Motif ID: UCCAGUU
Z-value: 1.535
Mature miRNA associated with seed UCCAGUU:
Name | miRBase Accession |
---|---|
hsa-miR-145-5p | MIMAT0000437 |
hsa-miR-5195-3p | MIMAT0021127 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 2.0 | GO:0010757 | chronological cell aging(GO:0001300) arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540) negative regulation of plasminogen activation(GO:0010757) negative regulation of cell adhesion mediated by integrin(GO:0033629) |
0.6 | 3.2 | GO:0033632 | regulation of cell-cell adhesion mediated by integrin(GO:0033632) |
0.5 | 1.6 | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096) |
0.5 | 1.5 | GO:0002514 | B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663) |
0.5 | 0.9 | GO:0060535 | trachea cartilage morphogenesis(GO:0060535) cartilage morphogenesis(GO:0060536) |
0.4 | 1.7 | GO:0006663 | platelet activating factor biosynthetic process(GO:0006663) positive regulation of vesicle fusion(GO:0031340) regulation of prostaglandin biosynthetic process(GO:0031392) positive regulation of prostaglandin biosynthetic process(GO:0031394) regulation of unsaturated fatty acid biosynthetic process(GO:2001279) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280) |
0.4 | 1.6 | GO:0050928 | negative regulation of positive chemotaxis(GO:0050928) |
0.4 | 2.2 | GO:0060710 | chorio-allantoic fusion(GO:0060710) |
0.3 | 1.8 | GO:0014049 | positive regulation of glutamate secretion(GO:0014049) |
0.3 | 1.7 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
0.3 | 2.7 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
0.3 | 1.0 | GO:0034959 | neuropeptide catabolic process(GO:0010813) substance P catabolic process(GO:0010814) calcitonin catabolic process(GO:0010816) endothelin maturation(GO:0034959) |
0.3 | 0.8 | GO:0045603 | positive regulation of endothelial cell differentiation(GO:0045603) |
0.2 | 0.4 | GO:0003176 | aortic valve development(GO:0003176) aortic valve morphogenesis(GO:0003180) |
0.2 | 0.6 | GO:0061298 | progesterone secretion(GO:0042701) retina vasculature development in camera-type eye(GO:0061298) retina vasculature morphogenesis in camera-type eye(GO:0061299) |
0.2 | 0.6 | GO:0046881 | positive regulation of gonadotropin secretion(GO:0032278) positive regulation of follicle-stimulating hormone secretion(GO:0046881) |
0.2 | 0.9 | GO:0021535 | cell migration in hindbrain(GO:0021535) |
0.2 | 0.8 | GO:0044854 | membrane raft assembly(GO:0001765) plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) positive regulation of dopamine receptor signaling pathway(GO:0060161) caveola assembly(GO:0070836) membrane assembly(GO:0071709) |
0.1 | 0.9 | GO:0045722 | positive regulation of gluconeogenesis(GO:0045722) |
0.1 | 0.4 | GO:0045726 | regulation of integrin biosynthetic process(GO:0045113) positive regulation of integrin biosynthetic process(GO:0045726) |
0.1 | 0.1 | GO:0046586 | regulation of calcium-dependent cell-cell adhesion(GO:0046586) |
0.1 | 0.2 | GO:0032060 | bleb assembly(GO:0032060) |
0.1 | 0.9 | GO:0048251 | elastic fiber assembly(GO:0048251) |
0.1 | 0.5 | GO:0007386 | compartment pattern specification(GO:0007386) |
0.1 | 1.2 | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482) |
0.1 | 0.2 | GO:0046520 | diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520) |
0.1 | 0.6 | GO:0032528 | microvillus assembly(GO:0030033) microvillus organization(GO:0032528) |
0.1 | 0.1 | GO:0006679 | glucosylceramide biosynthetic process(GO:0006679) |
0.1 | 0.2 | GO:0060689 | cell differentiation involved in salivary gland development(GO:0060689) |
0.1 | 0.4 | GO:0032527 | retrograde protein transport, ER to cytosol(GO:0030970) protein exit from endoplasmic reticulum(GO:0032527) |
0.1 | 0.2 | GO:0033025 | mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025) PMA-inducible membrane protein ectodomain proteolysis(GO:0051088) |
0.1 | 0.4 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
0.1 | 0.3 | GO:0051051 | negative regulation of transport(GO:0051051) |
0.1 | 0.6 | GO:0031053 | primary miRNA processing(GO:0031053) |
0.1 | 0.1 | GO:0070672 | response to interleukin-15(GO:0070672) |
0.1 | 0.6 | GO:0006621 | protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437) |
0.1 | 0.3 | GO:0016080 | synaptic vesicle targeting(GO:0016080) |
0.0 | 0.7 | GO:0007220 | Notch receptor processing(GO:0007220) |
0.0 | 0.5 | GO:0007351 | tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595) |
0.0 | 0.8 | GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949) |
0.0 | 1.9 | GO:0048009 | insulin-like growth factor receptor signaling pathway(GO:0048009) |
0.0 | 0.3 | GO:0035020 | regulation of Rac protein signal transduction(GO:0035020) |
0.0 | 0.4 | GO:0001569 | patterning of blood vessels(GO:0001569) |
0.0 | 0.3 | GO:0009249 | protein lipoylation(GO:0009249) |
0.0 | 0.2 | GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185) |
0.0 | 0.2 | GO:0019471 | peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401) 4-hydroxyproline metabolic process(GO:0019471) peptidyl-proline hydroxylation(GO:0019511) |
0.0 | 0.5 | GO:0014003 | oligodendrocyte development(GO:0014003) |
0.0 | 0.2 | GO:0019985 | translesion synthesis(GO:0019985) |
0.0 | 0.3 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
0.0 | 3.2 | GO:0030048 | actin filament-based movement(GO:0030048) |
0.0 | 0.3 | GO:0035196 | production of miRNAs involved in gene silencing by miRNA(GO:0035196) |
0.0 | 0.1 | GO:0042487 | regulation of odontogenesis of dentin-containing tooth(GO:0042487) |
0.0 | 0.4 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
0.0 | 1.2 | GO:0045768 | obsolete positive regulation of anti-apoptosis(GO:0045768) |
0.0 | 1.0 | GO:0002208 | somatic recombination of immunoglobulin genes involved in immune response(GO:0002204) somatic diversification of immunoglobulins involved in immune response(GO:0002208) isotype switching(GO:0045190) |
0.0 | 0.3 | GO:0034446 | substrate adhesion-dependent cell spreading(GO:0034446) |
0.0 | 0.9 | GO:0007257 | activation of JUN kinase activity(GO:0007257) |
0.0 | 0.3 | GO:0051602 | response to electrical stimulus(GO:0051602) |
0.0 | 0.1 | GO:0060744 | thelarche(GO:0042695) development of secondary female sexual characteristics(GO:0046543) mammary gland branching involved in thelarche(GO:0060744) |
0.0 | 0.3 | GO:0032288 | myelin assembly(GO:0032288) |
0.0 | 0.4 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
0.0 | 0.1 | GO:0001999 | renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure(GO:0001999) |
0.0 | 0.4 | GO:1903729 | regulation of establishment of protein localization to plasma membrane(GO:0090003) regulation of protein localization to plasma membrane(GO:1903076) regulation of plasma membrane organization(GO:1903729) regulation of protein localization to cell periphery(GO:1904375) |
0.0 | 0.1 | GO:0034063 | stress granule assembly(GO:0034063) |
0.0 | 1.7 | GO:0007498 | mesoderm development(GO:0007498) |
0.0 | 0.4 | GO:0032011 | ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012) |
0.0 | 0.2 | GO:0007172 | signal complex assembly(GO:0007172) |
0.0 | 0.1 | GO:0097576 | vacuole fusion(GO:0097576) |
0.0 | 1.9 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
0.0 | 0.4 | GO:0006783 | heme biosynthetic process(GO:0006783) |
0.0 | 0.2 | GO:0043508 | negative regulation of JUN kinase activity(GO:0043508) |
0.0 | 0.2 | GO:0000768 | syncytium formation by plasma membrane fusion(GO:0000768) myoblast fusion(GO:0007520) |
0.0 | 0.1 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
0.0 | 0.0 | GO:0051481 | negative regulation of cytosolic calcium ion concentration(GO:0051481) |
0.0 | 0.1 | GO:0060391 | positive regulation of SMAD protein import into nucleus(GO:0060391) |
0.0 | 0.3 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.3 | 1.1 | GO:0005955 | calcineurin complex(GO:0005955) |
0.3 | 1.0 | GO:0031310 | intrinsic component of endosome membrane(GO:0031302) intrinsic component of vacuolar membrane(GO:0031310) |
0.2 | 1.5 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
0.1 | 0.6 | GO:0000153 | cytoplasmic ubiquitin ligase complex(GO:0000153) |
0.1 | 0.5 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
0.1 | 0.5 | GO:0044298 | neuronal cell body membrane(GO:0032809) cell body membrane(GO:0044298) |
0.1 | 2.3 | GO:0031528 | microvillus membrane(GO:0031528) |
0.1 | 1.2 | GO:0016461 | unconventional myosin complex(GO:0016461) |
0.1 | 1.7 | GO:0042588 | zymogen granule(GO:0042588) |
0.1 | 1.1 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
0.0 | 1.8 | GO:0043195 | terminal bouton(GO:0043195) |
0.0 | 0.2 | GO:0032444 | activin responsive factor complex(GO:0032444) |
0.0 | 1.7 | GO:0005637 | nuclear inner membrane(GO:0005637) |
0.0 | 0.2 | GO:0001741 | XY body(GO:0001741) |
0.0 | 2.7 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
0.0 | 0.3 | GO:0043218 | compact myelin(GO:0043218) |
0.0 | 0.8 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
0.0 | 0.2 | GO:0042598 | obsolete vesicular fraction(GO:0042598) |
0.0 | 2.5 | GO:0016459 | myosin complex(GO:0016459) |
0.0 | 0.8 | GO:0005811 | lipid particle(GO:0005811) |
0.0 | 0.2 | GO:0042575 | DNA polymerase complex(GO:0042575) |
0.0 | 1.7 | GO:0030665 | clathrin-coated vesicle membrane(GO:0030665) |
0.0 | 0.4 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
0.0 | 0.1 | GO:0016939 | kinesin II complex(GO:0016939) |
0.0 | 2.9 | GO:0005938 | cell cortex(GO:0005938) |
0.0 | 0.3 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
0.0 | 1.2 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
