Motif ID: TCF7L2
Z-value: 2.035
Transcription factors associated with TCF7L2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| TCF7L2 | ENSG00000148737.11 | TCF7L2 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 6.6 | GO:0048619 | embryonic hindgut morphogenesis(GO:0048619) |
| 1.6 | 6.5 | GO:0033197 | response to vitamin E(GO:0033197) |
| 1.6 | 4.8 | GO:0003308 | negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) |
| 0.6 | 2.8 | GO:0007614 | short-term memory(GO:0007614) |
| 0.5 | 1.4 | GO:0060028 | convergent extension involved in axis elongation(GO:0060028) |
| 0.4 | 2.0 | GO:0035414 | negative regulation of catenin import into nucleus(GO:0035414) |
| 0.4 | 5.3 | GO:0034446 | substrate adhesion-dependent cell spreading(GO:0034446) |
| 0.3 | 3.5 | GO:0046851 | negative regulation of bone resorption(GO:0045779) negative regulation of bone remodeling(GO:0046851) |
| 0.3 | 4.2 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 0.2 | 0.7 | GO:0051451 | myoblast migration(GO:0051451) |
| 0.2 | 1.2 | GO:0032509 | endosome transport via multivesicular body sorting pathway(GO:0032509) plasma membrane to endosome transport(GO:0048227) |
| 0.2 | 0.9 | GO:0010727 | negative regulation of hydrogen peroxide metabolic process(GO:0010727) |
| 0.2 | 1.8 | GO:0060100 | regulation of phagocytosis, engulfment(GO:0060099) positive regulation of phagocytosis, engulfment(GO:0060100) regulation of membrane invagination(GO:1905153) positive regulation of membrane invagination(GO:1905155) |
| 0.2 | 0.7 | GO:0034122 | negative regulation of toll-like receptor signaling pathway(GO:0034122) |
| 0.2 | 1.6 | GO:0032000 | positive regulation of fatty acid beta-oxidation(GO:0032000) |
| 0.1 | 4.6 | GO:0048008 | platelet-derived growth factor receptor signaling pathway(GO:0048008) |
| 0.1 | 4.5 | GO:0050873 | brown fat cell differentiation(GO:0050873) |
| 0.1 | 0.7 | GO:0070682 | proteasome regulatory particle assembly(GO:0070682) |
| 0.1 | 0.2 | GO:0061298 | retina vasculature development in camera-type eye(GO:0061298) retina vasculature morphogenesis in camera-type eye(GO:0061299) |
| 0.1 | 4.6 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
| 0.1 | 1.0 | GO:0006654 | phosphatidic acid biosynthetic process(GO:0006654) |
| 0.1 | 0.4 | GO:0009609 | response to symbiont(GO:0009608) response to symbiotic bacterium(GO:0009609) |
| 0.1 | 0.3 | GO:0032196 | transposition, DNA-mediated(GO:0006313) transposition(GO:0032196) |
| 0.1 | 0.8 | GO:0010658 | striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667) |
| 0.1 | 2.1 | GO:0009954 | proximal/distal pattern formation(GO:0009954) |
| 0.1 | 0.2 | GO:0036072 | intramembranous ossification(GO:0001957) direct ossification(GO:0036072) |
| 0.1 | 0.7 | GO:0021952 | central nervous system projection neuron axonogenesis(GO:0021952) |
| 0.1 | 0.6 | GO:0001885 | endothelial cell development(GO:0001885) |
| 0.1 | 6.1 | GO:0015718 | monocarboxylic acid transport(GO:0015718) |
| 0.0 | 0.5 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.0 | 1.4 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
| 0.0 | 3.8 | GO:0007229 | integrin-mediated signaling pathway(GO:0007229) |
| 0.0 | 0.5 | GO:0032148 | activation of protein kinase B activity(GO:0032148) |
| 0.0 | 0.3 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
| 0.0 | 2.4 | GO:0001837 | epithelial to mesenchymal transition(GO:0001837) |
| 0.0 | 0.8 | GO:0032781 | positive regulation of ATPase activity(GO:0032781) |
| 0.0 | 0.2 | GO:0051176 | positive regulation of sulfur metabolic process(GO:0051176) |
| 0.0 | 1.3 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
| 0.0 | 5.4 | GO:0071466 | xenobiotic metabolic process(GO:0006805) response to xenobiotic stimulus(GO:0009410) cellular response to xenobiotic stimulus(GO:0071466) |
| 0.0 | 0.4 | GO:0006662 | glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904) |
| 0.0 | 8.6 | GO:0097485 | axon guidance(GO:0007411) neuron projection guidance(GO:0097485) |
| 0.0 | 8.3 | GO:0016567 | protein ubiquitination(GO:0016567) |
| 0.0 | 0.1 | GO:0060164 | regulation of timing of neuron differentiation(GO:0060164) |
| 0.0 | 0.1 | GO:0019228 | neuronal action potential(GO:0019228) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 6.6 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) beta-catenin-TCF complex(GO:1990907) |
