Motif ID: ZBTB6
Z-value: 1.892
Transcription factors associated with ZBTB6:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| ZBTB6 | ENSG00000186130.4 | ZBTB6 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 2.5 | GO:0048627 | myoblast development(GO:0048627) |
| 0.4 | 1.3 | GO:0035408 | histone H3-T6 phosphorylation(GO:0035408) |
| 0.4 | 11.8 | GO:0007398 | ectoderm development(GO:0007398) |
| 0.3 | 0.8 | GO:0002678 | positive regulation of chronic inflammatory response(GO:0002678) positive regulation of guanylate cyclase activity(GO:0031284) |
| 0.2 | 1.5 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.2 | 1.0 | GO:0010508 | positive regulation of autophagy(GO:0010508) |
| 0.2 | 0.8 | GO:0021819 | layer formation in cerebral cortex(GO:0021819) |
| 0.2 | 0.5 | GO:0007000 | nucleolus organization(GO:0007000) |
| 0.2 | 0.7 | GO:0071108 | protein K48-linked deubiquitination(GO:0071108) |
| 0.2 | 0.6 | GO:0072048 | pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048) |
| 0.2 | 0.6 | GO:0042335 | cuticle development(GO:0042335) |
| 0.1 | 1.0 | GO:0043552 | positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552) |
| 0.1 | 0.4 | GO:0018283 | metal incorporation into metallo-sulfur cluster(GO:0018282) iron incorporation into metallo-sulfur cluster(GO:0018283) |
| 0.1 | 0.5 | GO:0043551 | regulation of phosphatidylinositol 3-kinase activity(GO:0043551) |
| 0.1 | 0.5 | GO:0010457 | centriole-centriole cohesion(GO:0010457) |
| 0.1 | 1.1 | GO:0048799 | organ maturation(GO:0048799) bone maturation(GO:0070977) |
| 0.1 | 0.4 | GO:0010586 | miRNA metabolic process(GO:0010586) miRNA catabolic process(GO:0010587) |
| 0.1 | 0.4 | GO:0090086 | negative regulation of protein deubiquitination(GO:0090086) |
| 0.1 | 0.4 | GO:0048852 | diencephalon morphogenesis(GO:0048852) |
| 0.1 | 0.2 | GO:0010035 | response to inorganic substance(GO:0010035) |
| 0.1 | 0.8 | GO:0045176 | apical protein localization(GO:0045176) |
| 0.1 | 0.8 | GO:0006477 | protein sulfation(GO:0006477) |
| 0.1 | 0.3 | GO:0045603 | positive regulation of endothelial cell differentiation(GO:0045603) |
| 0.1 | 0.4 | GO:0009103 | lipopolysaccharide biosynthetic process(GO:0009103) |
| 0.1 | 1.1 | GO:0051085 | chaperone mediated protein folding requiring cofactor(GO:0051085) |
| 0.1 | 0.3 | GO:0071109 | superior temporal gyrus development(GO:0071109) |
| 0.1 | 0.3 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) |
| 0.1 | 0.5 | GO:0006290 | pyrimidine dimer repair(GO:0006290) |
| 0.1 | 0.6 | GO:0072010 | renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311) |
| 0.1 | 0.3 | GO:0046984 | regulation of hemoglobin biosynthetic process(GO:0046984) |
| 0.1 | 0.8 | GO:0032464 | positive regulation of protein homooligomerization(GO:0032464) |
| 0.1 | 0.1 | GO:0043116 | negative regulation of vascular permeability(GO:0043116) |
| 0.1 | 0.2 | GO:0007206 | phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206) |
| 0.1 | 0.1 | GO:0046619 | optic placode formation involved in camera-type eye formation(GO:0046619) |
| 0.1 | 0.6 | GO:0061029 | eyelid development in camera-type eye(GO:0061029) |
| 0.1 | 0.3 | GO:0021978 | telencephalon regionalization(GO:0021978) |
| 0.1 | 0.4 | GO:0001672 | regulation of chromatin assembly or disassembly(GO:0001672) |
| 0.1 | 1.4 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
| 0.1 | 0.3 | GO:0046778 | modification by virus of host mRNA processing(GO:0046778) |
| 0.1 | 0.6 | GO:0006983 | ER overload response(GO:0006983) |
| 0.1 | 0.1 | GO:0070601 | centromeric sister chromatid cohesion(GO:0070601) regulation of centromeric sister chromatid cohesion(GO:0070602) |
| 0.1 | 1.8 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.1 | 0.2 | GO:0090274 | regulation of somatostatin secretion(GO:0090273) positive regulation of somatostatin secretion(GO:0090274) |
| 0.1 | 0.2 | GO:0032075 | positive regulation of nuclease activity(GO:0032075) |
| 0.1 | 0.2 | GO:0021913 | regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913) |
