Motif ID: ZNF35

Z-value: 0.898


Transcription factors associated with ZNF35:

Gene SymbolEntrez IDGene Name
ZNF35 ENSG00000169981.6 ZNF35



Activity profile for motif ZNF35.

activity profile for motif ZNF35


Sorted Z-values histogram for motif ZNF35

Sorted Z-values for motif ZNF35



Network of associatons between targets according to the STRING database.



First level regulatory network of ZNF35

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr3_-_148939835 1.464 ENST00000264613.6
 CP
ceruloplasmin (ferroxidase)
chrX_+_9431324 0.890 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
 TBL1X





transducin (beta)-like 1X-linked





chr4_+_68424434 0.820 ENST00000265404.2
ENST00000396225.1
 STAP1

signal transducing adaptor family member 1

chr9_+_42671887 0.725 ENST00000456520.1
ENST00000377391.3
 CBWD7

COBW domain containing 7

chr12_+_51318513 0.696 ENST00000332160.4
 METTL7A
methyltransferase like 7A
chr10_-_52645379 0.682 ENST00000395489.2
 A1CF
APOBEC1 complementation factor
chr10_-_52645416 0.651 ENST00000374001.2
ENST00000373997.3
ENST00000373995.3
ENST00000282641.2
ENST00000395495.1
ENST00000414883.1
 A1CF





APOBEC1 complementation factor





chr6_-_133084580 0.647 ENST00000525270.1
ENST00000530536.1
ENST00000524919.1
 VNN2


vanin 2


chr12_+_25205446 0.630 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
 LRMP


lymphoid-restricted membrane protein


chr1_+_214161272 0.554 ENST00000498508.2
ENST00000366958.4
 PROX1

prospero homeobox 1

chr12_+_54891495 0.548 ENST00000293373.6
 NCKAP1L
NCK-associated protein 1-like
chr12_+_25205666 0.529 ENST00000547044.1
 LRMP
lymphoid-restricted membrane protein
chr7_-_87342564 0.488 ENST00000265724.3
ENST00000416177.1
 ABCB1

ATP-binding cassette, sub-family B (MDR/TAP), member 1

chr6_+_32812568 0.420 ENST00000414474.1
 PSMB9
proteasome (prosome, macropain) subunit, beta type, 9
chr8_-_95274536 0.399 ENST00000297596.2
ENST00000396194.2
 GEM

GTP binding protein overexpressed in skeletal muscle

chr12_-_102872317 0.359 ENST00000424202.2
 IGF1
insulin-like growth factor 1 (somatomedin C)
chr12_+_4382917 0.347 ENST00000261254.3
 CCND2
cyclin D2
chr7_+_123488124 0.334 ENST00000476325.1
 HYAL4
hyaluronoglucosaminidase 4
chrM_+_4431 0.317 ENST00000361453.3
 MT-ND2
mitochondrially encoded NADH dehydrogenase 2
chr15_+_35270552 0.276 ENST00000391457.2
 AC114546.1
HCG37415; PRO1914; Uncharacterized protein
chrX_-_138724677 0.248 ENST00000370573.4
ENST00000338585.6
ENST00000370576.4
 MCF2


MCF.2 cell line derived transforming sequence


chr3_-_49066811 0.247 ENST00000442157.1
ENST00000326739.4
 IMPDH2

IMP (inosine 5'-monophosphate) dehydrogenase 2

chr3_-_58523010 0.246 ENST00000459701.2
ENST00000302819.5
 ACOX2

acyl-CoA oxidase 2, branched chain

chr1_-_169599353 0.235 ENST00000367793.2
ENST00000367794.2
ENST00000367792.2
ENST00000367791.2
ENST00000367788.2
 SELP




selectin P (granule membrane protein 140kDa, antigen CD62)




chr3_+_69985792 0.223 ENST00000531774.1
 MITF
microphthalmia-associated transcription factor
chr4_+_129730947 0.220 ENST00000452328.2
ENST00000504089.1
 PHF17

jade family PHD finger 1

chr2_-_191878162 0.219 ENST00000540176.1
 STAT1
signal transducer and activator of transcription 1, 91kDa
chr17_+_41561317 0.214 ENST00000540306.1
ENST00000262415.3
ENST00000605777.1
 DHX8


DEAH (Asp-Glu-Ala-His) box polypeptide 8


chr6_-_135271219 0.211 ENST00000367847.2
ENST00000367845.2
 ALDH8A1

aldehyde dehydrogenase 8 family, member A1

chr5_-_58571935 0.155 ENST00000503258.1
 PDE4D
phosphodiesterase 4D, cAMP-specific
chr12_-_22487618 0.153 ENST00000404299.3
ENST00000396037.4
 ST8SIA1

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1

chr5_-_39203093 0.145 ENST00000515010.1
 FYB
FYN binding protein
chr14_-_31889782 0.144 ENST00000543095.2
 HEATR5A
HEAT repeat containing 5A
chr1_-_12677714 0.128 ENST00000376223.2
 DHRS3
dehydrogenase/reductase (SDR family) member 3
chr7_+_80231466 0.124 ENST00000309881.7
ENST00000534394.1
 CD36

CD36 molecule (thrombospondin receptor)

chr21_-_42219065 0.105 ENST00000400454.1
 DSCAM
Down syndrome cell adhesion molecule
chr4_-_89744365 0.096 ENST00000513837.1
ENST00000503556.1
 FAM13A

family with sequence similarity 13, member A

chr18_+_74240610 0.091 ENST00000578092.1
ENST00000578613.1
ENST00000583578.1
 LINC00908


long intergenic non-protein coding RNA 908


chr13_+_109248500 0.085 ENST00000356711.2
 MYO16
myosin XVI
chr17_-_42295870 0.072 ENST00000526094.1
ENST00000529383.1
ENST00000530828.1
 UBTF


upstream binding transcription factor, RNA polymerase I


chr7_+_74072288 0.068 ENST00000443166.1
 GTF2I
general transcription factor IIi
chr3_+_29323043 0.065 ENST00000452462.1
ENST00000456853.1
 RBMS3

RNA binding motif, single stranded interacting protein 3

chr7_+_27282319 0.054 ENST00000222761.3
 EVX1
even-skipped homeobox 1
chr19_-_12833164 0.035 ENST00000356861.5
 TNPO2
transportin 2
chr13_-_41240717 0.034 ENST00000379561.5
 FOXO1
forkhead box O1
chr7_-_83824169 0.030 ENST00000265362.4
 SEMA3A
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
chr3_+_69985734 0.020 ENST00000314557.6
ENST00000394351.3
 MITF

microphthalmia-associated transcription factor

chr19_-_13617247 0.013 ENST00000573710.2
 CACNA1A
calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0016554 cytidine to uridine editing(GO:0016554)
0.2 0.6 GO:0055005 optic placode formation involved in camera-type eye formation(GO:0046619) ventricular cardiac myofibril assembly(GO:0055005) regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251)
0.1 0.7 GO:0060100 regulation of phagocytosis, engulfment(GO:0060099) positive regulation of phagocytosis, engulfment(GO:0060100) regulation of membrane invagination(GO:1905153) positive regulation of membrane invagination(GO:1905155)
0.1 1.5 GO:0006825 copper ion transport(GO:0006825)
0.1 1.2 GO:0006906 vesicle fusion(GO:0006906)
0.1 0.4 GO:0035630 glycolate metabolic process(GO:0009441) bone mineralization involved in bone maturation(GO:0035630)
0.0 0.2 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.0 0.6 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.2 GO:0042905 retinal metabolic process(GO:0042574) 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0 0.2 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.3 GO:0006027 glycosaminoglycan catabolic process(GO:0006027)
0.0 0.2 GO:0043982 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.0 0.3 GO:1904031 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0 0.1 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
0.0 0.8 GO:0061025 membrane fusion(GO:0061025)
0.0 0.1 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.1 GO:0045943 positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0 0.2 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.0 0.2 GO:0043330 response to exogenous dsRNA(GO:0043330)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.3 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.1 0.5 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.4 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.7 GO:0005811 lipid particle(GO:0005811)
0.0 0.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 0.9 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.4 GO:0005839 proteasome core complex(GO:0005839)
0.0 0.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.2 0.6 GO:0050692 DBD domain binding(GO:0050692)
0.1 0.6 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.1 0.5 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.1 0.2 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.1 0.2 GO:0042806 fucose binding(GO:0042806)
0.1 0.2 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 1.3 GO:0019239 deaminase activity(GO:0019239)
0.0 0.3 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.0 0.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.2 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.0 0.2 GO:0003828 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0 0.1 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
0.0 0.4 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.5 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 0.4 GO:0019003 GDP binding(GO:0019003)
0.0 0.9 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.4 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 ST_TYPE_I_INTERFERON_PATHWAY Type I Interferon (alpha/beta IFN) Pathway