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ENCODE cell lines, expression (Ernst 2011)

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Results for BBX

Z-value: 0.62

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Transcription factors associated with BBX

Gene Symbol Gene ID Gene Info
BBX
ENSG00000114439.14 BBX

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BBXhg19_v2_chr3_+_107241783_1072418500.371.5e-01Click!

Activity profile of BBX motif

Sorted Z-values of BBX motif

Network of associatons between targets according to the STRING database.

First level regulatory network of BBX

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr4_+_155484155 2.34 ENST00000509493.1
 FGB
 fibrinogen beta chain
chr9_-_116837249 2.11 ENST00000466610.2
 AMBP
 alpha-1-microglobulin/bikunin precursor
chr4_+_155484103 1.80 ENST00000302068.4
 FGB
 fibrinogen beta chain
chr4_-_70080449 1.50 ENST00000446444.1
 UGT2B11
 UDP glucuronosyltransferase 2 family, polypeptide B11
chr9_-_5833027 1.17 ENST00000339450.5
 ERMP1
 endoplasmic reticulum metallopeptidase 1
chr4_-_186697044 0.96 ENST00000437304.2
 SORBS2
 sorbin and SH3 domain containing 2
chr6_+_31895254 0.95 ENST00000299367.5
ENST00000442278.2
 C2
 complement component 2
chr11_+_22689648 0.93 ENST00000278187.3
 GAS2
 growth arrest-specific 2
chr4_-_186733363 0.88 ENST00000393523.2
ENST00000393528.3
ENST00000449407.2
 SORBS2
 sorbin and SH3 domain containing 2
chr4_-_186696425 0.75 ENST00000430503.1
ENST00000319454.6
ENST00000450341.1
 SORBS2
 sorbin and SH3 domain containing 2
chr12_-_52887034 0.72 ENST00000330722.6
 KRT6A
 keratin 6A
chr22_+_44319619 0.65 ENST00000216180.3
 PNPLA3
 patatin-like phospholipase domain containing 3
chr16_+_56672571 0.61 ENST00000290705.8
 MT1A
 metallothionein 1A
chr13_+_50570019 0.60 ENST00000442421.1
 TRIM13
 tripartite motif containing 13
chr1_-_59043166 0.37 ENST00000371225.2
 TACSTD2
 tumor-associated calcium signal transducer 2
chr14_+_23235886 0.37 ENST00000604262.1
ENST00000431881.2
ENST00000412791.1
ENST00000358043.5
 OXA1L
 oxidase (cytochrome c) assembly 1-like
chr1_+_229440129 0.35 ENST00000366688.3
 SPHAR
 S-phase response (cyclin related)
chr16_+_28763108 0.34 ENST00000357796.3
ENST00000550983.1
 NPIPB9
 nuclear pore complex interacting protein family, member B9
chr5_-_78809950 0.32 ENST00000334082.6
 HOMER1
 homer homolog 1 (Drosophila)
chr1_+_55464600 0.30 ENST00000371265.4
 BSND
 Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr2_+_101437487 0.30 ENST00000427413.1
ENST00000542504.1
 NPAS2
 neuronal PAS domain protein 2
chr17_+_66255310 0.27 ENST00000448504.2
 ARSG
 arylsulfatase G
chr20_-_30310656 0.26 ENST00000376055.4
 BCL2L1
 BCL2-like 1
chr16_-_28374829 0.26 ENST00000532254.1
 NPIPB6
 nuclear pore complex interacting protein family, member B6
chr5_+_140514782 0.25 ENST00000231134.5
 PCDHB5
 protocadherin beta 5
chr20_-_56286479 0.24 ENST00000265626.4
 PMEPA1
 prostate transmembrane protein, androgen induced 1
chr5_+_140480083 0.24 ENST00000231130.2
 PCDHB3
 protocadherin beta 3
chrX_+_54834004 0.24 ENST00000375068.1
 MAGED2
 melanoma antigen family D, 2
chr9_+_35161998 0.23 ENST00000396787.1
ENST00000378495.3
ENST00000378496.4
 UNC13B
 unc-13 homolog B (C. elegans)
chr14_+_94492674 0.20 ENST00000203664.5
ENST00000553723.1
 OTUB2
 OTU domain, ubiquitin aldehyde binding 2
chr6_-_25874440 0.19 ENST00000361703.6
ENST00000397060.4
 SLC17A3
 solute carrier family 17 (organic anion transporter), member 3
chr7_-_16872932 0.19 ENST00000419572.2
ENST00000412973.1
 AGR2
 anterior gradient 2
chr20_-_30310693 0.19 ENST00000307677.4
ENST00000420653.1
 BCL2L1
 BCL2-like 1
chr19_+_47421933 0.19 ENST00000404338.3
 ARHGAP35
 Rho GTPase activating protein 35
chr18_-_21017817 0.18 ENST00000542162.1
ENST00000383233.3
ENST00000582336.1
ENST00000450466.2
ENST00000578520.1
ENST00000399707.1
 TMEM241
 transmembrane protein 241
chr2_-_62081254 0.17 ENST00000405894.3
 FAM161A
 family with sequence similarity 161, member A
chr20_-_30310336 0.16 ENST00000434194.1
ENST00000376062.2
 BCL2L1
 BCL2-like 1
chr2_-_62081148 0.15 ENST00000404929.1
 FAM161A
 family with sequence similarity 161, member A
chr1_-_36948879 0.14 ENST00000373106.1
ENST00000373104.1
ENST00000373103.1
 CSF3R
 colony stimulating factor 3 receptor (granulocyte)
chr1_+_117963209 0.14 ENST00000449370.2
 MAN1A2
 mannosidase, alpha, class 1A, member 2
chr4_+_69313145 0.13 ENST00000305363.4
 TMPRSS11E
 transmembrane protease, serine 11E
chr6_-_150067696 0.13 ENST00000340413.2
ENST00000367403.3
 NUP43
 nucleoporin 43kDa
chr15_+_65823092 0.13 ENST00000566074.1
 PTPLAD1
 protein tyrosine phosphatase-like A domain containing 1
chr6_+_72922590 0.12 ENST00000523963.1
 RIMS1
 regulating synaptic membrane exocytosis 1
chr10_-_94003003 0.11 ENST00000412050.4
 CPEB3
 cytoplasmic polyadenylation element binding protein 3
chr22_+_32871224 0.11 ENST00000452138.1
ENST00000382058.3
ENST00000397426.1
 FBXO7
 F-box protein 7
chr11_+_118443098 0.11 ENST00000392859.3
ENST00000359415.4
ENST00000534182.2
ENST00000264028.4
 ARCN1
 archain 1
chr6_+_72922505 0.11 ENST00000401910.3
 RIMS1
 regulating synaptic membrane exocytosis 1
chr12_-_10978957 0.10 ENST00000240619.2
 TAS2R10
 taste receptor, type 2, member 10
chr13_+_33160553 0.10 ENST00000315596.10
 PDS5B
 PDS5, regulator of cohesion maintenance, homolog B (S. cerevisiae)
chr3_+_148583043 0.09 ENST00000296046.3
 CPA3
 carboxypeptidase A3 (mast cell)
chr13_+_28494130 0.08 ENST00000381033.4
 PDX1
 pancreatic and duodenal homeobox 1
chr8_-_6783588 0.07 ENST00000297436.2
 DEFA6
 defensin, alpha 6, Paneth cell-specific
chr2_-_55237484 0.07 ENST00000394609.2
 RTN4
 reticulon 4
chr1_+_52082751 0.07 ENST00000447887.1
ENST00000435686.2
ENST00000428468.1
ENST00000453295.1
 OSBPL9
 oxysterol binding protein-like 9
chr1_-_216978709 0.06 ENST00000360012.3
 ESRRG
 estrogen-related receptor gamma
chrX_-_140786896 0.04 ENST00000370515.3
 SPANXD
 SPANX family, member D
chr12_-_21487829 0.03 ENST00000445053.1
ENST00000452078.1
ENST00000458504.1
ENST00000422327.1
ENST00000421294.1
 SLCO1A2
 solute carrier organic anion transporter family, member 1A2
chrX_+_140677562 0.03 ENST00000370518.3
 SPANXA2
 SPANX family, member A2
chr17_-_8263538 0.02 ENST00000535173.1
 AC135178.1
 HCG1985372; Uncharacterized protein; cDNA FLJ37541 fis, clone BRCAN2026340
chr14_+_22337014 0.02 ENST00000390436.2
 TRAV13-1
 T cell receptor alpha variable 13-1
chr11_+_58390132 0.02 ENST00000361987.4
 CNTF
 ciliary neurotrophic factor
chr19_+_7828035 0.02 ENST00000327325.5
ENST00000394122.2
ENST00000248228.4
ENST00000334806.5
ENST00000359059.5
ENST00000357361.2
ENST00000596363.1
ENST00000595751.1
ENST00000596707.1
ENST00000597522.1
ENST00000595496.1
 CLEC4M
 C-type lectin domain family 4, member M
chr3_+_111260856 0.01 ENST00000352690.4
 CD96
 CD96 molecule
chr17_+_45331184 0.01 ENST00000559488.1
ENST00000571680.1
ENST00000435993.2
 ITGB3
 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)

