Motif ID: ZNF423

Z-value: 1.147


Transcription factors associated with ZNF423:

Gene SymbolEntrez IDGene Name
ZNF423 ENSG00000102935.7 ZNF423



Activity profile for motif ZNF423.

activity profile for motif ZNF423


Sorted Z-values histogram for motif ZNF423

Sorted Z-values for motif ZNF423



Network of associatons between targets according to the STRING database.



First level regulatory network of ZNF423

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_135385202 2.028 ENST00000514554.1
 TGFBI
transforming growth factor, beta-induced, 68kDa
chr10_+_17271266 1.973 ENST00000224237.5
 VIM
vimentin
chr2_+_46769798 1.616 ENST00000238738.4
 RHOQ
ras homolog family member Q
chrX_+_49028265 1.489 ENST00000376322.3
ENST00000376327.5
 PLP2

proteolipid protein 2 (colonic epithelium-enriched)

chrX_-_51239425 1.464 ENST00000375992.3
 NUDT11
nudix (nucleoside diphosphate linked moiety X)-type motif 11
chr9_+_112542591 1.345 ENST00000413420.1
ENST00000302798.7
ENST00000555236.1
ENST00000510514.5
ENST00000483909.1
ENST00000314527.4
 PALM2-AKAP2

AKAP2

PALM2

PALM2-AKAP2 readthrough

A kinase (PRKA) anchor protein 2

paralemmin 2

chr9_+_112542572 1.280 ENST00000374530.3
 PALM2-AKAP2
PALM2-AKAP2 readthrough
chr10_-_121296045 1.130 ENST00000392865.1
 RGS10
regulator of G-protein signaling 10
chr3_-_69129501 1.047 ENST00000540295.1
ENST00000415609.2
ENST00000361055.4
ENST00000349511.4
 UBA3



ubiquitin-like modifier activating enzyme 3



chr11_-_44972390 0.778 ENST00000395648.3
ENST00000531928.2
 TP53I11

tumor protein p53 inducible protein 11

chr11_-_61658853 0.771 ENST00000525588.1
ENST00000540820.1
 FADS3

fatty acid desaturase 3

chr11_-_61659006 0.640 ENST00000278829.2
 FADS3
fatty acid desaturase 3
chr9_-_16870704 0.639 ENST00000380672.4
ENST00000380667.2
ENST00000380666.2
ENST00000486514.1
 BNC2



basonuclin 2



chrX_-_107019181 0.612 ENST00000315660.4
ENST00000372384.2
ENST00000502650.1
ENST00000506724.1
 TSC22D3



TSC22 domain family, member 3



chr10_-_75255724 0.597 ENST00000342558.3
ENST00000360663.5
ENST00000394829.2
ENST00000394828.2
ENST00000394822.2
 PPP3CB




protein phosphatase 3, catalytic subunit, beta isozyme




chrX_-_107018969 0.550 ENST00000372383.4
 TSC22D3
TSC22 domain family, member 3
chr1_-_203055129 0.536 ENST00000241651.4
 MYOG
myogenin (myogenic factor 4)
chr16_-_11681316 0.535 ENST00000571688.1
 LITAF
lipopolysaccharide-induced TNF factor
chr11_-_44972476 0.528 ENST00000527685.1
ENST00000308212.5
 TP53I11

tumor protein p53 inducible protein 11

chr19_-_15311713 0.527 ENST00000601011.1
ENST00000263388.2
 NOTCH3

notch 3

chr7_-_30029367 0.499 ENST00000242059.5
 SCRN1
secernin 1
chr11_-_67120974 0.474 ENST00000539074.1
ENST00000312419.3
 POLD4

polymerase (DNA-directed), delta 4, accessory subunit

chr11_-_44971702 0.465 ENST00000533940.1
ENST00000533937.1
 TP53I11

tumor protein p53 inducible protein 11

chrX_-_1572629 0.446 ENST00000534940.1
 ASMTL
acetylserotonin O-methyltransferase-like
chr8_+_22022223 0.433 ENST00000306385.5
 BMP1
bone morphogenetic protein 1
chr7_-_5570229 0.424 ENST00000331789.5
 ACTB
actin, beta
chr11_+_73019282 0.401 ENST00000263674.3
 ARHGEF17
Rho guanine nucleotide exchange factor (GEF) 17
chr16_-_11681023 0.387 ENST00000570904.1
ENST00000574701.1
 LITAF

lipopolysaccharide-induced TNF factor

chr8_-_103668114 0.375 ENST00000285407.6
 KLF10
Kruppel-like factor 10
chr10_-_118032979 0.371 ENST00000355422.6
 GFRA1
GDNF family receptor alpha 1
chr5_-_172756506 0.361 ENST00000265087.4
 STC2
stanniocalcin 2
chr21_-_18985230 0.357 ENST00000457956.1
ENST00000348354.6
 BTG3

BTG family, member 3

chr1_-_155177677 0.351 ENST00000368378.3
ENST00000541990.1
ENST00000457183.2
 THBS3


thrombospondin 3


chr10_-_75255668 0.343 ENST00000545874.1
 PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr12_-_57522813 0.335 ENST00000556155.1
 STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr3_-_52931557 0.328 ENST00000355083.5
ENST00000504329.1
 TMEM110
TMEM110-MUSTN1
transmembrane protein 110
TMEM110-MUSTN1 readthrough
chr15_+_100106244 0.321 ENST00000557942.1
 MEF2A
myocyte enhancer factor 2A
chr19_+_41770236 0.310 ENST00000392006.3
 HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr15_+_100106155 0.296 ENST00000557785.1
ENST00000558049.1
ENST00000449277.2
 MEF2A


myocyte enhancer factor 2A


chr19_-_11689752 0.270 ENST00000592659.1
ENST00000592828.1
ENST00000218758.5
ENST00000412435.2
 ACP5



acid phosphatase 5, tartrate resistant



chr6_-_91296602 0.265 ENST00000369325.3
ENST00000369327.3
 MAP3K7

mitogen-activated protein kinase kinase kinase 7

chr9_-_99382065 0.265 ENST00000265659.2
ENST00000375241.1
ENST00000375236.1
 CDC14B


cell division cycle 14B


chr6_-_91296737 0.259 ENST00000369332.3
ENST00000369329.3
 MAP3K7

mitogen-activated protein kinase kinase kinase 7

chr9_-_99381660 0.254 ENST00000375240.3
ENST00000463569.1
 CDC14B

cell division cycle 14B

chr12_-_118810688 0.249 ENST00000542532.1
ENST00000392533.3
 TAOK3

TAO kinase 3

chr22_-_43045574 0.239 ENST00000352397.5
 CYB5R3
cytochrome b5 reductase 3
chr8_+_22423168 0.238 ENST00000518912.1
ENST00000428103.1
 SORBS3

sorbin and SH3 domain containing 3

chr21_-_18985158 0.230 ENST00000339775.6
 BTG3
BTG family, member 3
chr6_-_32160622 0.230 ENST00000487761.1
ENST00000375040.3
 GPSM3

G-protein signaling modulator 3

chr15_-_59225758 0.222 ENST00000558486.1
ENST00000560682.1
ENST00000249736.7
ENST00000559880.1
ENST00000536328.1
 SLTM




SAFB-like, transcription modulator




chr2_-_120980939 0.217 ENST00000426077.2
 TMEM185B
transmembrane protein 185B
chr11_-_64013663 0.217 ENST00000392210.2
 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr22_+_35653445 0.213 ENST00000420166.1
ENST00000444518.2
ENST00000455359.1
ENST00000216106.5
 HMGXB4



HMG box domain containing 4



chr6_-_143266297 0.189 ENST00000367603.2
 HIVEP2
human immunodeficiency virus type I enhancer binding protein 2
chr11_-_6495082 0.188 ENST00000536344.1
 TRIM3
tripartite motif containing 3
chr11_-_64510409 0.187 ENST00000394429.1
ENST00000394428.1
 RASGRP2

RAS guanyl releasing protein 2 (calcium and DAG-regulated)

chr10_+_135340859 0.183 ENST00000252945.3
ENST00000421586.1
ENST00000418356.1
 CYP2E1


cytochrome P450, family 2, subfamily E, polypeptide 1


chr19_-_57183114 0.182 ENST00000537055.2
ENST00000601659.1
 ZNF835

zinc finger protein 835

chr10_+_88428206 0.160 ENST00000429277.2
ENST00000458213.2
ENST00000352360.5
 LDB3


LIM domain binding 3


chr4_+_4388805 0.158 ENST00000504171.1
 NSG1
Homo sapiens neuron specific gene family member 1 (NSG1), transcript variant 3, mRNA.
chr19_-_10679644 0.149 ENST00000393599.2
 CDKN2D
cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
chr17_+_6347729 0.148 ENST00000572447.1
 FAM64A
family with sequence similarity 64, member A
chr15_+_41523335 0.142 ENST00000334660.5
 CHP1
calcineurin-like EF-hand protein 1
chr4_+_4387983 0.142 ENST00000397958.1
 NSG1
Homo sapiens neuron specific gene family member 1 (NSG1), transcript variant 3, mRNA.
chr17_+_77020325 0.135 ENST00000311661.4
 C1QTNF1
C1q and tumor necrosis factor related protein 1
chr15_-_59225844 0.124 ENST00000380516.2
 SLTM
SAFB-like, transcription modulator
chr2_+_62932779 0.123 ENST00000427809.1
ENST00000405482.1
ENST00000431489.1
 EHBP1


EH domain binding protein 1


chr11_-_1036706 0.121 ENST00000421673.2
 MUC6
mucin 6, oligomeric mucus/gel-forming
chr8_+_22422749 0.121 ENST00000523900.1
 SORBS3
sorbin and SH3 domain containing 3
chr17_+_77020224 0.115 ENST00000339142.2
 C1QTNF1
C1q and tumor necrosis factor related protein 1
chr17_+_6347761 0.115 ENST00000250056.8
ENST00000571373.1
ENST00000570337.2
ENST00000572595.2
ENST00000576056.1
 FAM64A




family with sequence similarity 64, member A




chr19_+_41770269 0.112 ENST00000378215.4
 HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr4_+_4388245 0.105 ENST00000433139.2
 NSG1
Homo sapiens neuron specific gene family member 1 (NSG1), transcript variant 3, mRNA.
chrX_+_136648297 0.096 ENST00000287538.5
 ZIC3
Zic family member 3
chr8_+_22022653 0.094 ENST00000354870.5
ENST00000397816.3
ENST00000306349.8
 BMP1


bone morphogenetic protein 1


chr11_-_6495101 0.090 ENST00000528227.1
ENST00000359518.3
ENST00000345851.3
ENST00000537602.1
 TRIM3



tripartite motif containing 3



chr5_+_141303373 0.089 ENST00000432126.2
ENST00000194118.4
 KIAA0141

KIAA0141

chr11_-_44972418 0.085 ENST00000525680.1
ENST00000528290.1
ENST00000530035.1
 TP53I11


tumor protein p53 inducible protein 11


chr8_+_30241995 0.078 ENST00000397323.4
ENST00000339877.4
ENST00000320203.4
ENST00000287771.5
 RBPMS



RNA binding protein with multiple splicing



chr17_-_73179046 0.070 ENST00000314523.7
ENST00000420826.2
 SUMO2

small ubiquitin-like modifier 2

chr1_+_1222489 0.070 ENST00000379099.3
 SCNN1D
sodium channel, non-voltage-gated 1, delta subunit
chr3_-_48594248 0.065 ENST00000545984.1
ENST00000232375.3
ENST00000416568.1
ENST00000383734.2
ENST00000541519.1
ENST00000412035.1
 PFKFB4





6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4





chr6_-_35480705 0.063 ENST00000229771.6
 TULP1
tubby like protein 1
chr3_+_32726774 0.061 ENST00000538368.1
 CNOT10
CCR4-NOT transcription complex, subunit 10
chr3_+_180630444 0.061 ENST00000491062.1
ENST00000468861.1
ENST00000445140.2
ENST00000484958.1
 FXR1



fragile X mental retardation, autosomal homolog 1



chr16_+_333152 0.060 ENST00000219406.6
ENST00000404312.1
ENST00000456379.1
 PDIA2


protein disulfide isomerase family A, member 2


chr8_+_30241934 0.059 ENST00000538486.1
 RBPMS
RNA binding protein with multiple splicing
chr17_-_73178599 0.057 ENST00000578238.1
 SUMO2
small ubiquitin-like modifier 2
chr15_-_83316711 0.055 ENST00000568128.1
 CPEB1
cytoplasmic polyadenylation element binding protein 1
chr20_+_43029911 0.048 ENST00000443598.2
ENST00000316099.4
ENST00000415691.2
 HNF4A


hepatocyte nuclear factor 4, alpha


chr1_+_155278625 0.046 ENST00000368356.4
ENST00000356657.6
 FDPS

farnesyl diphosphate synthase

chr16_+_27325202 0.040 ENST00000395762.2
ENST00000562142.1
ENST00000561742.1
ENST00000543915.2
ENST00000449195.1
ENST00000380922.3
ENST00000563002.1
 IL4R






interleukin 4 receptor






chr10_+_124913930 0.033 ENST00000368858.5
 BUB3
BUB3 mitotic checkpoint protein
chr15_-_66649010 0.032 ENST00000367709.4
ENST00000261881.4
 TIPIN

TIMELESS interacting protein

chr19_+_10531150 0.030 ENST00000352831.6
 PDE4A
phosphodiesterase 4A, cAMP-specific
chr10_-_76859247 0.026 ENST00000472493.2
ENST00000605915.1
ENST00000478873.2
 DUSP13


dual specificity phosphatase 13


chr19_+_41770349 0.026 ENST00000602130.1
 HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr1_+_10459111 0.025 ENST00000541529.1
ENST00000270776.8
ENST00000483936.1
ENST00000538557.1
 PGD



phosphogluconate dehydrogenase



chr19_-_23941639 0.017 ENST00000395385.3
ENST00000531570.1
ENST00000528059.1
 ZNF681


zinc finger protein 681


chr15_+_41523417 0.017 ENST00000560397.1
 CHP1
calcineurin-like EF-hand protein 1
chr7_-_100491854 0.016 ENST00000426415.1
ENST00000430554.1
ENST00000412389.1
 ACHE


acetylcholinesterase (Yt blood group)


chr7_-_100253993 0.012 ENST00000461605.1
ENST00000160382.5
 ACTL6B

actin-like 6B

chr7_-_27219849 0.008 ENST00000396344.4
 HOXA10
homeobox A10
chr8_+_22423219 0.006 ENST00000523965.1
ENST00000521554.1
 SORBS3

sorbin and SH3 domain containing 3

chr19_+_20011775 0.002 ENST00000592160.1
ENST00000343769.5
ENST00000592245.1
 ZNF93

AC007204.2
zinc finger protein 93

AC007204.2
chr19_-_23941680 0.000 ENST00000402377.3
 ZNF681
zinc finger protein 681

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.1 1.0 GO:0045116 protein neddylation(GO:0045116)
0.1 0.3 GO:0048295 positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.1 0.5 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.1 0.4 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.1 2.0 GO:0045103 intermediate filament-based process(GO:0045103)
0.1 0.3 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.1 0.5 GO:0042693 muscle cell fate commitment(GO:0042693)
0.1 0.4 GO:0003416 endochondral bone growth(GO:0003416) growth plate cartilage development(GO:0003417) bone growth(GO:0098868)
0.0 0.1 GO:0048102 autophagic cell death(GO:0048102)
0.0 0.5 GO:0007220 Notch receptor processing(GO:0007220)
0.0 0.4 GO:0046697 decidualization(GO:0046697)
0.0 0.2 GO:0016098 monoterpenoid metabolic process(GO:0016098)
0.0 1.4 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636)
0.0 0.5 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.0 0.5 GO:0061036 positive regulation of cartilage development(GO:0061036)
0.0 0.5 GO:0031572 G2 DNA damage checkpoint(GO:0031572)
0.0 2.0 GO:0030198 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.0 0.1 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0 1.3 GO:0008360 regulation of cell shape(GO:0008360)
0.0 0.1 GO:0030277 epithelial structure maintenance(GO:0010669) maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.0 GO:0046639 negative regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043371) negative regulation of T-helper cell differentiation(GO:0045623) negative regulation of alpha-beta T cell differentiation(GO:0046639) negative regulation of CD4-positive, alpha-beta T cell activation(GO:2000515)
0.0 0.4 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.0 0.0 GO:0060398 regulation of growth hormone receptor signaling pathway(GO:0060398)
0.0 0.1 GO:0006003 fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0 0.0 GO:0048478 replication fork protection(GO:0048478)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.4 GO:0070688 MLL5-L complex(GO:0070688)
0.0 0.2 GO:0016589 NURF complex(GO:0016589)
0.0 1.6 GO:0005884 actin filament(GO:0005884)
0.0 1.9 GO:0005882 intermediate filament(GO:0005882)
0.0 0.5 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.2 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.4 GO:0030530 obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0019956 chemokine binding(GO:0019956)
0.3 1.5 GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.2 1.4 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.1 1.6 GO:0005522 profilin binding(GO:0005522)
0.1 0.4 GO:0017096 acetylserotonin O-methyltransferase activity(GO:0017096)
0.1 1.0 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.1 0.4 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.0 1.9 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.4 GO:0050780 dopamine receptor binding(GO:0050780)
0.0 0.4 GO:0050998 nitric-oxide synthase binding(GO:0050998)
0.0 0.9 GO:0050699 WW domain binding(GO:0050699)
0.0 0.5 GO:0016805 dipeptidase activity(GO:0016805)
0.0 2.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 0.3 GO:0008199 acid phosphatase activity(GO:0003993) ferric iron binding(GO:0008199)
0.0 0.5 GO:0070888 E-box binding(GO:0070888)
0.0 0.2 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0 0.5 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.1 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.0 GO:0004913 interleukin-4 receptor activity(GO:0004913)
0.0 0.5 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.2 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.5 ST_TUMOR_NECROSIS_FACTOR_PATHWAY Tumor Necrosis Factor Pathway.