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ENCODE cell lines, expression (Ernst 2011)

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Results for AR_NR3C2

Z-value: 1.30

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Transcription factors associated with AR_NR3C2

Gene Symbol Gene ID Gene Info
AR
ENSG00000169083.11 AR
NR3C2
ENSG00000151623.10 NR3C2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ARhg19_v2_chrX_+_66764375_667644650.292.7e-01Click!
NR3C2hg19_v2_chr4_-_149365827_149365870,
hg19_v2_chr4_-_149363662_149363688		0.165.5e-01Click!

Activity profile of AR_NR3C2 motif

Sorted Z-values of AR_NR3C2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of AR_NR3C2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr16_+_56659687 8.85 ENST00000568293.1
ENST00000330439.6
 MT1E
 metallothionein 1E
chr16_+_56642041 7.52 ENST00000245185.5
 MT2A
 metallothionein 2A
chr16_+_56642489 6.60 ENST00000561491.1
 MT2A
 metallothionein 2A
chr16_+_56716336 6.21 ENST00000394485.4
ENST00000562939.1
 MT1X
 metallothionein 1X
chr8_-_49834299 5.21 ENST00000396822.1
 SNAI2
 snail family zinc finger 2
chr8_-_49833978 4.83 ENST00000020945.1
 SNAI2
 snail family zinc finger 2
chr7_-_94285402 3.04 ENST00000428696.2
ENST00000445866.2
 SGCE
 sarcoglycan, epsilon
chr7_-_94285511 3.03 ENST00000265735.7
 SGCE
 sarcoglycan, epsilon
chr2_+_238395879 2.84 ENST00000445024.2
ENST00000338530.4
ENST00000409373.1
 MLPH
 melanophilin
chr2_+_238395803 2.74 ENST00000264605.3
 MLPH
 melanophilin
chr16_+_56672571 2.72 ENST00000290705.8
 MT1A
 metallothionein 1A
chr16_+_56666563 2.61 ENST00000570233.1
 MT1M
 metallothionein 1M
chr4_+_75310851 2.50 ENST00000395748.3
ENST00000264487.2
 AREG
 amphiregulin
chr11_+_18287721 2.48 ENST00000356524.4
 SAA1
 serum amyloid A1
chr11_+_18287801 2.38 ENST00000532858.1
ENST00000405158.2
 SAA1
 serum amyloid A1
chr4_+_75311019 2.38 ENST00000502307.1
 AREG
 amphiregulin
chr4_+_75480629 2.35 ENST00000380846.3
 AREGB
 amphiregulin B
chr7_-_94285472 1.56 ENST00000437425.2
ENST00000447873.1
ENST00000415788.2
 SGCE
 sarcoglycan, epsilon
chr5_+_140186647 1.24 ENST00000512229.2
ENST00000356878.4
ENST00000530339.1
 PCDHA4
 protocadherin alpha 4
chr8_+_9046503 1.08 ENST00000512942.2
 RP11-10A14.5
 RP11-10A14.5
chrX_+_17755563 0.99 ENST00000380045.3
ENST00000380041.3
ENST00000380043.3
ENST00000398080.1
 SCML1
 sex comb on midleg-like 1 (Drosophila)
chr18_+_56530136 0.89 ENST00000591083.1
 ZNF532
 zinc finger protein 532
chr18_+_7754957 0.83 ENST00000400053.4
 PTPRM
 protein tyrosine phosphatase, receptor type, M
chr6_-_111927062 0.74 ENST00000359831.4
 TRAF3IP2
 TRAF3 interacting protein 2
chrX_+_2609317 0.73 ENST00000381187.3
ENST00000381184.1
 CD99
 CD99 molecule
chrX_+_2609356 0.70 ENST00000381180.3
ENST00000449611.1
 CD99
 CD99 molecule
chrX_+_2609207 0.66 ENST00000381192.3
 CD99
 CD99 molecule
chr12_+_53443680 0.65 ENST00000314250.6
ENST00000451358.1
 TENC1
 tensin like C1 domain containing phosphatase (tensin 2)
chr7_+_94285637 0.62 ENST00000482108.1
ENST00000488574.1
 PEG10
 paternally expressed 10
chr16_+_67207838 0.61 ENST00000566871.1
ENST00000268605.7
 NOL3
 nucleolar protein 3 (apoptosis repressor with CARD domain)
chr1_-_145715565 0.55 ENST00000369288.2
ENST00000369290.1
ENST00000401557.3
 CD160
 CD160 molecule
chr12_+_125549925 0.54 ENST00000316519.6
 AACS
 acetoacetyl-CoA synthetase
chr16_-_66584059 0.53 ENST00000417693.3
ENST00000544898.1
ENST00000569718.1
ENST00000527284.1
ENST00000299697.7
ENST00000451102.2
 TK2
 thymidine kinase 2, mitochondrial
chr8_-_62602327 0.52 ENST00000445642.3
ENST00000517847.2
ENST00000389204.4
ENST00000517661.1
ENST00000517903.1
ENST00000522603.1
ENST00000522349.1
ENST00000522835.1
ENST00000541428.1
ENST00000518306.1
 ASPH
 aspartate beta-hydroxylase
chr14_-_107211459 0.51 ENST00000390636.2
 IGHV3-73
 immunoglobulin heavy variable 3-73
chr16_+_67207872 0.51 ENST00000563258.1
ENST00000568146.1
 NOL3
 nucleolar protein 3 (apoptosis repressor with CARD domain)
chr22_+_23046750 0.51 ENST00000390307.2
 IGLV3-22
 immunoglobulin lambda variable 3-22 (gene/pseudogene)
chr15_+_31658349 0.45 ENST00000558844.1
 KLF13
 Kruppel-like factor 13
chr12_+_125549973 0.44 ENST00000536752.1
ENST00000261686.6
 AACS
 acetoacetyl-CoA synthetase
chr12_+_53443963 0.43 ENST00000546602.1
ENST00000552570.1
ENST00000549700.1
 TENC1
 tensin like C1 domain containing phosphatase (tensin 2)
chr8_+_91013577 0.42 ENST00000220764.2
 DECR1
 2,4-dienoyl CoA reductase 1, mitochondrial
chr19_+_35630344 0.39 ENST00000455515.2
 FXYD1
 FXYD domain containing ion transport regulator 1
chr1_-_27693349 0.36 ENST00000374040.3
ENST00000357582.2
ENST00000493901.1
 MAP3K6
 mitogen-activated protein kinase kinase kinase 6
chr17_+_41323204 0.33 ENST00000542611.1
ENST00000590996.1
ENST00000389312.4
ENST00000589872.1
 NBR1
 neighbor of BRCA1 gene 1
chr12_+_66582919 0.33 ENST00000545837.1
ENST00000457197.2
 IRAK3
 interleukin-1 receptor-associated kinase 3
chr11_-_506739 0.33 ENST00000529306.1
ENST00000438658.2
ENST00000527485.1
ENST00000397615.2
ENST00000397614.1
 RNH1
 ribonuclease/angiogenin inhibitor 1
chr17_-_19290117 0.30 ENST00000497081.2
 MFAP4
 microfibrillar-associated protein 4
chr4_-_8442438 0.28 ENST00000356406.5
ENST00000413009.2
 ACOX3
 acyl-CoA oxidase 3, pristanoyl
chr17_+_38333263 0.27 ENST00000456989.2
ENST00000543876.1
ENST00000544503.1
ENST00000264644.6
ENST00000538884.1
 RAPGEFL1
 Rap guanine nucleotide exchange factor (GEF)-like 1
chr2_+_27435179 0.27 ENST00000606999.1
ENST00000405489.3
 ATRAID
 all-trans retinoic acid-induced differentiation factor
chr19_+_57874835 0.25 ENST00000543226.1
ENST00000596755.1
ENST00000282282.3
ENST00000597658.1
 TRAPPC2P1
ZNF547
AC003002.4
 trafficking protein particle complex 2 pseudogene 1
zinc finger protein 547
Uncharacterized protein
chr8_-_21669826 0.23 ENST00000517328.1
 GFRA2
 GDNF family receptor alpha 2
chr19_-_8408139 0.22 ENST00000330915.3
ENST00000593649.1
ENST00000595639.1
 KANK3
 KN motif and ankyrin repeat domains 3
chr17_-_19290483 0.20 ENST00000395592.2
ENST00000299610.4
 MFAP4
 microfibrillar-associated protein 4
chr12_-_10251603 0.20 ENST00000457018.2
 CLEC1A
 C-type lectin domain family 1, member A
chr8_+_91013676 0.19 ENST00000519410.1
ENST00000522161.1
ENST00000517761.1
ENST00000520227.1
 DECR1
 2,4-dienoyl CoA reductase 1, mitochondrial
chr1_+_22979676 0.16 ENST00000432749.2
ENST00000314933.6
 C1QB
 complement component 1, q subcomponent, B chain
chr1_+_22979474 0.16 ENST00000509305.1
 C1QB
 complement component 1, q subcomponent, B chain
chr19_+_35630926 0.15 ENST00000588081.1
ENST00000589121.1
 FXYD1
 FXYD domain containing ion transport regulator 1
chr3_-_58563094 0.13 ENST00000464064.1
 FAM107A
 family with sequence similarity 107, member A
chr19_+_35630628 0.13 ENST00000588715.1
ENST00000588607.1
 FXYD1
 FXYD domain containing ion transport regulator 1
chr19_+_58570605 0.12 ENST00000359978.6
ENST00000401053.4
ENST00000439855.2
ENST00000313434.5
ENST00000511556.1
ENST00000506786.1
 ZNF135
 zinc finger protein 135
chr16_-_67978016 0.10 ENST00000264005.5
 LCAT
 lecithin-cholesterol acyltransferase
chr17_-_16472483 0.09 ENST00000395824.1
ENST00000448349.2
ENST00000395825.3
 ZNF287
 zinc finger protein 287
chr15_+_42694573 0.08 ENST00000397200.4
ENST00000569827.1
 CAPN3
 calpain 3, (p94)
chr1_+_76262552 0.08 ENST00000263187.3
 MSH4
 mutS homolog 4
chr22_+_19939026 0.07 ENST00000406520.3
 COMT
 catechol-O-methyltransferase
chr19_-_14117074 0.06 ENST00000588885.1
ENST00000254325.4
 RFX1
 regulatory factor X, 1 (influences HLA class II expression)
chr12_-_56615693 0.06 ENST00000394013.2
ENST00000345093.4
ENST00000551711.1
ENST00000552656.1
 RNF41
 ring finger protein 41
chr11_+_114270752 0.05 ENST00000540163.1
 RBM7
 RNA binding motif protein 7
chr5_-_179499086 0.05 ENST00000261947.4
 RNF130
 ring finger protein 130
chr2_+_242577027 0.05 ENST00000402096.1
ENST00000404914.3
 ATG4B
 autophagy related 4B, cysteine peptidase
chr12_-_11002063 0.05 ENST00000544994.1
ENST00000228811.4
ENST00000540107.1
 PRR4
 proline rich 4 (lacrimal)
chr5_-_179499108 0.04 ENST00000521389.1
 RNF130
 ring finger protein 130
chr19_+_54704610 0.02 ENST00000302907.4
 RPS9
 ribosomal protein S9
chr4_-_69215467 0.01 ENST00000579690.1
 YTHDC1
 YTH domain containing 1
chr2_+_102953608 0.01 ENST00000311734.2
ENST00000409584.1
 IL1RL1
 interleukin 1 receptor-like 1
chr3_+_13521665 0.00 ENST00000295757.3
ENST00000402259.1
ENST00000402271.1
ENST00000446613.2
ENST00000404548.1
ENST00000404040.1
 HDAC11
 histone deacetylase 11
chr5_-_179498703 0.00 ENST00000522208.2
 RNF130
 ring finger protein 130

Gene Ontology Analysis

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.9 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 4.9 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.1 14.1 PID AP1 PATHWAY AP-1 transcription factor network
0.1 9.2 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 14.1 GO:0046870 cadmium ion binding(GO:0046870)
0.2 0.5 GO:0004137 deoxycytidine kinase activity(GO:0004137) thymidine kinase activity(GO:0004797)
0.2 0.6 GO:0008670 2,4-dienoyl-CoA reductase (NADPH) activity(GO:0008670)
0.1 1.1 GO:0035877 death effector domain binding(GO:0035877)
0.1 4.9 GO:0042056 chemoattractant activity(GO:0042056)
0.1 1.0 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
0.1 4.9 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 9.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 5.6 GO:0017022 myosin binding(GO:0017022)
0.1 0.3 GO:0016402 pristanoyl-CoA oxidase activity(GO:0016402)
0.0 0.5 GO:0032393 MHC class I receptor activity(GO:0032393)
0.0 0.2 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.0 0.8 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.1 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.0 20.1 GO:0008270 zinc ion binding(GO:0008270)
0.0 0.5 GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors(GO:0016706)
0.0 0.5 GO:0003823 antigen binding(GO:0003823)
0.0 0.7 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.4 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.9 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 14.1 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.6 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.3 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.5 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 10.0 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
2.8 14.1 GO:1990169 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
1.0 6.2 GO:0036018 cellular response to erythropoietin(GO:0036018)
0.6 4.9 GO:0060744 thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.6 14.2 GO:0071294 cellular response to zinc ion(GO:0071294)
0.4 5.6 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.4 1.1 GO:0014876 response to injury involved in regulation of muscle adaptation(GO:0014876)
0.2 0.5 GO:0018197 peptidyl-aspartic acid modification(GO:0018197) peptidyl-aspartic acid hydroxylation(GO:0042264)
0.2 1.0 GO:0034201 response to oleic acid(GO:0034201)
0.1 0.5 GO:0046104 thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
0.1 4.9 GO:0050716 positive regulation of interleukin-1 secretion(GO:0050716)
0.1 0.7 GO:0010734 protein glutathionylation(GO:0010731) regulation of protein glutathionylation(GO:0010732) negative regulation of protein glutathionylation(GO:0010734)
0.1 0.3 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.0 0.5 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.4 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.7 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.0 0.8 GO:0010842 retina layer formation(GO:0010842)
0.0 0.2 GO:0033689 negative regulation of osteoblast proliferation(GO:0033689)
0.0 0.1 GO:0090107 regulation of high-density lipoprotein particle assembly(GO:0090107)
0.0 0.2 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0 6.8 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 0.3 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.0 0.1 GO:0031337 cellular response to phosphate starvation(GO:0016036) positive regulation of sulfur amino acid metabolic process(GO:0031337) positive regulation of homocysteine metabolic process(GO:0050668)
0.0 0.1 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 7.6 GO:0016012 sarcoglycan complex(GO:0016012)
0.2 4.9 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.1 0.5 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.1 0.3 GO:0005602 complement component C1 complex(GO:0005602)
0.1 4.9 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 0.5 GO:0071953 elastic fiber(GO:0071953)
0.0 5.6 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.7 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 30.5 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 0.5 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.1 GO:0005713 recombination nodule(GO:0005713)
0.0 7.5 GO:0000790 nuclear chromatin(GO:0000790)
0.0 1.1 GO:0016529 sarcoplasmic reticulum(GO:0016529)