Motif ID: THRA_RXRB
Z-value: 2.224
Transcription factors associated with THRA_RXRB:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| RXRB | ENSG00000204231.6 | RXRB |
| THRA | ENSG00000126351.8 | THRA |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 4.3 | GO:0051066 | dihydrobiopterin metabolic process(GO:0051066) |
| 0.4 | 5.3 | GO:0042832 | defense response to protozoan(GO:0042832) |
| 0.4 | 1.7 | GO:0018352 | protein-pyridoxal-5-phosphate linkage(GO:0018352) |
| 0.4 | 1.9 | GO:0030951 | establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951) |
| 0.3 | 1.0 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 0.3 | 2.7 | GO:0015074 | DNA integration(GO:0015074) |
| 0.3 | 4.3 | GO:0018298 | protein-chromophore linkage(GO:0018298) |
| 0.2 | 2.0 | GO:0007064 | mitotic sister chromatid cohesion(GO:0007064) kinetochore assembly(GO:0051382) kinetochore organization(GO:0051383) |
| 0.2 | 12.6 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.2 | 0.6 | GO:0030449 | regulation of complement activation(GO:0030449) negative regulation of complement activation(GO:0045916) regulation of protein activation cascade(GO:2000257) negative regulation of protein activation cascade(GO:2000258) |
| 0.2 | 0.8 | GO:0072180 | mesonephric duct morphogenesis(GO:0072180) |
| 0.2 | 0.4 | GO:0051971 | positive regulation of transmission of nerve impulse(GO:0051971) |
| 0.2 | 0.7 | GO:0090073 | positive regulation of protein homodimerization activity(GO:0090073) |
| 0.2 | 0.4 | GO:0045603 | positive regulation of endothelial cell differentiation(GO:0045603) |
| 0.2 | 1.2 | GO:0040032 | post-embryonic body morphogenesis(GO:0040032) |
| 0.2 | 0.8 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.2 | 0.5 | GO:0070171 | negative regulation of tooth mineralization(GO:0070171) |
| 0.1 | 1.6 | GO:0002920 | regulation of humoral immune response(GO:0002920) |
| 0.1 | 1.2 | GO:0030422 | production of siRNA involved in RNA interference(GO:0030422) |
| 0.1 | 0.4 | GO:0007028 | cytoplasm organization(GO:0007028) |
| 0.1 | 0.7 | GO:0050685 | positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313) |
| 0.1 | 0.7 | GO:0030490 | maturation of SSU-rRNA(GO:0030490) |
| 0.1 | 0.5 | GO:0014820 | tonic smooth muscle contraction(GO:0014820) artery smooth muscle contraction(GO:0014824) |
| 0.1 | 0.4 | GO:2001259 | positive regulation of calcium ion transmembrane transporter activity(GO:1901021) positive regulation of cation channel activity(GO:2001259) |
| 0.1 | 1.4 | GO:0006984 | ER-nucleus signaling pathway(GO:0006984) |
| 0.1 | 1.4 | GO:0090399 | replicative senescence(GO:0090399) |
| 0.1 | 0.5 | GO:0009313 | oligosaccharide catabolic process(GO:0009313) |
| 0.1 | 1.0 | GO:0050858 | negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.1 | 0.3 | GO:0015910 | peroxisomal long-chain fatty acid import(GO:0015910) |
| 0.1 | 1.1 | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059) |
| 0.1 | 0.4 | GO:0015742 | alpha-ketoglutarate transport(GO:0015742) |
| 0.1 | 0.3 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 0.1 | 1.0 | GO:0042438 | melanin metabolic process(GO:0006582) melanin biosynthetic process(GO:0042438) |
| 0.1 | 0.4 | GO:0045040 | outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040) |
| 0.1 | 2.5 | GO:0002286 | T cell activation involved in immune response(GO:0002286) |
| 0.1 | 0.2 | GO:0032509 | endosome transport via multivesicular body sorting pathway(GO:0032509) |
| 0.1 | 0.4 | GO:0050957 | equilibrioception(GO:0050957) |
| 0.1 | 0.9 | GO:0006750 | glutathione biosynthetic process(GO:0006750) |
| 0.1 | 0.5 | GO:0046784 | viral mRNA export from host cell nucleus(GO:0046784) |
| 0.1 | 0.5 | GO:0051290 | protein heterotetramerization(GO:0051290) |
| 0.1 | 0.3 | GO:0051790 | short-chain fatty acid biosynthetic process(GO:0051790) |
| 0.1 | 0.1 | GO:0006590 | thyroid hormone generation(GO:0006590) |
| 0.1 | 0.4 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.0 | 0.5 | GO:0046902 | regulation of mitochondrial membrane permeability(GO:0046902) regulation of membrane permeability(GO:0090559) |
| 0.0 | 0.4 | GO:0046653 | tetrahydrofolate metabolic process(GO:0046653) |
| 0.0 | 1.0 | GO:0007628 | adult walking behavior(GO:0007628) walking behavior(GO:0090659) |
| 0.0 | 0.8 | GO:0050812 | acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812) |
| 0.0 | 0.1 | GO:0006420 | arginyl-tRNA aminoacylation(GO:0006420) |
| 0.0 | 0.1 | GO:0090034 | regulation of chaperone-mediated protein complex assembly(GO:0090034) positive regulation of chaperone-mediated protein complex assembly(GO:0090035) |
| 0.0 | 0.2 | GO:0002860 | natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860) |
| 0.0 | 0.2 | GO:0018101 | protein citrullination(GO:0018101) |
| 0.0 | 0.2 | GO:0006999 | nuclear pore organization(GO:0006999) |
| 0.0 | 0.3 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.0 | 1.4 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
| 0.0 | 1.6 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
| 0.0 | 0.5 | GO:0060056 | mammary gland involution(GO:0060056) |
| 0.0 | 1.0 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.0 | 0.1 | GO:0010642 | negative regulation of platelet-derived growth factor receptor signaling pathway(GO:0010642) |
| 0.0 | 0.3 | GO:0007168 | receptor guanylyl cyclase signaling pathway(GO:0007168) |
| 0.0 | 0.7 | GO:0043666 | regulation of phosphoprotein phosphatase activity(GO:0043666) |
| 0.0 | 2.7 | GO:0006094 | gluconeogenesis(GO:0006094) |
| 0.0 | 0.1 | GO:0007500 | mesodermal cell fate determination(GO:0007500) |
| 0.0 | 0.2 | GO:1901984 | negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757) |
| 0.0 | 0.5 | GO:0050728 | negative regulation of inflammatory response(GO:0050728) |
| 0.0 | 0.4 | GO:0060438 | trachea development(GO:0060438) |
| 0.0 | 0.3 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.0 | 1.4 | GO:0006821 | chloride transport(GO:0006821) |
| 0.0 | 0.4 | GO:0000291 | nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
| 0.0 | 0.2 | GO:0045670 | regulation of osteoclast differentiation(GO:0045670) |
| 0.0 | 0.1 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
| 0.0 | 0.7 | GO:0008633 | obsolete activation of pro-apoptotic gene products(GO:0008633) |
| 0.0 | 0.1 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 0.0 | 0.1 | GO:0032227 | negative regulation of synaptic transmission, dopaminergic(GO:0032227) |
| 0.0 | 0.1 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) phosphatidylethanolamine metabolic process(GO:0046337) |
| 0.0 | 0.2 | GO:0030252 | growth hormone secretion(GO:0030252) |
| 0.0 | 0.3 | GO:0035019 | somatic stem cell population maintenance(GO:0035019) |
| 0.0 | 1.2 | GO:0007202 | activation of phospholipase C activity(GO:0007202) |
| 0.0 | 0.1 | GO:0009314 | response to radiation(GO:0009314) |
| 0.0 | 0.1 | GO:0001880 | Mullerian duct regression(GO:0001880) |
| 0.0 | 0.2 | GO:0045947 | negative regulation of translational initiation(GO:0045947) |
| 0.0 | 1.1 | GO:0034339 | obsolete regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor(GO:0034339) |
| 0.0 | 0.4 | GO:0071804 | cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805) |
| 0.0 | 0.1 | GO:0007603 | phototransduction, visible light(GO:0007603) |
| 0.0 | 0.5 | GO:0060041 | retina development in camera-type eye(GO:0060041) |
| 0.0 | 0.4 | GO:0072659 | protein localization to plasma membrane(GO:0072659) protein localization to cell periphery(GO:1990778) |
| 0.0 | 0.1 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 0.0 | 0.1 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 4.3 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.4 | 2.7 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.3 | 1.0 | GO:0030895 | apolipoprotein B mRNA editing enzyme complex(GO:0030895) |
| 0.2 | 0.8 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
| 0.2 | 0.7 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.1 | 0.3 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.1 | 1.2 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.1 | 0.3 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.1 | 0.7 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
| 0.1 | 0.7 | GO:0033162 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.1 | 1.6 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.1 | 0.5 | GO:0000445 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
| 0.1 | 0.9 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.1 | 1.9 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 0.5 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.0 | 0.6 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 1.0 | GO:0045263 | proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263) |
| 0.0 | 0.4 | GO:0016442 | RISC complex(GO:0016442) RNAi effector complex(GO:0031332) |
| 0.0 | 0.8 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 0.2 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.0 | 0.3 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 0.0 | 2.2 | GO:0000781 | chromosome, telomeric region(GO:0000781) |
| 0.0 | 0.6 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.0 | 0.5 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.0 | 0.4 | GO:0032421 | stereocilium(GO:0032420) stereocilium bundle(GO:0032421) |
| 0.0 | 0.4 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 1.6 | GO:0030424 | axon(GO:0030424) |
| 0.0 | 1.1 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 0.6 | GO:0005761 | organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761) |
| 0.0 | 2.0 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.0 | 3.7 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 0.9 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 0.7 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 0.3 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.0 | 0.2 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 1.1 | GO:0009986 | cell surface(GO:0009986) |
| 0.0 | 0.3 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.0 | 1.0 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 0.0 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.0 | 0.2 | GO:0016471 | vacuolar proton-transporting V-type ATPase complex(GO:0016471) |
| 0.0 | 0.3 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 4.3 | GO:0019238 | cyclohydrolase activity(GO:0019238) |
| 0.7 | 2.7 | GO:0008907 | integrase activity(GO:0008907) |
| 0.5 | 1.4 | GO:0008192 | RNA guanylyltransferase activity(GO:0008192) |
| 0.4 | 2.7 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.4 | 25.6 | GO:0003823 | antigen binding(GO:0003823) |
| 0.3 | 0.8 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.3 | 0.8 | GO:0016418 | S-acetyltransferase activity(GO:0016418) |
| 0.2 | 1.9 | GO:0019237 | centromeric DNA binding(GO:0019237) |
| 0.2 | 0.8 | GO:0060422 | peptidyl-dipeptidase inhibitor activity(GO:0060422) |
| 0.2 | 1.6 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) |
| 0.2 | 1.0 | GO:0004167 | dopachrome isomerase activity(GO:0004167) |
| 0.2 | 0.7 | GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) |
| 0.1 | 1.2 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
| 0.1 | 0.7 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.1 | 1.2 | GO:0004117 | calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) |
| 0.1 | 0.4 | GO:0047977 | hepoxilin-epoxide hydrolase activity(GO:0047977) |
| 0.1 | 1.7 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.1 | 0.3 | GO:0050613 | delta14-sterol reductase activity(GO:0050613) |
| 0.1 | 3.3 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.1 | 0.5 | GO:0031708 | bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708) |
| 0.1 | 0.7 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.1 | 0.5 | GO:0061134 | peptidase activator activity(GO:0016504) peptidase activator activity involved in apoptotic process(GO:0016505) peptidase regulator activity(GO:0061134) |
| 0.1 | 0.5 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.1 | 0.4 | GO:0016647 | oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647) |
| 0.1 | 0.3 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
| 0.1 | 0.9 | GO:0003840 | gamma-glutamyltransferase activity(GO:0003840) |
| 0.1 | 0.3 | GO:0046790 | virion binding(GO:0046790) |
| 0.1 | 0.4 | GO:0030911 | TPR domain binding(GO:0030911) |
| 0.1 | 0.4 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.1 | 0.5 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.1 | 5.9 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 1.4 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.0 | 0.4 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.0 | 2.2 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
| 0.0 | 0.2 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.0 | 0.3 | GO:0004996 | thyroid-stimulating hormone receptor activity(GO:0004996) |
| 0.0 | 4.4 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 0.5 | GO:0004568 | chitinase activity(GO:0004568) |
| 0.0 | 0.1 | GO:0004814 | arginine-tRNA ligase activity(GO:0004814) |
| 0.0 | 0.2 | GO:0004668 | protein-arginine deiminase activity(GO:0004668) |
| 0.0 | 0.3 | GO:0016681 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.0 | 0.4 | GO:0015301 | anion:anion antiporter activity(GO:0015301) |
| 0.0 | 0.2 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.0 | 0.3 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.0 | 0.1 | GO:0042903 | tubulin deacetylase activity(GO:0042903) |
| 0.0 | 1.4 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 0.2 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.0 | 0.5 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
| 0.0 | 2.0 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 0.3 | GO:0004873 | asialoglycoprotein receptor activity(GO:0004873) |
| 0.0 | 0.7 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 1.2 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.0 | 0.1 | GO:0004103 | choline kinase activity(GO:0004103) |
| 0.0 | 0.2 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 0.6 | GO:0019843 | rRNA binding(GO:0019843) |
| 0.0 | 0.2 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.0 | 0.1 | GO:0005026 | transforming growth factor beta receptor activity, type II(GO:0005026) |
| 0.0 | 0.2 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.0 | 0.1 | GO:0005112 | Notch binding(GO:0005112) |
| 0.0 | 0.4 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.3 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 0.6 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 0.4 | GO:0003724 | RNA helicase activity(GO:0003724) |
| 0.0 | 0.4 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.0 | 0.5 | GO:0042826 | histone deacetylase binding(GO:0042826) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | ST_TUMOR_NECROSIS_FACTOR_PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 1.0 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
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