Motif ID: ZBTB49

Z-value: 1.287


Transcription factors associated with ZBTB49:

Gene SymbolEntrez IDGene Name
ZBTB49 ENSG00000168826.11 ZBTB49



Activity profile for motif ZBTB49.

activity profile for motif ZBTB49


Sorted Z-values histogram for motif ZBTB49

Sorted Z-values for motif ZBTB49



Network of associatons between targets according to the STRING database.



First level regulatory network of ZBTB49

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr6_-_49604545 4.765 ENST00000371175.4
ENST00000229810.7
 RHAG

Rh-associated glycoprotein

chrX_-_151903184 4.183 ENST00000357916.4
ENST00000393869.3
 MAGEA12

melanoma antigen family A, 12

chrX_-_151903101 3.467 ENST00000393900.3
 MAGEA12
melanoma antigen family A, 12
chrX_+_30265256 2.927 ENST00000397548.2
 MAGEB1
melanoma antigen family B, 1
chrX_+_151903253 2.431 ENST00000452779.2
ENST00000370291.2
 CSAG1

chondrosarcoma associated gene 1

chrX_+_52780318 1.898 ENST00000375515.3
ENST00000276049.6
 SSX2B

synovial sarcoma, X breakpoint 2B

chr22_+_21996549 1.857 ENST00000248958.4
 SDF2L1
stromal cell-derived factor 2-like 1
chrX_+_9431324 1.738 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
 TBL1X





transducin (beta)-like 1X-linked





chr7_-_103629963 1.339 ENST00000428762.1
ENST00000343529.5
ENST00000424685.2
 RELN


reelin


chr1_+_182808474 1.049 ENST00000367549.3
 DHX9
DEAH (Asp-Glu-Ala-His) box helicase 9
chr21_-_26979786 0.851 ENST00000419219.1
ENST00000352957.4
ENST00000307301.7
 MRPL39


mitochondrial ribosomal protein L39


chrX_+_101854096 0.843 ENST00000246174.2
ENST00000537008.1
ENST00000541409.1
 ARMCX5


armadillo repeat containing, X-linked 5


chr12_+_53835539 0.838 ENST00000547368.1
ENST00000379786.4
ENST00000551945.1
 PRR13


proline rich 13


chr12_+_53835383 0.811 ENST00000429243.2
 PRR13
proline rich 13
chr7_-_44613494 0.782 ENST00000431640.1
ENST00000258772.5
 DDX56

DEAD (Asp-Glu-Ala-Asp) box helicase 56

chr4_-_2243839 0.771 ENST00000511885.2
ENST00000506763.1
ENST00000514395.1
ENST00000502440.1
ENST00000243706.4
ENST00000443786.2
 POLN
HAUS3




polymerase (DNA directed) nu
HAUS augmin-like complex, subunit 3




chr8_-_99129338 0.737 ENST00000520507.1
 HRSP12
heat-responsive protein 12
chr11_+_117857063 0.728 ENST00000227752.3
ENST00000541785.1
ENST00000545409.1
 IL10RA


interleukin 10 receptor, alpha


chr3_+_39424828 0.697 ENST00000273158.4
ENST00000431510.1
 SLC25A38

solute carrier family 25, member 38

chr8_-_99129384 0.682 ENST00000521560.1
ENST00000254878.3
 HRSP12

heat-responsive protein 12

chr7_+_99006232 0.652 ENST00000403633.2
 BUD31
BUD31 homolog (S. cerevisiae)
chr9_-_123676827 0.588 ENST00000546084.1
 TRAF1
TNF receptor-associated factor 1
chr8_-_59572093 0.586 ENST00000427130.2
 NSMAF
neutral sphingomyelinase (N-SMase) activation associated factor
chr10_+_94352956 0.571 ENST00000260731.3
 KIF11
kinesin family member 11
chrX_+_101854426 0.562 ENST00000536530.1
ENST00000473968.1
ENST00000604957.1
ENST00000477663.1
ENST00000479502.1
 ARMCX5




armadillo repeat containing, X-linked 5




chr1_+_26869597 0.553 ENST00000530003.1
 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr17_+_80009741 0.525 ENST00000578552.1
ENST00000320548.4
ENST00000581578.1
ENST00000583885.1
ENST00000583641.1
ENST00000581418.1
ENST00000355130.2
ENST00000306823.6
ENST00000392358.2
 GPS1








G protein pathway suppressor 1








chr11_+_4116005 0.509 ENST00000300738.5
 RRM1
ribonucleotide reductase M1
chr14_+_35591858 0.487 ENST00000603544.1
 KIAA0391
KIAA0391
chr10_+_64893039 0.483 ENST00000277746.6
ENST00000435510.2
 NRBF2

nuclear receptor binding factor 2

chr11_+_4116054 0.477 ENST00000423050.2
 RRM1
ribonucleotide reductase M1
chr5_+_154238149 0.474 ENST00000519430.1
ENST00000520671.1
ENST00000521583.1
ENST00000518028.1
ENST00000519404.1
ENST00000519394.1
ENST00000518775.1
 CNOT8






CCR4-NOT transcription complex, subunit 8






chr6_-_43655511 0.469 ENST00000372133.3
ENST00000372116.1
ENST00000427312.1
 MRPS18A


mitochondrial ribosomal protein S18A


chr18_-_11148587 0.453 ENST00000302079.6
ENST00000580640.1
ENST00000503781.3
 PIEZO2


piezo-type mechanosensitive ion channel component 2


chr8_-_82024290 0.431 ENST00000220597.4
 PAG1
phosphoprotein associated with glycosphingolipid microdomains 1
chr4_-_53525406 0.415 ENST00000451218.2
ENST00000441222.3
 USP46

ubiquitin specific peptidase 46

chr18_+_32558208 0.401 ENST00000436190.2
 MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr9_-_116102530 0.397 ENST00000374195.3
ENST00000341761.4
 WDR31

WD repeat domain 31

chr8_+_24151553 0.391 ENST00000265769.4
ENST00000540823.1
ENST00000397649.3
 ADAM28


ADAM metallopeptidase domain 28


chr12_+_53835508 0.379 ENST00000541275.1
ENST00000551003.1
ENST00000549068.1
ENST00000549740.1
ENST00000546581.1
ENST00000549581.1
 PCBP2
PRR13




poly(rC) binding protein 2
proline rich 13




chr2_+_95691445 0.369 ENST00000353004.3
ENST00000354078.3
ENST00000349807.3
 MAL


mal, T-cell differentiation protein


chr22_-_19166343 0.361 ENST00000215882.5
 SLC25A1
solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
chr3_+_196594727 0.352 ENST00000445299.2
ENST00000323460.5
ENST00000419026.1
 SENP5


SUMO1/sentrin specific peptidase 5


chr1_-_151319283 0.344 ENST00000392746.3
 RFX5
regulatory factor X, 5 (influences HLA class II expression)
chr2_+_95691417 0.341 ENST00000309988.4
 MAL
mal, T-cell differentiation protein
chr8_+_24151620 0.341 ENST00000437154.2
 ADAM28
ADAM metallopeptidase domain 28
chr5_-_77590480 0.331 ENST00000519295.1
ENST00000255194.6
 AP3B1

adaptor-related protein complex 3, beta 1 subunit

chr7_+_148936732 0.330 ENST00000335870.2
 ZNF212
zinc finger protein 212
chr15_-_55489097 0.323 ENST00000260443.4
 RSL24D1
ribosomal L24 domain containing 1
chrX_+_64887512 0.318 ENST00000360270.5
 MSN
moesin
chr15_-_25684110 0.306 ENST00000232165.3
 UBE3A
ubiquitin protein ligase E3A
chr2_+_27237615 0.304 ENST00000458529.1
ENST00000402218.1
 MAPRE3

microtubule-associated protein, RP/EB family, member 3

chr10_+_88428370 0.295 ENST00000372066.3
ENST00000263066.6
ENST00000372056.4
ENST00000310944.6
ENST00000361373.4
ENST00000542786.1
 LDB3





LIM domain binding 3





chr2_+_89890533 0.292 ENST00000429992.2
 IGKV2D-40
immunoglobulin kappa variable 2D-40
chr5_+_154238096 0.291 ENST00000517568.1
ENST00000524105.1
ENST00000285896.6
 CNOT8


CCR4-NOT transcription complex, subunit 8


chr19_-_59070239 0.286 ENST00000595957.1
ENST00000253023.3
 UBE2M

ubiquitin-conjugating enzyme E2M

chr5_+_154238042 0.284 ENST00000519211.1
ENST00000522458.1
ENST00000519903.1
ENST00000521450.1
ENST00000403027.2
 CNOT8




CCR4-NOT transcription complex, subunit 8




chr14_+_35591928 0.233 ENST00000605870.1
ENST00000557404.3
 KIAA0391

KIAA0391

chr19_+_18669809 0.207 ENST00000602094.1
 KXD1
KxDL motif containing 1
chr10_+_88428206 0.189 ENST00000429277.2
ENST00000458213.2
ENST00000352360.5
 LDB3


LIM domain binding 3


chr22_-_29196030 0.186 ENST00000405219.3
 XBP1
X-box binding protein 1
chr19_-_6481776 0.183 ENST00000543576.1
ENST00000590173.1
ENST00000381480.2
 DENND1C


DENN/MADD domain containing 1C


chr8_+_99129513 0.182 ENST00000522319.1
ENST00000401707.2
 POP1

processing of precursor 1, ribonuclease P/MRP subunit (S. cerevisiae)

chr5_+_154237778 0.170 ENST00000523698.1
ENST00000517876.1
ENST00000520472.1
 CNOT8


CCR4-NOT transcription complex, subunit 8


chr14_+_79746249 0.169 ENST00000428277.2
 NRXN3
neurexin 3
chr3_+_52232102 0.160 ENST00000469224.1
ENST00000394965.2
ENST00000310271.2
ENST00000484952.1
 ALAS1



aminolevulinate, delta-, synthase 1



chr19_+_17862274 0.105 ENST00000596536.1
ENST00000593870.1
ENST00000598086.1
ENST00000598932.1
ENST00000595023.1
ENST00000594068.1
ENST00000596507.1
ENST00000595033.1
ENST00000597718.1
 FCHO1








FCH domain only 1








chrX_-_153210107 0.086 ENST00000369997.3
ENST00000393700.3
ENST00000412763.1
 RENBP


renin binding protein


chr10_-_12084770 0.082 ENST00000357604.5
 UPF2
UPF2 regulator of nonsense transcripts homolog (yeast)
chr14_-_35591433 0.076 ENST00000261475.5
ENST00000555644.1
 PPP2R3C

protein phosphatase 2, regulatory subunit B'', gamma

chr16_-_28621353 0.065 ENST00000567512.1
 SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr22_-_29196546 0.058 ENST00000403532.3
ENST00000216037.6
 XBP1

X-box binding protein 1

chr1_+_8021954 0.058 ENST00000377491.1
ENST00000377488.1
 PARK7

parkinson protein 7

chr9_-_97401782 0.056 ENST00000375326.4
 FBP1
fructose-1,6-bisphosphatase 1
chr14_+_35591735 0.035 ENST00000604948.1
ENST00000605201.1
ENST00000250377.7
ENST00000321130.10
ENST00000534898.4
 KIAA0391




KIAA0391




chr17_-_3195876 0.028 ENST00000323404.1
 OR3A1
olfactory receptor, family 3, subfamily A, member 1
chr2_-_48982708 0.025 ENST00000428232.1
ENST00000405626.1
ENST00000294954.7
 LHCGR


luteinizing hormone/choriogonadotropin receptor


chr15_+_93749295 0.021 ENST00000599897.1
 AC112693.2
AC112693.2
chr20_-_32700075 0.019 ENST00000374980.2
 EIF2S2
eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.8 GO:0015670 carbon dioxide transport(GO:0015670)
0.2 0.7 GO:0031580 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
0.1 1.0 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.1 1.3 GO:0021800 cerebral cortex tangential migration(GO:0021800)
0.1 0.6 GO:0007100 mitotic centrosome separation(GO:0007100)
0.1 0.3 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003)
0.1 1.4 GO:0006449 regulation of translational termination(GO:0006449)
0.1 1.0 GO:0051290 protein heterotetramerization(GO:0051290)
0.0 0.3 GO:0022614 membrane to membrane docking(GO:0022614)
0.0 0.3 GO:0045116 protein neddylation(GO:0045116)
0.0 0.8 GO:0051225 spindle assembly(GO:0051225)
0.0 1.2 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0 0.4 GO:0050687 negative regulation of defense response to virus(GO:0050687)
0.0 0.9 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.4 GO:0032228 regulation of synaptic transmission, GABAergic(GO:0032228)
0.0 0.3 GO:0060736 prostate gland growth(GO:0060736)
0.0 0.2 GO:0034661 ncRNA catabolic process(GO:0034661)
0.0 1.7 GO:0007605 sensory perception of sound(GO:0007605)
0.0 0.6 GO:0006672 ceramide metabolic process(GO:0006672)
0.0 0.6 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 0.5 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 0.4 GO:0035338 long-chain fatty-acyl-CoA metabolic process(GO:0035336) long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.0 0.8 GO:0008033 tRNA processing(GO:0008033)
0.0 0.1 GO:0006013 mannose metabolic process(GO:0006013)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.0 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 0.7 GO:0000300 obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.1 0.8 GO:0070652 HAUS complex(GO:0070652)
0.0 2.3 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.5 GO:0031143 pseudopodium(GO:0031143)
0.0 0.5 GO:0008180 COP9 signalosome(GO:0008180)
0.0 1.3 GO:0005761 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.0 0.2 GO:0030681 nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681)
0.0 0.3 GO:0031528 microvillus membrane(GO:0031528)
0.0 1.0 GO:1990204 oxidoreductase complex(GO:1990204)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 4.8 GO:0030506 ankyrin binding(GO:0030506)
0.2 1.0 GO:0061731 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1 0.4 GO:0015142 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.1 1.8 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.1 0.7 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.1 0.3 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.1 0.2 GO:0003870 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.0 1.3 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.1 GO:0004476 mannose-6-phosphate isomerase activity(GO:0004476)
0.0 0.8 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.5 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 1.7 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.6 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.1 GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.0 0.2 GO:0004526 ribonuclease P activity(GO:0004526)
0.0 1.3 GO:0004519 endonuclease activity(GO:0004519)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.6 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.