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ENCODE cell lines, expression (Ernst 2011)

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Results for AAGGUGC

Z-value: 0.86

Motif logo

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miRNA associated with seed AAGGUGC

NamemiRBASE accession
hsa-miR-18a-5p
MIMAT0000072
hsa-miR-18b-5p
MIMAT0001412
hsa-miR-4735-3p
MIMAT0019861

Activity profile of AAGGUGC motif

Sorted Z-values of AAGGUGC motif

Network of associatons between targets according to the STRING database.

First level regulatory network of AAGGUGC

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_+_235860616 3.39 ENST00000392011.2
 SH3BP4
 SH3-domain binding protein 4
chr3_-_123603137 3.19 ENST00000360304.3
ENST00000359169.1
ENST00000346322.5
ENST00000360772.3
 MYLK
 myosin light chain kinase
chr1_-_20812690 3.15 ENST00000375078.3
 CAMK2N1
 calcium/calmodulin-dependent protein kinase II inhibitor 1
chr15_+_39873268 2.43 ENST00000397591.2
ENST00000260356.5
 THBS1
 thrombospondin 1
chr2_+_36582857 2.26 ENST00000280527.2
 CRIM1
 cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr22_+_38093005 2.01 ENST00000406386.3
 TRIOBP
 TRIO and F-actin binding protein
chr6_-_132272504 1.65 ENST00000367976.3
 CTGF
 connective tissue growth factor
chr8_-_18871159 1.64 ENST00000327040.8
ENST00000440756.2
 PSD3
 pleckstrin and Sec7 domain containing 3
chr9_-_74383799 1.57 ENST00000377044.4
 TMEM2
 transmembrane protein 2
chr3_+_105085734 1.53 ENST00000306107.5
 ALCAM
 activated leukocyte cell adhesion molecule
chr4_-_157892498 1.16 ENST00000502773.1
 PDGFC
 platelet derived growth factor C
chr3_-_114790179 1.10 ENST00000462705.1
 ZBTB20
 zinc finger and BTB domain containing 20
chr3_+_107241783 1.01 ENST00000415149.2
ENST00000402543.1
ENST00000325805.8
ENST00000427402.1
 BBX
 bobby sox homolog (Drosophila)
chr3_+_187930719 0.97 ENST00000312675.4
 LPP
 LIM domain containing preferred translocation partner in lipoma
chr1_-_120612240 0.84 ENST00000256646.2
 NOTCH2
 notch 2
chr4_-_186877502 0.84 ENST00000431902.1
ENST00000284776.7
ENST00000415274.1
 SORBS2
 sorbin and SH3 domain containing 2
chr6_-_11232891 0.83 ENST00000379433.5
ENST00000379446.5
 NEDD9
 neural precursor cell expressed, developmentally down-regulated 9
chr5_-_73937244 0.83 ENST00000302351.4
ENST00000510316.1
ENST00000508331.1
 ENC1
 ectodermal-neural cortex 1 (with BTB domain)
chr10_-_735553 0.77 ENST00000280886.6
ENST00000423550.1
 DIP2C
 DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr11_+_108093839 0.76 ENST00000452508.2
 ATM
 ataxia telangiectasia mutated
chr15_-_56209306 0.76 ENST00000506154.1
ENST00000338963.2
ENST00000508342.1
 NEDD4
 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
chr20_+_34700333 0.74 ENST00000441639.1
 EPB41L1
 erythrocyte membrane protein band 4.1-like 1
chr6_+_39760783 0.73 ENST00000398904.2
ENST00000538976.1
 DAAM2
 dishevelled associated activator of morphogenesis 2
chr3_-_185542817 0.69 ENST00000382199.2
 IGF2BP2
 insulin-like growth factor 2 mRNA binding protein 2
chr1_-_161993616 0.69 ENST00000294794.3
 OLFML2B
 olfactomedin-like 2B
chr6_-_111136513 0.54 ENST00000368911.3
 CDK19
 cyclin-dependent kinase 19
chr3_+_37903432 0.51 ENST00000443503.2
 CTDSPL
 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr11_-_34379546 0.51 ENST00000435224.2
 ABTB2
 ankyrin repeat and BTB (POZ) domain containing 2
chr9_+_125703282 0.50 ENST00000373647.4
ENST00000402311.1
 RABGAP1
 RAB GTPase activating protein 1
chr3_+_171758344 0.49 ENST00000336824.4
ENST00000423424.1
 FNDC3B
 fibronectin type III domain containing 3B
chr1_-_95007193 0.43 ENST00000370207.4
ENST00000334047.7
 F3
 coagulation factor III (thromboplastin, tissue factor)
chr17_-_1395954 0.43 ENST00000359786.5
 MYO1C
 myosin IC
chr12_-_44200052 0.39 ENST00000548315.1
ENST00000552521.1
ENST00000546662.1
ENST00000548403.1
ENST00000546506.1
 TWF1
 twinfilin actin-binding protein 1
chr10_-_119806085 0.37 ENST00000355624.3
 RAB11FIP2
 RAB11 family interacting protein 2 (class I)
chr20_+_56884752 0.36 ENST00000244040.3
 RAB22A
 RAB22A, member RAS oncogene family
chr17_+_48423453 0.36 ENST00000017003.2
ENST00000509778.1
ENST00000507602.1
 XYLT2
 xylosyltransferase II
chr17_+_40834580 0.35 ENST00000264638.4
 CNTNAP1
 contactin associated protein 1
chr6_-_99873145 0.35 ENST00000369239.5
ENST00000438806.1
 PNISR
 PNN-interacting serine/arginine-rich protein
chr21_-_36260980 0.31 ENST00000344691.4
ENST00000358356.5
 RUNX1
 runt-related transcription factor 1
chr4_+_154125565 0.31 ENST00000338700.5
 TRIM2
 tripartite motif containing 2
chr2_-_26101374 0.31 ENST00000435504.4
 ASXL2
 additional sex combs like 2 (Drosophila)
chr2_+_46926048 0.29 ENST00000306503.5
 SOCS5
 suppressor of cytokine signaling 5
chr12_+_49212514 0.29 ENST00000301050.2
ENST00000548279.1
ENST00000547230.1
 CACNB3
 calcium channel, voltage-dependent, beta 3 subunit
chr2_+_28615669 0.27 ENST00000379619.1
ENST00000264716.4
 FOSL2
 FOS-like antigen 2
chr7_-_111846435 0.26 ENST00000437633.1
ENST00000428084.1
 DOCK4
 dedicator of cytokinesis 4
chr19_-_36523709 0.26 ENST00000592017.1
ENST00000360535.4
 CLIP3
 CAP-GLY domain containing linker protein 3
chr5_-_59189545 0.24 ENST00000340635.6
 PDE4D
 phosphodiesterase 4D, cAMP-specific
chr11_-_72853091 0.24 ENST00000311172.7
ENST00000409314.1
 FCHSD2
 FCH and double SH3 domains 2
chr4_+_183164574 0.23 ENST00000511685.1
 TENM3
 teneurin transmembrane protein 3
chr16_+_69599861 0.23 ENST00000354436.2
 NFAT5
 nuclear factor of activated T-cells 5, tonicity-responsive
chr19_-_46000251 0.22 ENST00000590526.1
ENST00000344680.4
ENST00000245923.4
 RTN2
 reticulon 2
chr10_-_81205373 0.22 ENST00000372336.3
 ZCCHC24
 zinc finger, CCHC domain containing 24
chr16_-_74640986 0.19 ENST00000422840.2
ENST00000565260.1
ENST00000447066.2
ENST00000205061.5
 GLG1
 golgi glycoprotein 1
chr7_-_121036337 0.18 ENST00000426156.1
ENST00000359943.3
ENST00000412653.1
 FAM3C
 family with sequence similarity 3, member C
chr20_+_5107420 0.18 ENST00000460006.1
 CDS2
 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2
chr11_-_79151695 0.16 ENST00000278550.7
 TENM4
 teneurin transmembrane protein 4
