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ENCODE cell lines, expression (Ernst 2011)

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Results for BRCA1

Z-value: 0.68

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Transcription factors associated with BRCA1

Gene Symbol Gene ID Gene Info
BRCA1
ENSG00000012048.15 BRCA1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BRCA1hg19_v2_chr17_-_41277370_412774190.888.3e-06Click!

Activity profile of BRCA1 motif

Sorted Z-values of BRCA1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of BRCA1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr10_-_69597810 1.47 ENST00000483798.2
 DNAJC12
 DnaJ (Hsp40) homolog, subfamily C, member 12
chr17_+_74372662 1.43 ENST00000591651.1
ENST00000545180.1
 SPHK1
 sphingosine kinase 1
chr15_-_58358607 1.31 ENST00000249750.4
 ALDH1A2
 aldehyde dehydrogenase 1 family, member A2
chr14_+_103058948 1.03 ENST00000262241.6
 RCOR1
 REST corepressor 1
chr7_-_23510086 0.96 ENST00000258729.3
 IGF2BP3
 insulin-like growth factor 2 mRNA binding protein 3
chr6_+_16129308 0.87 ENST00000356840.3
ENST00000349606.4
 MYLIP
 myosin regulatory light chain interacting protein
chr3_+_193853927 0.85 ENST00000232424.3
 HES1
 hes family bHLH transcription factor 1
chr18_+_55888767 0.70 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
 NEDD4L
 neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr17_-_56296580 0.69 ENST00000313863.6
ENST00000546108.1
ENST00000337050.7
ENST00000393119.2
 MKS1
 Meckel syndrome, type 1
chr4_-_140005443 0.56 ENST00000510408.1
ENST00000420916.2
ENST00000358635.3
 ELF2
 E74-like factor 2 (ets domain transcription factor)
chr6_+_33172407 0.52 ENST00000374662.3
 HSD17B8
 hydroxysteroid (17-beta) dehydrogenase 8
chr1_+_10271674 0.50 ENST00000377086.1
 KIF1B
 kinesin family member 1B
chr10_-_36813162 0.50 ENST00000440465.1
 NAMPTL
 nicotinamide phosphoribosyltransferase-like
chr6_+_42981922 0.49 ENST00000326974.4
ENST00000244670.8
 KLHDC3
 kelch domain containing 3
chr11_+_117947724 0.47 ENST00000534111.1
 TMPRSS4
 transmembrane protease, serine 4
chr17_-_7082861 0.45 ENST00000269299.3
 ASGR1
 asialoglycoprotein receptor 1
chr11_+_117947782 0.41 ENST00000522307.1
ENST00000523251.1
ENST00000437212.3
ENST00000522824.1
ENST00000522151.1
 TMPRSS4
 transmembrane protease, serine 4
chr10_+_28822636 0.41 ENST00000442148.1
ENST00000448193.1
 WAC
 WW domain containing adaptor with coiled-coil
chr3_+_185303962 0.41 ENST00000296257.5
 SENP2
 SUMO1/sentrin/SMT3 specific peptidase 2
chr3_-_176914238 0.39 ENST00000430069.1
ENST00000428970.1
 TBL1XR1
 transducin (beta)-like 1 X-linked receptor 1
chr7_+_73868439 0.36 ENST00000424337.2
 GTF2IRD1
 GTF2I repeat domain containing 1
chr20_-_48530230 0.35 ENST00000422556.1
 SPATA2
 spermatogenesis associated 2
chr20_+_52105495 0.33 ENST00000439873.2
 AL354993.1
 Cell growth-inhibiting protein 7; HCG1784586; Uncharacterized protein
chr8_+_22022800 0.33 ENST00000397814.3
 BMP1
 bone morphogenetic protein 1
chr12_-_12491608 0.33 ENST00000545735.1
 MANSC1
 MANSC domain containing 1
chr1_+_159141397 0.32 ENST00000368124.4
ENST00000368125.4
ENST00000416746.1
 CADM3
 cell adhesion molecule 3
chr17_-_41738931 0.32 ENST00000329168.3
ENST00000549132.1
 MEOX1
 mesenchyme homeobox 1
chr17_-_60142609 0.31 ENST00000397786.2
 MED13
 mediator complex subunit 13
chr11_+_47291645 0.31 ENST00000395336.3
ENST00000402192.2
 MADD
 MAP-kinase activating death domain
chr6_+_123100620 0.30 ENST00000368444.3
 FABP7
 fatty acid binding protein 7, brain
chr5_-_68665084 0.28 ENST00000509462.1
 TAF9
 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr8_-_81083341 0.28 ENST00000519303.2
 TPD52
 tumor protein D52
chr11_-_6817128 0.28 ENST00000332601.3
 OR6A2
 olfactory receptor, family 6, subfamily A, member 2
chrX_+_49644470 0.27 ENST00000508866.2
 USP27X
 ubiquitin specific peptidase 27, X-linked
chr17_-_41739283 0.27 ENST00000393661.2
ENST00000318579.4
 MEOX1
 mesenchyme homeobox 1
chr10_-_61900762 0.26 ENST00000355288.2
 ANK3
 ankyrin 3, node of Ranvier (ankyrin G)
chr19_-_48389651 0.26 ENST00000222002.3
 SULT2A1
 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr5_-_68665296 0.25 ENST00000512152.1
ENST00000503245.1
ENST00000512561.1
ENST00000380822.4
 TAF9
 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr13_-_31038370 0.25 ENST00000399489.1
ENST00000339872.4
 HMGB1
 high mobility group box 1
chr19_+_46850320 0.25 ENST00000391919.1
 PPP5C
 protein phosphatase 5, catalytic subunit
chr1_-_173020056 0.24 ENST00000239468.2
ENST00000404377.3
 TNFSF18
 tumor necrosis factor (ligand) superfamily, member 18
chr2_-_152118352 0.23 ENST00000331426.5
 RBM43
 RNA binding motif protein 43
chr19_+_46850251 0.22 ENST00000012443.4
 PPP5C
 protein phosphatase 5, catalytic subunit
chr18_-_23671139 0.21 ENST00000579061.1
ENST00000542420.2
 SS18
 synovial sarcoma translocation, chromosome 18
chr1_-_217250231 0.20 ENST00000493748.1
ENST00000463665.1
 ESRRG
 estrogen-related receptor gamma
chr15_-_88799948 0.20 ENST00000394480.2
 NTRK3
 neurotrophic tyrosine kinase, receptor, type 3
chr11_+_47291193 0.19 ENST00000428807.1
ENST00000402799.1
ENST00000406482.1
ENST00000349238.3
ENST00000311027.5
ENST00000407859.3
ENST00000395344.3
ENST00000444117.1
 MADD
 MAP-kinase activating death domain
chr14_-_69261310 0.19 ENST00000336440.3
 ZFP36L1
 ZFP36 ring finger protein-like 1
chr5_+_139493665 0.18 ENST00000331327.3
 PURA
 purine-rich element binding protein A
chr1_-_227505289 0.18 ENST00000366765.3
 CDC42BPA
 CDC42 binding protein kinase alpha (DMPK-like)
chr6_-_170862322 0.17 ENST00000262193.6
 PSMB1
 proteasome (prosome, macropain) subunit, beta type, 1
chr12_-_67072714 0.17 ENST00000545666.1
ENST00000398016.3
ENST00000359742.4
ENST00000286445.7
ENST00000538211.1
 GRIP1
 glutamate receptor interacting protein 1
chr5_-_68665469 0.16 ENST00000217893.5
 TAF9
 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa
chr9_-_86593238 0.14 ENST00000351839.3
 HNRNPK
 heterogeneous nuclear ribonucleoprotein K
chr1_-_160232312 0.13 ENST00000440682.1
 DCAF8
 DDB1 and CUL4 associated factor 8
chr11_-_119234876 0.13 ENST00000525735.1
 USP2
 ubiquitin specific peptidase 2
chr2_+_203879568 0.12 ENST00000449802.1
 NBEAL1
 neurobeachin-like 1
chr4_+_619386 0.12 ENST00000496514.1
 PDE6B
 phosphodiesterase 6B, cGMP-specific, rod, beta
chr14_-_60097297 0.11 ENST00000395090.1
 RTN1
 reticulon 1
chr12_-_117319236 0.11 ENST00000257572.5
 HRK
 harakiri, BCL2 interacting protein (contains only BH3 domain)
chr10_+_92631709 0.11 ENST00000413330.1
ENST00000277882.3
 RPP30
 ribonuclease P/MRP 30kDa subunit
chr14_+_32030582 0.11 ENST00000550649.1
ENST00000281081.7
 NUBPL
 nucleotide binding protein-like
chr11_-_71823266 0.10 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
 ANAPC15
 anaphase promoting complex subunit 15
chr19_+_45394477 0.08 ENST00000252487.5
ENST00000405636.2
ENST00000592434.1
ENST00000426677.2
ENST00000589649.1
 TOMM40
 translocase of outer mitochondrial membrane 40 homolog (yeast)
chr6_-_25832254 0.08 ENST00000476801.1
ENST00000244527.4
ENST00000427328.1
 SLC17A1
 solute carrier family 17 (organic anion transporter), member 1
chr8_-_16859690 0.08 ENST00000180166.5
 FGF20
 fibroblast growth factor 20
chr19_-_40324767 0.06 ENST00000601972.1
ENST00000430012.2
ENST00000323039.5
ENST00000348817.3
 DYRK1B
 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
chr4_+_619347 0.05 ENST00000255622.6
 PDE6B
 phosphodiesterase 6B, cGMP-specific, rod, beta
chr16_-_790982 0.04 ENST00000301694.5
ENST00000251588.2
 NARFL
 nuclear prelamin A recognition factor-like
chr19_+_45971246 0.04 ENST00000585836.1
ENST00000417353.2
ENST00000353609.3
ENST00000591858.1
ENST00000443841.2
ENST00000590335.1
 FOSB
 FBJ murine osteosarcoma viral oncogene homolog B
chr5_+_140186647 0.04 ENST00000512229.2
ENST00000356878.4
ENST00000530339.1
 PCDHA4
 protocadherin alpha 4
chr12_-_49418407 0.03 ENST00000526209.1
 KMT2D
 lysine (K)-specific methyltransferase 2D
chr1_-_160232197 0.03 ENST00000419626.1
ENST00000610139.1
ENST00000475733.1
ENST00000407642.2
ENST00000368073.3
ENST00000326837.2
 DCAF8
 DDB1 and CUL4 associated factor 8
chr13_+_30002741 0.02 ENST00000380808.2
 MTUS2
 microtubule associated tumor suppressor candidate 2
chr6_-_42981651 0.02 ENST00000244711.3
 MEA1
 male-enhanced antigen 1
chr14_-_60097524 0.02 ENST00000342503.4
 RTN1
 reticulon 1
chr17_+_36908984 0.01 ENST00000225426.4
ENST00000579088.1
 PSMB3
 proteasome (prosome, macropain) subunit, beta type, 3
chr1_+_161736072 0.01 ENST00000367942.3
 ATF6
 activating transcription factor 6
chrX_+_10124977 0.00 ENST00000380833.4
 CLCN4
 chloride channel, voltage-sensitive 4

