Motif ID: THRB

Z-value: 0.869


Transcription factors associated with THRB:

Gene SymbolEntrez IDGene Name
THRB ENSG00000151090.13 THRB



Activity profile for motif THRB.

activity profile for motif THRB


Sorted Z-values histogram for motif THRB

Sorted Z-values for motif THRB



Network of associatons between targets according to the STRING database.



First level regulatory network of THRB

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_-_21810765 2.790 ENST00000450584.1
ENST00000350669.1
 LDHB

lactate dehydrogenase B

chr12_-_21810726 2.776 ENST00000396076.1
 LDHB
lactate dehydrogenase B
chr20_+_37434329 2.295 ENST00000299824.1
ENST00000373331.2
 PPP1R16B

protein phosphatase 1, regulatory subunit 16B

chr8_+_28174649 0.901 ENST00000301908.3
 PNOC
prepronociceptin
chr10_+_60145155 0.890 ENST00000373895.3
 TFAM
transcription factor A, mitochondrial
chr8_-_124037890 0.805 ENST00000519018.1
ENST00000523036.1
 DERL1

derlin 1

chr6_-_99842041 0.796 ENST00000254759.3
ENST00000369242.1
 COQ3

coenzyme Q3 methyltransferase

chr10_+_62538089 0.787 ENST00000519078.2
ENST00000395284.3
ENST00000316629.4
 CDK1


cyclin-dependent kinase 1


chr10_+_62538248 0.764 ENST00000448257.2
 CDK1
cyclin-dependent kinase 1
chr11_+_73498898 0.716 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
 MRPL48





mitochondrial ribosomal protein L48





chr11_+_5617952 0.593 ENST00000354852.5
 TRIM6-TRIM34
TRIM6-TRIM34 readthrough
chr10_+_35456444 0.547 ENST00000361599.4
 CREM
cAMP responsive element modulator
chr16_-_69368774 0.433 ENST00000562949.1
 RP11-343C2.12
Conserved oligomeric Golgi complex subunit 8
chr18_-_47808120 0.408 ENST00000587605.1
ENST00000591416.1
ENST00000382948.5
ENST00000269471.5
ENST00000269468.5
ENST00000347968.3
ENST00000436910.1
ENST00000349085.2
 MBD1







methyl-CpG binding domain protein 1







chr8_-_100905925 0.375 ENST00000518171.1
 COX6C
cytochrome c oxidase subunit VIc
chr6_+_151042224 0.359 ENST00000358517.2
 PLEKHG1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr1_-_207224307 0.350 ENST00000315927.4
 YOD1
YOD1 deubiquitinase
chr8_-_100905850 0.332 ENST00000520271.1
ENST00000522940.1
ENST00000523016.1
ENST00000517682.2
ENST00000297564.2
 COX6C




cytochrome c oxidase subunit VIc




chr18_-_47808050 0.312 ENST00000590208.1
 MBD1
methyl-CpG binding domain protein 1
chr11_-_47399942 0.286 ENST00000227163.4
 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr4_+_114214125 0.277 ENST00000509550.1
 ANK2
ankyrin 2, neuronal
chrX_-_1511617 0.260 ENST00000381401.5
 SLC25A6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chr8_+_28174496 0.245 ENST00000518479.1
 PNOC
prepronociceptin
chr13_-_24007815 0.236 ENST00000382298.3
 SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chrY_-_1461617 0.220 ENSTR0000381401.5
 SLC25A6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chrX_+_101854096 0.220 ENST00000246174.2
ENST00000537008.1
ENST00000541409.1
 ARMCX5


armadillo repeat containing, X-linked 5


chr18_-_47807829 0.206 ENST00000585672.1
ENST00000457839.2
ENST00000353909.3
ENST00000339998.6
ENST00000398493.1
 MBD1




methyl-CpG binding domain protein 1




chr11_-_64014379 0.162 ENST00000309318.3
 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr11_-_47400078 0.153 ENST00000378538.3
 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr8_-_100905363 0.150 ENST00000524245.1
 COX6C
cytochrome c oxidase subunit VIc
chr8_+_22102626 0.139 ENST00000519237.1
ENST00000397802.4
 POLR3D

polymerase (RNA) III (DNA directed) polypeptide D, 44kDa

chr8_+_22102611 0.138 ENST00000306433.4
 POLR3D
polymerase (RNA) III (DNA directed) polypeptide D, 44kDa
chr11_-_45307817 0.119 ENST00000020926.3
 SYT13
synaptotagmin XIII
chr1_-_113498943 0.115 ENST00000369626.3
 SLC16A1
solute carrier family 16 (monocarboxylate transporter), member 1
chr7_+_102937869 0.095 ENST00000249269.4
ENST00000428154.1
ENST00000420236.2
 PMPCB


peptidase (mitochondrial processing) beta


chr11_+_46366918 0.075 ENST00000528615.1
ENST00000395574.3
 DGKZ

diacylglycerol kinase, zeta

chr3_+_50606901 0.046 ENST00000455834.1
 HEMK1
HemK methyltransferase family member 1
chr3_+_50606577 0.020 ENST00000434410.1
ENST00000232854.4
 HEMK1

HemK methyltransferase family member 1

chr7_-_38394118 0.015 ENST00000390345.2
 TRGV4
T cell receptor gamma variable 4
chr1_-_154164534 0.010 ENST00000271850.7
ENST00000368530.2
 TPM3

tropomyosin 3

chr7_-_100253993 0.005 ENST00000461605.1
ENST00000160382.5
 ACTL6B

actin-like 6B


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 5.6 GO:0006089 lactate metabolic process(GO:0006089)
0.3 1.6 GO:0034501 protein localization to kinetochore(GO:0034501)
0.2 0.9 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.2 2.3 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.2 0.5 GO:0046732 induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by virus of host immune response(GO:0075528)
0.1 0.8 GO:0032527 retrograde protein transport, ER to cytosol(GO:0030970) protein exit from endoplasmic reticulum(GO:0032527)
0.1 0.8 GO:0006743 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744)
0.0 0.2 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.4 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.3 GO:0006386 transcription elongation from RNA polymerase III promoter(GO:0006385) termination of RNA polymerase III transcription(GO:0006386)
0.0 1.1 GO:0007218 neuropeptide signaling pathway(GO:0007218)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0070852 cell body fiber(GO:0070852)
0.0 0.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 0.5 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 1.6 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.9 GO:0042645 mitochondrial nucleoid(GO:0042645)
0.0 0.9 GO:0000792 heterochromatin(GO:0000792)
0.0 5.5 GO:0005625 obsolete soluble fraction(GO:0005625)
0.0 0.8 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 5.6 GO:0004457 lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459)
0.2 0.9 GO:0008327 methyl-CpG binding(GO:0008327)
0.2 0.9 GO:0070363 mitochondrial light strand promoter sense binding(GO:0070363)
0.2 1.1 GO:0001515 opioid peptide activity(GO:0001515)
0.2 0.5 GO:0015217 purine ribonucleotide transmembrane transporter activity(GO:0005346) ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
0.1 1.6 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.5 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.8 GO:0008171 O-methyltransferase activity(GO:0008171)
0.0 0.8 GO:0042288 MHC class I protein binding(GO:0042288)
0.0 0.9 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 2.1 GO:0019903 protein phosphatase binding(GO:0019903)
0.0 0.2 GO:0070628 proteasome binding(GO:0070628)