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ENCODE cell lines, expression (Ernst 2011)

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Results for AIRE

Z-value: 0.51

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Transcription factors associated with AIRE

Gene Symbol Gene ID Gene Info
AIRE
ENSG00000160224.12 AIRE

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
AIREhg19_v2_chr21_+_45705752_457057670.214.3e-01Click!

Activity profile of AIRE motif

Sorted Z-values of AIRE motif

Network of associatons between targets according to the STRING database.

First level regulatory network of AIRE

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr12_+_75874984 1.78 ENST00000550491.1
 GLIPR1
 GLI pathogenesis-related 1
chr16_+_32077386 1.67 ENST00000354689.6
 IGHV3OR16-9
 immunoglobulin heavy variable 3/OR16-9 (non-functional)
chr12_+_75874580 1.39 ENST00000456650.3
 GLIPR1
 GLI pathogenesis-related 1
chr17_-_38721711 1.08 ENST00000578085.1
ENST00000246657.2
 CCR7
 chemokine (C-C motif) receptor 7
chr11_+_35211511 0.86 ENST00000524922.1
 CD44
 CD44 molecule (Indian blood group)
chr13_-_46756351 0.76 ENST00000323076.2
 LCP1
 lymphocyte cytosolic protein 1 (L-plastin)
chr8_+_54764346 0.70 ENST00000297313.3
ENST00000344277.6
 RGS20
 regulator of G-protein signaling 20
chr12_+_75874460 0.70 ENST00000266659.3
 GLIPR1
 GLI pathogenesis-related 1
chr14_-_106668095 0.65 ENST00000390606.2
 IGHV3-20
 immunoglobulin heavy variable 3-20
chr2_-_225811747 0.59 ENST00000409592.3
 DOCK10
 dedicator of cytokinesis 10
chr5_+_118690466 0.53 ENST00000503646.1
 TNFAIP8
 tumor necrosis factor, alpha-induced protein 8
chr1_+_174843548 0.52 ENST00000478442.1
ENST00000465412.1
 RABGAP1L
 RAB GTPase activating protein 1-like
chr7_-_137028534 0.45 ENST00000348225.2
 PTN
 pleiotrophin
chr7_-_55606346 0.44 ENST00000545390.1
 VOPP1
 vesicular, overexpressed in cancer, prosurvival protein 1
chr7_-_137028498 0.44 ENST00000393083.2
 PTN
 pleiotrophin
chr14_-_55658252 0.44 ENST00000395425.2
 DLGAP5
 discs, large (Drosophila) homolog-associated protein 5
chr15_-_22448819 0.42 ENST00000604066.1
 IGHV1OR15-1
 immunoglobulin heavy variable 1/OR15-1 (non-functional)
chr14_-_55658323 0.40 ENST00000554067.1
ENST00000247191.2
 DLGAP5
 discs, large (Drosophila) homolog-associated protein 5
chr22_+_40322595 0.37 ENST00000420971.1
ENST00000544756.1
 GRAP2
 GRB2-related adaptor protein 2
chr22_+_40322623 0.36 ENST00000399090.2
 GRAP2
 GRB2-related adaptor protein 2
chr19_-_48753104 0.35 ENST00000447740.2
 CARD8
 caspase recruitment domain family, member 8
chr19_-_48752812 0.33 ENST00000359009.4
 CARD8
 caspase recruitment domain family, member 8
chr1_-_52456352 0.29 ENST00000371655.3
 RAB3B
 RAB3B, member RAS oncogene family
chr4_-_47465666 0.28 ENST00000381571.4
 COMMD8
 COMM domain containing 8
chr2_-_136633940 0.26 ENST00000264156.2
 MCM6
 minichromosome maintenance complex component 6
chr1_+_79115503 0.24 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
 IFI44
 interferon-induced protein 44
chr12_-_15038779 0.23 ENST00000228938.5
ENST00000539261.1
 MGP
 matrix Gla protein
chr19_-_36643329 0.23 ENST00000589154.1
 COX7A1
 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
chr19_+_18208603 0.23 ENST00000262811.6
 MAST3
 microtubule associated serine/threonine kinase 3
chr14_-_107283278 0.22 ENST00000390639.2
 IGHV7-81
 immunoglobulin heavy variable 7-81 (non-functional)
chr17_+_34171081 0.22 ENST00000585577.1
 TAF15
 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
chr4_-_57524061 0.21 ENST00000508121.1
 HOPX
 HOP homeobox
chr3_-_121264848 0.21 ENST00000264233.5
 POLQ
 polymerase (DNA directed), theta
chr8_-_145652336 0.21 ENST00000529182.1
ENST00000526054.1
 VPS28
 vacuolar protein sorting 28 homolog (S. cerevisiae)
chr2_+_62423242 0.20 ENST00000301998.4
 B3GNT2
 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
chr1_+_174670143 0.19 ENST00000367687.1
ENST00000347255.2
 RABGAP1L
 RAB GTPase activating protein 1-like
chr4_-_104119528 0.18 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
 CENPE
 centromere protein E, 312kDa
chr14_-_106967788 0.17 ENST00000390622.2
 IGHV1-46
 immunoglobulin heavy variable 1-46
chr12_-_25101920 0.17 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
 BCAT1
 branched chain amino-acid transaminase 1, cytosolic
chr4_-_120243545 0.16 ENST00000274024.3
 FABP2
 fatty acid binding protein 2, intestinal
chr12_+_12202774 0.15 ENST00000589718.1
 BCL2L14
 BCL2-like 14 (apoptosis facilitator)
chr15_+_85523671 0.15 ENST00000310298.4
ENST00000557957.1
 PDE8A
 phosphodiesterase 8A
chr12_+_12202785 0.15 ENST00000586576.1
ENST00000464885.2
 BCL2L14
 BCL2-like 14 (apoptosis facilitator)
chr12_-_6580094 0.15 ENST00000361716.3
 VAMP1
 vesicle-associated membrane protein 1 (synaptobrevin 1)
chr6_+_26538566 0.14 ENST00000377575.2
 HMGN4
 high mobility group nucleosomal binding domain 4
chr9_-_113761720 0.14 ENST00000541779.1
ENST00000374430.2
 LPAR1
 lysophosphatidic acid receptor 1
chr1_-_154600421 0.14 ENST00000368471.3
ENST00000292205.5
 ADAR
 adenosine deaminase, RNA-specific
chr17_+_41857793 0.13 ENST00000449302.3
 C17orf105
 chromosome 17 open reading frame 105
chr21_+_30502806 0.12 ENST00000399928.1
ENST00000399926.1
 MAP3K7CL
 MAP3K7 C-terminal like
chr5_-_77844974 0.12 ENST00000515007.2
 LHFPL2
 lipoma HMGIC fusion partner-like 2
chr9_-_70429731 0.11 ENST00000377413.1
 FOXD4L4
 forkhead box D4-like 4
chr4_+_76649797 0.11 ENST00000538159.1
ENST00000514213.2
 USO1
 USO1 vesicle transport factor
chr3_-_121468602 0.11 ENST00000340645.5
 GOLGB1
 golgin B1
chr12_-_6579808 0.11 ENST00000535180.1
ENST00000400911.3
 VAMP1
 vesicle-associated membrane protein 1 (synaptobrevin 1)
chr19_-_10491234 0.10 ENST00000524462.1
ENST00000531836.1
ENST00000525621.1
 TYK2
 tyrosine kinase 2
chr9_+_42717234 0.10 ENST00000377590.1
 FOXD4L2
 forkhead box D4-like 2
chr19_-_23869999 0.10 ENST00000601935.1
ENST00000359788.4
ENST00000600313.1
ENST00000596211.1
ENST00000599168.1
 ZNF675
 zinc finger protein 675
chr12_+_10658489 0.09 ENST00000538173.1
 EIF2S3L
 Putative eukaryotic translation initiation factor 2 subunit 3-like protein
chr5_+_32788945 0.09 ENST00000326958.1
 AC026703.1
 AC026703.1
chr7_+_20686946 0.09 ENST00000443026.2
ENST00000406935.1
 ABCB5
 ATP-binding cassette, sub-family B (MDR/TAP), member 5
chrX_-_153191708 0.08 ENST00000393721.1
ENST00000370028.3
 ARHGAP4
 Rho GTPase activating protein 4
chr3_-_121468513 0.08 ENST00000494517.1
ENST00000393667.3
 GOLGB1
 golgin B1
chr12_-_50677255 0.08 ENST00000551691.1
ENST00000394943.3
ENST00000341247.4
 LIMA1
 LIM domain and actin binding 1
chr2_+_201981527 0.08 ENST00000441224.1
 CFLAR
 CASP8 and FADD-like apoptosis regulator
chr1_-_161208013 0.08 ENST00000515452.1
ENST00000367983.4
 NR1I3
 nuclear receptor subfamily 1, group I, member 3
chr12_+_4758264 0.08 ENST00000266544.5
 NDUFA9
 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39kDa
chr9_-_104198042 0.07 ENST00000374855.4
 ALDOB
 aldolase B, fructose-bisphosphate
chr11_-_85376121 0.07 ENST00000527447.1
 CREBZF
 CREB/ATF bZIP transcription factor
chrX_-_139866723 0.06 ENST00000370532.2
 CDR1
 cerebellar degeneration-related protein 1, 34kDa
chr12_-_11463353 0.06 ENST00000279575.1
ENST00000535904.1
ENST00000445719.2
 PRB4
 proline-rich protein BstNI subfamily 4
chr15_-_38519066 0.06 ENST00000561320.1
ENST00000561161.1
 RP11-346D14.1
 RP11-346D14.1
chr15_+_52043758 0.06 ENST00000249700.4
ENST00000539962.2
 TMOD2
 tropomodulin 2 (neuronal)
chr7_-_64023441 0.05 ENST00000309683.6
 ZNF680
 zinc finger protein 680
chr1_+_152627927 0.05 ENST00000444515.1
ENST00000536536.1
 LINC00302
 long intergenic non-protein coding RNA 302
chr4_-_88450612 0.05 ENST00000418378.1
ENST00000282470.6
 SPARCL1
 SPARC-like 1 (hevin)
chrX_-_153191674 0.05 ENST00000350060.5
ENST00000370016.1
 ARHGAP4
 Rho GTPase activating protein 4
chr1_+_207669613 0.05 ENST00000367049.4
ENST00000529814.1
 CR1
 complement component (3b/4b) receptor 1 (Knops blood group)
chr3_-_123710199 0.05 ENST00000184183.4
 ROPN1
 rhophilin associated tail protein 1
chr9_-_70178815 0.05 ENST00000377420.1
 FOXD4L5
 forkhead box D4-like 5
chr1_-_161207986 0.04 ENST00000506209.1
ENST00000367980.2
 NR1I3
 nuclear receptor subfamily 1, group I, member 3
chr7_-_87936195 0.04 ENST00000414498.1
ENST00000301959.5
ENST00000380079.4
 STEAP4
 STEAP family member 4
chr1_+_207669573 0.04 ENST00000400960.2
ENST00000534202.1
 CR1
 complement component (3b/4b) receptor 1 (Knops blood group)
chr10_-_46030841 0.04 ENST00000453424.2
 MARCH8
 membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
chr6_+_42141029 0.04 ENST00000372958.1
 GUCA1A
 guanylate cyclase activator 1A (retina)
chr17_+_7210294 0.04 ENST00000336452.7
 EIF5A
 eukaryotic translation initiation factor 5A
chrX_-_49041242 0.04 ENST00000453382.1
ENST00000540849.1
ENST00000536904.1
ENST00000432913.1
 PRICKLE3
 prickle homolog 3 (Drosophila)
chr14_+_21236586 0.03 ENST00000326783.3
 EDDM3B
 epididymal protein 3B
chr17_+_3323862 0.03 ENST00000291231.1
 OR3A3
 olfactory receptor, family 3, subfamily A, member 3
chr12_+_12223867 0.03 ENST00000308721.5
 BCL2L14
 BCL2-like 14 (apoptosis facilitator)
chr12_-_76462713 0.03 ENST00000552056.1
 NAP1L1
 nucleosome assembly protein 1-like 1
chr12_+_20963647 0.03 ENST00000381545.3
 SLCO1B3
 solute carrier organic anion transporter family, member 1B3
chr1_-_167883327 0.03 ENST00000476818.2
ENST00000367851.4
ENST00000367848.1
 ADCY10
 adenylate cyclase 10 (soluble)
chr2_+_1417228 0.03 ENST00000382269.3
ENST00000337415.3
ENST00000345913.4
ENST00000346956.3
ENST00000349624.3
ENST00000539820.1
ENST00000329066.4
ENST00000382201.3
 TPO
 thyroid peroxidase
chr6_+_26104104 0.03 ENST00000377803.2
 HIST1H4C
 histone cluster 1, H4c
chr22_-_32767017 0.02 ENST00000400234.1
 RFPL3S
 RFPL3 antisense
chr19_-_59084922 0.02 ENST00000215057.2
ENST00000599369.1
 MZF1
 myeloid zinc finger 1
chr1_+_100810575 0.02 ENST00000542213.1
 CDC14A
 cell division cycle 14A
chr9_+_71986182 0.01 ENST00000303068.7
 FAM189A2
 family with sequence similarity 189, member A2
chr22_+_25202232 0.01 ENST00000400358.4
ENST00000400359.4
 SGSM1
 small G protein signaling modulator 1
chr6_-_31514516 0.01 ENST00000303892.5
ENST00000483251.1
 ATP6V1G2
 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr12_-_6579833 0.01 ENST00000396308.3
 VAMP1
 vesicle-associated membrane protein 1 (synaptobrevin 1)
chr15_+_27112948 0.01 ENST00000555060.1
 GABRA5
 gamma-aminobutyric acid (GABA) A receptor, alpha 5
chr16_+_3254247 0.01 ENST00000304646.2
 OR1F1
 olfactory receptor, family 1, subfamily F, member 1
chr2_-_166060571 0.00 ENST00000360093.3
 SCN3A
 sodium channel, voltage-gated, type III, alpha subunit
chr6_-_32806506 0.00 ENST00000374897.2
ENST00000452392.2
 TAP2
TAP2
 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
Uncharacterized protein
chr6_-_31514333 0.00 ENST00000376151.4
 ATP6V1G2
 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr1_-_158300747 0.00 ENST00000451207.1
 CD1B
 CD1b molecule
chr20_-_33735070 0.00 ENST00000374491.3
ENST00000542871.1
ENST00000374492.3
 EDEM2
 ER degradation enhancer, mannosidase alpha-like 2
chr20_-_43150601 0.00 ENST00000541235.1
ENST00000255175.1
ENST00000342374.4
 SERINC3
 serine incorporator 3

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
0.1 3.0 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.7 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.1 4.1 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.8 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.8 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.2 GO:0000813 ESCRT I complex(GO:0000813)
0.0 0.1 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.2 GO:1990023 mitotic spindle midzone(GO:1990023)
0.0 0.3 GO:0042555 MCM complex(GO:0042555)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0032089 NACHT domain binding(GO:0032089)
0.2 0.9 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
0.1 1.1 GO:0019957 C-C chemokine binding(GO:0019957)
0.1 0.2 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.1 3.0 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.0 0.2 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.1 GO:0003726 double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0 0.1 GO:0004877 complement component C4b receptor activity(GO:0001861) complement component C3b receptor activity(GO:0004877)
0.0 0.9 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.2 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.0 0.2 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0 0.1 GO:0004882 androgen receptor activity(GO:0004882)
0.0 0.4 GO:0004871 signal transducer activity(GO:0004871)
0.0 0.1 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
0.0 0.1 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.5 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 0.3 GO:0031489 myosin V binding(GO:0031489)
0.0 0.0 GO:0052851 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.7 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.9 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 0.9 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.8 PID AURORA A PATHWAY Aurora A signaling
0.0 0.7 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 0.6 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.0 0.1 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:2000525 dendritic cell dendrite assembly(GO:0097026) regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) regulation of dendritic cell dendrite assembly(GO:2000547)
0.3 0.9 GO:1904395 retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.2 1.0 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.1 0.9 GO:1900623 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.1 0.2 GO:2000395 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328) ubiquitin-dependent endocytosis(GO:0070086) regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
0.1 0.2 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.1 0.7 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713)
0.1 0.3 GO:0018125 peptidyl-cysteine methylation(GO:0018125) positive regulation of neurotransmitter uptake(GO:0051582) positive regulation of dopamine uptake involved in synaptic transmission(GO:0051586) positive regulation of catecholamine uptake involved in synaptic transmission(GO:0051944)
0.0 0.6 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.8 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.1 GO:1900369 regulation of RNA interference(GO:1900368) negative regulation of RNA interference(GO:1900369)
0.0 3.0 GO:0006910 phagocytosis, recognition(GO:0006910)
0.0 0.1 GO:1904566 response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904565) cellular response to 1-oleoyl-sn-glycerol 3-phosphate(GO:1904566)
0.0 0.1 GO:0030451 regulation of complement activation, alternative pathway(GO:0030451) negative regulation of complement activation, alternative pathway(GO:0045957)
0.0 0.2 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.0 0.2 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0 0.3 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.1 GO:0006001 fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.0 0.1 GO:0048749 compound eye development(GO:0048749)
0.0 0.1 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.0 0.3 GO:0035493 SNARE complex assembly(GO:0035493)
0.0 0.1 GO:2000660 negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.0 0.1 GO:0010764 negative regulation of fibroblast migration(GO:0010764)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.9 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.0 3.9 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.2 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.0 1.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.3 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 0.7 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.0 0.7 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events