Motif ID: TLX2
Z-value: 1.982
Transcription factors associated with TLX2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| TLX2 | ENSG00000115297.9 | TLX2 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 3.2 | GO:0032641 | lymphotoxin A production(GO:0032641) lymphotoxin A biosynthetic process(GO:0042109) |
| 1.0 | 3.0 | GO:0034205 | beta-amyloid formation(GO:0034205) |
| 0.8 | 2.5 | GO:0030205 | dermatan sulfate metabolic process(GO:0030205) dermatan sulfate biosynthetic process(GO:0030208) |
| 0.6 | 2.6 | GO:1904037 | positive regulation of epithelial cell apoptotic process(GO:1904037) positive regulation of endothelial cell apoptotic process(GO:2000353) |
| 0.6 | 2.4 | GO:0032849 | positive regulation of cellular pH reduction(GO:0032849) |
| 0.5 | 1.4 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) |
| 0.4 | 2.6 | GO:0002430 | complement receptor mediated signaling pathway(GO:0002430) |
| 0.4 | 1.7 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.4 | 1.9 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 0.3 | 1.3 | GO:0032933 | SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501) |
| 0.2 | 1.1 | GO:0014049 | positive regulation of glutamate secretion(GO:0014049) |
| 0.2 | 0.8 | GO:0048295 | positive regulation of isotype switching to IgE isotypes(GO:0048295) |
| 0.2 | 0.6 | GO:0071476 | response to vitamin B1(GO:0010266) cellular hypotonic response(GO:0071476) |
| 0.2 | 0.8 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
| 0.2 | 4.8 | GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504) |
| 0.2 | 2.4 | GO:1901797 | negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797) |
| 0.2 | 1.1 | GO:0007352 | zygotic specification of dorsal/ventral axis(GO:0007352) |
| 0.2 | 2.0 | GO:0002544 | chronic inflammatory response(GO:0002544) |
| 0.2 | 0.5 | GO:0032497 | detection of lipopolysaccharide(GO:0032497) |
| 0.2 | 1.0 | GO:0010842 | retina layer formation(GO:0010842) |
| 0.2 | 0.5 | GO:0032707 | negative regulation of interleukin-23 production(GO:0032707) |
| 0.2 | 0.9 | GO:0050765 | negative regulation of phagocytosis(GO:0050765) |
| 0.1 | 0.6 | GO:2000114 | regulation of establishment of cell polarity(GO:2000114) |
| 0.1 | 2.3 | GO:0048843 | negative regulation of axon extension involved in axon guidance(GO:0048843) |
| 0.1 | 0.7 | GO:0018106 | peptidyl-histidine phosphorylation(GO:0018106) |
| 0.1 | 1.5 | GO:0010224 | response to UV-B(GO:0010224) |
| 0.1 | 0.7 | GO:0046642 | negative regulation of alpha-beta T cell proliferation(GO:0046642) |
| 0.1 | 0.9 | GO:0050862 | positive regulation of T cell receptor signaling pathway(GO:0050862) |
| 0.1 | 0.6 | GO:0010447 | response to acidic pH(GO:0010447) |
| 0.1 | 0.6 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.1 | 0.5 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.1 | 0.3 | GO:0071801 | epithelial fluid transport(GO:0042045) regulation of cytolysis(GO:0042268) podosome assembly(GO:0071800) regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803) |
| 0.1 | 0.5 | GO:0006295 | nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295) |
| 0.1 | 0.7 | GO:0010591 | regulation of lamellipodium assembly(GO:0010591) |
| 0.1 | 0.2 | GO:0002887 | negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301) |
| 0.1 | 3.3 | GO:0006298 | mismatch repair(GO:0006298) |
| 0.1 | 0.1 | GO:0032696 | negative regulation of interleukin-13 production(GO:0032696) negative regulation of interleukin-5 production(GO:0032714) |
| 0.1 | 0.6 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905) |
| 0.1 | 0.2 | GO:0043163 | cell envelope organization(GO:0043163) external encapsulating structure organization(GO:0045229) |
| 0.1 | 1.2 | GO:0060438 | trachea development(GO:0060438) |
| 0.1 | 0.3 | GO:0034616 | response to laminar fluid shear stress(GO:0034616) |
| 0.1 | 0.9 | GO:0014009 | glial cell proliferation(GO:0014009) |
| 0.1 | 0.3 | GO:0046340 | diacylglycerol catabolic process(GO:0046340) |
