Motif ID: TCF7
Z-value: 1.599
Transcription factors associated with TCF7:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| TCF7 | ENSG00000081059.15 | TCF7 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 4.3 | GO:0003308 | negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) |
| 0.9 | 3.7 | GO:0070208 | protein heterotrimerization(GO:0070208) |
| 0.9 | 3.7 | GO:0030913 | paranodal junction assembly(GO:0030913) |
| 0.8 | 2.4 | GO:0003350 | pulmonary myocardium development(GO:0003350) |
| 0.5 | 3.6 | GO:0042483 | negative regulation of odontogenesis(GO:0042483) |
| 0.5 | 1.4 | GO:0021570 | rhombomere 4 development(GO:0021570) |
| 0.4 | 2.0 | GO:0006789 | bilirubin conjugation(GO:0006789) biphenyl metabolic process(GO:0018879) biphenyl catabolic process(GO:0070980) |
| 0.4 | 1.2 | GO:0043371 | negative regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043371) negative regulation of T-helper cell differentiation(GO:0045623) negative regulation of CD4-positive, alpha-beta T cell activation(GO:2000515) |
| 0.3 | 0.9 | GO:0014831 | intestine smooth muscle contraction(GO:0014827) gastro-intestinal system smooth muscle contraction(GO:0014831) |
| 0.2 | 1.6 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
| 0.2 | 3.0 | GO:0034446 | substrate adhesion-dependent cell spreading(GO:0034446) |
| 0.2 | 0.7 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 0.2 | 1.3 | GO:0042989 | sequestering of actin monomers(GO:0042989) |
| 0.2 | 1.1 | GO:0050765 | negative regulation of phagocytosis(GO:0050765) |
| 0.2 | 0.2 | GO:0051589 | negative regulation of neurotransmitter transport(GO:0051589) |
| 0.2 | 5.0 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
| 0.1 | 0.4 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.1 | 1.7 | GO:0060391 | positive regulation of SMAD protein import into nucleus(GO:0060391) |
| 0.1 | 1.1 | GO:0051014 | actin filament severing(GO:0051014) |
| 0.1 | 0.3 | GO:0010834 | obsolete telomere maintenance via telomere shortening(GO:0010834) |
| 0.1 | 0.4 | GO:0019471 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511) |
| 0.1 | 0.2 | GO:0009698 | phenylpropanoid metabolic process(GO:0009698) coumarin metabolic process(GO:0009804) |
| 0.1 | 0.7 | GO:0051085 | chaperone mediated protein folding requiring cofactor(GO:0051085) |
| 0.1 | 0.6 | GO:0071480 | cellular response to gamma radiation(GO:0071480) |
| 0.1 | 0.3 | GO:0050668 | positive regulation of sulfur amino acid metabolic process(GO:0031337) positive regulation of cellular amino acid metabolic process(GO:0045764) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) positive regulation of homocysteine metabolic process(GO:0050668) |
| 0.1 | 1.8 | GO:0045103 | intermediate filament-based process(GO:0045103) |
| 0.1 | 1.2 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 0.2 | GO:0043006 | activation of phospholipase A2 activity by calcium-mediated signaling(GO:0043006) |
| 0.1 | 0.2 | GO:0051552 | flavone metabolic process(GO:0051552) |
| 0.1 | 0.2 | GO:0050747 | positive regulation of lipoprotein metabolic process(GO:0050747) |
| 0.1 | 2.0 | GO:0043462 | regulation of ATPase activity(GO:0043462) |
| 0.1 | 0.3 | GO:0051205 | protein insertion into membrane(GO:0051205) |
| 0.1 | 4.5 | GO:0007229 | integrin-mediated signaling pathway(GO:0007229) |
| 0.0 | 1.2 | GO:0006911 | phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324) |
| 0.0 | 0.2 | GO:0034337 | RNA folding(GO:0034337) DNA hypomethylation(GO:0044028) hypomethylation of CpG island(GO:0044029) regulation of DNA methylation(GO:0044030) |
| 0.0 | 0.2 | GO:1903301 | regulation of glucokinase activity(GO:0033131) positive regulation of glucokinase activity(GO:0033133) regulation of hexokinase activity(GO:1903299) positive regulation of hexokinase activity(GO:1903301) |
| 0.0 | 0.5 | GO:1901984 | negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757) |
| 0.0 | 0.4 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.0 | 1.2 | GO:0009954 | proximal/distal pattern formation(GO:0009954) |
| 0.0 | 1.2 | GO:0015949 | nucleobase-containing small molecule interconversion(GO:0015949) |
| 0.0 | 8.3 | GO:0006184 | obsolete GTP catabolic process(GO:0006184) |
| 0.0 | 0.2 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.0 | 1.1 | GO:0055007 | cardiac muscle cell differentiation(GO:0055007) |
| 0.0 | 0.5 | GO:0071479 | cellular response to ionizing radiation(GO:0071479) |
| 0.0 | 0.3 | GO:0021591 | ventricular system development(GO:0021591) |
| 0.0 | 0.3 | GO:0006654 | phosphatidic acid biosynthetic process(GO:0006654) |
| 0.0 | 0.2 | GO:0045040 | outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040) |
| 0.0 | 0.8 | GO:0031424 | keratinization(GO:0031424) |
| 0.0 | 0.2 | GO:0007195 | adenylate cyclase-inhibiting dopamine receptor signaling pathway(GO:0007195) |
| 0.0 | 0.2 | GO:0006707 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 0.0 | 0.1 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.0 | 2.6 | GO:0015718 | monocarboxylic acid transport(GO:0015718) |
| 0.0 | 2.3 | GO:0030198 | extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062) |
| 0.0 | 1.8 | GO:0007498 | mesoderm development(GO:0007498) |
| 0.0 | 0.3 | GO:0006448 | regulation of translational elongation(GO:0006448) |
| 0.0 | 0.1 | GO:0019322 | pentose biosynthetic process(GO:0019322) |
| 0.0 | 0.7 | GO:0043401 | steroid hormone mediated signaling pathway(GO:0043401) |
| 0.0 | 0.8 | GO:0048813 | dendrite morphogenesis(GO:0048813) |
| 0.0 | 0.2 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.0 | 0.1 | GO:0032057 | negative regulation of translational initiation in response to stress(GO:0032057) |
| 0.0 | 0.4 | GO:0006891 | intra-Golgi vesicle-mediated transport(GO:0006891) |
| 0.0 | 0.6 | GO:0016358 | dendrite development(GO:0016358) |
| 0.0 | 1.3 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.0 | 0.1 | GO:0015705 | iodide transport(GO:0015705) transcytosis(GO:0045056) |
| 0.0 | 0.2 | GO:0048485 | sympathetic nervous system development(GO:0048485) |
| 0.0 | 0.4 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.0 | 0.3 | GO:0044349 | nucleotide-excision repair, DNA damage removal(GO:0000718) DNA excision(GO:0044349) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.2 | GO:0005607 | laminin-2 complex(GO:0005607) |
| 0.5 | 0.9 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.3 | 4.1 | GO:0005606 | laminin-1 complex(GO:0005606) |
| 0.3 | 3.7 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.2 | 3.9 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.2 | 1.6 | GO:0016942 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) |
| 0.2 | 1.4 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.1 | 2.0 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.1 | 0.3 | GO:0005674 | transcription factor TFIIF complex(GO:0005674) |
| 0.1 | 0.8 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.1 | 0.4 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.1 | 0.3 | GO:0031305 | integral component of mitochondrial inner membrane(GO:0031305) |
| 0.0 | 2.2 | GO:0098636 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.0 | 0.8 | GO:0032806 | carboxy-terminal domain protein kinase complex(GO:0032806) |
| 0.0 | 0.4 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 0.0 | 0.7 | GO:0019861 | obsolete flagellum(GO:0019861) |
| 0.0 | 0.2 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.0 | 0.8 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 0.2 | GO:0070435 | Shc-EGFR complex(GO:0070435) |
| 0.0 | 0.7 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 5.8 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 1.1 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.0 | 2.4 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 10.3 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 0.1 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.0 | 0.3 | GO:0000783 | telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783) |
| 0.0 | 2.7 | GO:0005938 | cell cortex(GO:0005938) |
| 0.0 | 0.3 | GO:0061200 | clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202) |
| 0.0 | 0.8 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 0.6 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 2.0 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 7.8 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 0.1 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.0 | 0.1 | GO:0005851 | eukaryotic translation initiation factor 2B complex(GO:0005851) |
| 0.0 | 0.3 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.4 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.4 | 4.3 | GO:0030547 | receptor inhibitor activity(GO:0030547) receptor antagonist activity(GO:0048019) |
