Motif ID: ZBTB4
Z-value: 1.835
Transcription factors associated with ZBTB4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| ZBTB4 | ENSG00000174282.7 | ZBTB4 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 3.6 | GO:0048549 | positive regulation of pinocytosis(GO:0048549) |
| 0.5 | 8.4 | GO:0050812 | acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812) |
| 0.5 | 2.4 | GO:0015827 | tryptophan transport(GO:0015827) leucine import(GO:0060356) |
| 0.4 | 2.3 | GO:0032460 | negative regulation of protein oligomerization(GO:0032460) negative regulation of protein homooligomerization(GO:0032463) |
| 0.3 | 1.4 | GO:0060662 | tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662) |
| 0.2 | 12.1 | GO:0007045 | cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041) |
| 0.2 | 0.7 | GO:0000389 | mRNA 3'-splice site recognition(GO:0000389) |
| 0.2 | 0.5 | GO:0071109 | superior temporal gyrus development(GO:0071109) |
| 0.1 | 0.9 | GO:0032527 | retrograde protein transport, ER to cytosol(GO:0030970) protein exit from endoplasmic reticulum(GO:0032527) |
| 0.1 | 1.8 | GO:0032288 | myelin assembly(GO:0032288) |
| 0.1 | 0.4 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.1 | 0.5 | GO:0015891 | iron chelate transport(GO:0015688) siderophore transport(GO:0015891) |
| 0.1 | 0.9 | GO:0031274 | pseudopodium assembly(GO:0031269) regulation of pseudopodium assembly(GO:0031272) positive regulation of pseudopodium assembly(GO:0031274) |
| 0.1 | 2.3 | GO:0007176 | regulation of epidermal growth factor-activated receptor activity(GO:0007176) |
| 0.1 | 1.0 | GO:0001706 | endoderm formation(GO:0001706) |
| 0.1 | 0.3 | GO:0007028 | cytoplasm organization(GO:0007028) ribonucleoprotein complex disassembly(GO:0032988) |
| 0.1 | 1.2 | GO:0006743 | ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) |
| 0.1 | 0.3 | GO:0008356 | asymmetric cell division(GO:0008356) |
| 0.1 | 0.4 | GO:0090084 | negative regulation of inclusion body assembly(GO:0090084) |
| 0.1 | 0.5 | GO:0009051 | pentose-phosphate shunt, oxidative branch(GO:0009051) |
| 0.1 | 3.7 | GO:0048678 | response to axon injury(GO:0048678) |
| 0.1 | 0.5 | GO:0045116 | protein neddylation(GO:0045116) |
| 0.1 | 0.3 | GO:0060251 | regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626) regulation of glial cell proliferation(GO:0060251) negative regulation of glial cell proliferation(GO:0060253) |
| 0.1 | 0.1 | GO:0051602 | response to electrical stimulus(GO:0051602) |
| 0.1 | 0.4 | GO:0034616 | response to laminar fluid shear stress(GO:0034616) |
| 0.1 | 0.4 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.0 | 0.7 | GO:0033523 | histone monoubiquitination(GO:0010390) histone H2B ubiquitination(GO:0033523) |
| 0.0 | 0.0 | GO:0007403 | glial cell fate determination(GO:0007403) |
| 0.0 | 0.3 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.0 | 0.3 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.0 | 0.2 | GO:0060052 | neurofilament cytoskeleton organization(GO:0060052) |
| 0.0 | 0.6 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.0 | 0.3 | GO:0042693 | muscle cell fate commitment(GO:0042693) |
| 0.0 | 1.0 | GO:0006490 | dolichol-linked oligosaccharide biosynthetic process(GO:0006488) oligosaccharide-lipid intermediate biosynthetic process(GO:0006490) |
| 0.0 | 1.2 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
| 0.0 | 0.2 | GO:0060707 | trophoblast giant cell differentiation(GO:0060707) |
| 0.0 | 0.5 | GO:0007184 | SMAD protein import into nucleus(GO:0007184) |
| 0.0 | 0.6 | GO:0060334 | regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334) |
| 0.0 | 0.1 | GO:0006573 | valine metabolic process(GO:0006573) |
| 0.0 | 0.1 | GO:0051124 | synaptic growth at neuromuscular junction(GO:0051124) |
| 0.0 | 0.2 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
| 0.0 | 0.5 | GO:0045214 | sarcomere organization(GO:0045214) |
| 0.0 | 0.1 | GO:0006880 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
| 0.0 | 0.8 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
| 0.0 | 0.4 | GO:0003333 | amino acid transmembrane transport(GO:0003333) |
| 0.0 | 0.1 | GO:0034643 | establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497) |
| 0.0 | 0.1 | GO:0034654 | nucleobase-containing compound biosynthetic process(GO:0034654) |
| 0.0 | 0.8 | GO:0006826 | iron ion transport(GO:0006826) |
| 0.0 | 0.2 | GO:0000045 | autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037) |
| 0.0 | 0.2 | GO:0030813 | positive regulation of nucleotide catabolic process(GO:0030813) positive regulation of glycolytic process(GO:0045821) positive regulation of nucleoside metabolic process(GO:0045979) positive regulation of cofactor metabolic process(GO:0051194) positive regulation of coenzyme metabolic process(GO:0051197) positive regulation of ATP metabolic process(GO:1903580) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 15.3 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.4 | 2.3 | GO:0070435 | Shc-EGFR complex(GO:0070435) |
| 0.2 | 1.8 | GO:0043218 | compact myelin(GO:0043218) |
| 0.2 | 0.7 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.1 | 2.3 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.1 | 8.4 | GO:0008287 | protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293) |
| 0.1 | 8.0 | GO:0016459 | myosin complex(GO:0016459) |
| 0.1 | 0.4 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.1 | 2.6 | GO:0030532 | small nuclear ribonucleoprotein complex(GO:0030532) |
| 0.1 | 0.7 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.1 | 0.3 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
| 0.0 | 0.5 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.0 | 0.8 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.2 | GO:0005883 | neurofilament(GO:0005883) |
| 0.0 | 0.1 | GO:0070288 | intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288) |
| 0.0 | 0.2 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.0 | 0.3 | GO:0035253 | ciliary rootlet(GO:0035253) |
| 0.0 | 2.9 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 1.8 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 0.5 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.0 | 1.0 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 3.7 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 8.4 | GO:0004741 | magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724) [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 0.6 | 11.6 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.3 | 2.4 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.2 | 1.0 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.2 | 2.3 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.2 | 1.9 | GO:0004157 | dihydropyrimidinase activity(GO:0004157) |
| 0.2 | 1.4 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.2 | 0.5 | GO:0017057 | 6-phosphogluconolactonase activity(GO:0017057) |
| 0.2 | 0.5 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.1 | 2.3 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.1 | 0.9 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.1 | 1.4 | GO:0050780 | dopamine receptor binding(GO:0050780) |
| 0.1 | 0.3 | GO:0097642 | calcitonin family receptor activity(GO:0097642) |
| 0.1 | 0.3 | GO:0019003 | GDP binding(GO:0019003) |
| 0.1 | 1.4 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.1 | 0.2 | GO:0005412 | glucose:sodium symporter activity(GO:0005412) |
| 0.0 | 0.7 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 0.0 | 1.1 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 1.0 | GO:0030553 | cGMP binding(GO:0030553) |
| 0.0 | 8.4 | GO:0003774 | motor activity(GO:0003774) |
| 0.0 | 0.2 | GO:0043891 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891) |
| 0.0 | 0.8 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.0 | 0.4 | GO:0031419 | cobalamin binding(GO:0031419) |
| 0.0 | 0.3 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
| 0.0 | 4.1 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 1.2 | GO:0016709 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709) |
| 0.0 | 0.4 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.0 | 4.8 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.1 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.0 | 0.4 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 0.3 | GO:0016409 | palmitoyltransferase activity(GO:0016409) |
| 0.0 | 4.3 | GO:0030674 | protein binding, bridging(GO:0030674) |
| 0.0 | 0.1 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.0 | 0.4 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 0.3 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.9 | GO:0016773 | phosphotransferase activity, alcohol group as acceptor(GO:0016773) |
| 0.0 | 1.6 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389) |
| 0.0 | 0.1 | GO:0003920 | GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657) |
| 0.0 | 0.0 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.0 | 0.2 | GO:0003756 | protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.0 | ST_INTEGRIN_SIGNALING_PATHWAY | Integrin Signaling Pathway |
| 0.0 | 1.0 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 0.5 | SIG_IL4RECEPTOR_IN_B_LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