| 0.1 | 1.3 | GO:0031529 | ruffle organization(GO:0031529) |
| 0.1 | 0.3 | GO:0009186 | deoxyribonucleoside diphosphate metabolic process(GO:0009186) |
| 0.1 | 0.2 | GO:0010836 | negative regulation of protein ADP-ribosylation(GO:0010836) negative regulation of protein glycosylation(GO:0060051) |
| 0.1 | 0.3 | GO:0033700 | phospholipid efflux(GO:0033700) |
| 0.1 | 0.8 | GO:0034447 | very-low-density lipoprotein particle clearance(GO:0034447) |
| 0.1 | 0.7 | GO:0045070 | positive regulation of viral genome replication(GO:0045070) |
| 0.1 | 1.7 | GO:0015813 | L-glutamate transport(GO:0015813) |
| 0.1 | 0.4 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
| 0.0 | 0.1 | GO:0070781 | response to biotin(GO:0070781) |
| 0.0 | 0.2 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.0 | 0.8 | GO:0050930 | induction of positive chemotaxis(GO:0050930) |
| 0.0 | 0.2 | GO:0008356 | asymmetric cell division(GO:0008356) |
| 0.0 | 0.4 | GO:0045766 | positive regulation of angiogenesis(GO:0045766) |
| 0.0 | 0.8 | GO:0006878 | cellular copper ion homeostasis(GO:0006878) |
| 0.0 | 2.1 | GO:0090263 | positive regulation of canonical Wnt signaling pathway(GO:0090263) |
| 0.0 | 0.5 | GO:0006743 | ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) |
| 0.0 | 0.2 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 0.0 | 0.3 | GO:0071353 | cellular response to interleukin-4(GO:0071353) |
| 0.0 | 0.3 | GO:0001782 | B cell homeostasis(GO:0001782) |
| 0.0 | 0.3 | GO:0015074 | DNA integration(GO:0015074) |
| 0.0 | 0.1 | GO:0046322 | negative regulation of fatty acid oxidation(GO:0046322) |
| 0.0 | 0.5 | GO:0033209 | tumor necrosis factor-mediated signaling pathway(GO:0033209) |
| 0.0 | 0.6 | GO:0030838 | positive regulation of actin filament polymerization(GO:0030838) |
| 0.0 | 0.4 | GO:0006108 | malate metabolic process(GO:0006108) NADH metabolic process(GO:0006734) |
| 0.0 | 0.2 | GO:0051571 | positive regulation of histone H3-K4 methylation(GO:0051571) |
| 0.0 | 0.3 | GO:0000018 | regulation of DNA recombination(GO:0000018) |
| 0.0 | 1.0 | GO:0050999 | regulation of nitric-oxide synthase activity(GO:0050999) |
| 0.0 | 0.1 | GO:0008588 | release of cytoplasmic sequestered NF-kappaB(GO:0008588) |
| 0.0 | 0.1 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) chloride ion homeostasis(GO:0055064) |
| 0.0 | 0.2 | GO:0030277 | epithelial structure maintenance(GO:0010669) maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.0 | 0.1 | GO:0070995 | NADPH oxidation(GO:0070995) |
| 0.0 | 0.9 | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124) |
| 0.0 | 0.2 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.0 | 2.3 | GO:0007229 | integrin-mediated signaling pathway(GO:0007229) |
| 0.0 | 0.5 | GO:0001954 | positive regulation of cell-matrix adhesion(GO:0001954) |
| 0.0 | 0.1 | GO:1903332 | regulation of protein folding(GO:1903332) |
| 0.0 | 0.6 | GO:0042554 | superoxide anion generation(GO:0042554) |
| 0.0 | 3.6 | GO:0042113 | B cell activation(GO:0042113) |
| 0.0 | 0.4 | GO:0007032 | endosome organization(GO:0007032) |
| 0.0 | 0.1 | GO:0031117 | positive regulation of microtubule depolymerization(GO:0031117) |
| 0.0 | 0.2 | GO:0051294 | establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294) |
| 0.0 | 0.1 | GO:0006707 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 0.0 | 1.6 | GO:0017156 | calcium ion regulated exocytosis(GO:0017156) |
| 0.0 | 2.3 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.0 | 3.6 | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123) |
| 0.0 | 1.5 | GO:0006821 | chloride transport(GO:0006821) |
| 0.0 | 0.3 | GO:0051496 | positive regulation of stress fiber assembly(GO:0051496) |
| 0.0 | 0.1 | GO:0071318 | cellular response to ATP(GO:0071318) |
| 0.0 | 0.3 | GO:0001893 | maternal placenta development(GO:0001893) |
| 0.0 | 0.0 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780) |
| 0.0 | 0.1 | GO:0060068 | vagina development(GO:0060068) prostate epithelial cord elongation(GO:0060523) |
| 0.0 | 1.3 | GO:0050680 | negative regulation of epithelial cell proliferation(GO:0050680) |
| 0.0 | 0.5 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
| 0.0 | 0.1 | GO:0036260 | 7-methylguanosine mRNA capping(GO:0006370) 7-methylguanosine RNA capping(GO:0009452) RNA capping(GO:0036260) |
| 0.0 | 0.2 | GO:0048096 | chromatin-mediated maintenance of transcription(GO:0048096) |
| 0.0 | 0.7 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
| 0.0 | 0.1 | GO:0035520 | monoubiquitinated protein deubiquitination(GO:0035520) |
| 0.0 | 0.2 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
| 0.0 | 0.1 | GO:0006591 | ornithine metabolic process(GO:0006591) regulation of growth hormone receptor signaling pathway(GO:0060398) |
| 0.0 | 0.1 | GO:0042493 | response to drug(GO:0042493) |
| 0.0 | 0.1 | GO:0090025 | regulation of monocyte chemotaxis(GO:0090025) positive regulation of monocyte chemotaxis(GO:0090026) |
| 0.0 | 0.1 | GO:0021527 | spinal cord association neuron differentiation(GO:0021527) |
| 0.0 | 0.2 | GO:0032456 | endocytic recycling(GO:0032456) |
| 0.0 | 0.4 | GO:0051156 | glucose 6-phosphate metabolic process(GO:0051156) |
| 0.0 | 0.3 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 0.0 | 0.1 | GO:0008212 | mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212) |
| 0.0 | 0.1 | GO:0030147 | obsolete natriuresis(GO:0030147) |
| 0.0 | 0.1 | GO:0042905 | 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.0 | 0.1 | GO:0031293 | membrane protein intracellular domain proteolysis(GO:0031293) |
| 0.0 | 0.6 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.0 | 0.2 | GO:0010165 | response to X-ray(GO:0010165) |
| 0.0 | 0.1 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 0.0 | 0.5 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 3.0 | GO:0014802 | terminal cisterna(GO:0014802) endoplasmic reticulum subcompartment(GO:0098827) |
| 0.3 | 0.9 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
| 0.2 | 4.8 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.2 | 1.1 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.2 | 1.5 | GO:0005593 | FACIT collagen trimer(GO:0005593) |
| 0.2 | 2.6 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.1 | 0.9 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.1 | 2.3 | GO:0043205 | fibril(GO:0043205) |
| 0.1 | 0.6 | GO:0030868 | smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425) |
| 0.1 | 0.6 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.1 | 2.5 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 1.5 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 0.4 | GO:0042272 | nuclear RNA export factor complex(GO:0042272) |
| 0.1 | 1.3 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.1 | 0.6 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.1 | 0.9 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.1 | 0.2 | GO:0010370 | perinucleolar chromocenter(GO:0010370) |
| 0.1 | 1.8 | GO:0005902 | microvillus(GO:0005902) |
| 0.1 | 7.5 | GO:0005765 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.1 | 0.4 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.1 | 0.6 | GO:0000109 | nucleotide-excision repair complex(GO:0000109) |
| 0.0 | 0.6 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.0 | 1.7 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 1.2 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 2.2 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 0.2 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) histone pre-mRNA 3'end processing complex(GO:0071204) |
| 0.0 | 0.2 | GO:0005954 | calcium- and calmodulin-dependent protein kinase complex(GO:0005954) |
| 0.0 | 1.4 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.0 | 0.2 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.0 | 0.8 | GO:0034361 | very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385) |
| 0.0 | 0.7 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.0 | 0.2 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 0.2 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.0 | 0.2 | GO:0000931 | gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274) |
| 0.0 | 0.2 | GO:0016585 | obsolete chromatin remodeling complex(GO:0016585) |
| 0.0 | 2.0 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.0 | 1.4 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 1.5 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 0.2 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 0.3 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.0 | 0.1 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 2.5 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 0.2 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 0.7 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 0.5 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 0.1 | GO:0000796 | condensin complex(GO:0000796) |
| 0.0 | 0.2 | GO:0070688 | MLL5-L complex(GO:0070688) |
| 0.0 | 0.1 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.0 | 0.4 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 0.4 | GO:0005903 | brush border(GO:0005903) |
| 0.0 | 0.6 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 0.1 | GO:0035253 | ciliary rootlet(GO:0035253) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 3.3 | GO:0032558 | purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558) |
| 0.5 | 1.4 | GO:0031997 | N-terminal myristoylation domain binding(GO:0031997) |
| 0.4 | 2.6 | GO:0004875 | complement receptor activity(GO:0004875) |
| 0.4 | 3.0 | GO:0005219 | ryanodine-sensitive calcium-release channel activity(GO:0005219) |
| 0.4 | 1.9 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.3 | 1.2 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.3 | 0.9 | GO:0042610 | CD8 receptor binding(GO:0042610) |
| 0.3 | 0.9 | GO:0002114 | interleukin-33 receptor activity(GO:0002114) |
| 0.3 | 9.5 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.3 | 1.3 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.2 | 2.5 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
| 0.2 | 0.9 | GO:0043423 | 3-phosphoinositide-dependent protein kinase binding(GO:0043423) |
| 0.2 | 0.7 | GO:0033867 | Fas-activated serine/threonine kinase activity(GO:0033867) |
| 0.2 | 1.0 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.2 | 0.6 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.2 | 0.8 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
| 0.2 | 0.8 | GO:0016531 | copper chaperone activity(GO:0016531) |
| 0.2 | 0.9 | GO:0004591 | oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591) |
| 0.2 | 5.2 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.1 | 2.2 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.1 | 0.4 | GO:0003854 | 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854) |
| 0.1 | 1.2 | GO:0070053 | thrombospondin receptor activity(GO:0070053) |
| 0.1 | 0.6 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.1 | 1.7 | GO:0008199 | ferric iron binding(GO:0008199) |
| 0.1 | 1.1 | GO:0004157 | dihydropyrimidinase activity(GO:0004157) |
| 0.1 | 0.8 | GO:0030229 | very-low-density lipoprotein particle receptor activity(GO:0030229) |
| 0.1 | 1.3 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.1 | 0.4 | GO:0030060 | L-malate dehydrogenase activity(GO:0030060) |
| 0.1 | 0.5 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.1 | 0.3 | GO:0033878 | hormone-sensitive lipase activity(GO:0033878) |
| 0.1 | 0.3 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.1 | 2.4 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 0.1 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.1 | 2.9 | GO:0015026 | coreceptor activity(GO:0015026) |
| 0.1 | 0.3 | GO:0005041 | low-density lipoprotein receptor activity(GO:0005041) |
| 0.1 | 1.3 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.1 | 1.3 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 0.6 | GO:0043422 | protein kinase B binding(GO:0043422) |
| 0.1 | 0.7 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.1 | 0.6 | GO:0005497 | androgen binding(GO:0005497) |
| 0.1 | 0.3 | GO:0070679 | inositol 1,4,5 trisphosphate binding(GO:0070679) |
| 0.1 | 0.5 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.1 | 0.3 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.1 | 0.5 | GO:0019826 | oxygen sensor activity(GO:0019826) |
| 0.1 | 1.2 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.1 | 0.4 | GO:0004340 | glucokinase activity(GO:0004340) |
| 0.1 | 0.2 | GO:0000247 | C-8 sterol isomerase activity(GO:0000247) |
| 0.1 | 1.5 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 0.1 | GO:0004796 | thromboxane-A synthase activity(GO:0004796) |
| 0.0 | 0.2 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.0 | 0.9 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 0.6 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.0 | 0.5 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 0.0 | 1.0 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.0 | 0.4 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.0 | 0.2 | GO:0004060 | arylamine N-acetyltransferase activity(GO:0004060) |
| 0.0 | 0.2 | GO:0070492 | oligosaccharide binding(GO:0070492) |
| 0.0 | 0.3 | GO:0046934 | obsolete inositol or phosphatidylinositol kinase activity(GO:0004428) phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813) |
| 0.0 | 0.2 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.0 | 0.9 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.4 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
| 0.0 | 3.1 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.1 | GO:0034190 | apolipoprotein receptor binding(GO:0034190) |
| 0.0 | 0.1 | GO:0008174 | mRNA methyltransferase activity(GO:0008174) |
| 0.0 | 0.4 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 0.5 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) |
| 0.0 | 0.3 | GO:0017176 | phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176) |
| 0.0 | 0.2 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.0 | 0.8 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 0.5 | GO:0004659 | prenyltransferase activity(GO:0004659) |
| 0.0 | 0.3 | GO:0015665 | alcohol transmembrane transporter activity(GO:0015665) |
| 0.0 | 0.3 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.0 | 1.1 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 0.1 | GO:0008518 | reduced folate carrier activity(GO:0008518) |
| 0.0 | 0.2 | GO:0015385 | sodium:proton antiporter activity(GO:0015385) |
| 0.0 | 0.2 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
| 0.0 | 0.1 | GO:0004466 | long-chain-acyl-CoA dehydrogenase activity(GO:0004466) |
| 0.0 | 0.3 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.0 | 0.1 | GO:0034056 | estrogen response element binding(GO:0034056) |
| 0.0 | 0.1 | GO:0042301 | phosphate ion binding(GO:0042301) |
| 0.0 | 0.1 | GO:0008020 | G-protein coupled photoreceptor activity(GO:0008020) |
| 0.0 | 0.5 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 0.8 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 0.0 | GO:0004809 | tRNA (guanine-N2-)-methyltransferase activity(GO:0004809) |
| 0.0 | 0.1 | GO:0016854 | racemase and epimerase activity(GO:0016854) |
| 0.0 | 0.1 | GO:0016668 | oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668) |
| 0.0 | 0.1 | GO:0031420 | potassium ion binding(GO:0030955) alkali metal ion binding(GO:0031420) |
| 0.0 | 0.6 | GO:0050136 | NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.2 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 0.3 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | SA_PTEN_PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.1 | 0.8 | SIG_IL4RECEPTOR_IN_B_LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.1 | 2.5 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 2.3 | SIG_BCR_SIGNALING_PATHWAY | Members of the BCR signaling pathway |
| 0.0 | 0.5 | SA_B_CELL_RECEPTOR_COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 1.0 | ST_T_CELL_SIGNAL_TRANSDUCTION | T Cell Signal Transduction |
