Motif ID: TP73
Z-value: 0.859
Transcription factors associated with TP73:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| TP73 | ENSG00000078900.10 | TP73 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.4 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 0.1 | 0.4 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.1 | 1.0 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.1 | 2.0 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 0.2 | GO:0015825 | L-serine transport(GO:0015825) |
| 0.0 | 0.6 | GO:0045408 | regulation of interleukin-6 biosynthetic process(GO:0045408) |
| 0.0 | 0.2 | GO:1903332 | regulation of protein folding(GO:1903332) |
| 0.0 | 0.1 | GO:0048295 | positive regulation of isotype switching to IgE isotypes(GO:0048295) |
| 0.0 | 0.2 | GO:0009298 | GDP-mannose biosynthetic process(GO:0009298) |
| 0.0 | 0.2 | GO:0019471 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511) |
| 0.0 | 0.2 | GO:0042693 | muscle cell fate commitment(GO:0042693) |
| 0.0 | 1.6 | GO:0090263 | positive regulation of canonical Wnt signaling pathway(GO:0090263) |
| 0.0 | 0.2 | GO:0032007 | negative regulation of TOR signaling(GO:0032007) |
| 0.0 | 0.0 | GO:0042536 | negative regulation of tumor necrosis factor biosynthetic process(GO:0042536) positive regulation of interleukin-10 biosynthetic process(GO:0045082) |
| 0.0 | 0.2 | GO:0051044 | positive regulation of membrane protein ectodomain proteolysis(GO:0051044) |
| 0.0 | 0.9 | GO:0017148 | negative regulation of translation(GO:0017148) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.0 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 1.0 | GO:0098636 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.0 | 0.1 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
| 0.0 | 0.0 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.0 | 0.3 | GO:0031526 | brush border membrane(GO:0031526) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.1 | 0.9 | GO:0003847 | 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) |
| 0.1 | 2.8 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.1 | 0.2 | GO:0022889 | L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889) |
| 0.1 | 0.4 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.0 | 0.1 | GO:0008332 | low voltage-gated calcium channel activity(GO:0008332) |
| 0.0 | 1.4 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 0.2 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545) |
| 0.0 | 0.3 | GO:0050780 | dopamine receptor binding(GO:0050780) |
| 0.0 | 0.8 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 0.2 | GO:0016868 | intramolecular transferase activity, phosphotransferases(GO:0016868) |
| 0.0 | 0.3 | GO:0030159 | receptor signaling complex scaffold activity(GO:0030159) |
| 0.0 | 1.0 | GO:0008307 | structural constituent of muscle(GO:0008307) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.4 | SA_B_CELL_RECEPTOR_COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 1.0 | ST_G_ALPHA_I_PATHWAY | G alpha i Pathway |
