Motif ID: TBX3
Z-value: 1.100
Transcription factors associated with TBX3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| TBX3 | ENSG00000135111.10 | TBX3 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.0 | GO:0051712 | positive regulation of killing of cells of other organism(GO:0051712) |
| 0.2 | 1.2 | GO:0006216 | cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087) |
| 0.2 | 0.5 | GO:0045838 | CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361) positive regulation of regulatory T cell differentiation(GO:0045591) positive regulation of membrane potential(GO:0045838) |
| 0.1 | 0.6 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 0.1 | 0.4 | GO:0002384 | hepatic immune response(GO:0002384) positive regulation of transmission of nerve impulse(GO:0051971) |
| 0.1 | 0.4 | GO:0032328 | alanine transport(GO:0032328) |
| 0.1 | 0.7 | GO:0034616 | response to laminar fluid shear stress(GO:0034616) |
| 0.1 | 0.5 | GO:0015693 | magnesium ion transport(GO:0015693) |
| 0.1 | 0.2 | GO:0015959 | diadenosine polyphosphate metabolic process(GO:0015959) |
| 0.1 | 0.2 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.0 | 0.2 | GO:0046340 | diacylglycerol catabolic process(GO:0046340) |
| 0.0 | 0.2 | GO:0032099 | negative regulation of appetite(GO:0032099) |
| 0.0 | 0.3 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
| 0.0 | 0.2 | GO:0071218 | cellular response to misfolded protein(GO:0071218) |
| 0.0 | 0.5 | GO:0007204 | positive regulation of cytosolic calcium ion concentration(GO:0007204) |
| 0.0 | 0.2 | GO:0072383 | plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386) |
| 0.0 | 0.9 | GO:0000303 | response to superoxide(GO:0000303) |
| 0.0 | 2.1 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 0.2 | GO:0050862 | positive regulation of T cell receptor signaling pathway(GO:0050862) |
| 0.0 | 0.2 | GO:0019985 | translesion synthesis(GO:0019985) |
| 0.0 | 0.4 | GO:0006027 | glycosaminoglycan catabolic process(GO:0006027) |
| 0.0 | 0.2 | GO:0032364 | oxygen homeostasis(GO:0032364) |
| 0.0 | 0.5 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.0 | 0.4 | GO:0046135 | pyrimidine nucleoside catabolic process(GO:0046135) |
| 0.0 | 0.1 | GO:0017183 | peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) |
| 0.0 | 0.1 | GO:1901503 | ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503) |
| 0.0 | 0.1 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
| 0.0 | 0.4 | GO:0043968 | histone deubiquitination(GO:0016578) histone H2A acetylation(GO:0043968) |
| 0.0 | 0.3 | GO:0007276 | gamete generation(GO:0007276) |
| 0.0 | 0.0 | GO:0035106 | operant conditioning(GO:0035106) |
| 0.0 | 0.1 | GO:0008343 | adult feeding behavior(GO:0008343) |
| 0.0 | 0.5 | GO:0042147 | retrograde transport, endosome to Golgi(GO:0042147) |
| 0.0 | 0.1 | GO:0018076 | N-terminal peptidyl-lysine acetylation(GO:0018076) response to cobalt ion(GO:0032025) |
| 0.0 | 0.3 | GO:0006750 | glutathione biosynthetic process(GO:0006750) |
| 0.0 | 0.1 | GO:0043457 | regulation of cellular respiration(GO:0043457) |
| 0.0 | 0.1 | GO:0015811 | sulfur amino acid transport(GO:0000101) L-cystine transport(GO:0015811) |
| 0.0 | 0.2 | GO:0031998 | regulation of fatty acid beta-oxidation(GO:0031998) |
| 0.0 | 0.5 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.0 | 0.1 | GO:0051918 | negative regulation of fibrinolysis(GO:0051918) |
| 0.0 | 0.0 | GO:0003085 | negative regulation of systemic arterial blood pressure(GO:0003085) |
| 0.0 | 1.0 | GO:0006959 | humoral immune response(GO:0006959) |
| 0.0 | 0.1 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.0 | 0.0 | GO:0006428 | isoleucyl-tRNA aminoacylation(GO:0006428) |
| 0.0 | 0.1 | GO:0046514 | ceramide catabolic process(GO:0046514) |
| 0.0 | 0.2 | GO:0046655 | folic acid metabolic process(GO:0046655) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.4 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.1 | 0.6 | GO:0042825 | TAP complex(GO:0042825) |
| 0.1 | 1.2 | GO:0000178 | exosome (RNase complex)(GO:0000178) |
| 0.1 | 0.7 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.1 | 0.3 | GO:0042272 | nuclear RNA export factor complex(GO:0042272) |
| 0.1 | 0.2 | GO:0005873 | plus-end kinesin complex(GO:0005873) |
| 0.0 | 0.3 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.0 | 0.2 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.0 | 0.4 | GO:0000125 | PCAF complex(GO:0000125) |
| 0.0 | 1.2 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.0 | 0.5 | GO:0071203 | WASH complex(GO:0071203) |
| 0.0 | 0.2 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.0 | 1.8 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 0.1 | GO:0016942 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) |
| 0.0 | 0.5 | GO:0055038 | recycling endosome membrane(GO:0055038) |
| 0.0 | 0.2 | GO:0008091 | spectrin(GO:0008091) |
| 0.0 | 0.3 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.0 | 0.5 | GO:0030660 | Golgi-associated vesicle membrane(GO:0030660) |
| 0.0 | 0.2 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.0 | 0.2 | GO:0005771 | multivesicular body(GO:0005771) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.9 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.2 | 1.2 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 0.2 | 1.0 | GO:0019863 | IgE binding(GO:0019863) |
| 0.2 | 0.5 | GO:0015095 | magnesium ion transmembrane transporter activity(GO:0015095) |
| 0.1 | 0.4 | GO:0015193 | L-proline transmembrane transporter activity(GO:0015193) |
| 0.1 | 0.6 | GO:0046980 | oligopeptide-transporting ATPase activity(GO:0015421) tapasin binding(GO:0046980) |
| 0.1 | 0.4 | GO:0000405 | bubble DNA binding(GO:0000405) |
| 0.1 | 0.7 | GO:0004522 | ribonuclease A activity(GO:0004522) |
| 0.1 | 0.2 | GO:0033878 | hormone-sensitive lipase activity(GO:0033878) |
| 0.1 | 0.7 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.1 | 0.5 | GO:0016494 | C-X-C chemokine receptor activity(GO:0016494) |
| 0.1 | 0.4 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.0 | 0.1 | GO:0003953 | NAD+ nucleosidase activity(GO:0003953) |
| 0.0 | 0.2 | GO:0015056 | corticotrophin-releasing factor receptor activity(GO:0015056) |
| 0.0 | 0.1 | GO:0004946 | bombesin receptor activity(GO:0004946) |
| 0.0 | 2.2 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 1.2 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 0.2 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) ATP-dependent microtubule motor activity(GO:1990939) |
| 0.0 | 0.2 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 0.0 | 0.2 | GO:0042731 | PH domain binding(GO:0042731) |
| 0.0 | 0.1 | GO:0017040 | ceramidase activity(GO:0017040) |
| 0.0 | 0.2 | GO:0016151 | nucleotide diphosphatase activity(GO:0004551) nickel cation binding(GO:0016151) |
| 0.0 | 0.1 | GO:0004528 | phosphodiesterase I activity(GO:0004528) |
| 0.0 | 0.2 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813) |
| 0.0 | 0.2 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.0 | 0.3 | GO:0005131 | growth hormone receptor binding(GO:0005131) |
| 0.0 | 0.1 | GO:0008466 | glycogenin glucosyltransferase activity(GO:0008466) |
| 0.0 | 0.7 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 0.1 | GO:0015361 | low-affinity sodium:dicarboxylate symporter activity(GO:0015361) |
| 0.0 | 0.7 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.2 | GO:0031543 | peptidyl-proline dioxygenase activity(GO:0031543) |
| 0.0 | 0.3 | GO:0016565 | obsolete general transcriptional repressor activity(GO:0016565) |
| 0.0 | 0.1 | GO:0031994 | insulin-like growth factor I binding(GO:0031994) |
| 0.0 | 0.1 | GO:0004995 | tachykinin receptor activity(GO:0004995) |
| 0.0 | 0.3 | GO:0003840 | gamma-glutamyltransferase activity(GO:0003840) |
| 0.0 | 0.3 | GO:0000155 | phosphorelay sensor kinase activity(GO:0000155) |
| 0.0 | 0.4 | GO:0008373 | sialyltransferase activity(GO:0008373) |
| 0.0 | 0.0 | GO:0004822 | isoleucine-tRNA ligase activity(GO:0004822) |
| 0.0 | 0.2 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | ST_IL_13_PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.0 | 0.4 | ST_STAT3_PATHWAY | STAT3 Pathway |
