Motif ID: UGUGCUU
Z-value: 0.632
Mature miRNA associated with seed UGUGCUU:
Name | miRBase Accession |
---|---|
hsa-miR-218-5p | MIMAT0000275 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 0.3 | GO:0051823 | regulation of synapse structural plasticity(GO:0051823) |
0.1 | 0.4 | GO:0048935 | peripheral nervous system neuron development(GO:0048935) |
0.1 | 0.3 | GO:0070634 | transepithelial ammonium transport(GO:0070634) |
0.1 | 0.3 | GO:0009048 | dosage compensation by inactivation of X chromosome(GO:0009048) |
0.1 | 0.3 | GO:0007109 | obsolete cytokinesis, completion of separation(GO:0007109) protein hexamerization(GO:0034214) |
0.1 | 0.3 | GO:0051573 | negative regulation of histone H3-K9 methylation(GO:0051573) |
0.1 | 0.3 | GO:0032776 | DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116) |
0.1 | 0.3 | GO:0060017 | parathyroid gland development(GO:0060017) |
0.1 | 0.5 | GO:0043982 | histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982) |
0.1 | 0.2 | GO:0017055 | negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055) |
0.1 | 0.4 | GO:0021903 | rostrocaudal neural tube patterning(GO:0021903) |
0.1 | 0.2 | GO:2000078 | epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287) regulation of type B pancreatic cell development(GO:2000074) positive regulation of type B pancreatic cell development(GO:2000078) |
0.0 | 0.3 | GO:0007256 | activation of JNKK activity(GO:0007256) |
0.0 | 0.5 | GO:0022027 | interkinetic nuclear migration(GO:0022027) |
0.0 | 0.3 | GO:0032916 | transforming growth factor beta3 production(GO:0032907) regulation of transforming growth factor beta3 production(GO:0032910) positive regulation of transforming growth factor beta3 production(GO:0032916) |
0.0 | 0.2 | GO:0070537 | histone H2A K63-linked deubiquitination(GO:0070537) |
0.0 | 0.1 | GO:0008050 | female courtship behavior(GO:0008050) |
0.0 | 0.2 | GO:0060708 | spongiotrophoblast differentiation(GO:0060708) |
0.0 | 0.3 | GO:0009082 | branched-chain amino acid biosynthetic process(GO:0009082) |
0.0 | 0.3 | GO:0090005 | negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376) |
0.0 | 0.1 | GO:0007028 | cytoplasm organization(GO:0007028) |
0.0 | 0.1 | GO:0034625 | fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626) |
0.0 | 0.3 | GO:0046349 | UDP-N-acetylglucosamine biosynthetic process(GO:0006048) amino sugar biosynthetic process(GO:0046349) |
0.0 | 0.3 | GO:0019264 | L-serine catabolic process(GO:0006565) glycine biosynthetic process from serine(GO:0019264) |
0.0 | 0.5 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
0.0 | 0.3 | GO:0006102 | isocitrate metabolic process(GO:0006102) |
0.0 | 0.2 | GO:0045767 | obsolete regulation of anti-apoptosis(GO:0045767) |
0.0 | 0.1 | GO:0033147 | negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147) |
0.0 | 0.1 | GO:0014889 | muscle atrophy(GO:0014889) |
0.0 | 0.2 | GO:0043984 | histone H4-K16 acetylation(GO:0043984) |
0.0 | 0.1 | GO:0055005 | optic placode formation involved in camera-type eye formation(GO:0046619) ventricular cardiac myofibril assembly(GO:0055005) embryonic retina morphogenesis in camera-type eye(GO:0060059) regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251) |
0.0 | 0.2 | GO:0010459 | negative regulation of heart rate(GO:0010459) |
0.0 | 0.2 | GO:0045722 | positive regulation of gluconeogenesis(GO:0045722) |
0.0 | 0.1 | GO:0072202 | cell differentiation involved in metanephros development(GO:0072202) |
0.0 | 0.1 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
0.0 | 0.3 | GO:0006474 | N-terminal protein amino acid acetylation(GO:0006474) |
