Motif ID: TP53
Z-value: 2.069
Transcription factors associated with TP53:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| TP53 | ENSG00000141510.11 | TP53 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 4.6 | GO:0031642 | negative regulation of myelination(GO:0031642) negative regulation of axon regeneration(GO:0048681) negative regulation of neuron projection regeneration(GO:0070571) |
| 1.1 | 3.4 | GO:0034205 | beta-amyloid formation(GO:0034205) |
| 1.0 | 5.1 | GO:0044854 | membrane raft assembly(GO:0001765) nitric oxide homeostasis(GO:0033484) negative regulation of tyrosine phosphorylation of Stat5 protein(GO:0042524) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836) membrane assembly(GO:0071709) |
| 0.9 | 2.6 | GO:0007207 | phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207) |
| 0.7 | 4.8 | GO:0090025 | regulation of monocyte chemotaxis(GO:0090025) positive regulation of monocyte chemotaxis(GO:0090026) |
| 0.7 | 2.0 | GO:0030205 | dermatan sulfate metabolic process(GO:0030205) dermatan sulfate biosynthetic process(GO:0030208) |
| 0.4 | 2.2 | GO:0006927 | obsolete transformed cell apoptotic process(GO:0006927) |
| 0.4 | 3.7 | GO:0001946 | lymphangiogenesis(GO:0001946) lymph vessel morphogenesis(GO:0036303) |
| 0.3 | 3.2 | GO:0090083 | regulation of inclusion body assembly(GO:0090083) |
| 0.3 | 1.3 | GO:0090343 | positive regulation of cell aging(GO:0090343) |
| 0.2 | 0.7 | GO:0006423 | cysteinyl-tRNA aminoacylation(GO:0006423) |
| 0.2 | 0.9 | GO:0072385 | minus-end-directed organelle transport along microtubule(GO:0072385) microtubule anchoring at microtubule organizing center(GO:0072393) |
| 0.2 | 0.6 | GO:0001732 | formation of cytoplasmic translation initiation complex(GO:0001732) cytoplasmic translation(GO:0002181) cytoplasmic translational initiation(GO:0002183) |
| 0.2 | 1.5 | GO:0060325 | face morphogenesis(GO:0060325) |
| 0.2 | 0.5 | GO:0046521 | sphingoid catabolic process(GO:0046521) |
| 0.2 | 2.0 | GO:0007141 | male meiosis I(GO:0007141) |
| 0.2 | 1.2 | GO:0042149 | cellular response to glucose starvation(GO:0042149) |
| 0.2 | 2.3 | GO:0050872 | white fat cell differentiation(GO:0050872) |
| 0.1 | 0.4 | GO:0030812 | negative regulation of nucleotide catabolic process(GO:0030812) |
| 0.1 | 4.2 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 0.7 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672) |
| 0.1 | 0.8 | GO:0051894 | positive regulation of focal adhesion assembly(GO:0051894) positive regulation of cell junction assembly(GO:1901890) positive regulation of adherens junction organization(GO:1903393) |
| 0.1 | 1.7 | GO:0051927 | obsolete negative regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051927) |
| 0.1 | 0.5 | GO:0010957 | negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137) |
| 0.1 | 0.4 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.1 | 0.5 | GO:0071569 | protein ufmylation(GO:0071569) |
| 0.1 | 0.3 | GO:0071344 | diphosphate metabolic process(GO:0071344) |
| 0.1 | 6.6 | GO:0050821 | protein stabilization(GO:0050821) |
| 0.1 | 0.8 | GO:0006564 | L-serine biosynthetic process(GO:0006564) |
| 0.1 | 0.2 | GO:0070544 | histone H3-K36 demethylation(GO:0070544) |
| 0.1 | 1.3 | GO:1901224 | activation of NF-kappaB-inducing kinase activity(GO:0007250) NIK/NF-kappaB signaling(GO:0038061) regulation of NIK/NF-kappaB signaling(GO:1901222) positive regulation of NIK/NF-kappaB signaling(GO:1901224) |
| 0.1 | 0.7 | GO:0051898 | negative regulation of protein kinase B signaling(GO:0051898) |
| 0.1 | 1.0 | GO:0006984 | ER-nucleus signaling pathway(GO:0006984) |
| 0.1 | 0.5 | GO:0006474 | N-terminal protein amino acid acetylation(GO:0006474) |
| 0.0 | 4.7 | GO:0007605 | sensory perception of sound(GO:0007605) |
| 0.0 | 0.7 | GO:0060765 | regulation of androgen receptor signaling pathway(GO:0060765) |
| 0.0 | 0.2 | GO:0031580 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
| 0.0 | 0.1 | GO:0071801 | podosome assembly(GO:0071800) regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803) |
| 0.0 | 3.8 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.0 | 1.6 | GO:0007613 | memory(GO:0007613) |
| 0.0 | 0.1 | GO:0032070 | regulation of deoxyribonuclease activity(GO:0032070) |