chr1_+_84543734 0.16 ENST00000370689.2
 PRKACB
 protein kinase, cAMP-dependent, catalytic, beta
chr16_+_30960375 0.15 ENST00000318663.4
ENST00000566237.1
ENST00000562699.1
 ORAI3
 ORAI calcium release-activated calcium modulator 3
chr5_-_142783175 0.15 ENST00000231509.3
ENST00000394464.2
 NR3C1
 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr12_+_12764773 0.15 ENST00000228865.2
 CREBL2
 cAMP responsive element binding protein-like 2
chr10_+_72575643 0.14 ENST00000373202.3
 SGPL1
 sphingosine-1-phosphate lyase 1
chr10_+_102295616 0.14 ENST00000299163.6
 HIF1AN
 hypoxia inducible factor 1, alpha subunit inhibitor
chr14_-_81687197 0.13 ENST00000553612.1
 GTF2A1
 general transcription factor IIA, 1, 19/37kDa
chr7_+_90225796 0.13 ENST00000380050.3
 CDK14
 cyclin-dependent kinase 14
chr20_+_60697480 0.12 ENST00000370915.1
ENST00000253001.4
ENST00000400318.2
ENST00000279068.6
ENST00000279069.7
 LSM14B
 LSM14B, SCD6 homolog B (S. cerevisiae)
chr10_+_111767720 0.10 ENST00000356080.4
ENST00000277900.8
 ADD3
 adducin 3 (gamma)
chr17_+_46985731 0.10 ENST00000360943.5
 UBE2Z
 ubiquitin-conjugating enzyme E2Z
chr17_+_68165657 0.10 ENST00000243457.3
 KCNJ2
 potassium inwardly-rectifying channel, subfamily J, member 2
chr11_+_94822968 0.10 ENST00000278505.4
 ENDOD1
 endonuclease domain containing 1
chr17_-_62340581 0.09 ENST00000258991.3
ENST00000583738.1
ENST00000584379.1
 TEX2
 testis expressed 2
chr20_+_30865429 0.08 ENST00000375712.3
 KIF3B
 kinesin family member 3B
chr17_-_40306934 0.07 ENST00000592574.1
ENST00000550406.1
ENST00000547517.1
ENST00000393860.3
ENST00000346213.4
 CTD-2132N18.3
RAB5C
 Uncharacterized protein
RAB5C, member RAS oncogene family
chr16_-_17564738 0.06 ENST00000261381.6
 XYLT1
 xylosyltransferase I
chr5_+_31193847 0.06 ENST00000514738.1
ENST00000265071.2
 CDH6
 cadherin 6, type 2, K-cadherin (fetal kidney)
chr20_+_43104508 0.06 ENST00000262605.4
ENST00000372904.3
 TTPAL
 tocopherol (alpha) transfer protein-like
chr20_+_43595115 0.06 ENST00000372806.3
ENST00000396731.4
ENST00000372801.1
ENST00000499879.2
 STK4
 serine/threonine kinase 4
chr15_+_73344791 0.04 ENST00000261908.6
 NEO1
 neogenin 1
chr9_+_91003271 0.04 ENST00000375859.3
ENST00000541629.1
 SPIN1
 spindlin 1
chr19_+_3572925 0.04 ENST00000333651.6
ENST00000417382.1
ENST00000453933.1
ENST00000262949.7
 HMG20B
 high mobility group 20B
chr3_-_169899504 0.04 ENST00000474275.1
ENST00000484931.1
ENST00000494943.1
ENST00000497658.1
ENST00000465896.1
ENST00000475729.1
ENST00000495893.2
ENST00000481639.1
ENST00000467570.1
ENST00000466189.1
 PHC3
 polyhomeotic homolog 3 (Drosophila)
chr1_-_204329013 0.01 ENST00000272203.3
ENST00000414478.1
 PLEKHA6
 pleckstrin homology domain containing, family A member 6
chr18_-_45456930 0.01 ENST00000262160.6
ENST00000587269.1
 SMAD2
 SMAD family member 2
chr2_+_24714729 0.01 ENST00000406961.1
ENST00000405141.1
 NCOA1
 nuclear receptor coactivator 1
chr6_-_53409890 0.00 ENST00000229416.6
 GCLC
 glutamate-cysteine ligase, catalytic subunit
chr1_+_78245303 0.00 ENST00000370791.3
ENST00000443751.2
 FAM73A
 family with sequence similarity 73, member A

Gene Ontology Analysis

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.2 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.0 2.4 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 1.6 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.0 0.7 PID NFKAPPAB CANONICAL PATHWAY Canonical NF-kappaB pathway
0.0 0.7 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.8 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 0.7 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 2.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.4 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.4 GO:0045160 myosin I complex(GO:0045160)
0.0 1.5 GO:0042101 T cell receptor complex(GO:0042101)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 3.2 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 3.4 GO:0005905 clathrin-coated pit(GO:0005905)
0.0 0.4 GO:0033010 paranodal junction(GO:0033010)
0.0 0.2 GO:0014802 terminal cisterna(GO:0014802)
0.0 1.6 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.1 GO:0005873 plus-end kinesin complex(GO:0005873)
0.0 0.8 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.3 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.0 0.4 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 2.0 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.5 GO:0016592 mediator complex(GO:0016592)
0.0 2.0 GO:0030496 midbody(GO:0030496)
0.0 0.3 GO:0032420 stereocilium(GO:0032420)
0.0 0.6 GO:0055038 recycling endosome membrane(GO:0055038)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0002605 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) negative regulation of dendritic cell antigen processing and presentation(GO:0002605)
0.5 1.6 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
0.5 2.4 GO:0030047 actin modification(GO:0030047)
0.4 3.2 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.3 0.8 GO:1904884 signal transduction involved in G2 DNA damage checkpoint(GO:0072425) signal transduction involved in mitotic G2 DNA damage checkpoint(GO:0072434) telomerase catalytic core complex assembly(GO:1904868) regulation of telomerase catalytic core complex assembly(GO:1904882) positive regulation of telomerase catalytic core complex assembly(GO:1904884)
0.2 0.8 GO:0044111 development involved in symbiotic interaction(GO:0044111)
0.1 0.4 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.1 0.8 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 3.4 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.1 1.6 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 0.8 GO:0061314 Notch signaling involved in heart development(GO:0061314)
0.1 0.4 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.1 0.2 GO:0032289 central nervous system myelin formation(GO:0032289)
0.1 1.6 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.1 0.3 GO:0045906 negative regulation of vasoconstriction(GO:0045906)
0.1 0.3 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 1.5 GO:0048846 axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284)
0.1 0.4 GO:0002175 protein localization to paranode region of axon(GO:0002175)
0.0 0.3 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.0 0.1 GO:0042264 peptidyl-aspartic acid hydroxylation(GO:0042264)
0.0 1.2 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 1.9 GO:0048009 insulin-like growth factor receptor signaling pathway(GO:0048009)
0.0 0.4 GO:0030202 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.0 0.2 GO:0097338 response to clozapine(GO:0097338)
0.0 0.3 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0 0.8 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.2 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.2 GO:0006655 phosphatidylglycerol biosynthetic process(GO:0006655)
0.0 0.1 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.0 0.3 GO:0061577 calcium ion transmembrane transport via high voltage-gated calcium channel(GO:0061577)
0.0 1.1 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.1 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 0.2 GO:0097264 self proteolysis(GO:0097264)
0.0 0.7 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.5 GO:0097237 cellular response to toxic substance(GO:0097237)
0.0 0.1 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.1 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.4 GO:0003091 renal water homeostasis(GO:0003091)
0.0 0.1 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0070052 collagen V binding(GO:0070052)
0.6 3.2 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.5 3.2 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.2 2.0 GO:0045159 myosin II binding(GO:0045159)
0.2 1.0 GO:0038049 transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049)
0.1 1.6 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.1 0.4 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.1 3.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 0.8 GO:0004677 DNA-dependent protein kinase activity(GO:0004677)
0.1 0.8 GO:0050815 phosphoserine binding(GO:0050815)
0.1 3.9 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 0.3 GO:0097001 ceramide binding(GO:0097001)
0.1 1.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 1.2 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.1 0.2 GO:0004605 phosphatidate cytidylyltransferase activity(GO:0004605)
0.0 0.8 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.4 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.3 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.1 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 0.7 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.2 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.0 0.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.2 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.4 GO:0003785 actin monomer binding(GO:0003785)
0.0 1.1 GO:0017048 Rho GTPase binding(GO:0017048)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.1 0.8 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 1.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 3.2 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.7 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.7 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 2.4 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.9 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 0.4 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0 0.5 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins