Motif ID: ZFHX3

Z-value: 0.742


Transcription factors associated with ZFHX3:

Gene SymbolEntrez IDGene Name
ZFHX3 ENSG00000140836.10 ZFHX3



Activity profile for motif ZFHX3.

activity profile for motif ZFHX3


Sorted Z-values histogram for motif ZFHX3

Sorted Z-values for motif ZFHX3



Network of associatons between targets according to the STRING database.



First level regulatory network of ZFHX3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr11_+_22696314 1.337 ENST00000532398.1
ENST00000433790.1
 GAS2

growth arrest-specific 2

chr4_-_155511887 0.922 ENST00000302053.3
ENST00000403106.3
 FGA

fibrinogen alpha chain

chr9_-_123812542 0.805 ENST00000223642.1
 C5
complement component 5
chr17_-_64225508 0.710 ENST00000205948.6
 APOH
apolipoprotein H (beta-2-glycoprotein I)
chr12_-_91546926 0.614 ENST00000550758.1
 DCN
decorin
chr5_+_118690466 0.582 ENST00000503646.1
 TNFAIP8
tumor necrosis factor, alpha-induced protein 8
chr19_+_926000 0.566 ENST00000263620.3
 ARID3A
AT rich interactive domain 3A (BRIGHT-like)
chrX_-_110655306 0.562 ENST00000371993.2
 DCX
doublecortin
chr17_+_41052808 0.554 ENST00000592383.1
ENST00000253801.2
ENST00000585489.1
 G6PC


glucose-6-phosphatase, catalytic subunit


chr1_+_192544857 0.516 ENST00000367459.3
ENST00000469578.2
 RGS1

regulator of G-protein signaling 1

chr14_+_95027772 0.469 ENST00000555095.1
ENST00000298841.5
ENST00000554220.1
ENST00000553780.1
 SERPINA4

SERPINA5

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5

chr4_+_100495864 0.440 ENST00000265517.5
ENST00000422897.2
 MTTP

microsomal triglyceride transfer protein

chr12_+_59989791 0.434 ENST00000552432.1
 SLC16A7
solute carrier family 16 (monocarboxylate transporter), member 7
chr5_+_95066823 0.418 ENST00000506817.1
ENST00000379982.3
 RHOBTB3

Rho-related BTB domain containing 3

chr8_-_70745575 0.411 ENST00000524945.1
 SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr22_-_30970560 0.392 ENST00000402369.1
ENST00000406361.1
 GAL3ST1

galactose-3-O-sulfotransferase 1

chr10_-_75226166 0.365 ENST00000544628.1
 PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chrX_-_32173579 0.354 ENST00000359836.1
ENST00000343523.2
ENST00000378707.3
ENST00000541735.1
ENST00000474231.1
 DMD




dystrophin




chr19_-_46234119 0.325 ENST00000317683.3
 FBXO46
F-box protein 46
chr17_-_26697304 0.323 ENST00000536498.1
 VTN
vitronectin
chrX_+_9431324 0.323 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
 TBL1X





transducin (beta)-like 1X-linked





chr2_-_60780607 0.319 ENST00000537768.1
ENST00000335712.6
ENST00000356842.4
 BCL11A


B-cell CLL/lymphoma 11A (zinc finger protein)


chr2_-_60780702 0.315 ENST00000359629.5
 BCL11A
B-cell CLL/lymphoma 11A (zinc finger protein)
chr19_-_36304201 0.310 ENST00000301175.3
 PRODH2
proline dehydrogenase (oxidase) 2
chr2_-_60780536 0.302 ENST00000538214.1
 BCL11A
B-cell CLL/lymphoma 11A (zinc finger protein)
chr15_+_58724184 0.247 ENST00000433326.2
 LIPC
lipase, hepatic
chrX_+_84258832 0.206 ENST00000373173.2
 APOOL
apolipoprotein O-like
chr17_-_60142609 0.205 ENST00000397786.2
 MED13
mediator complex subunit 13
chr3_-_114477787 0.200 ENST00000464560.1
 ZBTB20
zinc finger and BTB domain containing 20
chr1_-_160549235 0.199 ENST00000368054.3
ENST00000368048.3
ENST00000311224.4
ENST00000368051.3
ENST00000534968.1
 CD84




CD84 molecule




chr7_-_100026280 0.193 ENST00000360951.4
ENST00000398027.2
ENST00000324725.6
ENST00000472716.1
 ZCWPW1



zinc finger, CW type with PWWP domain 1



chr20_-_33735070 0.184 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
 EDEM2


ER degradation enhancer, mannosidase alpha-like 2


chr12_+_59989918 0.181 ENST00000547379.1
ENST00000549465.1
 SLC16A7

solute carrier family 16 (monocarboxylate transporter), member 7

chr14_+_39703084 0.165 ENST00000553728.1
 RP11-407N17.3
cTAGE family member 5 isoform 4
chr8_+_98900132 0.164 ENST00000520016.1
 MATN2
matrilin 2
chr12_-_101801505 0.149 ENST00000539055.1
ENST00000551688.1
ENST00000551671.1
ENST00000261636.8
 ARL1



ADP-ribosylation factor-like 1



chr19_+_50016610 0.121 ENST00000596975.1
 FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr3_-_49066811 0.116 ENST00000442157.1
ENST00000326739.4
 IMPDH2

IMP (inosine 5'-monophosphate) dehydrogenase 2

chr6_-_116447283 0.112 ENST00000452729.1
ENST00000243222.4
 COL10A1

collagen, type X, alpha 1

chr6_+_28317685 0.102 ENST00000252211.2
ENST00000341464.5
ENST00000377255.3
 ZKSCAN3


zinc finger with KRAB and SCAN domains 3


chr19_+_54466179 0.100 ENST00000270458.2
 CACNG8
calcium channel, voltage-dependent, gamma subunit 8
chr7_-_44580861 0.092 ENST00000546276.1
ENST00000289547.4
ENST00000381160.3
ENST00000423141.1
 NPC1L1



NPC1-like 1



chrX_+_1710484 0.091 ENST00000313871.3
ENST00000381261.3
 AKAP17A

A kinase (PRKA) anchor protein 17A

chr4_-_100356291 0.091 ENST00000476959.1
ENST00000482593.1
 ADH7

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

chr16_+_87636474 0.084 ENST00000284262.2
 JPH3
junctophilin 3
chr7_+_100026406 0.081 ENST00000414441.1
 MEPCE
methylphosphate capping enzyme
chr2_+_185463093 0.077 ENST00000302277.6
 ZNF804A
zinc finger protein 804A
chr20_-_21494654 0.071 ENST00000377142.4
 NKX2-2
NK2 homeobox 2
chr3_+_69812701 0.069 ENST00000472437.1
 MITF
microphthalmia-associated transcription factor
chr11_-_61687739 0.057 ENST00000531922.1
ENST00000301773.5
 RAB3IL1

RAB3A interacting protein (rabin3)-like 1

chr21_+_40824003 0.054 ENST00000452550.1
 SH3BGR
SH3 domain binding glutamic acid-rich protein
chr12_-_7818474 0.053 ENST00000229304.4
 APOBEC1
apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1
chr12_+_53835508 0.051 ENST00000541275.1
ENST00000551003.1
ENST00000549068.1
ENST00000549740.1
ENST00000546581.1
ENST00000549581.1
 PCBP2
PRR13




poly(rC) binding protein 2
proline rich 13




chr22_+_39101728 0.042 ENST00000216044.5
ENST00000484657.1
 GTPBP1

GTP binding protein 1

chr16_-_15474904 0.032 ENST00000534094.1
 NPIPA5
nuclear pore complex interacting protein family, member A5
chr1_+_159557607 0.029 ENST00000255040.2
 APCS
amyloid P component, serum
chr12_-_2944184 0.013 ENST00000337508.4
 NRIP2
nuclear receptor interacting protein 2
chr11_+_8040739 0.008 ENST00000534099.1
 TUB
tubby bipartite transcription factor
chr4_-_100356551 0.001 ENST00000209665.4
 ADH7
alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
chr20_+_42187608 0.000 ENST00000373100.1
 SGK2
serum/glucocorticoid regulated kinase 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0002689 negative regulation of leukocyte chemotaxis(GO:0002689)
0.2 0.6 GO:0006848 pyruvate transport(GO:0006848)
0.1 0.6 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.1 0.4 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 0.7 GO:0034392 negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.1 0.3 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 0.6 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 0.6 GO:0019987 obsolete negative regulation of anti-apoptosis(GO:0019987)
0.1 0.3 GO:0006562 proline catabolic process(GO:0006562)
0.0 0.1 GO:0010430 ethanol catabolic process(GO:0006068) fatty acid omega-oxidation(GO:0010430)
0.0 0.2 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.5 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.0 0.9 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.1 GO:0021529 spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780)
0.0 0.1 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.1 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.4 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 1.3 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.1 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0005579 membrane attack complex(GO:0005579)
0.1 0.9 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.3 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.0 0.6 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.7 GO:0042627 chylomicron(GO:0042627)
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 1.3 GO:0005884 actin filament(GO:0005884)
0.0 0.4 GO:0043034 costamere(GO:0043034)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0050833 pyruvate secondary active transmembrane transporter activity(GO:0005477) pyruvate transmembrane transporter activity(GO:0050833)
0.1 0.7 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.1 0.6 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1 0.5 GO:0032190 acrosin binding(GO:0032190)
0.1 0.3 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.1 0.4 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.0 0.9 GO:0043499 obsolete eukaryotic cell surface binding(GO:0043499)
0.0 0.4 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0035276 ethanol binding(GO:0035276)
0.0 0.1 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.0 0.1 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.3 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.6 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.8 GO:0008009 chemokine activity(GO:0008009)
0.0 0.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.1 GO:0008158 hedgehog receptor activity(GO:0008158)
0.0 0.2 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.2 GO:0004806 triglyceride lipase activity(GO:0004806)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway