Project

ENCODE cell lines, expression (Ernst 2011)

Navigation
Downloads

Results for ATF4

Z-value: 1.09

Motif logo

logo of

Transcription factors associated with ATF4

Gene Symbol Gene ID Gene Info
ATF4
ENSG00000128272.10 ATF4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ATF4hg19_v2_chr22_+_39916558_39916579-0.185.0e-01Click!

Activity profile of ATF4 motif

Sorted Z-values of ATF4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:

Promoter Score Transcript Gene Gene Info
chr17_+_1665253 3.57 ENST00000254722.4
 SERPINF1
 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr17_+_1665345 3.08 ENST00000576406.1
ENST00000571149.1
 SERPINF1
 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr17_-_79895097 2.15 ENST00000402252.2
ENST00000583564.1
ENST00000585244.1
ENST00000337943.5
ENST00000579698.1
 PYCR1
 pyrroline-5-carboxylate reductase 1
chr17_-_79895154 2.15 ENST00000405481.4
ENST00000585215.1
ENST00000577624.1
ENST00000403172.4
 PYCR1
 pyrroline-5-carboxylate reductase 1
chr8_-_38008783 2.14 ENST00000276449.4
 STAR
 steroidogenic acute regulatory protein
chr12_+_57849048 1.97 ENST00000266646.2
 INHBE
 inhibin, beta E
chrX_+_9431324 1.83 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
 TBL1X
 transducin (beta)-like 1X-linked
chr21_-_44495919 1.69 ENST00000398158.1
 CBS
 cystathionine-beta-synthase
chr21_-_44495964 1.68 ENST00000398168.1
ENST00000398165.3
 CBS
 cystathionine-beta-synthase
chr9_-_99381660 1.64 ENST00000375240.3
ENST00000463569.1
 CDC14B
 cell division cycle 14B
chr12_+_93963590 1.56 ENST00000340600.2
 SOCS2
 suppressor of cytokine signaling 2
chr12_+_57624085 1.34 ENST00000553474.1
 SHMT2
 serine hydroxymethyltransferase 2 (mitochondrial)
chr14_+_24563510 1.33 ENST00000545054.2
ENST00000561286.1
ENST00000558096.1
 PCK2
 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr19_-_47288162 1.22 ENST00000594991.1
 SLC1A5
 solute carrier family 1 (neutral amino acid transporter), member 5
chr14_+_24563262 1.20 ENST00000559250.1
ENST00000216780.4
ENST00000560736.1
ENST00000396973.4
ENST00000559837.1
 PCK2
 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr1_-_38412683 1.11 ENST00000373024.3
ENST00000373023.2
 INPP5B
 inositol polyphosphate-5-phosphatase, 75kDa
chr19_-_47287990 1.05 ENST00000593713.1
ENST00000598022.1
ENST00000434726.2
 SLC1A5
 solute carrier family 1 (neutral amino acid transporter), member 5
chr12_-_57914275 1.03 ENST00000547303.1
ENST00000552740.1
ENST00000547526.1
ENST00000551116.1
ENST00000346473.3
 DDIT3
 DNA-damage-inducible transcript 3
chr19_+_11350278 0.94 ENST00000252453.8
 C19orf80
 chromosome 19 open reading frame 80
chr1_+_212782012 0.89 ENST00000341491.4
ENST00000366985.1
 ATF3
 activating transcription factor 3
chr12_+_57624119 0.89 ENST00000555773.1
ENST00000554975.1
ENST00000449049.3
ENST00000393827.4
 SHMT2
 serine hydroxymethyltransferase 2 (mitochondrial)
chr17_-_46703826 0.88 ENST00000550387.1
ENST00000311177.5
 HOXB9
 homeobox B9
chr12_+_57623477 0.87 ENST00000557487.1
ENST00000555634.1
ENST00000556689.1
 SHMT2
 serine hydroxymethyltransferase 2 (mitochondrial)
chr12_+_57623869 0.83 ENST00000414700.3
ENST00000557703.1
 SHMT2
 serine hydroxymethyltransferase 2 (mitochondrial)
chr1_-_149832704 0.82 ENST00000392933.1
ENST00000369157.2
ENST00000392932.4
 HIST2H4B
 histone cluster 2, H4b
chr10_-_101190202 0.80 ENST00000543866.1
ENST00000370508.5
 GOT1
 glutamic-oxaloacetic transaminase 1, soluble
chr16_-_70323422 0.77 ENST00000261772.8
 AARS
 alanyl-tRNA synthetase
chr9_+_100745615 0.72 ENST00000339399.4
 ANP32B
 acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr1_+_149804218 0.71 ENST00000610125.1
 HIST2H4A
 histone cluster 2, H4a
chr9_+_80912059 0.71 ENST00000347159.2
ENST00000376588.3
 PSAT1
 phosphoserine aminotransferase 1
chr14_-_92413727 0.65 ENST00000267620.10
 FBLN5
 fibulin 5
chr12_-_25101920 0.64 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
 BCAT1
 branched chain amino-acid transaminase 1, cytosolic
chr11_+_118955583 0.61 ENST00000278715.3
ENST00000536813.1
ENST00000537841.1
ENST00000542729.1
ENST00000546302.1
ENST00000442944.2
ENST00000544387.1
ENST00000543090.1
 HMBS
 hydroxymethylbilane synthase
chr14_-_92413353 0.60 ENST00000556154.1
 FBLN5
 fibulin 5
chr16_-_18908196 0.59 ENST00000565324.1
ENST00000561947.1
 SMG1
 SMG1 phosphatidylinositol 3-kinase-related kinase
chr17_-_77813186 0.56 ENST00000448310.1
ENST00000269397.4
 CBX4
 chromobox homolog 4
chr1_+_33283043 0.55 ENST00000373476.1
ENST00000373475.5
ENST00000529027.1
ENST00000398243.3
 S100PBP
 S100P binding protein
chr1_-_220219775 0.54 ENST00000609181.1
 EPRS
 glutamyl-prolyl-tRNA synthetase
chr12_-_25102252 0.47 ENST00000261192.7
 BCAT1
 branched chain amino-acid transaminase 1, cytosolic
chr5_-_145562147 0.44 ENST00000545646.1
ENST00000274562.9
ENST00000510191.1
ENST00000394434.2
 LARS
 leucyl-tRNA synthetase
chr1_-_220220000 0.43 ENST00000366923.3
 EPRS
 glutamyl-prolyl-tRNA synthetase
chr11_-_33913708 0.41 ENST00000257818.2
 LMO2
 LIM domain only 2 (rhombotin-like 1)
chr17_-_76836963 0.40 ENST00000312010.6
 USP36
 ubiquitin specific peptidase 36
chr3_+_148415571 0.37 ENST00000497524.1
ENST00000349243.3
ENST00000542281.1
ENST00000418473.2
ENST00000404754.2
 AGTR1
 angiotensin II receptor, type 1
chr5_+_33441053 0.35 ENST00000541634.1
ENST00000455217.2
ENST00000414361.2
 TARS
 threonyl-tRNA synthetase
chr22_+_50919995 0.35 ENST00000362068.2
ENST00000395737.1
 ADM2
 adrenomedullin 2
chr22_+_42229100 0.34 ENST00000361204.4
 SREBF2
 sterol regulatory element binding transcription factor 2
chr5_+_44809027 0.34 ENST00000507110.1
 MRPS30
 mitochondrial ribosomal protein S30
chr22_+_50919944 0.33 ENST00000395738.2
 ADM2
 adrenomedullin 2
chr3_-_33686743 0.33 ENST00000333778.6
ENST00000539981.1
 CLASP2
 cytoplasmic linker associated protein 2
chr12_-_10324716 0.32 ENST00000545927.1
ENST00000432556.2
ENST00000309539.3
ENST00000544577.1
 OLR1
 oxidized low density lipoprotein (lectin-like) receptor 1
chr20_+_8112824 0.32 ENST00000378641.3
 PLCB1
 phospholipase C, beta 1 (phosphoinositide-specific)
chr7_-_50860565 0.31 ENST00000403097.1
 GRB10
 growth factor receptor-bound protein 10
chrX_+_24072833 0.31 ENST00000253039.4
 EIF2S3
 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
chr7_+_30634297 0.31 ENST00000389266.3
 GARS
 glycyl-tRNA synthetase
chr5_+_33440802 0.29 ENST00000502553.1
ENST00000514259.1
ENST00000265112.3
 TARS
 threonyl-tRNA synthetase
chr1_+_228353495 0.29 ENST00000366711.3
 IBA57
 IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
chr17_+_56315936 0.26 ENST00000543544.1
 LPO
 lactoperoxidase
chr1_+_154244987 0.24 ENST00000328703.7
ENST00000457918.2
ENST00000483970.2
ENST00000435087.1
ENST00000532105.1
 HAX1
 HCLS1 associated protein X-1
chr14_-_25045446 0.23 ENST00000216336.2
 CTSG
 cathepsin G
chr7_+_99006232 0.21 ENST00000403633.2
 BUD31
 BUD31 homolog (S. cerevisiae)
chr10_+_111765562 0.20 ENST00000360162.3
 ADD3
 adducin 3 (gamma)
chr11_-_8680383 0.20 ENST00000299550.6
 TRIM66
 tripartite motif containing 66
chr17_-_76836729 0.18 ENST00000587783.1
ENST00000542802.3
ENST00000586531.1
ENST00000589424.1
ENST00000590546.2
 USP36
 ubiquitin specific peptidase 36
chr1_+_162602244 0.16 ENST00000367922.3
ENST00000367921.3
 DDR2
 discoidin domain receptor tyrosine kinase 2
chr10_+_63661053 0.15 ENST00000279873.7
 ARID5B
 AT rich interactive domain 5B (MRF1-like)
chr12_-_50298000 0.14 ENST00000550635.2
 FAIM2
 Fas apoptotic inhibitory molecule 2
chr16_+_67694849 0.11 ENST00000602551.1
ENST00000458121.2
ENST00000219255.3
 PARD6A
 par-6 family cell polarity regulator alpha
chr1_-_44497118 0.11 ENST00000537678.1
ENST00000466926.1
 SLC6A9
 solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr1_-_167883327 0.10 ENST00000476818.2
ENST00000367851.4
ENST00000367848.1
 ADCY10
 adenylate cyclase 10 (soluble)
chr1_-_167883353 0.07 ENST00000545172.1
 ADCY10
 adenylate cyclase 10 (soluble)
chr4_+_77870856 0.05 ENST00000264893.6
ENST00000502584.1
ENST00000510641.1
 SEPT11
 septin 11
chr12_-_50297638 0.05 ENST00000320634.3
 FAIM2
 Fas apoptotic inhibitory molecule 2
chr7_+_99006550 0.02 ENST00000222969.5
 BUD31
 BUD31 homolog (S. cerevisiae)
chr16_-_67694597 0.02 ENST00000393919.4
ENST00000219251.8
 ACD
 adrenocortical dysplasia homolog (mouse)

Gene Ontology Analysis

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 6.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.5 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 1.5 PID IL2 1PATHWAY IL2-mediated signaling events
0.0 1.9 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 1.1 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.8 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.3 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.6 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.1 2.0 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 3.4 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 1.0 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 1.8 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.1 2.1 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.1 2.0 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 1.1 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 2.4 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.6 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 1.6 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 1.2 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0 0.6 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.3 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.6 6.7 GO:0043203 axon hillock(GO:0043203)
0.5 3.9 GO:0070552 BRISC complex(GO:0070552)
0.3 2.1 GO:0030061 mitochondrial crista(GO:0030061)
0.1 1.0 GO:0097452 GAIT complex(GO:0097452)
0.1 1.3 GO:0071953 elastic fiber(GO:0071953)
0.1 0.3 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.1 0.3 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.6 GO:0035102 PRC1 complex(GO:0035102)
0.0 0.3 GO:0045180 basal cortex(GO:0045180)
0.0 1.8 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.4 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 7.4 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 1.1 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 1.6 GO:0000922 spindle pole(GO:0000922)
0.0 1.8 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.4 GO:0004122 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809)
1.1 4.3 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.8 2.5 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.6 3.9 GO:0004793 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.3 2.3 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
0.3 0.8 GO:0080130 phosphatidylserine decarboxylase activity(GO:0004609) L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.3 1.6 GO:0008269 JAK pathway signal transduction adaptor activity(GO:0008269)
0.3 0.8 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.2 0.6 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.2 1.1 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1 0.4 GO:0004819 glutamine-tRNA ligase activity(GO:0004819) valine-tRNA ligase activity(GO:0004832)
0.1 0.4 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.1 2.1 GO:0017127 cholesterol transporter activity(GO:0017127)
0.1 1.1 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.1 1.0 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 6.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.7 GO:0008483 transaminase activity(GO:0008483)
0.1 1.0 GO:0035613 RNA stem-loop binding(GO:0035613)
0.0 1.6 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 0.2 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.0 2.0 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.6 GO:0019789 SUMO transferase activity(GO:0019789) SUMO binding(GO:0032183)
0.0 0.3 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0 0.1 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.0 0.3 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.0 1.8 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.2 GO:0019966 interleukin-1 binding(GO:0019966)
0.0 0.3 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.3 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 0.6 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 0.3 GO:0005521 lamin binding(GO:0005521)
0.0 0.7 GO:0070063 RNA polymerase binding(GO:0070063)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 6.7 GO:0071279 cellular response to cobalt ion(GO:0071279)
1.1 3.4 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
0.7 4.3 GO:0055129 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.7 2.1 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894)
0.6 2.3 GO:1903803 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.6 3.9 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
0.3 2.5 GO:0006116 NADH oxidation(GO:0006116)
0.3 0.9 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.3 0.8 GO:0006106 fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533)
0.3 0.8 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.2 0.9 GO:0032792 negative regulation of CREB transcription factor activity(GO:0032792)
0.2 0.6 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
0.2 1.1 GO:0009099 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.2 0.3 GO:0090427 activation of meiosis(GO:0090427)
0.1 0.4 GO:0006425 glutaminyl-tRNA aminoacylation(GO:0006425) valyl-tRNA aminoacylation(GO:0006438)
0.1 0.7 GO:0042816 vitamin B6 metabolic process(GO:0042816)
0.1 1.3 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 1.6 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.1 0.4 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.1 1.6 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.1 0.3 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.1 0.3 GO:0015960 diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966)
0.0 0.6 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.0 0.3 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0 1.1 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.2 GO:0090091 positive regulation of extracellular matrix disassembly(GO:0090091)
0.0 0.1 GO:0061536 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.0 2.0 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 0.2 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
0.0 0.2 GO:0070943 neutrophil mediated cytotoxicity(GO:0070942) neutrophil mediated killing of symbiont cell(GO:0070943) neutrophil mediated killing of bacterium(GO:0070944)
0.0 0.7 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.0 0.3 GO:0046325 negative regulation of glucose import(GO:0046325)
0.0 0.4 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.0 1.8 GO:0016575 histone deacetylation(GO:0016575)
0.0 0.3 GO:0006783 heme biosynthetic process(GO:0006783)
0.0 0.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.2 GO:0021702 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.0 0.1 GO:0045217 cell-cell junction maintenance(GO:0045217) positive regulation of protein localization to centrosome(GO:1904781)
0.0 0.7 GO:0045776 negative regulation of blood pressure(GO:0045776)