Gene Ontology Analysis

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.4 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 1.3 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.1 0.5 GO:0070404 NADH binding(GO:0070404)
0.1 0.4 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 0.7 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 0.2 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.1 0.5 GO:0004873 asialoglycoprotein receptor activity(GO:0004873)
0.0 0.7 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 0.2 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.0 0.3 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.0 0.2 GO:0050682 AF-2 domain binding(GO:0050682)
0.0 0.3 GO:1990380 Lys63-specific deubiquitinase activity(GO:0061578) Lys48-specific deubiquitinase activity(GO:1990380)
0.0 1.0 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.6 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.3 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 1.0 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 0.5 GO:0005123 death receptor binding(GO:0005123)
0.0 0.2 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004) neurotrophin receptor activity(GO:0005030)
0.0 0.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 0.4 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0046521 sphingoid catabolic process(GO:0046521)
0.3 1.5 GO:0061009 common bile duct development(GO:0061009)
0.2 0.9 GO:0032803 regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803)
0.2 0.5 GO:1904647 response to rotenone(GO:1904647)
0.1 0.6 GO:0001757 somite specification(GO:0001757) sclerotome development(GO:0061056)
0.1 1.3 GO:0035799 ureter maturation(GO:0035799)
0.1 0.7 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 0.4 GO:0071894 histone H2B conserved C-terminal lysine ubiquitination(GO:0071894)
0.1 1.0 GO:0070933 histone H4 deacetylation(GO:0070933)
0.1 0.5 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 0.5 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 0.4 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.1 0.3 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.2 GO:0048687 modulation by virus of host transcription(GO:0019056) positive regulation of sprouting of injured axon(GO:0048687) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026)
0.1 0.4 GO:0060613 fat pad development(GO:0060613)
0.1 0.2 GO:0048382 mesendoderm development(GO:0048382)
0.1 0.2 GO:0002840 plasmacytoid dendritic cell activation(GO:0002270) T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) regulation of restriction endodeoxyribonuclease activity(GO:0032072) negative regulation of apoptotic cell clearance(GO:2000426)
0.1 0.2 GO:2000320 negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.1 0.7 GO:0000492 box C/D snoRNP assembly(GO:0000492)
0.1 0.4 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.1 GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
0.0 0.5 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.2 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.0 0.6 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
0.0 0.1 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.0 0.3 GO:0060134 prepulse inhibition(GO:0060134)
0.0 0.5 GO:0035825 reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0 0.2 GO:0034380 high-density lipoprotein particle assembly(GO:0034380)
0.0 0.3 GO:0006068 ethanol catabolic process(GO:0006068) steroid catabolic process(GO:0006706)
0.0 0.3 GO:0071108 protein K63-linked deubiquitination(GO:0070536) protein K48-linked deubiquitination(GO:0071108)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 GO:0070761 pre-snoRNP complex(GO:0070761)
0.1 0.5 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.7 GO:0036038 MKS complex(GO:0036038)
0.0 1.0 GO:1990391 DNA repair complex(GO:1990391)
0.0 0.1 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.3 GO:0043194 axon initial segment(GO:0043194)
0.0 0.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.1 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.0 0.2 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.0 0.7 GO:0005771 multivesicular body(GO:0005771)
0.0 0.5 GO:1904115 axon cytoplasm(GO:1904115)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.9 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.7 PID MYC PATHWAY C-MYC pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.4 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.9 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.4 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.2 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.0 0.2 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)