Motif ID: UCACAGU

Z-value: 1.020


Mature miRNA associated with seed UCACAGU:

NamemiRBase Accession
hsa-miR-27a-3p MIMAT0000084
hsa-miR-27b-3p MIMAT0000419



Activity profile for motif UCACAGU.

activity profile for motif UCACAGU


Sorted Z-values histogram for motif UCACAGU

Sorted Z-values for motif UCACAGU



Network of associatons between targets according to the STRING database.



First level regulatory network of UCACAGU

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_121322832 2.162 ENST00000260197.7
SORL1
sortilin-related receptor, L(DLR class) A repeats containing
chr2_-_38303218 1.522 ENST00000407341.1
ENST00000260630.3
CYP1B1

cytochrome P450, family 1, subfamily B, polypeptide 1

chr7_+_94285637 1.172 ENST00000482108.1
ENST00000488574.1
PEG10

paternally expressed 10

chr1_-_92351769 1.120 ENST00000212355.4
TGFBR3
transforming growth factor, beta receptor III
chr1_-_93426998 1.068 ENST00000370310.4
FAM69A
family with sequence similarity 69, member A
chr15_+_81071684 0.958 ENST00000220244.3
ENST00000394685.3
ENST00000356249.5
KIAA1199


KIAA1199


chr17_-_53499310 0.945 ENST00000262065.3
MMD
monocyte to macrophage differentiation-associated
chr6_+_391739 0.943 ENST00000380956.4
IRF4
interferon regulatory factor 4
chr10_-_90712520 0.923 ENST00000224784.6
ACTA2
actin, alpha 2, smooth muscle, aorta
chr1_+_65613217 0.881 ENST00000545314.1
AK4
adenylate kinase 4
chr5_-_111093406 0.864 ENST00000379671.3
NREP
neuronal regeneration related protein
chr15_-_61521495 0.821 ENST00000335670.6
RORA
RAR-related orphan receptor A
chr1_-_57045228 0.803 ENST00000371250.3
PPAP2B
phosphatidic acid phosphatase type 2B
chr10_+_63661053 0.761 ENST00000279873.7
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr19_-_7293942 0.740 ENST00000341500.5
ENST00000302850.5
INSR

insulin receptor

chr9_-_130742792 0.737 ENST00000373095.1
FAM102A
family with sequence similarity 102, member A
chr4_+_55095264 0.671 ENST00000257290.5
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr7_-_103629963 0.669 ENST00000428762.1
ENST00000343529.5
ENST00000424685.2
RELN


reelin


chr10_+_88516396 0.661 ENST00000372037.3
BMPR1A
bone morphogenetic protein receptor, type IA
chr11_-_115375107 0.643 ENST00000545380.1
ENST00000452722.3
ENST00000537058.1
ENST00000536727.1
ENST00000542447.2
ENST00000331581.6
CADM1





cell adhesion molecule 1





chr6_+_114178512 0.642 ENST00000368635.4
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr9_+_137218362 0.630 ENST00000481739.1
RXRA
retinoid X receptor, alpha
chr8_-_28243934 0.628 ENST00000521185.1
ENST00000520290.1
ENST00000344423.5
ZNF395


zinc finger protein 395


chr11_+_58939965 0.619 ENST00000227451.3
DTX4
deltex homolog 4 (Drosophila)
chr1_+_70876891 0.613 ENST00000411986.2
CTH
cystathionase (cystathionine gamma-lyase)
chr5_-_1524015 0.576 ENST00000283415.3
LPCAT1
lysophosphatidylcholine acyltransferase 1
chr3_-_124774802 0.552 ENST00000311127.4
HEG1
heart development protein with EGF-like domains 1
chr6_+_138188551 0.543 ENST00000237289.4
ENST00000433680.1
TNFAIP3

tumor necrosis factor, alpha-induced protein 3

chr9_+_103790991 0.538 ENST00000374874.3
LPPR1
Lipid phosphate phosphatase-related protein type 1
chr18_-_74207146 0.530 ENST00000443185.2
ZNF516
zinc finger protein 516
chr1_-_154842741 0.515 ENST00000271915.4
KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr8_-_22550815 0.510 ENST00000317216.2
EGR3
early growth response 3
chr14_-_90085458 0.507 ENST00000345097.4
ENST00000555855.1
ENST00000555353.1
FOXN3


forkhead box N3


chr5_+_162864575 0.496 ENST00000512163.1
ENST00000393929.1
ENST00000340828.2
ENST00000511683.2
ENST00000510097.1
ENST00000511490.2
ENST00000510664.1
CCNG1






cyclin G1






chr1_+_213123915 0.488 ENST00000366968.4
ENST00000490792.1
VASH2

vasohibin 2

chr5_-_115910630 0.487 ENST00000343348.6
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr3_-_72496035 0.482 ENST00000477973.2
RYBP
RING1 and YY1 binding protein
chr12_-_15942309 0.481 ENST00000544064.1
ENST00000543523.1
ENST00000536793.1
EPS8


epidermal growth factor receptor pathway substrate 8


chr2_-_227664474 0.459 ENST00000305123.5
IRS1
insulin receptor substrate 1
chr4_-_153457197 0.454 ENST00000281708.4
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr19_-_46234119 0.453 ENST00000317683.3
FBXO46
F-box protein 46
chr7_-_81399438 0.424 ENST00000222390.5
HGF
hepatocyte growth factor (hepapoietin A; scatter factor)
chr2_+_163200598 0.423 ENST00000437150.2
ENST00000453113.2
GCA

grancalcin, EF-hand calcium binding protein

chr6_-_24911195 0.418 ENST00000259698.4
FAM65B
family with sequence similarity 65, member B
chr2_-_69614373 0.415 ENST00000361060.5
ENST00000357308.4
GFPT1

glutamine--fructose-6-phosphate transaminase 1

chr9_+_71320596 0.414 ENST00000265382.3
PIP5K1B
phosphatidylinositol-4-phosphate 5-kinase, type I, beta
chr18_+_13218769 0.412 ENST00000399848.3
ENST00000361205.4
LDLRAD4

low density lipoprotein receptor class A domain containing 4

chr5_+_110559784 0.402 ENST00000282356.4
CAMK4
calcium/calmodulin-dependent protein kinase IV
chr20_+_34700333 0.399 ENST00000441639.1
EPB41L1
erythrocyte membrane protein band 4.1-like 1
chr16_+_85646763 0.395 ENST00000411612.1
ENST00000253458.7
GSE1

Gse1 coiled-coil protein

chr5_+_82767284 0.382 ENST00000265077.3
VCAN
versican
chr8_-_57123815 0.379 ENST00000316981.3
ENST00000423799.2
ENST00000429357.2
PLAG1


pleiomorphic adenoma gene 1


chr13_-_111214015 0.365 ENST00000267328.3
RAB20
RAB20, member RAS oncogene family
chr14_-_92413727 0.365 ENST00000267620.10
FBLN5
fibulin 5
chr19_+_4229495 0.364 ENST00000221847.5
EBI3
Epstein-Barr virus induced 3
chr20_+_46130601 0.363 ENST00000341724.6
NCOA3
nuclear receptor coactivator 3
chr9_-_36400213 0.360 ENST00000259605.6
ENST00000353739.4
RNF38

ring finger protein 38

chr2_-_20212422 0.357 ENST00000421259.2
ENST00000407540.3
MATN3

matrilin 3

chr17_-_58603568 0.355 ENST00000083182.3
APPBP2
amyloid beta precursor protein (cytoplasmic tail) binding protein 2
chr3_+_53195136 0.354 ENST00000394729.2
ENST00000330452.3
PRKCD

protein kinase C, delta

chr5_-_95297678 0.353 ENST00000237853.4
ELL2
elongation factor, RNA polymerase II, 2
chr8_-_103425047 0.350 ENST00000520539.1
UBR5
ubiquitin protein ligase E3 component n-recognin 5
chr16_+_69599861 0.347 ENST00000354436.2
NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr10_-_81205373 0.340 ENST00000372336.3
ZCCHC24
zinc finger, CCHC domain containing 24
chr2_-_64881018 0.333 ENST00000313349.3
SERTAD2
SERTA domain containing 2
chr2_+_228336849 0.332 ENST00000409979.2
ENST00000310078.8
AGFG1

ArfGAP with FG repeats 1

chr14_-_64194745 0.332 ENST00000247225.6
SGPP1
sphingosine-1-phosphate phosphatase 1
chr4_-_39640700 0.327 ENST00000295958.5
SMIM14
small integral membrane protein 14
chr19_+_45251804 0.325 ENST00000164227.5
BCL3
B-cell CLL/lymphoma 3
chr13_+_33160553 0.321 ENST00000315596.10
PDS5B
PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr18_+_55102917 0.320 ENST00000491143.2
ONECUT2
one cut homeobox 2
chr8_-_127570603 0.318 ENST00000304916.3
FAM84B
family with sequence similarity 84, member B
chr12_+_60083118 0.315 ENST00000261187.4
ENST00000543448.1
SLC16A7

solute carrier family 16 (monocarboxylate transporter), member 7

chr1_-_200992827 0.314 ENST00000332129.2
ENST00000422435.2
KIF21B

kinesin family member 21B

chr16_-_70719925 0.313 ENST00000338779.6
MTSS1L
metastasis suppressor 1-like
chr17_-_40761375 0.312 ENST00000543197.1
ENST00000309428.5
FAM134C

family with sequence similarity 134, member C

chr8_+_38758737 0.308 ENST00000521746.1
ENST00000420274.1
PLEKHA2

pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2

chrX_+_23352133 0.306 ENST00000379361.4
PTCHD1
patched domain containing 1
chr15_+_73344791 0.304 ENST00000261908.6
NEO1
neogenin 1
chr12_-_102874416 0.302 ENST00000392904.1
ENST00000337514.6
IGF1

insulin-like growth factor 1 (somatomedin C)

chr21_+_35445827 0.301 ENST00000381151.3
ENST00000608209.1
SLC5A3
SLC5A3
solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
sodium/myo-inositol cotransporter
chr2_+_30454390 0.301 ENST00000395323.3
ENST00000406087.1
ENST00000404397.1
LBH


limb bud and heart development


chr10_+_111767720 0.292 ENST00000356080.4
ENST00000277900.8
ADD3

adducin 3 (gamma)

chrX_-_110655391 0.290 ENST00000356915.2
ENST00000356220.3
DCX

doublecortin

chr16_+_2587998 0.288 ENST00000441549.3
ENST00000268673.7
PDPK1

3-phosphoinositide dependent protein kinase-1

chr2_-_68479614 0.286 ENST00000234310.3
PPP3R1
protein phosphatase 3, regulatory subunit B, alpha
chr16_+_23847339 0.279 ENST00000303531.7
PRKCB
protein kinase C, beta
chr15_-_37390482 0.278 ENST00000559085.1
ENST00000397624.3
MEIS2

Meis homeobox 2

chr5_+_65018017 0.274 ENST00000380985.5
ENST00000502464.1
NLN

neurolysin (metallopeptidase M3 family)

chr10_+_127408263 0.273 ENST00000337623.3
C10orf137
erythroid differentiation regulatory factor 1
chr8_+_28351707 0.273 ENST00000537916.1
ENST00000523546.1
ENST00000240093.3
FZD3


frizzled family receptor 3


chr20_+_5107420 0.270 ENST00000460006.1
CDS2
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
chr18_+_9136758 0.269 ENST00000383440.2
ENST00000262126.4
ENST00000577992.1
ANKRD12


ankyrin repeat domain 12


chr19_+_38397839 0.266 ENST00000222345.6
SIPA1L3
signal-induced proliferation-associated 1 like 3
chr5_-_121413974 0.265 ENST00000231004.4
LOX
lysyl oxidase
chr10_-_94003003 0.262 ENST00000412050.4
CPEB3
cytoplasmic polyadenylation element binding protein 3
chr3_+_23986748 0.256 ENST00000312521.4
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr10_+_104474207 0.255 ENST00000602831.1
ENST00000369893.5
SFXN2

sideroflexin 2

chr16_-_11680791 0.254 ENST00000571976.1
ENST00000413364.2
LITAF

lipopolysaccharide-induced TNF factor

chr7_+_90225796 0.254 ENST00000380050.3
CDK14
cyclin-dependent kinase 14
chr16_-_71758602 0.253 ENST00000568954.1
PHLPP2
PH domain and leucine rich repeat protein phosphatase 2
chr3_-_178790057 0.252 ENST00000311417.2
ZMAT3
zinc finger, matrin-type 3
chr10_+_112257596 0.251 ENST00000369583.3
DUSP5
dual specificity phosphatase 5
chr1_-_149889382 0.250 ENST00000369145.1
ENST00000369146.3
SV2A

synaptic vesicle glycoprotein 2A

chr19_-_49576198 0.250 ENST00000221444.1
KCNA7
potassium voltage-gated channel, shaker-related subfamily, member 7
chr3_+_58223228 0.249 ENST00000478253.1
ENST00000295962.4
ABHD6

abhydrolase domain containing 6

chr2_+_169312350 0.244 ENST00000305747.6
CERS6
ceramide synthase 6
chr13_-_77900814 0.243 ENST00000544440.2
MYCBP2
MYC binding protein 2, E3 ubiquitin protein ligase
chr1_-_19229248 0.242 ENST00000375341.3
ALDH4A1
aldehyde dehydrogenase 4 family, member A1
chr8_-_37756972 0.242 ENST00000330843.4
ENST00000522727.1
ENST00000287263.4
RAB11FIP1


RAB11 family interacting protein 1 (class I)


chr8_+_26240414 0.240 ENST00000380629.2
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr8_-_8751068 0.239 ENST00000276282.6
MFHAS1
malignant fibrous histiocytoma amplified sequence 1
chr17_-_73389737 0.239 ENST00000392563.1
GRB2
growth factor receptor-bound protein 2
chr1_+_192544857 0.235 ENST00000367459.3
ENST00000469578.2
RGS1

regulator of G-protein signaling 1

chr3_-_114790179 0.233 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chr16_+_11762270 0.233 ENST00000329565.5
SNN
stannin
chr5_-_93447333 0.232 ENST00000395965.3
ENST00000505869.1
ENST00000509163.1
FAM172A


family with sequence similarity 172, member A


chr5_-_81046922 0.232 ENST00000514493.1
ENST00000320672.4
SSBP2

single-stranded DNA binding protein 2

chr10_+_60272814 0.232 ENST00000373886.3
BICC1
bicaudal C homolog 1 (Drosophila)
chr3_+_186330712 0.231 ENST00000411641.2
ENST00000273784.5
AHSG

alpha-2-HS-glycoprotein

chr17_+_30813576 0.230 ENST00000313401.3
CDK5R1
cyclin-dependent kinase 5, regulatory subunit 1 (p35)
chr16_-_73082274 0.230 ENST00000268489.5
ZFHX3
zinc finger homeobox 3
chr11_-_73309228 0.228 ENST00000356467.4
ENST00000064778.4
FAM168A

family with sequence similarity 168, member A

chr7_-_139876812 0.226 ENST00000397560.2
JHDM1D
lysine (K)-specific demethylase 7A
chr10_-_124768300 0.225 ENST00000368886.5
IKZF5
IKAROS family zinc finger 5 (Pegasus)
chr12_-_81331697 0.225 ENST00000552864.1
LIN7A
lin-7 homolog A (C. elegans)
chr8_-_41166953 0.225 ENST00000220772.3
SFRP1
secreted frizzled-related protein 1
chr3_+_16926441 0.224 ENST00000418129.2
ENST00000396755.2
PLCL2

phospholipase C-like 2

chr9_-_127905736 0.221 ENST00000336505.6
ENST00000373549.4
SCAI

suppressor of cancer cell invasion

chr10_+_52751010 0.220 ENST00000373985.1
PRKG1
protein kinase, cGMP-dependent, type I
chr4_+_113970772 0.216 ENST00000504454.1
ENST00000394537.3
ENST00000357077.4
ENST00000264366.6
ANK2



ankyrin 2, neuronal



chr11_-_30038490 0.215 ENST00000328224.6
KCNA4
potassium voltage-gated channel, shaker-related subfamily, member 4
chr10_-_15762124 0.208 ENST00000378076.3
ITGA8
integrin, alpha 8
chrX_-_46618490 0.206 ENST00000328306.4
SLC9A7
solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7
chr2_+_85198216 0.201 ENST00000456682.1
ENST00000409785.4
KCMF1

potassium channel modulatory factor 1

chr6_-_46293378 0.201 ENST00000330430.6
RCAN2
regulator of calcineurin 2
chr8_-_94753229 0.201 ENST00000518597.1
ENST00000399300.2
ENST00000517700.1
RBM12B


RNA binding motif protein 12B


chr18_+_2655692 0.198 ENST00000320876.6
SMCHD1
structural maintenance of chromosomes flexible hinge domain containing 1
chr3_+_107241783 0.196 ENST00000415149.2
ENST00000402543.1
ENST00000325805.8
ENST00000427402.1
BBX



bobby sox homolog (Drosophila)



chr6_+_126112001 0.196 ENST00000392477.2
NCOA7
nuclear receptor coactivator 7
chr1_+_203274639 0.195 ENST00000290551.4
BTG2
BTG family, member 2
chr8_-_122653630 0.194 ENST00000303924.4
HAS2
hyaluronan synthase 2
chr8_-_98290087 0.188 ENST00000322128.3
TSPYL5
TSPY-like 5
chr12_-_106641728 0.187 ENST00000378026.4
CKAP4
cytoskeleton-associated protein 4
chr3_-_21792838 0.186 ENST00000281523.2
ZNF385D
zinc finger protein 385D
chr1_-_108507631 0.185 ENST00000527011.1
ENST00000370056.4
VAV3

vav 3 guanine nucleotide exchange factor

chr2_+_7057523 0.185 ENST00000320892.6
RNF144A
ring finger protein 144A
chr19_+_4969116 0.184 ENST00000588337.1
ENST00000159111.4
ENST00000381759.4
KDM4B


lysine (K)-specific demethylase 4B


chr12_+_862089 0.180 ENST00000315939.6
ENST00000537687.1
ENST00000447667.2
WNK1


WNK lysine deficient protein kinase 1


chr2_-_166930131 0.179 ENST00000303395.4
ENST00000409050.1
ENST00000423058.2
ENST00000375405.3
SCN1A



sodium channel, voltage-gated, type I, alpha subunit



chr2_-_172290482 0.179 ENST00000442541.1
ENST00000392599.2
ENST00000375258.4
METTL8


methyltransferase like 8


chr2_-_39348137 0.178 ENST00000426016.1
SOS1
son of sevenless homolog 1 (Drosophila)
chr15_+_33010175 0.178 ENST00000300177.4
ENST00000560677.1
ENST00000560830.1
GREM1


gremlin 1, DAN family BMP antagonist


chr18_-_31803435 0.172 ENST00000589544.1
ENST00000269185.4
ENST00000261592.5
NOL4


nucleolar protein 4


chr22_-_39239987 0.171 ENST00000333039.2
NPTXR
neuronal pentraxin receptor
chr1_+_87380299 0.171 ENST00000370551.4
ENST00000370550.5
HS2ST1

heparan sulfate 2-O-sulfotransferase 1

chr16_-_48644061 0.164 ENST00000262384.3
N4BP1
NEDD4 binding protein 1
chr11_-_77532050 0.161 ENST00000308488.6
RSF1
remodeling and spacing factor 1
chr2_-_24149977 0.159 ENST00000238789.5
ATAD2B
ATPase family, AAA domain containing 2B
chr17_+_46184911 0.155 ENST00000580219.1
ENST00000452859.2
ENST00000393405.2
ENST00000439357.2
ENST00000359238.2
SNX11




sorting nexin 11




chr1_+_211433275 0.154 ENST00000367005.4
RCOR3
REST corepressor 3
chr17_-_76713100 0.154 ENST00000585509.1
CYTH1
cytohesin 1
chr3_-_129407535 0.154 ENST00000432054.2
TMCC1
transmembrane and coiled-coil domain family 1
chr11_-_60674037 0.153 ENST00000541371.1
ENST00000227524.4
PRPF19

pre-mRNA processing factor 19

chr12_-_75905374 0.152 ENST00000438169.2
ENST00000229214.4
KRR1

KRR1, small subunit (SSU) processome component, homolog (yeast)

chr2_-_232645977 0.152 ENST00000409772.1
PDE6D
phosphodiesterase 6D, cGMP-specific, rod, delta
chr6_+_30524663 0.151 ENST00000376560.3
PRR3
proline rich 3
chr19_+_19496624 0.151 ENST00000494516.2
ENST00000360315.3
ENST00000252577.5
GATAD2A


GATA zinc finger domain containing 2A


chr1_-_67896095 0.151 ENST00000370994.4
SERBP1
SERPINE1 mRNA binding protein 1
chr3_+_38495333 0.150 ENST00000352511.4
ACVR2B
activin A receptor, type IIB
chr6_+_37787262 0.149 ENST00000287218.4
ZFAND3
zinc finger, AN1-type domain 3
chr5_+_133984462 0.149 ENST00000398844.2
ENST00000322887.4
SEC24A

SEC24 family member A

chr3_+_54156664 0.148 ENST00000474759.1
ENST00000288197.5
CACNA2D3

calcium channel, voltage-dependent, alpha 2/delta subunit 3

chrX_+_108780062 0.147 ENST00000372106.1
NXT2
nuclear transport factor 2-like export factor 2
chr1_+_39456895 0.147 ENST00000432648.3
ENST00000446189.2
ENST00000372984.4
AKIRIN1


akirin 1


chr2_-_165697920 0.145 ENST00000342193.4
ENST00000375458.2
COBLL1

cordon-bleu WH2 repeat protein-like 1

chr20_-_33999766 0.144 ENST00000349714.5
ENST00000438533.1
ENST00000359226.2
ENST00000374384.2
ENST00000374377.5
ENST00000407996.2
ENST00000424405.1
ENST00000542501.1
ENST00000397554.1
ENST00000540457.1
ENST00000374380.2
ENST00000374385.5
UQCC1











ubiquinol-cytochrome c reductase complex assembly factor 1











chrX_+_30671476 0.144 ENST00000378946.3
ENST00000378943.3
ENST00000378945.3
ENST00000427190.1
ENST00000378941.3
GK




glycerol kinase




chr10_-_52645416 0.142 ENST00000374001.2
ENST00000373997.3
ENST00000373995.3
ENST00000282641.2
ENST00000395495.1
ENST00000414883.1
A1CF





APOBEC1 complementation factor





chr11_-_74109422 0.141 ENST00000298198.4
PGM2L1
phosphoglucomutase 2-like 1
chr5_+_65440032 0.140 ENST00000334121.6
SREK1
splicing regulatory glutamine/lysine-rich protein 1
chr5_+_32585605 0.140 ENST00000265073.4
ENST00000515355.1
ENST00000502897.1
ENST00000510442.1
SUB1



SUB1 homolog (S. cerevisiae)



chr17_-_35969409 0.139 ENST00000394378.2
ENST00000585472.1
ENST00000591288.1
ENST00000502449.2
ENST00000345615.4
ENST00000346661.4
ENST00000585689.1
ENST00000339208.6
SYNRG







synergin, gamma







chr2_-_100939195 0.138 ENST00000393437.3
LONRF2
LON peptidase N-terminal domain and ring finger 2
chr14_+_71108460 0.136 ENST00000256367.2
TTC9
tetratricopeptide repeat domain 9
chr6_+_34759837 0.136 ENST00000192788.5
ENST00000452449.2
UHRF1BP1

UHRF1 binding protein 1

chr11_-_67888671 0.133 ENST00000265689.4
CHKA
choline kinase alpha
chr1_+_205473720 0.132 ENST00000429964.2
ENST00000506784.1
ENST00000360066.2
CDK18


cyclin-dependent kinase 18


chr18_-_45456930 0.131 ENST00000262160.6
ENST00000587269.1
SMAD2

SMAD family member 2

chr12_-_12419703 0.131 ENST00000543091.1
ENST00000261349.4
LRP6

low density lipoprotein receptor-related protein 6

chr7_+_74072011 0.131 ENST00000324896.4
ENST00000353920.4
ENST00000346152.4
ENST00000416070.1
GTF2I



general transcription factor IIi



chr13_-_76056250 0.128 ENST00000377636.3
ENST00000431480.2
ENST00000377625.2
ENST00000425511.1
TBC1D4



TBC1 domain family, member 4



chr3_-_125313934 0.128 ENST00000296220.5
OSBPL11
oxysterol binding protein-like 11
chr16_-_22385901 0.128 ENST00000268383.2
CDR2
cerebellar degeneration-related protein 2, 62kDa
chr14_-_100070363 0.128 ENST00000380243.4
CCDC85C
coiled-coil domain containing 85C
chr5_-_132073210 0.128 ENST00000378735.1
ENST00000378746.4
KIF3A

kinesin family member 3A

chr9_+_114659046 0.125 ENST00000374279.3
UGCG
UDP-glucose ceramide glucosyltransferase
chr5_-_132948216 0.125 ENST00000265342.7
FSTL4
follistatin-like 4
chr13_+_26828275 0.123 ENST00000381527.3
CDK8
cyclin-dependent kinase 8
chr3_-_171178157 0.123 ENST00000465393.1
ENST00000436636.2
ENST00000369326.5
ENST00000538048.1
ENST00000341852.6
TNIK




TRAF2 and NCK interacting kinase





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0045082 positive regulation of interleukin-10 biosynthetic process(GO:0045082)
0.4 1.1 GO:0060318 definitive erythrocyte differentiation(GO:0060318)
0.2 0.7 GO:0060267 transformation of host cell by virus(GO:0019087) positive regulation of respiratory burst(GO:0060267)
0.2 1.6 GO:0060325 face morphogenesis(GO:0060325)
0.2 0.5 GO:0034139 regulation of toll-like receptor 2 signaling pathway(GO:0034135) regulation of toll-like receptor 3 signaling pathway(GO:0034139) negative regulation of epithelial cell apoptotic process(GO:1904036) negative regulation of endothelial cell apoptotic process(GO:2000352)
0.2 0.6 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.2 0.6 GO:0018352 protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.2 0.5 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.2 1.5 GO:0009404 toxin metabolic process(GO:0009404)
0.1 0.4 GO:2000121 regulation of removal of superoxide radicals(GO:2000121)
0.1 0.2 GO:0090244 Wnt signaling pathway involved in somitogenesis(GO:0090244) negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1 0.6 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.1 0.3 GO:0035408 histone H3-T6 phosphorylation(GO:0035408)
0.1 0.3 GO:0071679 facial nucleus development(GO:0021754) cell proliferation in midbrain(GO:0033278) commissural neuron axon guidance(GO:0071679)
0.1 0.4 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 0.3 GO:0006668 sphinganine-1-phosphate metabolic process(GO:0006668)
0.1 0.3 GO:0048935 peripheral nervous system neuron development(GO:0048935)
0.1 0.3 GO:0006848 pyruvate transport(GO:0006848)
0.1 0.2 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.1 0.7 GO:0008354 germ cell migration(GO:0008354)
0.1 0.5 GO:0048149 behavioral response to ethanol(GO:0048149)
0.1 0.3 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.1 0.2 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.1 0.1 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.1 0.1 GO:0060430 lung saccule development(GO:0060430) Clara cell differentiation(GO:0060486) Type II pneumocyte differentiation(GO:0060510)
0.1 0.1 GO:0034244 negative regulation of DNA-templated transcription, elongation(GO:0032785) negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244) regulation of photoreceptor cell differentiation(GO:0046532) negative regulation of smooth muscle cell differentiation(GO:0051151)
0.1 0.7 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.1 0.4 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.1 0.3 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 1.1 GO:0051057 positive regulation of small GTPase mediated signal transduction(GO:0051057)
0.1 0.2 GO:0001832 blastocyst growth(GO:0001832) inner cell mass cell proliferation(GO:0001833)
0.0 0.2 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.0 0.1 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.3 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.1 GO:0032927 positive regulation of activin receptor signaling pathway(GO:0032927)
0.0 0.1 GO:0019695 choline metabolic process(GO:0019695)
0.0 0.1 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.0 0.3 GO:0033160 positive regulation of protein import into nucleus, translocation(GO:0033160)
0.0 0.1 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.1 GO:0006679 glucosylceramide biosynthetic process(GO:0006679)
0.0 0.4 GO:0006002 fructose 6-phosphate metabolic process(GO:0006002)
0.0 0.4 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.2 GO:0006562 proline catabolic process(GO:0006562)
0.0 0.1 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.2 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.0 0.5 GO:0032876 regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)
0.0 0.1 GO:0051451 myoblast migration(GO:0051451)
0.0 0.1 GO:0021896 forebrain astrocyte differentiation(GO:0021896) forebrain astrocyte development(GO:0021897)
0.0 0.0 GO:0060242 contact inhibition(GO:0060242)
0.0 0.1 GO:0044340 canonical Wnt signaling pathway involved in regulation of cell proliferation(GO:0044340)
0.0 0.2 GO:0050685 positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313)
0.0 0.2 GO:0018106 peptidyl-histidine phosphorylation(GO:0018106)
0.0 0.1 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0 0.5 GO:0051319 mitotic G2 phase(GO:0000085) G2 phase(GO:0051319)
0.0 0.2 GO:0045767 obsolete regulation of anti-apoptosis(GO:0045767)
0.0 0.9 GO:0019835 cytolysis(GO:0019835)
0.0 0.1 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.0 0.2 GO:0060676 ureteric bud formation(GO:0060676) mesonephric tubule formation(GO:0072172)
0.0 0.1 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.0 0.3 GO:0001706 endoderm formation(GO:0001706)
0.0 0.2 GO:0071480 cellular response to gamma radiation(GO:0071480)
0.0 0.1 GO:0007182 common-partner SMAD protein phosphorylation(GO:0007182)
0.0 0.1 GO:0071428 rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.0 0.4 GO:0060736 prostate gland growth(GO:0060736)
0.0 0.2 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.0 0.4 GO:0032613 interleukin-10 production(GO:0032613)
0.0 0.1 GO:0035330 regulation of hippo signaling(GO:0035330)
0.0 0.2 GO:1901799 negative regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032435) negative regulation of proteasomal protein catabolic process(GO:1901799) negative regulation of proteolysis involved in cellular protein catabolic process(GO:1903051) negative regulation of cellular protein catabolic process(GO:1903363)
0.0 0.2 GO:0016584 nucleosome positioning(GO:0016584)
0.0 0.1 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.1 GO:0035020 regulation of Rac protein signal transduction(GO:0035020)
0.0 1.1 GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845)
0.0 0.1 GO:0007144 female meiosis I(GO:0007144)
0.0 0.3 GO:0032148 activation of protein kinase B activity(GO:0032148)
0.0 0.1 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.1 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0 0.1 GO:0045722 positive regulation of gluconeogenesis(GO:0045722)
0.0 0.2 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.0 0.1 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.1 GO:0007143 female meiotic division(GO:0007143)
0.0 0.2 GO:0003084 positive regulation of systemic arterial blood pressure(GO:0003084)
0.0 0.1 GO:0060292 long term synaptic depression(GO:0060292)
0.0 0.0 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0 0.3 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.1 GO:0046902 regulation of mitochondrial membrane permeability(GO:0046902) regulation of membrane permeability(GO:0090559)
0.0 0.2 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 0.6 GO:0001938 positive regulation of endothelial cell proliferation(GO:0001938)
0.0 0.1 GO:0000729 DNA double-strand break processing(GO:0000729)
0.0 0.4 GO:0008347 glial cell migration(GO:0008347)
0.0 0.0 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.2 GO:0008634 obsolete negative regulation of survival gene product expression(GO:0008634)
0.0 0.0 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 2.0 GO:0008203 cholesterol metabolic process(GO:0008203)
0.0 0.1 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.0 GO:0042816 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.0 0.4 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.1 GO:0071479 cellular response to ionizing radiation(GO:0071479)
0.0 0.1 GO:0045793 positive regulation of cell size(GO:0045793)
0.0 0.1 GO:0043113 receptor clustering(GO:0043113)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 0.9 GO:0000788 nuclear nucleosome(GO:0000788)
0.3 1.1 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.2 1.2 GO:0005899 insulin receptor complex(GO:0005899)
0.1 0.4 GO:0071953 elastic fiber(GO:0071953)
0.1 2.1 GO:0034362 low-density lipoprotein particle(GO:0034362)
0.1 0.3 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.1 0.3 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
0.1 0.3 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.2 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1 0.2 GO:0031213 RSF complex(GO:0031213)
0.0 0.1 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0 0.3 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.7 GO:0043073 germ cell nucleus(GO:0043073)
0.0 0.4 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.3 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.1 GO:0016939 kinesin II complex(GO:0016939)
0.0 0.1 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.0 0.3 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.2 GO:0042598 obsolete vesicular fraction(GO:0042598)
0.0 0.1 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.1 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.0 0.1 GO:0001740 Barr body(GO:0001740)
0.0 0.2 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.1 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.1 GO:0000137 Golgi cis cisterna(GO:0000137)
0.0 0.1 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.1 GO:0045298 tubulin complex(GO:0045298)
0.0 0.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 0.1 GO:0072487 MSL complex(GO:0072487)
0.0 0.4 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 0.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.1 GO:0019718 obsolete rough microsome(GO:0019718)
0.0 0.9 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.0 0.1 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.2 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.3 GO:0031594 neuromuscular junction(GO:0031594)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.2 0.7 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.2 1.1 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.2 0.6 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.2 0.5 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.1 0.6 GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.1 0.5 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 0.4 GO:0070548 L-glutamine aminotransferase activity(GO:0070548)
0.1 1.0 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.1 0.3 GO:0004676 3-phosphoinositide-dependent protein kinase activity(GO:0004676)
0.1 0.3 GO:0035403 histone kinase activity (H3-T6 specific)(GO:0035403)
0.1 2.1 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.1 0.3 GO:0050833 pyruvate secondary active transmembrane transporter activity(GO:0005477) pyruvate transmembrane transporter activity(GO:0050833)
0.1 0.2 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)
0.1 0.3 GO:0004723 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.1 1.5 GO:0070330 aromatase activity(GO:0070330)
0.1 0.2 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.1 0.4 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.1 0.2 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.1 0.2 GO:0061133 endopeptidase activator activity(GO:0061133)
0.1 0.8 GO:0004017 adenylate kinase activity(GO:0004017)
0.1 0.1 GO:0005113 patched binding(GO:0005113)
0.0 0.6 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.0 0.5 GO:0061659 ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 0.1 GO:0016362 activin receptor activity, type II(GO:0016362)
0.0 0.1 GO:0033265 choline binding(GO:0033265)
0.0 0.2 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 0.3 GO:0030955 potassium ion binding(GO:0030955)
0.0 0.2 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.1 GO:0004924 oncostatin-M receptor activity(GO:0004924) ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.3 GO:0008158 hedgehog receptor activity(GO:0008158)
0.0 0.3 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.3 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
0.0 0.1 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.4 GO:0016944 obsolete RNA polymerase II transcription elongation factor activity(GO:0016944)
0.0 0.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) ATP-dependent microtubule motor activity(GO:1990939)
0.0 0.1 GO:0008192 RNA guanylyltransferase activity(GO:0008192)
0.0 0.3 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.7 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024)
0.0 0.1 GO:0016524 latrotoxin receptor activity(GO:0016524)
0.0 0.1 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
0.0 0.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.5 GO:0043621 protein self-association(GO:0043621)
0.0 0.1 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.0 0.1 GO:0008420 CTD phosphatase activity(GO:0008420)
0.0 0.3 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.0 0.4 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.9 GO:0005080 protein kinase C binding(GO:0005080)
0.0 0.2 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.2 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.1 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.3 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.1 GO:0034187 obsolete apolipoprotein E binding(GO:0034187)
0.0 0.1 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.1 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 0.2 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0 0.2 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.1 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.0 GO:0031997 N-terminal myristoylation domain binding(GO:0031997)
0.0 0.4 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.0 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.2 GO:0005521 lamin binding(GO:0005521)
0.0 0.3 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 0.0 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
0.0 0.2 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.1 GO:0022821 potassium ion antiporter activity(GO:0022821)
0.0 0.1 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
0.0 0.0 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.0 0.1 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 0.2 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.0 0.0 GO:0030611 arsenate reductase activity(GO:0030611)
0.0 0.3 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.0 0.7 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.1 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.1 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.5 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.