Motif ID: TBX5
Z-value: 1.173
Transcription factors associated with TBX5:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| TBX5 | ENSG00000089225.15 | TBX5 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 9.5 | GO:0032331 | negative regulation of chondrocyte differentiation(GO:0032331) |
| 0.5 | 2.1 | GO:0051503 | purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) |
| 0.2 | 0.7 | GO:0060028 | convergent extension involved in axis elongation(GO:0060028) |
| 0.2 | 0.6 | GO:0048861 | leukemia inhibitory factor signaling pathway(GO:0048861) |
| 0.2 | 4.4 | GO:0008347 | glial cell migration(GO:0008347) |
| 0.2 | 0.5 | GO:0016048 | detection of temperature stimulus(GO:0016048) |
| 0.1 | 0.4 | GO:0021570 | rhombomere 4 development(GO:0021570) facial nucleus development(GO:0021754) |
| 0.1 | 1.2 | GO:0006069 | ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069) |
| 0.1 | 1.5 | GO:0010658 | striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667) |
| 0.1 | 0.5 | GO:0009698 | phenylpropanoid metabolic process(GO:0009698) coumarin metabolic process(GO:0009804) |
| 0.1 | 0.4 | GO:0060267 | respiratory burst involved in defense response(GO:0002679) negative regulation of vasodilation(GO:0045908) positive regulation of respiratory burst(GO:0060267) |
| 0.1 | 0.5 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 0.1 | 0.9 | GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185) |
| 0.1 | 0.3 | GO:0016264 | gap junction assembly(GO:0016264) |
| 0.1 | 0.4 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
| 0.1 | 0.9 | GO:0001946 | lymphangiogenesis(GO:0001946) lymph vessel morphogenesis(GO:0036303) |
| 0.1 | 1.3 | GO:1901797 | negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797) |
| 0.1 | 0.2 | GO:0032581 | ER-dependent peroxisome organization(GO:0032581) |
| 0.1 | 0.6 | GO:0042693 | muscle cell fate commitment(GO:0042693) |
| 0.1 | 0.2 | GO:0071280 | epithelial fluid transport(GO:0042045) cellular response to copper ion(GO:0071280) |
| 0.1 | 0.2 | GO:0006427 | histidyl-tRNA aminoacylation(GO:0006427) |
| 0.1 | 0.2 | GO:2000114 | regulation of establishment of cell polarity(GO:2000114) |
| 0.1 | 0.3 | GO:0042635 | positive regulation of hair cycle(GO:0042635) regulation of hair follicle development(GO:0051797) positive regulation of hair follicle development(GO:0051798) |
| 0.1 | 0.4 | GO:0042149 | cellular response to glucose starvation(GO:0042149) |
| 0.1 | 1.0 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 0.3 | GO:0006011 | UDP-glucose metabolic process(GO:0006011) UDP-glucuronate biosynthetic process(GO:0006065) |
| 0.0 | 0.2 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 0.0 | 0.5 | GO:0098927 | early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927) |
| 0.0 | 0.3 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.0 | 0.2 | GO:0048073 | regulation of eye pigmentation(GO:0048073) |
| 0.0 | 0.6 | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482) |
| 0.0 | 0.1 | GO:0002331 | immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329) pre-B cell allelic exclusion(GO:0002331) negative regulation of thymocyte apoptotic process(GO:0070244) |
| 0.0 | 0.9 | GO:0045103 | intermediate filament-based process(GO:0045103) |
| 0.0 | 0.3 | GO:0097384 | cellular lipid biosynthetic process(GO:0097384) |
| 0.0 | 0.1 | GO:0044314 | protein K27-linked ubiquitination(GO:0044314) |
| 0.0 | 3.2 | GO:0071772 | BMP signaling pathway(GO:0030509) response to BMP(GO:0071772) cellular response to BMP stimulus(GO:0071773) |
| 0.0 | 0.6 | GO:0045604 | regulation of epidermal cell differentiation(GO:0045604) |
| 0.0 | 0.1 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 0.0 | 0.1 | GO:0021938 | smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938) |
| 0.0 | 0.3 | GO:0021952 | central nervous system projection neuron axonogenesis(GO:0021952) |
| 0.0 | 0.4 | GO:0048268 | negative regulation of receptor-mediated endocytosis(GO:0048261) clathrin coat assembly(GO:0048268) |
| 0.0 | 1.1 | GO:0033572 | ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512) |
| 0.0 | 1.5 | GO:0001837 | epithelial to mesenchymal transition(GO:0001837) |
| 0.0 | 0.1 | GO:0031118 | rRNA pseudouridine synthesis(GO:0031118) |
| 0.0 | 0.9 | GO:0006942 | regulation of striated muscle contraction(GO:0006942) |
| 0.0 | 0.3 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.0 | 0.2 | GO:0016098 | monoterpenoid metabolic process(GO:0016098) |
| 0.0 | 0.1 | GO:0060423 | foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492) regulation of branching involved in lung morphogenesis(GO:0061046) positive regulation of branching involved in lung morphogenesis(GO:0061047) iris morphogenesis(GO:0061072) |
| 0.0 | 0.1 | GO:0001544 | initiation of primordial ovarian follicle growth(GO:0001544) |
| 0.0 | 1.1 | GO:0051318 | G1 phase(GO:0051318) |
| 0.0 | 0.2 | GO:0016045 | detection of bacterium(GO:0016045) |
| 0.0 | 0.4 | GO:0043330 | response to exogenous dsRNA(GO:0043330) |
| 0.0 | 0.1 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) |
| 0.0 | 0.1 | GO:0007196 | adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196) negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.0 | 5.3 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 0.0 | 2.1 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 0.1 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
| 0.0 | 0.1 | GO:0000042 | protein targeting to Golgi(GO:0000042) establishment of protein localization to Golgi(GO:0072600) |
| 0.0 | 0.3 | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540) |
| 0.0 | 0.4 | GO:0044349 | nucleotide-excision repair, DNA damage removal(GO:0000718) DNA excision(GO:0044349) |
| 0.0 | 0.1 | GO:0060363 | cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094) |
| 0.0 | 1.1 | GO:0000910 | cytokinesis(GO:0000910) |
| 0.0 | 0.3 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.0 | 0.2 | GO:0035329 | hippo signaling(GO:0035329) |
| 0.0 | 0.1 | GO:0060644 | mammary gland epithelial cell differentiation(GO:0060644) |
| 0.0 | 0.0 | GO:0007501 | mesodermal cell fate specification(GO:0007501) |
| 0.0 | 0.3 | GO:0031532 | actin cytoskeleton reorganization(GO:0031532) |
| 0.0 | 0.3 | GO:0015949 | nucleobase-containing small molecule interconversion(GO:0015949) |
| 0.0 | 1.3 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
| 0.0 | 0.0 | GO:0006740 | NADPH regeneration(GO:0006740) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 2.4 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.2 | 2.1 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.1 | 0.6 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.1 | 1.1 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 0.1 | 0.4 | GO:0031904 | endosome lumen(GO:0031904) |
| 0.1 | 0.5 | GO:0070695 | FHF complex(GO:0070695) |
| 0.1 | 0.9 | GO:0043218 | compact myelin(GO:0043218) |
| 0.1 | 0.2 | GO:0033655 | host(GO:0018995) host cell cytoplasm(GO:0030430) host cell part(GO:0033643) host intracellular part(GO:0033646) host cell cytoplasm part(GO:0033655) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217) |
| 0.1 | 0.3 | GO:0016342 | catenin complex(GO:0016342) |
| 0.1 | 1.1 | GO:0071203 | WASH complex(GO:0071203) |
| 0.1 | 0.9 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.0 | 0.9 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 13.0 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 0.5 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 1.5 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 0.4 | GO:0030122 | AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) |
| 0.0 | 1.0 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 0.4 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 0.4 | GO:0005675 | holo TFIIH complex(GO:0005675) |
| 0.0 | 0.4 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 1.0 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 2.4 | GO:0030017 | sarcomere(GO:0030017) |
| 0.0 | 0.1 | GO:0030893 | meiotic cohesin complex(GO:0030893) |
| 0.0 | 2.0 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 0.2 | GO:0030125 | clathrin vesicle coat(GO:0030125) |
| 0.0 | 0.3 | GO:0005640 | nuclear outer membrane(GO:0005640) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 9.4 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 0.2 | 2.0 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
| 0.2 | 5.9 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.2 | 0.6 | GO:0019981 | interleukin-6 receptor activity(GO:0004915) oncostatin-M receptor activity(GO:0004924) interleukin-6 binding(GO:0019981) interleukin-17 receptor activity(GO:0030368) |
| 0.2 | 2.1 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.2 | 1.5 | GO:0030297 | transmembrane receptor protein tyrosine kinase activator activity(GO:0030297) |
| 0.1 | 1.2 | GO:0005497 | androgen binding(GO:0005497) |
| 0.1 | 1.1 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.1 | 1.6 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093) |
| 0.1 | 0.5 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
| 0.1 | 0.4 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.1 | 1.6 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.1 | 0.3 | GO:0003983 | UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748) |
| 0.1 | 0.8 | GO:0005110 | frizzled-2 binding(GO:0005110) |
| 0.1 | 0.9 | GO:0030172 | troponin C binding(GO:0030172) |
| 0.1 | 0.5 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.1 | 0.2 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.1 | 0.2 | GO:0005223 | intracellular cGMP activated cation channel activity(GO:0005223) |
| 0.1 | 0.2 | GO:0004821 | histidine-tRNA ligase activity(GO:0004821) |
| 0.1 | 0.3 | GO:0000247 | C-8 sterol isomerase activity(GO:0000247) |
| 0.1 | 1.8 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.1 | 0.9 | GO:0015250 | water channel activity(GO:0015250) |
| 0.1 | 0.3 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.1 | 5.9 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.1 | 1.8 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.1 | 0.2 | GO:0016019 | peptidoglycan receptor activity(GO:0016019) |
| 0.0 | 1.0 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 1.1 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
| 0.0 | 0.2 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.0 | 1.4 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 0.6 | GO:0001619 | obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619) |
| 0.0 | 2.1 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.0 | 2.5 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 0.6 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 0.2 | GO:0005113 | patched binding(GO:0005113) |
| 0.0 | 0.9 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 0.2 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.0 | 0.9 | GO:0008601 | protein phosphatase type 2A regulator activity(GO:0008601) |
| 0.0 | 0.1 | GO:0004321 | fatty-acyl-CoA synthase activity(GO:0004321) |
| 0.0 | 0.2 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 0.3 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 1.4 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.0 | 0.4 | GO:0030553 | cGMP binding(GO:0030553) |
| 0.0 | 0.2 | GO:0070513 | death domain binding(GO:0070513) |
| 0.0 | 0.1 | GO:0022897 | peptide:proton symporter activity(GO:0015333) proton-dependent peptide secondary active transmembrane transporter activity(GO:0022897) |
| 0.0 | 0.1 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 0.4 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.0 | 0.5 | GO:0008408 | 3'-5' exonuclease activity(GO:0008408) |
| 0.0 | 0.3 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.0 | 0.3 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 0.2 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.0 | 0.3 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.0 | 0.1 | GO:0001640 | adenylate cyclase inhibiting G-protein coupled glutamate receptor activity(GO:0001640) G-protein coupled glutamate receptor activity(GO:0098988) |
| 0.0 | 0.0 | GO:0015389 | pyrimidine nucleobase transmembrane transporter activity(GO:0005350) pyrimidine- and adenine-specific:sodium symporter activity(GO:0015389) |
| 0.0 | 0.0 | GO:0004345 | glucose-6-phosphate dehydrogenase activity(GO:0004345) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.2 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.4 | ST_TYPE_I_INTERFERON_PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.0 | 1.0 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.3 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 0.5 | SA_G1_AND_S_PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 1.0 | SIG_BCR_SIGNALING_PATHWAY | Members of the BCR signaling pathway |