Gene Ontology Analysis

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.1 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 1.5 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.9 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.0 0.9 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.3 REACTOME THE ACTIVATION OF ARYLSULFATASES Genes involved in The activation of arylsulfatases
0.0 0.6 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 0.5 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.0 0.1 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.0 0.3 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.1 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.2 GO:0044305 calyx of Held(GO:0044305)
0.0 0.6 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.6 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.0 0.1 GO:1990037 Lewy body core(GO:1990037)
0.0 0.6 GO:0045095 keratin filament(GO:0045095)
0.0 2.8 GO:0030018 Z disc(GO:0030018)
0.0 0.1 GO:0030126 COPI vesicle coat(GO:0030126)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.1 GO:0019862 IgA binding(GO:0019862)
0.1 2.6 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 0.6 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.1 0.2 GO:0036080 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.1 0.6 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.6 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 1.5 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 4.1 GO:0051087 chaperone binding(GO:0051087)
0.0 0.1 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
0.0 0.2 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 0.3 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.0 0.2 GO:0019784 NEDD8-specific protease activity(GO:0019784)
0.0 0.3 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.2 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.1 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.6 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0 0.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.1 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.2 0.7 GO:0051710 regulation of cytolysis in other organism(GO:0051710)
0.1 2.1 GO:0033015 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.1 0.4 GO:0043461 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.1 0.3 GO:0007206 phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.1 0.6 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.1 2.6 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 0.9 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.1 0.6 GO:0036155 acylglycerol acyl-chain remodeling(GO:0036155)
0.1 0.2 GO:0036079 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.1 0.2 GO:0099525 presynaptic dense core granule exocytosis(GO:0099525)
0.0 0.4 GO:0090191 negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191)
0.0 1.5 GO:0008210 estrogen metabolic process(GO:0008210)
0.0 0.1 GO:0045900 negative regulation of translational elongation(GO:0045900)
0.0 0.6 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 0.2 GO:1903899 positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.0 0.2 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.1 GO:0021691 cerebellar Purkinje cell layer maturation(GO:0021691)
0.0 0.2 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.2 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.1 GO:1904381 Golgi apparatus mannose trimming(GO:1904381)
0.0 0.6 GO:0071294 cellular response to zinc ion(GO:0071294)
0.0 0.1 GO:0010157 response to chlorate(GO:0010157)
0.0 0.1 GO:0070294 renal sodium ion absorption(GO:0070294)
0.0 0.2 GO:0010990 regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.0 0.3 GO:0051775 response to redox state(GO:0051775)
0.0 0.2 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.0 0.4 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)