0.0 | 0.2 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
0.0 | 0.7 | GO:0005581 | collagen trimer(GO:0005581) |
0.0 | 0.4 | GO:0090568 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568) |
0.0 | 0.2 | GO:0030119 | AP-type membrane coat adaptor complex(GO:0030119) |
0.0 | 0.1 | GO:0005899 | insulin receptor complex(GO:0005899) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 1.9 | GO:0005010 | insulin-like growth factor-activated receptor activity(GO:0005010) |
0.4 | 1.5 | GO:0005026 | transforming growth factor beta receptor activity, type II(GO:0005026) |
0.3 | 2.7 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
0.3 | 1.2 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
0.2 | 0.6 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
0.2 | 1.8 | GO:0004157 | dihydropyrimidinase activity(GO:0004157) |
0.2 | 0.5 | GO:0016362 | activin receptor activity, type II(GO:0016362) |
0.2 | 1.7 | GO:0047498 | calcium-dependent phospholipase A2 activity(GO:0047498) |
0.2 | 1.0 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
0.1 | 3.3 | GO:0000146 | microfilament motor activity(GO:0000146) |
0.1 | 1.4 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
0.1 | 0.4 | GO:0019797 | procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544) |
0.1 | 2.3 | GO:0070410 | co-SMAD binding(GO:0070410) |
0.1 | 0.3 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
0.1 | 0.8 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
0.1 | 0.5 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
0.1 | 1.1 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093) |
0.1 | 1.2 | GO:0001619 | obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619) |
0.1 | 2.2 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
0.1 | 0.9 | GO:0016641 | oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641) |
0.1 | 0.8 | GO:0050780 | dopamine receptor binding(GO:0050780) |
0.1 | 0.3 | GO:0042328 | heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328) N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509) |
0.1 | 0.3 | GO:0042043 | neurexin family protein binding(GO:0042043) |
0.1 | 0.2 | GO:0047708 | biotinidase activity(GO:0047708) |
0.1 | 0.3 | GO:0008327 | methyl-CpG binding(GO:0008327) |
0.0 | 0.4 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
0.0 | 0.4 | GO:0043422 | protein kinase B binding(GO:0043422) |
0.0 | 0.4 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
0.0 | 2.1 | GO:0002020 | protease binding(GO:0002020) |
0.0 | 0.2 | GO:0051400 | BH domain binding(GO:0051400) |
0.0 | 0.4 | GO:0005114 | type II transforming growth factor beta receptor binding(GO:0005114) |
0.0 | 0.2 | GO:0004656 | procollagen-proline 4-dioxygenase activity(GO:0004656) peptidyl-proline 4-dioxygenase activity(GO:0031545) |
0.0 | 0.4 | GO:0008242 | omega peptidase activity(GO:0008242) |
0.0 | 0.0 | GO:0004119 | cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) |
0.0 | 1.5 | GO:1990782 | receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782) |
0.0 | 3.4 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
0.0 | 0.2 | GO:0016167 | glial cell-derived neurotrophic factor receptor activity(GO:0016167) |
0.0 | 0.6 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
0.0 | 0.7 | GO:0008186 | RNA-dependent ATPase activity(GO:0008186) |
0.0 | 0.5 | GO:0030332 | cyclin binding(GO:0030332) |
0.0 | 0.2 | GO:0042153 | obsolete RPTP-like protein binding(GO:0042153) |
0.0 | 0.2 | GO:0017049 | GTP-Rho binding(GO:0017049) |
0.0 | 0.3 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
0.0 | 0.2 | GO:0031996 | thioesterase binding(GO:0031996) |
0.0 | 0.4 | GO:0019894 | kinesin binding(GO:0019894) |
0.0 | 0.2 | GO:0046875 | ephrin receptor binding(GO:0046875) |
0.0 | 0.4 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
0.0 | 1.2 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
0.0 | 0.2 | GO:0050811 | GABA receptor binding(GO:0050811) |
0.0 | 0.2 | GO:0016409 | palmitoyltransferase activity(GO:0016409) |
0.0 | 0.1 | GO:0030371 | translation repressor activity(GO:0030371) |
0.0 | 0.9 | GO:0008301 | DNA binding, bending(GO:0008301) |
0.0 | 0.2 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
0.0 | 0.0 | GO:0031702 | type 1 angiotensin receptor binding(GO:0031702) |
0.0 | 0.2 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
0.0 | 0.3 | GO:0008373 | sialyltransferase activity(GO:0008373) |
0.0 | 0.4 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
0.0 | 1.0 | GO:0008307 | structural constituent of muscle(GO:0008307) |
0.0 | 0.1 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 1.2 | SIG_BCR_SIGNALING_PATHWAY | Members of the BCR signaling pathway |
0.0 | 0.4 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |