Motif ID: UUGUUCG

Z-value: 0.455


Mature miRNA associated with seed UUGUUCG:

NamemiRBase Accession
hsa-miR-375 MIMAT0000728



Activity profile for motif UUGUUCG.

activity profile for motif UUGUUCG


Sorted Z-values histogram for motif UUGUUCG

Sorted Z-values for motif UUGUUCG



Network of associatons between targets according to the STRING database.



First level regulatory network of UUGUUCG

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr15_+_81071684 0.704 ENST00000220244.3
ENST00000394685.3
ENST00000356249.5
 KIAA1199


KIAA1199


chr1_-_57045228 0.584 ENST00000371250.3
 PPAP2B
phosphatidic acid phosphatase type 2B
chr4_-_157892498 0.542 ENST00000502773.1
 PDGFC
platelet derived growth factor C
chr11_-_115375107 0.504 ENST00000545380.1
ENST00000452722.3
ENST00000537058.1
ENST00000536727.1
ENST00000542447.2
ENST00000331581.6
 CADM1





cell adhesion molecule 1





chr11_+_101981169 0.475 ENST00000526343.1
ENST00000282441.5
ENST00000537274.1
ENST00000345877.2
 YAP1



Yes-associated protein 1



chr1_-_225840747 0.382 ENST00000366843.2
ENST00000366844.3
 ENAH

enabled homolog (Drosophila)

chr10_-_126849068 0.368 ENST00000494626.2
ENST00000337195.5
 CTBP2

C-terminal binding protein 2

chr12_-_76425368 0.349 ENST00000602540.1
 PHLDA1
pleckstrin homology-like domain, family A, member 1
chr17_+_38599693 0.344 ENST00000542955.1
ENST00000269593.4
 IGFBP4

insulin-like growth factor binding protein 4

chr7_+_17338239 0.305 ENST00000242057.4
 AHR
aryl hydrocarbon receptor
chr8_-_122653630 0.276 ENST00000303924.4
 HAS2
hyaluronan synthase 2
chr9_-_21335356 0.269 ENST00000359039.4
 KLHL9
kelch-like family member 9
chr10_-_735553 0.268 ENST00000280886.6
ENST00000423550.1
 DIP2C

DIP2 disco-interacting protein 2 homolog C (Drosophila)

chr3_-_114790179 0.262 ENST00000462705.1
 ZBTB20
zinc finger and BTB domain containing 20
chr11_+_12695944 0.256 ENST00000361905.4
 TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr1_-_120612240 0.242 ENST00000256646.2
 NOTCH2
notch 2
chr16_+_86544113 0.223 ENST00000262426.4
 FOXF1
forkhead box F1
chr7_-_27183263 0.213 ENST00000222726.3
 HOXA5
homeobox A5
chr1_-_240775447 0.207 ENST00000318160.4
 GREM2
gremlin 2, DAN family BMP antagonist
chr14_-_30396948 0.201 ENST00000331968.5
 PRKD1
protein kinase D1
chr4_-_120550146 0.200 ENST00000354960.3
 PDE5A
phosphodiesterase 5A, cGMP-specific
chr17_+_27369918 0.191 ENST00000323372.4
 PIPOX
pipecolic acid oxidase
chr2_+_223725652 0.186 ENST00000357430.3
ENST00000392066.3
 ACSL3

acyl-CoA synthetase long-chain family member 3

chrX_+_73641286 0.175 ENST00000587091.1
 SLC16A2
solute carrier family 16, member 2 (thyroid hormone transporter)
chr14_-_70883708 0.159 ENST00000256366.4
 SYNJ2BP
synaptojanin 2 binding protein
chr14_+_67707826 0.149 ENST00000261681.4
 MPP5
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr9_-_110251836 0.145 ENST00000374672.4
 KLF4
Kruppel-like factor 4 (gut)
chr14_-_55878538 0.142 ENST00000247178.5
 ATG14
autophagy related 14
chr1_-_21377447 0.142 ENST00000374937.3
ENST00000264211.8
 EIF4G3

eukaryotic translation initiation factor 4 gamma, 3

chr4_+_184020398 0.137 ENST00000403733.3
ENST00000378925.3
 WWC2

WW and C2 domain containing 2

chr4_+_72204755 0.126 ENST00000512686.1
ENST00000340595.3
 SLC4A4

solute carrier family 4 (sodium bicarbonate cotransporter), member 4

chr14_+_74486043 0.125 ENST00000464394.1
ENST00000394009.3
 CCDC176

coiled-coil domain containing 176

chr9_-_16870704 0.122 ENST00000380672.4
ENST00000380667.2
ENST00000380666.2
ENST00000486514.1
 BNC2



basonuclin 2



chr18_+_19749386 0.122 ENST00000269216.3
 GATA6
GATA binding protein 6
chr16_+_56965960 0.119 ENST00000439977.2
ENST00000344114.4
ENST00000300302.5
ENST00000379792.2
 HERPUD1



homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1



chr11_+_44117741 0.117 ENST00000395673.3
ENST00000343631.3
 EXT2

exostosin glycosyltransferase 2

chr13_+_73632897 0.115 ENST00000377687.4
 KLF5
Kruppel-like factor 5 (intestinal)
chr2_+_46926048 0.114 ENST00000306503.5
 SOCS5
suppressor of cytokine signaling 5
chr11_-_86666427 0.101 ENST00000531380.1
 FZD4
frizzled family receptor 4
chr4_-_141677267 0.098 ENST00000442267.2
 TBC1D9
TBC1 domain family, member 9 (with GRAM domain)
chr11_+_68080077 0.097 ENST00000294304.7
 LRP5
low density lipoprotein receptor-related protein 5
chr8_-_116681221 0.081 ENST00000395715.3
 TRPS1
trichorhinophalangeal syndrome I
chrX_+_95939711 0.080 ENST00000373049.4
ENST00000324765.8
 DIAPH2

diaphanous-related formin 2

chr9_+_115983808 0.067 ENST00000374210.6
ENST00000374212.4
 SLC31A1

solute carrier family 31 (copper transporter), member 1

chr10_+_111967345 0.065 ENST00000332674.5
ENST00000453116.1
 MXI1

MAX interactor 1, dimerization protein

chr16_+_2587998 0.064 ENST00000441549.3
ENST00000268673.7
 PDPK1

3-phosphoinositide dependent protein kinase-1

chr16_-_12897642 0.064 ENST00000433677.2
ENST00000261660.4
ENST00000381774.4
 CPPED1


calcineurin-like phosphoesterase domain containing 1


chr9_+_4679555 0.061 ENST00000381858.1
ENST00000381854.3
 CDC37L1

cell division cycle 37-like 1

chr15_+_57210818 0.059 ENST00000438423.2
ENST00000267811.5
ENST00000452095.2
ENST00000559609.1
ENST00000333725.5
 TCF12




transcription factor 12




chr2_+_118846008 0.058 ENST00000245787.4
 INSIG2
insulin induced gene 2
chr9_-_135819987 0.055 ENST00000298552.3
ENST00000403810.1
 TSC1

tuberous sclerosis 1

chr10_+_45455207 0.053 ENST00000334940.6
ENST00000374417.2
ENST00000340258.5
ENST00000427758.1
 RASSF4



Ras association (RalGDS/AF-6) domain family member 4



chr11_+_120207787 0.052 ENST00000397843.2
ENST00000356641.3
 ARHGEF12

Rho guanine nucleotide exchange factor (GEF) 12

chr15_-_101792137 0.052 ENST00000254190.3
 CHSY1
chondroitin sulfate synthase 1
chr2_+_204192942 0.052 ENST00000295851.5
ENST00000261017.5
 ABI2

abl-interactor 2

chr10_+_126490354 0.049 ENST00000298492.5
 FAM175B
family with sequence similarity 175, member B
chr20_-_524455 0.048 ENST00000349736.5
ENST00000217244.3
 CSNK2A1

casein kinase 2, alpha 1 polypeptide

chr19_+_19496624 0.048 ENST00000494516.2
ENST00000360315.3
ENST00000252577.5
 GATAD2A


GATA zinc finger domain containing 2A


chr14_-_96830207 0.044 ENST00000359933.4
 ATG2B
autophagy related 2B
chr20_+_306221 0.044 ENST00000342665.2
 SOX12
SRY (sex determining region Y)-box 12
chr1_+_2160134 0.044 ENST00000378536.4
 SKI
v-ski avian sarcoma viral oncogene homolog
chr9_-_38069208 0.042 ENST00000377707.3
ENST00000377700.4
 SHB

