2 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
0.0 | 0.3 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
0.0 | 0.1 | GO:0004447 | iodide peroxidase activity(GO:0004447) |
0.0 | 0.6 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
0.0 | 0.1 | GO:0097642 | calcitonin family receptor activity(GO:0097642) |
0.0 | 0.1 | GO:0001640 | adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988) |
0.0 | 0.3 | GO:0016493 | C-C chemokine receptor activity(GO:0016493) |
0.0 | 0.1 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
0.0 | 0.0 | GO:0003996 | acyl-CoA ligase activity(GO:0003996) |
0.0 | 0.1 | GO:0015288 | porin activity(GO:0015288) |
0.0 | 0.2 | GO:0060589 | GTPase regulator activity(GO:0030695) nucleoside-triphosphatase regulator activity(GO:0060589) |
0.0 | 1.2 | GO:0004879 | RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531) |
0.0 | 0.1 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
0.0 | 0.1 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
0.0 | 0.3 | GO:0004889 | acetylcholine-activated cation-selective channel activity(GO:0004889) |
0.0 | 1.5 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
0.0 | 0.5 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
0.0 | 0.2 | GO:0004526 | ribonuclease P activity(GO:0004526) |
0.0 | 0.3 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
0.0 | 0.3 | GO:0043022 | ribosome binding(GO:0043022) |
0.0 | 0.1 | GO:0008494 | translation activator activity(GO:0008494) |
0.0 | 0.1 | GO:0043184 | vascular endothelial growth factor receptor 2 binding(GO:0043184) |
0.0 | 0.2 | GO:0004707 | MAP kinase activity(GO:0004707) |
0.0 | 0.1 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
0.0 | 0.1 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 0.8 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
0.0 | 1.5 | ST_T_CELL_SIGNAL_TRANSDUCTION | T Cell Signal Transduction |