Motif ID: TFCP2L1
Z-value: 1.837
Transcription factors associated with TFCP2L1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| TFCP2L1 | ENSG00000115112.7 | TFCP2L1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2.6 | GO:0071603 | negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) endothelial cell-cell adhesion(GO:0071603) |
| 0.7 | 2.2 | GO:0006478 | peptidyl-tyrosine sulfation(GO:0006478) |
| 0.7 | 2.0 | GO:0006051 | mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051) |
| 0.4 | 1.2 | GO:1903115 | regulation of muscle filament sliding(GO:0032971) regulation of actin filament-based movement(GO:1903115) |
| 0.4 | 0.7 | GO:0051451 | myoblast migration(GO:0051451) |
| 0.4 | 1.1 | GO:0009174 | UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049) |
| 0.4 | 1.8 | GO:0010761 | fibroblast migration(GO:0010761) |
| 0.3 | 2.2 | GO:0060414 | aorta development(GO:0035904) aorta morphogenesis(GO:0035909) aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.3 | 1.8 | GO:0060219 | camera-type eye photoreceptor cell differentiation(GO:0060219) |
| 0.3 | 1.3 | GO:0048682 | axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682) |
| 0.2 | 1.7 | GO:0016559 | peroxisome membrane biogenesis(GO:0016557) peroxisome fission(GO:0016559) |
| 0.1 | 0.6 | GO:0060272 | embryonic skeletal joint morphogenesis(GO:0060272) embryonic skeletal joint development(GO:0072498) |
| 0.1 | 0.4 | GO:0010701 | positive regulation of chronic inflammatory response(GO:0002678) positive regulation of norepinephrine secretion(GO:0010701) positive regulation of guanylate cyclase activity(GO:0031284) |
| 0.1 | 1.8 | GO:0032331 | negative regulation of chondrocyte differentiation(GO:0032331) |
| 0.1 | 2.3 | GO:0014037 | Schwann cell differentiation(GO:0014037) |
| 0.1 | 0.3 | GO:0001543 | ovarian follicle rupture(GO:0001543) |
| 0.1 | 4.1 | GO:0007045 | cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041) |
| 0.1 | 0.5 | GO:0015827 | tryptophan transport(GO:0015827) leucine import(GO:0060356) |
| 0.1 | 1.9 | GO:0043616 | keratinocyte proliferation(GO:0043616) |
| 0.1 | 8.5 | GO:0043542 | endothelial cell migration(GO:0043542) |
| 0.1 | 0.5 | GO:0099515 | nuclear migration along microfilament(GO:0031022) actin filament-based transport(GO:0099515) |
| 0.1 | 1.2 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
| 0.1 | 2.1 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 0.2 | GO:0001732 | formation of cytoplasmic translation initiation complex(GO:0001732) cytoplasmic translation(GO:0002181) cytoplasmic translational initiation(GO:0002183) |
| 0.1 | 0.6 | GO:0033137 | negative regulation of peptidyl-serine phosphorylation(GO:0033137) |
| 0.1 | 0.5 | GO:0021955 | central nervous system projection neuron axonogenesis(GO:0021952) central nervous system neuron axonogenesis(GO:0021955) |
| 0.1 | 1.6 | GO:0043044 | ATP-dependent chromatin remodeling(GO:0043044) |
| 0.0 | 0.7 | GO:0007035 | vacuolar acidification(GO:0007035) |
| 0.0 | 0.1 | GO:0042369 | vitamin D catabolic process(GO:0042369) |
| 0.0 | 1.7 | GO:0034332 | adherens junction organization(GO:0034332) |
| 0.0 | 0.5 | GO:0006621 | protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437) |
| 0.0 | 0.3 | GO:0042797 | 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797) |
| 0.0 | 0.3 | GO:0006562 | proline catabolic process(GO:0006562) |
| 0.0 | 3.1 | GO:0006821 | chloride transport(GO:0006821) |
| 0.0 | 0.4 | GO:0008089 | anterograde axonal transport(GO:0008089) |
| 0.0 | 0.2 | GO:0019509 | L-methionine biosynthetic process from methylthioadenosine(GO:0019509) |
| 0.0 | 2.5 | GO:0030282 | bone mineralization(GO:0030282) |
| 0.0 | 0.3 | GO:0045898 | regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) |
| 0.0 | 1.4 | GO:0015914 | phospholipid transport(GO:0015914) |
| 0.0 | 0.2 | GO:0006642 | triglyceride mobilization(GO:0006642) |
| 0.0 | 1.6 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 0.0 | 0.1 | GO:0006477 | protein sulfation(GO:0006477) |
| 0.0 | 0.3 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.0 | 2.0 | GO:0007229 | integrin-mediated signaling pathway(GO:0007229) |
| 0.0 | 0.4 | GO:0000768 | syncytium formation by plasma membrane fusion(GO:0000768) myoblast fusion(GO:0007520) |
| 0.0 | 0.1 | GO:0060017 | parathyroid gland development(GO:0060017) |
| 0.0 | 0.9 | GO:1905114 | cell surface receptor signaling pathway involved in cell-cell signaling(GO:1905114) |
| 0.0 | 0.0 | GO:0007538 | primary sex determination(GO:0007538) |
| 0.0 | 0.3 | GO:0006984 | ER-nucleus signaling pathway(GO:0006984) |
| 0.0 | 0.3 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.0 | 1.1 | GO:0010977 | negative regulation of neuron projection development(GO:0010977) |
| 0.0 | 3.7 | GO:0006184 | obsolete GTP catabolic process(GO:0006184) |
| 0.0 | 0.0 | GO:0010834 | obsolete telomere maintenance via telomere shortening(GO:0010834) |
| 0.0 | 0.4 | GO:0042398 | cellular modified amino acid biosynthetic process(GO:0042398) |
| 0.0 | 0.8 | GO:0050680 | negative regulation of epithelial cell proliferation(GO:0050680) |
| 0.0 | 0.2 | GO:0045669 | positive regulation of osteoblast differentiation(GO:0045669) |
| 0.0 | 0.6 | GO:0006081 | cellular aldehyde metabolic process(GO:0006081) |
| 0.0 | 0.1 | GO:0035520 | monoubiquitinated protein deubiquitination(GO:0035520) |
| 0.0 | 1.0 | GO:0046546 | male gonad development(GO:0008584) development of primary male sexual characteristics(GO:0046546) |
| 0.0 | 0.5 | GO:0031047 | gene silencing by RNA(GO:0031047) |
| 0.0 | 0.0 | GO:1902414 | protein localization to adherens junction(GO:0071896) protein localization to cell junction(GO:1902414) |
| 0.0 | 0.3 | GO:0030851 | granulocyte differentiation(GO:0030851) |
| 0.0 | 0.8 | GO:0097696 | JAK-STAT cascade(GO:0007259) STAT cascade(GO:0097696) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.3 | GO:0005608 | laminin-3 complex(GO:0005608) |
| 0.3 | 2.6 | GO:0071664 | catenin-TCF7L2 complex(GO:0071664) |
| 0.3 | 1.8 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.3 | 4.1 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.2 | 0.7 | GO:0000221 | vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) |
| 0.2 | 1.6 | GO:0016589 | NURF complex(GO:0016589) |
| 0.2 | 2.1 | GO:0005606 | laminin-1 complex(GO:0005606) |
| 0.1 | 1.7 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.1 | 1.8 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.0 | 1.2 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 0.6 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.0 | 0.3 | GO:0000127 | transcription factor TFIIIC complex(GO:0000127) |
| 0.0 | 0.5 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.0 | 2.0 | GO:0098636 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.0 | 2.0 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 0.2 | GO:0033179 | proton-transporting V-type ATPase, V0 domain(GO:0033179) |
| 0.0 | 0.4 | GO:0030867 | rough endoplasmic reticulum membrane(GO:0030867) |
| 0.0 | 0.1 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.0 | 0.3 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.0 | 1.2 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 0.0 | GO:0034750 | Scrib-APC-beta-catenin complex(GO:0034750) |
| 0.0 | 2.5 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.0 | 0.5 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 5.7 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.0 | 0.4 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 0.8 | GO:0005624 | obsolete membrane fraction(GO:0005624) |
| 0.0 | 0.1 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.0 | 0.7 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.2 | GO:0008476 | protein-tyrosine sulfotransferase activity(GO:0008476) |
| 0.7 | 2.0 | GO:0045127 | N-acetylglucosamine kinase activity(GO:0045127) |
| 0.4 | 2.2 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.4 | 1.8 | GO:0034235 | GPI anchor binding(GO:0034235) |
| 0.4 | 2.5 | GO:0030021 | extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345) |
| 0.3 | 2.6 | GO:0042153 | obsolete RPTP-like protein binding(GO:0042153) alpha-catenin binding(GO:0045294) |
| 0.3 | 1.1 | GO:0016635 | oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635) |
| 0.2 | 1.2 | GO:0008486 | diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) |
| 0.2 | 0.6 | GO:0004947 | bradykinin receptor activity(GO:0004947) |
| 0.2 | 1.2 | GO:0045159 | myosin II binding(GO:0045159) |
| 0.2 | 1.8 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 0.2 | 4.1 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.2 | 1.6 | GO:0031491 | nucleosome binding(GO:0031491) |
| 0.1 | 0.4 | GO:0008475 | procollagen-lysine 5-dioxygenase activity(GO:0008475) |
| 0.1 | 1.8 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
| 0.1 | 1.2 | GO:0031013 | troponin I binding(GO:0031013) |
| 0.1 | 0.6 | GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030) |
| 0.1 | 1.4 | GO:0016641 | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641) |
| 0.1 | 0.6 | GO:0030020 | extracellular matrix structural constituent conferring tensile strength(GO:0030020) |
| 0.1 | 1.4 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.1 | 2.0 | GO:0030291 | protein serine/threonine kinase inhibitor activity(GO:0030291) |
| 0.1 | 0.4 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 0.1 | 1.0 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.1 | 0.3 | GO:0004657 | proline dehydrogenase activity(GO:0004657) |
| 0.1 | 0.4 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) |
| 0.1 | 0.2 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.1 | 1.5 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.1 | 0.3 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.1 | 0.5 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.0 | 0.3 | GO:0051766 | inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766) |
| 0.0 | 0.5 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.0 | 1.1 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.0 | 0.3 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.0 | 0.2 | GO:0008967 | phosphoglycolate phosphatase activity(GO:0008967) |
| 0.0 | 0.4 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.0 | 0.9 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.0 | 0.5 | GO:0005521 | lamin binding(GO:0005521) |
| 0.0 | 1.8 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 0.1 | GO:0070576 | vitamin D 24-hydroxylase activity(GO:0070576) |
| 0.0 | 0.5 | GO:0003756 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.0 | 3.8 | GO:0035257 | nuclear hormone receptor binding(GO:0035257) |
| 0.0 | 0.3 | GO:0050780 | dopamine receptor binding(GO:0050780) |
| 0.0 | 0.3 | GO:0003709 | obsolete RNA polymerase III transcription factor activity(GO:0003709) |
| 0.0 | 0.1 | GO:0004768 | stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) |
| 0.0 | 0.7 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 0.1 | GO:0005025 | transforming growth factor beta receptor activity, type I(GO:0005025) |
| 0.0 | 0.7 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 1.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 1.4 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.2 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.0 | 1.0 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 1.2 | GO:0005254 | chloride channel activity(GO:0005254) |
| 0.0 | 10.0 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 0.3 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 0.7 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 0.8 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.2 | ST_INTEGRIN_SIGNALING_PATHWAY | Integrin Signaling Pathway |
| 0.1 | 2.0 | ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY | PI3K Pathway |
| 0.0 | 0.9 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 0.9 | ST_G_ALPHA_I_PATHWAY | G alpha i Pathway |