Src homology 2 domain containing adaptor protein B

chr9_+_26956371 0.041 ENST00000380062.5
ENST00000518614.1
 IFT74

intraflagellar transport 74 homolog (Chlamydomonas)

chr9_-_23821273 0.040 ENST00000380110.4
 ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr6_-_132834184 0.036 ENST00000367941.2
ENST00000367937.4
 STX7

syntaxin 7

chr22_+_40390930 0.035 ENST00000333407.6
 FAM83F
family with sequence similarity 83, member F
chr19_-_7293942 0.035 ENST00000341500.5
ENST00000302850.5
 INSR

insulin receptor

chr17_+_39845134 0.034 ENST00000591776.1
ENST00000469257.1
 EIF1

eukaryotic translation initiation factor 1

chr16_+_69458428 0.034 ENST00000512062.1
ENST00000307892.8
 CYB5B

cytochrome b5 type B (outer mitochondrial membrane)

chr12_-_51420128 0.034 ENST00000262051.7
ENST00000547732.1
ENST00000262052.5
ENST00000546488.1
ENST00000550714.1
ENST00000548193.1
ENST00000547579.1
ENST00000546743.1
 SLC11A2







solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2







chr17_+_14204389 0.032 ENST00000360954.2
 HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr7_-_558876 0.029 ENST00000354513.5
ENST00000402802.3
 PDGFA

platelet-derived growth factor alpha polypeptide

chr5_+_95997918 0.025 ENST00000395812.2
ENST00000395813.1
ENST00000359176.4
ENST00000325674.7
 CAST



calpastatin



chr14_-_68283291 0.023 ENST00000555452.1
ENST00000347230.4
 ZFYVE26

zinc finger, FYVE domain containing 26

chr19_+_47421933 0.021 ENST00000404338.3
 ARHGAP35
Rho GTPase activating protein 35
chr1_+_43148059 0.020 ENST00000321358.7
ENST00000332220.6
 YBX1

Y box binding protein 1

chr18_+_42260861 0.019 ENST00000282030.5
 SETBP1
SET binding protein 1
chr12_-_51477333 0.019 ENST00000228515.1
ENST00000548206.1
ENST00000546935.1
ENST00000548981.1
 CSRNP2



cysteine-serine-rich nuclear protein 2



chr2_-_131850951 0.018 ENST00000409185.1
ENST00000389915.3
 FAM168B

family with sequence similarity 168, member B

chr9_-_127533519 0.017 ENST00000487099.2
ENST00000344523.4
ENST00000373584.3
 NR6A1


nuclear receptor subfamily 6, group A, member 1


chrX_+_69664706 0.017 ENST00000194900.4
ENST00000374360.3
 DLG3

discs, large homolog 3 (Drosophila)

chr17_-_7832753 0.016 ENST00000303790.2
 KCNAB3
potassium voltage-gated channel, shaker-related subfamily, beta member 3
chr15_-_72410109 0.015 ENST00000564571.1
 MYO9A
myosin IXA
chr11_-_118047376 0.015 ENST00000278947.5
 SCN2B
sodium channel, voltage-gated, type II, beta subunit
chr8_-_117768023 0.015 ENST00000518949.1
ENST00000522453.1
ENST00000521861.1
ENST00000518995.1
 EIF3H



eukaryotic translation initiation factor 3, subunit H



chrX_-_18690210 0.013 ENST00000379984.3
 RS1
retinoschisin 1
chr1_+_15853308 0.012 ENST00000375838.1
ENST00000375847.3
ENST00000375849.1
 DNAJC16


DnaJ (Hsp40) homolog, subfamily C, member 16


chr19_-_18392422 0.011 ENST00000252818.3
 JUND
jun D proto-oncogene
chr2_-_178937478 0.010 ENST00000286063.6
 PDE11A
phosphodiesterase 11A
chr19_-_17799008 0.009 ENST00000519716.2
 UNC13A
unc-13 homolog A (C. elegans)
chr3_-_128369643 0.008 ENST00000296255.3
 RPN1
ribophorin I
chr8_-_38386175 0.007 ENST00000437935.2
ENST00000358138.1
 C8orf86

chromosome 8 open reading frame 86

chr12_+_56211703 0.003 ENST00000243045.5
ENST00000552672.1
ENST00000550836.1
 ORMDL2


ORM1-like 2 (S. cerevisiae)


chr11_-_74178582 0.002 ENST00000531854.1
ENST00000526855.1
ENST00000529425.1
ENST00000310128.4
ENST00000532569.1
 KCNE3




potassium voltage-gated channel, Isk-related family, member 3




chr17_-_617949 0.002 ENST00000401468.3
ENST00000574029.1
ENST00000291074.5
ENST00000571805.1
ENST00000437048.2
ENST00000446250.2
 VPS53





vacuolar protein sorting 53 homolog (S. cerevisiae)






Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.1 0.5 GO:0060242 contact inhibition(GO:0060242)
0.1 0.2 GO:0002887 negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301) establishment of epithelial cell apical/basal polarity(GO:0045198) epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.1 0.2 GO:0060574 trachea cartilage morphogenesis(GO:0060535) cartilage morphogenesis(GO:0060536) intestinal epithelial cell maturation(GO:0060574) intestinal epithelial cell development(GO:0060576)
0.1 0.2 GO:0061298 retina vasculature development in camera-type eye(GO:0061298) retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.1 0.6 GO:0008354 germ cell migration(GO:0008354)
0.0 0.1 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
0.0 0.3 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.1 GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043371) negative regulation of T-helper cell differentiation(GO:0045623) negative regulation of CD4-positive, alpha-beta T cell activation(GO:2000515)
0.0 0.0 GO:0019087 transformation of host cell by virus(GO:0019087)
0.0 0.1 GO:0010508 positive regulation of autophagy(GO:0010508)
0.0 0.4 GO:0050872 white fat cell differentiation(GO:0050872)
0.0 0.1 GO:0007500 mesodermal cell fate determination(GO:0007500)
0.0 0.2 GO:0046653 tetrahydrofolate metabolic process(GO:0046653)
0.0 0.1 GO:0060363 cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094)
0.0 0.3 GO:0035329 hippo signaling(GO:0035329)
0.0 0.1 GO:0071428 rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.0 0.2 GO:0007220 morphogenesis of an epithelial sheet(GO:0002011) Notch receptor processing(GO:0007220)
0.0 0.1 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.1 GO:0032528 microvillus assembly(GO:0030033) microvillus organization(GO:0032528)
0.0 0.6 GO:0045740 positive regulation of DNA replication(GO:0045740) positive regulation of fibroblast proliferation(GO:0048146)
0.0 0.0 GO:0070208 protein heterotrimerization(GO:0070208)
0.0 0.1 GO:0035434 copper ion transmembrane transport(GO:0035434)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.1 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 0.1 GO:0033596 TSC1-TSC2 complex(GO:0033596)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0042577 lipid phosphatase activity(GO:0042577)
0.0 0.2 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.0 0.2 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0 0.1 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328) N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509)
0.0 0.6 GO:0043498 obsolete cell surface binding(GO:0043498)
0.0 0.5 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.4 GO:0005522 profilin binding(GO:0005522)
0.0 0.2 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.1 GO:0004676 3-phosphoinositide-dependent protein kinase activity(GO:0004676)
0.0 0.1 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.1 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0 0.2 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.0 0.1 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510) bicarbonate transmembrane transporter activity(GO:0015106)
0.0 0.3 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.1 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)