| 0.4 | 5.3 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.4 | 1.4 | GO:0030936 | collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936) |
| 0.3 | 4.5 | GO:0005606 | laminin-1 complex(GO:0005606) |
| 0.2 | 0.9 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.2 | 0.7 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.2 | 5.4 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 1.0 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.1 | 0.7 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) |
| 0.1 | 10.2 | GO:0016459 | myosin complex(GO:0016459) |
| 0.1 | 1.8 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 0.8 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.1 | 4.6 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.1 | 3.8 | GO:0098636 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.1 | 10.8 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.0 | 1.2 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.0 | 5.0 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 0.4 | GO:0016585 | obsolete chromatin remodeling complex(GO:0016585) |
| 0.0 | 0.2 | GO:0033268 | node of Ranvier(GO:0033268) |
| 0.0 | 1.0 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 2.8 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 0.2 | GO:0005732 | small nucleolar ribonucleoprotein complex(GO:0005732) |
| 0.0 | 4.1 | GO:0030141 | secretory granule(GO:0030141) |
| 0.0 | 4.8 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 0.1 | GO:0000445 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 6.0 | GO:0008112 | nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760) |
| 1.2 | 4.7 | GO:0004504 | peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598) |
| 0.4 | 4.8 | GO:0030547 | receptor inhibitor activity(GO:0030547) receptor antagonist activity(GO:0048019) |
| 0.3 | 5.2 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.3 | 1.8 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.3 | 6.5 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.2 | 3.8 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.2 | 4.8 | GO:0043498 | obsolete cell surface binding(GO:0043498) |
| 0.2 | 1.2 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.2 | 1.4 | GO:0005110 | frizzled-2 binding(GO:0005110) |
| 0.1 | 0.9 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.1 | 6.1 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.1 | 1.0 | GO:0032052 | bile acid binding(GO:0032052) |
| 0.1 | 0.6 | GO:0000099 | sulfur amino acid transmembrane transporter activity(GO:0000099) neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294) |
| 0.1 | 5.3 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 0.8 | GO:0030297 | transmembrane receptor protein tyrosine kinase activator activity(GO:0030297) |
| 0.1 | 0.7 | GO:0005436 | sodium:phosphate symporter activity(GO:0005436) |
| 0.1 | 7.0 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 6.4 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 0.5 | GO:0043422 | protein kinase B binding(GO:0043422) |
| 0.1 | 0.2 | GO:0005105 | type 1 fibroblast growth factor receptor binding(GO:0005105) type 2 fibroblast growth factor receptor binding(GO:0005111) |
| 0.1 | 10.2 | GO:0003774 | motor activity(GO:0003774) |
| 0.1 | 0.3 | GO:0004803 | transposase activity(GO:0004803) |
| 0.0 | 5.8 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389) |
| 0.0 | 8.8 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 1.6 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.0 | 0.2 | GO:0016206 | catechol O-methyltransferase activity(GO:0016206) |
| 0.0 | 0.4 | GO:0003756 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.0 | 0.6 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 3.0 | GO:0005125 | cytokine activity(GO:0005125) |
| 0.0 | 0.6 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 0.6 | GO:0003704 | obsolete specific RNA polymerase II transcription factor activity(GO:0003704) |
| 0.0 | 0.2 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 2.3 | GO:0003714 | transcription corepressor activity(GO:0003714) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.5 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 5.5 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