| 0.3 | 3.7 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.2 | 1.6 | GO:0031994 | insulin-like growth factor I binding(GO:0031994) |
| 0.2 | 2.5 | GO:0016641 | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641) |
| 0.2 | 0.7 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
| 0.1 | 0.9 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.1 | 0.6 | GO:0004692 | cGMP-dependent protein kinase activity(GO:0004692) |
| 0.1 | 3.8 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.1 | 0.4 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545) |
| 0.1 | 1.7 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.1 | 1.2 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.1 | 0.3 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.1 | 0.4 | GO:0004169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169) |
| 0.1 | 0.3 | GO:0048039 | ubiquinone binding(GO:0048039) |
| 0.1 | 2.3 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 1.6 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.1 | 3.1 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.1 | 1.3 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.1 | 5.9 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 0.2 | GO:0004608 | phosphatidylethanolamine N-methyltransferase activity(GO:0004608) |
| 0.1 | 2.0 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 0.3 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 0.0 | 0.3 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.0 | 0.2 | GO:0017160 | Ral GTPase binding(GO:0017160) |
| 0.0 | 0.3 | GO:0003691 | double-stranded telomeric DNA binding(GO:0003691) |
| 0.0 | 0.2 | GO:0003873 | 6-phosphofructo-2-kinase activity(GO:0003873) |
| 0.0 | 0.2 | GO:0000099 | sulfur amino acid transmembrane transporter activity(GO:0000099) neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294) |
| 0.0 | 0.2 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.0 | 0.5 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 2.7 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 0.7 | GO:0008430 | selenium binding(GO:0008430) |
| 0.0 | 0.2 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
| 0.0 | 0.1 | GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616) |
| 0.0 | 0.2 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 0.0 | 0.1 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
| 0.0 | 1.4 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 2.0 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 0.5 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 0.3 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617) |
| 0.0 | 5.9 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 2.2 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.7 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 8.1 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 0.2 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.0 | 0.1 | GO:0010485 | H4 histone acetyltransferase activity(GO:0010485) |
| 0.0 | 0.5 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
| 0.0 | 0.1 | GO:0017057 | glucose-6-phosphate dehydrogenase activity(GO:0004345) 6-phosphogluconolactonase activity(GO:0017057) |
| 0.0 | 1.9 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389) |
| 0.0 | 0.1 | GO:0051378 | serotonin binding(GO:0051378) |
| 0.0 | 0.3 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.0 | 2.3 | GO:0005057 | receptor signaling protein activity(GO:0005057) |
| 0.0 | 0.3 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 3.0 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.0 | 0.1 | GO:0004447 | iodide peroxidase activity(GO:0004447) |
| 0.0 | 0.3 | GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656) |
| 0.0 | 0.1 | GO:0034875 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |
| 0.0 | 0.3 | GO:0016251 | obsolete general RNA polymerase II transcription factor activity(GO:0016251) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.6 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.8 | ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY | PI3K Pathway |
| 0.0 | 0.5 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 1.1 | ST_FAS_SIGNALING_PATHWAY | Fas Signaling Pathway |
| 0.0 | 0.2 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.2 | ST_INTEGRIN_SIGNALING_PATHWAY | Integrin Signaling Pathway |