| 0.0 | 3.0 | GO:0019882 | antigen processing and presentation(GO:0019882) |
| 0.0 | 0.8 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.0 | 0.4 | GO:0032876 | regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023) |
| 0.0 | 0.1 | GO:0001845 | phagolysosome assembly(GO:0001845) phagosome maturation(GO:0090382) |
| 0.0 | 0.4 | GO:0031290 | retinal ganglion cell axon guidance(GO:0031290) |
| 0.0 | 0.3 | GO:0001522 | pseudouridine synthesis(GO:0001522) |
| 0.0 | 0.6 | GO:0006662 | glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904) |
| 0.0 | 1.8 | GO:0009062 | fatty acid catabolic process(GO:0009062) |
| 0.0 | 0.4 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 0.1 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.0 | 1.3 | GO:0009653 | anatomical structure morphogenesis(GO:0009653) |
| 0.0 | 0.5 | GO:0006309 | DNA catabolic process, endonucleolytic(GO:0000737) apoptotic DNA fragmentation(GO:0006309) |
| 0.0 | 0.6 | GO:0016525 | negative regulation of angiogenesis(GO:0016525) |
| 0.0 | 0.0 | GO:0071374 | cellular response to parathyroid hormone stimulus(GO:0071374) |
| 0.0 | 0.1 | GO:0043030 | regulation of macrophage activation(GO:0043030) |
| 0.0 | 0.3 | GO:0045670 | regulation of osteoclast differentiation(GO:0045670) |
| 0.0 | 2.2 | GO:0007179 | transforming growth factor beta receptor signaling pathway(GO:0007179) |
| 0.0 | 0.3 | GO:0051496 | positive regulation of stress fiber assembly(GO:0051496) |
| 0.0 | 0.1 | GO:0045047 | protein targeting to ER(GO:0045047) establishment of protein localization to endoplasmic reticulum(GO:0072599) |
| 0.0 | 0.0 | GO:0045080 | positive regulation of chemokine biosynthetic process(GO:0045080) |
| 0.0 | 0.2 | GO:0035329 | hippo signaling(GO:0035329) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 4.2 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.9 | 3.4 | GO:0014802 | terminal cisterna(GO:0014802) endoplasmic reticulum subcompartment(GO:0098827) |
| 0.3 | 9.4 | GO:0030057 | desmosome(GO:0030057) |
| 0.3 | 3.5 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.2 | 4.9 | GO:0000299 | obsolete integral to membrane of membrane fraction(GO:0000299) |
| 0.1 | 0.5 | GO:0005863 | striated muscle myosin thick filament(GO:0005863) |
| 0.1 | 3.0 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 1.4 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.1 | 0.7 | GO:0005638 | lamin filament(GO:0005638) |
| 0.1 | 0.5 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.1 | 1.0 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 0.1 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 0.0 | 0.4 | GO:0070822 | Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822) |
| 0.0 | 0.4 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.0 | 3.2 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 2.1 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 0.8 | GO:0046930 | pore complex(GO:0046930) |
| 0.0 | 2.2 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 0.6 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.0 | 0.2 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.0 | 0.5 | GO:0005921 | gap junction(GO:0005921) |
| 0.0 | 1.5 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 0.4 | GO:0005838 | proteasome regulatory particle(GO:0005838) |
| 0.0 | 0.2 | GO:0000300 | obsolete peripheral to membrane of membrane fraction(GO:0000300) |
| 0.0 | 0.1 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
| 0.0 | 4.1 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 0.2 | GO:0005683 | U7 snRNP(GO:0005683) |
| 0.0 | 0.3 | GO:0005732 | small nucleolar ribonucleoprotein complex(GO:0005732) |
| 0.0 | 0.1 | GO:0032059 | bleb(GO:0032059) |
| 0.0 | 0.5 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 1.4 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 0.1 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) ER to Golgi transport vesicle(GO:0030134) |
| 0.0 | 0.1 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 0.6 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 0.4 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 1.6 | GO:0019717 | obsolete synaptosome(GO:0019717) |
| 0.0 | 0.0 | GO:0005766 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.0 | 0.9 | GO:0016363 | nuclear matrix(GO:0016363) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 17.7 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.4 | 3.4 | GO:0005219 | ryanodine-sensitive calcium-release channel activity(GO:0005219) |
| 0.4 | 3.5 | GO:0008517 | folic acid transporter activity(GO:0008517) |
| 0.4 | 5.1 | GO:0050998 | nitric-oxide synthase binding(GO:0050998) |
| 0.3 | 1.6 | GO:0004647 | phosphoserine phosphatase activity(GO:0004647) |
| 0.3 | 6.6 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 0.2 | 0.7 | GO:0004817 | cysteine-tRNA ligase activity(GO:0004817) |
| 0.2 | 0.4 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.2 | 1.3 | GO:0045569 | TRAIL binding(GO:0045569) |
| 0.2 | 1.4 | GO:0000293 | ferric-chelate reductase activity(GO:0000293) |
| 0.2 | 1.8 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.2 | 2.2 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
| 0.2 | 2.0 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
| 0.2 | 0.8 | GO:0051434 | BH3 domain binding(GO:0051434) |
| 0.1 | 0.9 | GO:0004128 | cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128) |
| 0.1 | 0.5 | GO:0017050 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 0.1 | 0.6 | GO:0051019 | mitogen-activated protein kinase binding(GO:0051019) |
| 0.1 | 0.5 | GO:0016681 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.1 | 1.3 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) |
| 0.1 | 2.9 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.1 | 0.8 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
| 0.1 | 0.2 | GO:0050698 | proteoglycan sulfotransferase activity(GO:0050698) |
| 0.1 | 2.1 | GO:0031683 | G-protein beta/gamma-subunit complex binding(GO:0031683) |
| 0.1 | 0.4 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.1 | 0.8 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 0.3 | GO:0004427 | inorganic diphosphatase activity(GO:0004427) |
| 0.0 | 0.6 | GO:0051635 | obsolete bacterial cell surface binding(GO:0051635) |
| 0.0 | 1.0 | GO:0000146 | microfilament motor activity(GO:0000146) |
| 0.0 | 0.5 | GO:0031369 | translation initiation factor binding(GO:0031369) |
| 0.0 | 0.1 | GO:0005137 | interleukin-5 receptor binding(GO:0005137) |
| 0.0 | 2.2 | GO:0042379 | chemokine receptor binding(GO:0042379) |
| 0.0 | 0.2 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.0 | 0.1 | GO:0030337 | DNA polymerase processivity factor activity(GO:0030337) |
| 0.0 | 0.7 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.0 | 0.6 | GO:0003756 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
| 0.0 | 0.1 | GO:0043426 | MRF binding(GO:0043426) |
| 0.0 | 5.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.2 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.0 | 1.9 | GO:0051287 | NAD binding(GO:0051287) |
| 0.0 | 1.1 | GO:0002020 | protease binding(GO:0002020) |
| 0.0 | 1.4 | GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811) |
| 0.0 | 0.2 | GO:0015355 | secondary active monocarboxylate transmembrane transporter activity(GO:0015355) |
| 0.0 | 0.2 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.0 | 0.4 | GO:0016790 | thiolester hydrolase activity(GO:0016790) |
| 0.0 | 0.2 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.0 | 0.9 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 0.3 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.0 | 1.1 | GO:0016810 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds(GO:0016810) |
| 0.0 | 0.2 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.0 | 1.7 | GO:0019838 | growth factor binding(GO:0019838) |
| 0.0 | 0.5 | GO:0097472 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472) |
| 0.0 | 0.0 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.0 | 0.1 | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 2.6 | ST_ADRENERGIC | Adrenergic Pathway |
| 0.0 | 0.7 | SA_G1_AND_S_PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 1.2 | SIG_CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 4.6 | ST_INTEGRIN_SIGNALING_PATHWAY | Integrin Signaling Pathway |
| 0.0 | 0.7 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 0.3 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
| 0.0 | 0.4 | SIG_IL4RECEPTOR_IN_B_LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