| 0.1 | 0.3 | GO:0033197 | response to vitamin E(GO:0033197) |
| 0.1 | 1.0 | GO:0071044 | histone mRNA catabolic process(GO:0071044) |
| 0.1 | 0.6 | GO:0006516 | glycoprotein catabolic process(GO:0006516) |
| 0.1 | 0.4 | GO:0035020 | regulation of Rac protein signal transduction(GO:0035020) |
| 0.1 | 2.8 | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154) |
| 0.1 | 0.4 | GO:0051294 | establishment of mitotic spindle orientation(GO:0000132) establishment of spindle orientation(GO:0051294) |
| 0.1 | 0.4 | GO:0006003 | fructose 2,6-bisphosphate metabolic process(GO:0006003) |
| 0.1 | 0.7 | GO:0032727 | positive regulation of interferon-alpha production(GO:0032727) |
| 0.1 | 0.4 | GO:0006102 | isocitrate metabolic process(GO:0006102) |
| 0.1 | 0.2 | GO:0006106 | fumarate metabolic process(GO:0006106) |
| 0.1 | 0.2 | GO:0010107 | potassium ion import(GO:0010107) |
| 0.1 | 0.1 | GO:0031999 | negative regulation of fatty acid beta-oxidation(GO:0031999) |
| 0.1 | 0.2 | GO:0008300 | isoprenoid catabolic process(GO:0008300) |
| 0.1 | 0.3 | GO:0034204 | lipid translocation(GO:0034204) phospholipid translocation(GO:0045332) |
| 0.1 | 4.6 | GO:0043542 | endothelial cell migration(GO:0043542) |
| 0.1 | 1.1 | GO:0060749 | mammary gland alveolus development(GO:0060749) mammary gland lobule development(GO:0061377) |
| 0.1 | 0.2 | GO:0007506 | gonadal mesoderm development(GO:0007506) |
| 0.1 | 0.3 | GO:0016561 | protein import into peroxisome matrix, translocation(GO:0016561) |
| 0.0 | 0.2 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 0.0 | 0.2 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.0 | 0.1 | GO:0007196 | adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196) |
| 0.0 | 6.6 | GO:0006921 | cellular component disassembly involved in execution phase of apoptosis(GO:0006921) execution phase of apoptosis(GO:0097194) |
| 0.0 | 0.4 | GO:0006474 | N-terminal protein amino acid acetylation(GO:0006474) |
| 0.0 | 0.1 | GO:0019919 | pathogenesis(GO:0009405) peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919) |
| 0.0 | 1.0 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.0 | 0.3 | GO:0006883 | cellular sodium ion homeostasis(GO:0006883) |
| 0.0 | 0.4 | GO:0048013 | ephrin receptor signaling pathway(GO:0048013) |
| 0.0 | 0.2 | GO:0010957 | negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137) |
| 0.0 | 0.3 | GO:0000019 | regulation of mitotic recombination(GO:0000019) positive regulation of protein autophosphorylation(GO:0031954) |
| 0.0 | 0.2 | GO:0000394 | RNA splicing, via endonucleolytic cleavage and ligation(GO:0000394) tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) small RNA loading onto RISC(GO:0070922) |
| 0.0 | 0.1 | GO:0031054 | targeting of mRNA for destruction involved in RNA interference(GO:0030423) pre-miRNA processing(GO:0031054) |
| 0.0 | 1.4 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.0 | 0.4 | GO:0015074 | DNA integration(GO:0015074) |
| 0.0 | 0.4 | GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process(GO:0042535) |
| 0.0 | 0.3 | GO:0001953 | negative regulation of cell-matrix adhesion(GO:0001953) |
| 0.0 | 0.3 | GO:0006939 | smooth muscle contraction(GO:0006939) |
| 0.0 | 0.1 | GO:0070734 | histone H3-K27 methylation(GO:0070734) |
| 0.0 | 0.1 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 0.0 | 0.1 | GO:0071313 | cellular response to caffeine(GO:0071313) |
| 0.0 | 0.4 | GO:0050930 | induction of positive chemotaxis(GO:0050930) |
| 0.0 | 0.2 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
| 0.0 | 0.1 | GO:1903961 | positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) positive regulation of anion transmembrane transport(GO:1903961) |
| 0.0 | 0.2 | GO:0036315 | cellular response to sterol(GO:0036315) cellular response to cholesterol(GO:0071397) |
| 0.0 | 0.2 | GO:0043001 | Golgi to plasma membrane protein transport(GO:0043001) |
| 0.0 | 0.1 | GO:0018206 | peptidyl-methionine modification(GO:0018206) |
| 0.0 | 0.3 | GO:0097061 | dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061) |
| 0.0 | 0.1 | GO:0006370 | 7-methylguanosine mRNA capping(GO:0006370) |
| 0.0 | 0.1 | GO:0046604 | regulation of mitotic centrosome separation(GO:0046602) positive regulation of mitotic centrosome separation(GO:0046604) |
| 0.0 | 0.1 | GO:0045838 | positive regulation of regulatory T cell differentiation(GO:0045591) positive regulation of membrane potential(GO:0045838) |
| 0.0 | 0.1 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
| 0.0 | 0.3 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.0 | 0.2 | GO:0045943 | positive regulation of transcription from RNA polymerase I promoter(GO:0045943) |
| 0.0 | 0.1 | GO:0034629 | cellular protein complex localization(GO:0034629) |
| 0.0 | 0.1 | GO:0030323 | respiratory tube development(GO:0030323) |
| 0.0 | 0.4 | GO:0015884 | folic acid transport(GO:0015884) |
| 0.0 | 0.1 | GO:0016075 | rRNA catabolic process(GO:0016075) |
| 0.0 | 0.1 | GO:0003321 | positive regulation of blood pressure by epinephrine-norepinephrine(GO:0003321) |
| 0.0 | 0.5 | GO:1902603 | carnitine shuttle(GO:0006853) carnitine transmembrane transport(GO:1902603) |
| 0.0 | 0.1 | GO:0061526 | acetylcholine secretion, neurotransmission(GO:0014055) regulation of acetylcholine secretion, neurotransmission(GO:0014056) acetylcholine secretion(GO:0061526) |
| 0.0 | 0.2 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 0.0 | 0.7 | GO:0017157 | regulation of exocytosis(GO:0017157) |
| 0.0 | 0.2 | GO:0005981 | regulation of glycogen catabolic process(GO:0005981) |
| 0.0 | 0.4 | GO:0046718 | viral entry into host cell(GO:0046718) |
| 0.0 | 0.1 | GO:0009404 | toxin metabolic process(GO:0009404) |
| 0.0 | 0.8 | GO:0006342 | chromatin silencing(GO:0006342) |
| 0.0 | 0.7 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.0 | 0.4 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.0 | 0.1 | GO:0030812 | regulation of peptidyl-threonine phosphorylation(GO:0010799) positive regulation of peptidyl-threonine phosphorylation(GO:0010800) negative regulation of nucleotide catabolic process(GO:0030812) |
| 0.0 | 0.1 | GO:0034086 | maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088) |
| 0.0 | 0.1 | GO:0014063 | regulation of serotonin secretion(GO:0014062) negative regulation of serotonin secretion(GO:0014063) |
| 0.0 | 0.4 | GO:0045749 | obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749) |
| 0.0 | 1.9 | GO:0007623 | circadian rhythm(GO:0007623) |
| 0.0 | 0.7 | GO:0001756 | somitogenesis(GO:0001756) |
| 0.0 | 0.1 | GO:0006177 | GMP biosynthetic process(GO:0006177) |
| 0.0 | 0.1 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
| 0.0 | 0.4 | GO:0032781 | positive regulation of ATPase activity(GO:0032781) |
| 0.0 | 0.2 | GO:0007080 | mitotic metaphase plate congression(GO:0007080) |
| 0.0 | 0.4 | GO:0016254 | preassembly of GPI anchor in ER membrane(GO:0016254) |
| 0.0 | 0.0 | GO:0031558 | obsolete induction of apoptosis in response to chemical stimulus(GO:0031558) determination of dorsal/ventral asymmetry(GO:0048262) determination of dorsal identity(GO:0048263) |
| 0.0 | 1.7 | GO:0051092 | positive regulation of NF-kappaB transcription factor activity(GO:0051092) |
| 0.0 | 0.1 | GO:0090267 | positive regulation of spindle checkpoint(GO:0090232) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) positive regulation of cell cycle checkpoint(GO:1901978) regulation of mitotic spindle checkpoint(GO:1903504) |
| 0.0 | 0.3 | GO:0048207 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114) |
| 0.0 | 0.4 | GO:0046466 | sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466) |
| 0.0 | 0.1 | GO:0015853 | adenine transport(GO:0015853) |
| 0.0 | 0.4 | GO:0007030 | Golgi organization(GO:0007030) |
| 0.0 | 0.2 | GO:0051090 | regulation of sequence-specific DNA binding transcription factor activity(GO:0051090) |
| 0.0 | 0.3 | GO:0043666 | regulation of phosphoprotein phosphatase activity(GO:0043666) |
| 0.0 | 0.1 | GO:0051926 | negative regulation of calcium ion transport(GO:0051926) |
| 0.0 | 0.2 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
| 0.0 | 0.1 | GO:0045070 | positive regulation of viral genome replication(GO:0045070) |
| 0.0 | 0.2 | GO:0030299 | intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856) |
| 0.0 | 0.1 | GO:0030277 | epithelial structure maintenance(GO:0010669) maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.0 | 0.4 | GO:0050772 | positive regulation of axonogenesis(GO:0050772) |
| 0.0 | 0.3 | GO:0042274 | ribosomal small subunit biogenesis(GO:0042274) |
| 0.0 | 0.1 | GO:0046655 | folic acid metabolic process(GO:0046655) |
| 0.0 | 0.5 | GO:0000184 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184) |
| 0.0 | 0.0 | GO:0071801 | podosome assembly(GO:0071800) regulation of podosome assembly(GO:0071801) positive regulation of podosome assembly(GO:0071803) |
| 0.0 | 0.0 | GO:0003056 | regulation of vascular smooth muscle contraction(GO:0003056) |
| 0.0 | 0.1 | GO:0007141 | male meiosis I(GO:0007141) |
| 0.0 | 0.2 | GO:0051568 | histone H3-K4 methylation(GO:0051568) |
| 0.0 | 0.1 | GO:0045008 | depyrimidination(GO:0045008) |
| 0.0 | 0.1 | GO:0008343 | adult feeding behavior(GO:0008343) |
| 0.0 | 0.2 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.0 | 0.2 | GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197) |
| 0.0 | 0.0 | GO:0070384 | Harderian gland development(GO:0070384) |
| 0.0 | 0.5 | GO:0050931 | melanocyte differentiation(GO:0030318) pigment cell differentiation(GO:0050931) |
| 0.0 | 0.1 | GO:0001961 | positive regulation of cytokine-mediated signaling pathway(GO:0001961) |
| 0.0 | 0.1 | GO:0007379 | segment specification(GO:0007379) |
| 0.0 | 0.2 | GO:0006298 | mismatch repair(GO:0006298) |
| 0.0 | 0.2 | GO:0007219 | Notch signaling pathway(GO:0007219) |
| 0.0 | 0.1 | GO:0009396 | folic acid-containing compound biosynthetic process(GO:0009396) |
| 0.0 | 0.4 | GO:0006271 | DNA strand elongation involved in DNA replication(GO:0006271) |
| 0.0 | 0.1 | GO:0090205 | intracellular sterol transport(GO:0032366) intracellular cholesterol transport(GO:0032367) positive regulation of cholesterol metabolic process(GO:0090205) |
| 0.0 | 0.2 | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 15.1 | GO:0045095 | keratin filament(GO:0045095) |
| 0.3 | 3.0 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.2 | 0.6 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.1 | 0.5 | GO:0097651 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) phosphatidylinositol 3-kinase complex, class I(GO:0097651) |
| 0.1 | 1.0 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.1 | 0.4 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.1 | 0.5 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.1 | 2.4 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 0.7 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 0.4 | GO:0005594 | collagen type IX trimer(GO:0005594) |
| 0.1 | 1.8 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 0.2 | GO:0070557 | PCNA-p21 complex(GO:0070557) |
| 0.1 | 1.2 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 0.4 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.1 | 0.3 | GO:0005945 | 6-phosphofructokinase complex(GO:0005945) |
| 0.1 | 0.2 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.1 | 0.2 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.1 | 0.6 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.1 | 0.3 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.0 | 0.4 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.0 | 0.3 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.0 | 0.2 | GO:0000214 | tRNA-intron endonuclease complex(GO:0000214) |
| 0.0 | 0.3 | GO:0033268 | node of Ranvier(GO:0033268) |
| 0.0 | 0.2 | GO:0000177 | cytoplasmic exosome (RNase complex)(GO:0000177) |
| 0.0 | 0.7 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 0.0 | 0.4 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.0 | 0.6 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 0.3 | GO:0042555 | MCM complex(GO:0042555) |
| 0.0 | 1.2 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 0.2 | GO:0005883 | neurofilament(GO:0005883) |
| 0.0 | 1.4 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 0.4 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 0.4 | GO:0031672 | A band(GO:0031672) |
| 0.0 | 0.1 | GO:0032009 | early phagosome(GO:0032009) |
| 0.0 | 0.1 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
| 0.0 | 1.7 | GO:0030136 | clathrin-coated vesicle(GO:0030136) |
| 0.0 | 0.3 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 0.1 | GO:0000931 | gamma-tubulin large complex(GO:0000931) gamma-tubulin ring complex(GO:0008274) |
| 0.0 | 0.2 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.0 | 0.2 | GO:0016585 | obsolete chromatin remodeling complex(GO:0016585) |
| 0.0 | 0.4 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.0 | 0.2 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.0 | 0.4 | GO:0016234 | inclusion body(GO:0016234) |
| 0.0 | 0.1 | GO:0005672 | transcription factor TFIIA complex(GO:0005672) |
| 0.0 | 0.8 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 0.5 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 0.3 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 0.6 | GO:0005814 | centriole(GO:0005814) |
| 0.0 | 0.1 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.0 | 0.1 | GO:0000791 | euchromatin(GO:0000791) |
| 0.0 | 0.6 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.0 | 0.2 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.0 | 0.5 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 0.6 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.5 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 0.4 | 1.3 | GO:0035403 | histone kinase activity (H3-T6 specific)(GO:0035403) |
| 0.4 | 1.1 | GO:0019797 | procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544) |
| 0.2 | 1.0 | GO:0050265 | RNA uridylyltransferase activity(GO:0050265) |
| 0.2 | 7.9 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.2 | 0.7 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.1 | 0.8 | GO:0001609 | G-protein coupled adenosine receptor activity(GO:0001609) |
| 0.1 | 0.4 | GO:0004376 | glycolipid mannosyltransferase activity(GO:0004376) |
| 0.1 | 0.8 | GO:0034187 | obsolete apolipoprotein E binding(GO:0034187) |
| 0.1 | 1.8 | GO:0034483 | heparan sulfate sulfotransferase activity(GO:0034483) |
| 0.1 | 1.8 | GO:0032393 | MHC class I receptor activity(GO:0032393) |
| 0.1 | 0.4 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.1 | 13.4 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 0.4 | GO:0004596 | peptide alpha-N-acetyltransferase activity(GO:0004596) |
| 0.1 | 0.4 | GO:0004449 | isocitrate dehydrogenase (NAD+) activity(GO:0004449) |
| 0.1 | 0.3 | GO:0031997 | N-terminal myristoylation domain binding(GO:0031997) |
| 0.1 | 2.8 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.1 | 0.8 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
| 0.1 | 1.0 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.1 | 0.5 | GO:0004095 | carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416) |
| 0.1 | 0.4 | GO:0032038 | myosin II heavy chain binding(GO:0032038) |
| 0.1 | 0.5 | GO:0043559 | insulin binding(GO:0043559) |
| 0.1 | 0.3 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
| 0.1 | 0.2 | GO:0016297 | oleoyl-[acyl-carrier-protein] hydrolase activity(GO:0004320) myristoyl-[acyl-carrier-protein] hydrolase activity(GO:0016295) palmitoyl-[acyl-carrier-protein] hydrolase activity(GO:0016296) acyl-[acyl-carrier-protein] hydrolase activity(GO:0016297) phosphopantetheine binding(GO:0031177) |
| 0.1 | 0.4 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.1 | 0.6 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) bicarbonate transmembrane transporter activity(GO:0015106) |
| 0.1 | 0.2 | GO:0004605 | phosphatidate cytidylyltransferase activity(GO:0004605) |
| 0.1 | 0.2 | GO:0004951 | cholecystokinin receptor activity(GO:0004951) |
| 0.1 | 0.3 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 0.1 | 0.3 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.1 | 0.6 | GO:0031419 | cobalamin binding(GO:0031419) |
| 0.1 | 0.6 | GO:0051400 | BH domain binding(GO:0051400) |
| 0.1 | 0.3 | GO:0004525 | ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296) |
| 0.1 | 1.4 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 0.4 | GO:0003873 | 6-phosphofructo-2-kinase activity(GO:0003873) |
| 0.1 | 0.4 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.1 | 0.3 | GO:0008443 | phosphofructokinase activity(GO:0008443) |
| 0.1 | 0.3 | GO:0016167 | glial cell-derived neurotrophic factor receptor activity(GO:0016167) |
| 0.1 | 0.5 | GO:0030515 | snoRNA binding(GO:0030515) |
| 0.1 | 0.5 | GO:0055056 | D-glucose transmembrane transporter activity(GO:0055056) |
| 0.1 | 0.2 | GO:0030337 | DNA polymerase processivity factor activity(GO:0030337) |
| 0.1 | 0.4 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.1 | 0.4 | GO:0030020 | extracellular matrix structural constituent conferring tensile strength(GO:0030020) |
| 0.0 | 0.2 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558) |
| 0.0 | 0.4 | GO:0046790 | virion binding(GO:0046790) |
| 0.0 | 0.2 | GO:0080030 | methyl indole-3-acetate esterase activity(GO:0080030) methyl salicylate esterase activity(GO:0080031) methyl jasmonate esterase activity(GO:0080032) |
| 0.0 | 0.6 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.0 | 0.4 | GO:0015280 | ligand-gated sodium channel activity(GO:0015280) |
| 0.0 | 0.8 | GO:0030296 | protein tyrosine kinase activator activity(GO:0030296) |
| 0.0 | 0.9 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.0 | 0.1 | GO:0000156 | phosphorelay response regulator activity(GO:0000156) |
| 0.0 | 0.3 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.0 | 0.2 | GO:0046404 | ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734) |
| 0.0 | 1.0 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.0 | 0.6 | GO:0005537 | mannose binding(GO:0005537) |
| 0.0 | 0.1 | GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314) |
| 0.0 | 0.2 | GO:0003747 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
| 0.0 | 0.1 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 0.0 | 0.1 | GO:0004949 | cannabinoid receptor activity(GO:0004949) |
| 0.0 | 0.1 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.0 | 0.7 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.0 | 0.2 | GO:0070569 | uridylyltransferase activity(GO:0070569) |
| 0.0 | 0.4 | GO:0070567 | cytidylyltransferase activity(GO:0070567) |
| 0.0 | 0.1 | GO:0035242 | protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242) |
| 0.0 | 0.2 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.0 | 0.2 | GO:0051766 | inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766) |
| 0.0 | 0.4 | GO:0016783 | sulfurtransferase activity(GO:0016783) |
| 0.0 | 0.3 | GO:0016671 | oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671) |
| 0.0 | 0.3 | GO:0030898 | actin-dependent ATPase activity(GO:0030898) |
| 0.0 | 0.3 | GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499) |
| 0.0 | 0.3 | GO:0030274 | LIM domain binding(GO:0030274) |
| 0.0 | 0.1 | GO:0070097 | delta-catenin binding(GO:0070097) |
| 0.0 | 0.1 | GO:0004937 | alpha1-adrenergic receptor activity(GO:0004937) |
| 0.0 | 1.3 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 1.9 | GO:0001948 | glycoprotein binding(GO:0001948) |
| 0.0 | 0.1 | GO:0004461 | beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831) lactose synthase activity(GO:0004461) |
| 0.0 | 0.1 | GO:0016882 | cyclo-ligase activity(GO:0016882) |
| 0.0 | 0.1 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.0 | 0.5 | GO:0070411 | I-SMAD binding(GO:0070411) |
| 0.0 | 0.2 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.0 | 0.1 | GO:0008432 | JUN kinase binding(GO:0008432) |
| 0.0 | 0.1 | GO:0004865 | protein serine/threonine phosphatase inhibitor activity(GO:0004865) |
| 0.0 | 0.2 | GO:0042562 | hormone binding(GO:0042562) |
| 0.0 | 0.2 | GO:0030284 | estrogen receptor activity(GO:0030284) |
| 0.0 | 0.4 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.0 | 0.1 | GO:0010485 | H4 histone acetyltransferase activity(GO:0010485) |
| 0.0 | 0.5 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.0 | 5.1 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.0 | 0.1 | GO:0004489 | methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489) |
| 0.0 | 0.1 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.0 | 0.4 | GO:0005542 | folic acid binding(GO:0005542) |
| 0.0 | 0.5 | GO:0005452 | inorganic anion exchanger activity(GO:0005452) |
| 0.0 | 0.3 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 0.0 | 0.2 | GO:0008159 | obsolete positive transcription elongation factor activity(GO:0008159) |
| 0.0 | 0.1 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.0 | 0.1 | GO:0008332 | low voltage-gated calcium channel activity(GO:0008332) |
| 0.0 | 0.2 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 0.1 | GO:0008174 | mRNA methyltransferase activity(GO:0008174) |
| 0.0 | 0.4 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) |
| 0.0 | 0.5 | GO:0005234 | extracellular-glutamate-gated ion channel activity(GO:0005234) |
| 0.0 | 0.0 | GO:0005137 | interleukin-5 receptor binding(GO:0005137) |
| 0.0 | 0.1 | GO:0008158 | hedgehog receptor activity(GO:0008158) |
| 0.0 | 0.1 | GO:0004994 | somatostatin receptor activity(GO:0004994) |
| 0.0 | 0.3 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.0 | 0.4 | GO:0016832 | aldehyde-lyase activity(GO:0016832) |
| 0.0 | 0.2 | GO:0031369 | translation initiation factor binding(GO:0031369) |
| 0.0 | 0.1 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 0.0 | 0.2 | GO:0047760 | butyrate-CoA ligase activity(GO:0047760) |
| 0.0 | 0.7 | GO:0008146 | sulfotransferase activity(GO:0008146) |
| 0.0 | 0.1 | GO:0003997 | acyl-CoA oxidase activity(GO:0003997) |
| 0.0 | 0.1 | GO:0004706 | JUN kinase kinase kinase activity(GO:0004706) |
| 0.0 | 0.1 | GO:0003696 | satellite DNA binding(GO:0003696) |
| 0.0 | 0.0 | GO:0048531 | beta-1,3-galactosyltransferase activity(GO:0048531) |
| 0.0 | 0.2 | GO:0003701 | obsolete RNA polymerase I transcription factor activity(GO:0003701) |
| 0.0 | 0.2 | GO:0015125 | bile acid transmembrane transporter activity(GO:0015125) |
| 0.0 | 0.0 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 0.0 | 0.1 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.0 | 0.1 | GO:0015288 | porin activity(GO:0015288) |
| 0.0 | 0.1 | GO:0016884 | carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884) |
| 0.0 | 0.1 | GO:0016520 | growth hormone-releasing hormone receptor activity(GO:0016520) |
| 0.0 | 0.3 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 0.0 | GO:0004936 | alpha-adrenergic receptor activity(GO:0004936) |
| 0.0 | 0.4 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.0 | 0.1 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.0 | 0.2 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 0.1 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.0 | 1.2 | GO:0003704 | obsolete specific RNA polymerase II transcription factor activity(GO:0003704) |
| 0.0 | 0.2 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.0 | 0.5 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.0 | 0.3 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 0.1 | GO:0047498 | calcium-dependent phospholipase A2 activity(GO:0047498) |
| 0.0 | 0.1 | GO:0019211 | phosphatase activator activity(GO:0019211) |
| 0.0 | 0.1 | GO:0003906 | DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.8 | SA_B_CELL_RECEPTOR_COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.1 | 1.9 | SIG_IL4RECEPTOR_IN_B_LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.0 | 0.3 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.2 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.1 | SA_PTEN_PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 0.1 | ST_IL_13_PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.0 | 0.2 | SA_G1_AND_S_PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.0 | 1.0 | SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.0 | 0.6 | ST_JNK_MAPK_PATHWAY | JNK MAPK Pathway |
| 0.0 | 0.4 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