0.0 | 0.1 | GO:1904036 | negative regulation of epithelial cell apoptotic process(GO:1904036) negative regulation of endothelial cell apoptotic process(GO:2000352) |
0.0 | 0.1 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
0.0 | 0.1 | GO:0050685 | positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313) |
0.0 | 0.1 | GO:0032933 | SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501) |
0.0 | 0.2 | GO:0007090 | obsolete regulation of S phase of mitotic cell cycle(GO:0007090) |
0.0 | 0.4 | GO:0071044 | histone mRNA catabolic process(GO:0071044) |
0.0 | 0.2 | GO:0043569 | negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569) |
0.0 | 0.2 | GO:0043306 | positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of leukocyte degranulation(GO:0043302) positive regulation of mast cell degranulation(GO:0043306) |
0.0 | 0.1 | GO:0001672 | regulation of chromatin assembly or disassembly(GO:0001672) |
0.0 | 0.2 | GO:0007202 | activation of phospholipase C activity(GO:0007202) regulation of phospholipase activity(GO:0010517) positive regulation of phospholipase activity(GO:0010518) positive regulation of phospholipase C activity(GO:0010863) regulation of lipase activity(GO:0060191) positive regulation of lipase activity(GO:0060193) regulation of phospholipase C activity(GO:1900274) |
0.0 | 0.4 | GO:0006270 | DNA replication initiation(GO:0006270) |
0.0 | 0.1 | GO:1903307 | positive regulation of calcium ion-dependent exocytosis(GO:0045956) positive regulation of regulated secretory pathway(GO:1903307) |
0.0 | 0.3 | GO:0006448 | regulation of translational elongation(GO:0006448) |
0.0 | 0.3 | GO:0032456 | endocytic recycling(GO:0032456) |
0.0 | 0.3 | GO:0051057 | positive regulation of small GTPase mediated signal transduction(GO:0051057) |
0.0 | 0.1 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
0.0 | 0.0 | GO:0043371 | negative regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043371) negative regulation of T-helper cell differentiation(GO:0045623) negative regulation of CD4-positive, alpha-beta T cell activation(GO:2000515) |
0.0 | 0.4 | GO:0007052 | mitotic spindle organization(GO:0007052) |
0.0 | 0.2 | GO:0042354 | fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355) |
0.0 | 0.0 | GO:0060124 | positive regulation of growth hormone secretion(GO:0060124) |
0.0 | 0.3 | GO:0006596 | polyamine biosynthetic process(GO:0006596) |
0.0 | 0.1 | GO:0007379 | segment specification(GO:0007379) |
0.0 | 0.1 | GO:0006772 | thiamine metabolic process(GO:0006772) |
0.0 | 0.1 | GO:0060992 | response to fungicide(GO:0060992) |
0.0 | 0.2 | GO:0006906 | vesicle fusion(GO:0006906) |
0.0 | 0.1 | GO:0016265 | obsolete death(GO:0016265) |
0.0 | 0.1 | GO:0048484 | enteric nervous system development(GO:0048484) |
0.0 | 0.0 | GO:0097576 | autophagosome maturation(GO:0097352) vacuole fusion(GO:0097576) |
0.0 | 0.1 | GO:0032075 | positive regulation of nuclease activity(GO:0032075) |
0.0 | 0.3 | GO:0002076 | osteoblast development(GO:0002076) |
0.0 | 0.5 | GO:0006271 | DNA strand elongation involved in DNA replication(GO:0006271) |
0.0 | 0.2 | GO:0051319 | mitotic G2 phase(GO:0000085) G2 phase(GO:0051319) |
0.0 | 0.2 | GO:0043968 | histone H2A acetylation(GO:0043968) |
0.0 | 0.2 | GO:0045604 | regulation of epidermal cell differentiation(GO:0045604) |
0.0 | 0.4 | GO:0001508 | action potential(GO:0001508) |
0.0 | 0.7 | GO:0061025 | membrane fusion(GO:0061025) |
0.0 | 0.2 | GO:0033235 | positive regulation of protein sumoylation(GO:0033235) |
0.0 | 0.2 | GO:0048260 | positive regulation of receptor-mediated endocytosis(GO:0048260) |
0.0 | 0.0 | GO:0071699 | olfactory placode formation(GO:0030910) olfactory placode development(GO:0071698) olfactory placode morphogenesis(GO:0071699) |
0.0 | 0.0 | GO:0060750 | epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750) |
0.0 | 0.1 | GO:0044060 | regulation of endocrine process(GO:0044060) |
0.0 | 0.3 | GO:0051925 | obsolete regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051925) |
0.0 | 0.1 | GO:0000012 | single strand break repair(GO:0000012) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 0.3 | GO:0016600 | flotillin complex(GO:0016600) |
0.1 | 0.3 | GO:0001740 | Barr body(GO:0001740) |
0.1 | 0.2 | GO:0097651 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) phosphatidylinositol 3-kinase complex, class I(GO:0097651) |
0.0 | 0.5 | GO:0016442 | RISC complex(GO:0016442) RNAi effector complex(GO:0031332) |
0.0 | 0.2 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
0.0 | 0.3 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
0.0 | 0.1 | GO:0032591 | dendritic spine membrane(GO:0032591) |
0.0 | 0.2 | GO:0072487 | MSL complex(GO:0072487) |
0.0 | 0.2 | GO:0042405 | nuclear RNA export factor complex(GO:0042272) nuclear inclusion body(GO:0042405) |
0.0 | 0.2 | GO:0070552 | BRISC complex(GO:0070552) |
0.0 | 0.2 | GO:0042575 | DNA polymerase complex(GO:0042575) |
0.0 | 0.2 | GO:0001891 | phagocytic cup(GO:0001891) |
0.0 | 0.5 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
0.0 | 0.1 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
0.0 | 0.3 | GO:0000791 | euchromatin(GO:0000791) |
0.0 | 0.3 | GO:0000808 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
0.0 | 0.2 | GO:0005638 | lamin filament(GO:0005638) |
0.0 | 0.2 | GO:0005677 | chromatin silencing complex(GO:0005677) |
0.0 | 0.2 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
0.0 | 0.2 | GO:0043190 | ATP-binding cassette (ABC) transporter complex(GO:0043190) |
0.0 | 0.3 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
0.0 | 0.1 | GO:0000137 | Golgi cis cisterna(GO:0000137) |
0.0 | 1.0 | GO:0055037 | recycling endosome(GO:0055037) |
0.0 | 0.2 | GO:0043596 | nuclear replication fork(GO:0043596) |
0.0 | 0.4 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
0.0 | 0.4 | GO:0031519 | PcG protein complex(GO:0031519) |
0.0 | 0.0 | GO:0031372 | UBC13-MMS2 complex(GO:0031372) |
0.0 | 0.1 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
0.0 | 0.1 | GO:0031205 | endoplasmic reticulum Sec complex(GO:0031205) |
0.0 | 0.1 | GO:0005614 | interstitial matrix(GO:0005614) |
0.0 | 0.4 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
0.0 | 0.2 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
0.0 | 0.7 | GO:0043197 | dendritic spine(GO:0043197) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.2 | 0.7 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
0.1 | 0.4 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
0.1 | 0.2 | GO:0015018 | galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018) |
0.1 | 0.3 | GO:0070548 | L-glutamine aminotransferase activity(GO:0070548) |
0.1 | 0.2 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
0.1 | 0.3 | GO:0004449 | isocitrate dehydrogenase (NAD+) activity(GO:0004449) |
0.1 | 0.2 | GO:0047184 | 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184) |
0.1 | 0.4 | GO:0004703 | G-protein coupled receptor kinase activity(GO:0004703) |
0.0 | 0.3 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
0.0 | 0.3 | GO:0052654 | branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656) |
0.0 | 0.1 | GO:0070097 | delta-catenin binding(GO:0070097) |
0.0 | 0.3 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
0.0 | 0.3 | GO:0008732 | glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732) |
0.0 | 0.2 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
0.0 | 0.3 | GO:0008073 | ornithine decarboxylase inhibitor activity(GO:0008073) |
0.0 | 0.3 | GO:0015166 | polyol transmembrane transporter activity(GO:0015166) |
0.0 | 0.1 | GO:0008489 | UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity(GO:0008489) |
0.0 | 0.1 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
0.0 | 0.3 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
0.0 | 0.2 | GO:0043559 | insulin binding(GO:0043559) |
0.0 | 0.2 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
0.0 | 0.1 | GO:0004119 | cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) |
0.0 | 0.1 | GO:0050692 | DBD domain binding(GO:0050692) |
0.0 | 0.3 | GO:0003688 | DNA replication origin binding(GO:0003688) |
0.0 | 0.0 | GO:0015271 | outward rectifier potassium channel activity(GO:0015271) |
0.0 | 0.2 | GO:0005237 | inhibitory extracellular ligand-gated ion channel activity(GO:0005237) |
0.0 | 0.1 | GO:0009922 | fatty acid elongase activity(GO:0009922) |
0.0 | 0.2 | GO:0046920 | alpha-(1->3)-fucosyltransferase activity(GO:0046920) |
0.0 | 0.2 | GO:0030911 | TPR domain binding(GO:0030911) |
0.0 | 0.1 | GO:0000156 | phosphorelay response regulator activity(GO:0000156) |
0.0 | 0.1 | GO:0032422 | translation repressor activity, nucleic acid binding(GO:0000900) purine-rich negative regulatory element binding(GO:0032422) |
0.0 | 0.1 | GO:0001641 | group II metabotropic glutamate receptor activity(GO:0001641) |
0.0 | 0.1 | GO:0005049 | nuclear export signal receptor activity(GO:0005049) |
0.0 | 0.4 | GO:0016896 | exoribonuclease activity, producing 5'-phosphomonoesters(GO:0016896) |
0.0 | 0.3 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093) |
0.0 | 0.3 | GO:0004526 | ribonuclease P activity(GO:0004526) |
0.0 | 0.1 | GO:0030611 | arsenate reductase activity(GO:0030611) |
0.0 | 0.3 | GO:0015377 | cation:chloride symporter activity(GO:0015377) |
0.0 | 0.2 | GO:0031701 | angiotensin receptor binding(GO:0031701) |
0.0 | 0.3 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617) |
0.0 | 0.2 | GO:0019789 | SUMO transferase activity(GO:0019789) |
0.0 | 0.1 | GO:0070259 | tyrosyl-DNA phosphodiesterase activity(GO:0070259) |
0.0 | 0.1 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
0.0 | 0.2 | GO:0043325 | phosphatidylinositol-3,4-bisphosphate binding(GO:0043325) |
0.0 | 0.4 | GO:0001540 | beta-amyloid binding(GO:0001540) |
0.0 | 0.2 | GO:0008266 | poly(U) RNA binding(GO:0008266) |
0.0 | 0.1 | GO:0003691 | double-stranded telomeric DNA binding(GO:0003691) |
0.0 | 0.4 | GO:0030552 | cAMP binding(GO:0030552) |
0.0 | 0.2 | GO:0050786 | RAGE receptor binding(GO:0050786) |
0.0 | 0.0 | GO:0008332 | low voltage-gated calcium channel activity(GO:0008332) |
0.0 | 0.1 | GO:0004692 | cGMP-dependent protein kinase activity(GO:0004692) |
0.0 | 0.1 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
0.0 | 0.2 | GO:0004017 | adenylate kinase activity(GO:0004017) |
0.0 | 0.1 | GO:0008504 | monoamine transmembrane transporter activity(GO:0008504) |
0.0 | 0.1 | GO:0016891 | endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891) |
0.0 | 0.4 | GO:0003725 | double-stranded RNA binding(GO:0003725) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 0.2 | ST_JAK_STAT_PATHWAY | Jak-STAT Pathway |
0.0 | 0.3 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |