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ENCODE cell lines, expression (Ernst 2011)

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Results for CBFB

Z-value: 0.68

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Transcription factors associated with CBFB

Gene Symbol Gene ID Gene Info
CBFB
ENSG00000067955.9 CBFB

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
CBFBhg19_v2_chr16_+_67062996_67063019-0.731.4e-03Click!

Activity profile of CBFB motif

Sorted Z-values of CBFB motif

Network of associatons between targets according to the STRING database.

First level regulatory network of CBFB

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr3_+_157154578 2.49 ENST00000295927.3
 PTX3
 pentraxin 3, long
chr11_+_114310237 1.83 ENST00000539119.1
 REXO2
 RNA exonuclease 2
chr3_-_99569821 1.83 ENST00000487087.1
 FILIP1L
 filamin A interacting protein 1-like
chr11_+_114310102 1.78 ENST00000265881.5
 REXO2
 RNA exonuclease 2
chr5_+_35856951 1.75 ENST00000303115.3
ENST00000343305.4
ENST00000506850.1
ENST00000511982.1
 IL7R
 interleukin 7 receptor
chr11_+_114310164 1.74 ENST00000544196.1
ENST00000539754.1
ENST00000539275.1
 REXO2
 RNA exonuclease 2
chr14_+_85996471 1.60 ENST00000330753.4
 FLRT2
 fibronectin leucine rich transmembrane protein 2
chr1_+_196621002 1.09 ENST00000367429.4
ENST00000439155.2
 CFH
 complement factor H
chr1_+_196621156 0.87 ENST00000359637.2
 CFH
 complement factor H
chr14_+_85996507 0.87 ENST00000554746.1
 FLRT2
 fibronectin leucine rich transmembrane protein 2
chr17_+_32582293 0.85 ENST00000580907.1
ENST00000225831.4
 CCL2
 chemokine (C-C motif) ligand 2
chr14_-_61116168 0.65 ENST00000247182.6
 SIX1
 SIX homeobox 1
chr1_-_240775447 0.63 ENST00000318160.4
 GREM2
 gremlin 2, DAN family BMP antagonist
chr4_-_156297949 0.60 ENST00000515654.1
 MAP9
 microtubule-associated protein 9
chr20_+_43343886 0.58 ENST00000190983.4
 WISP2
 WNT1 inducible signaling pathway protein 2
chr18_-_53089723 0.51 ENST00000561992.1
ENST00000562512.2
 TCF4
 transcription factor 4
chr3_-_189840223 0.47 ENST00000427335.2
 LEPREL1
 leprecan-like 1
chr21_-_36421535 0.47 ENST00000416754.1
ENST00000437180.1
ENST00000455571.1
 RUNX1
 runt-related transcription factor 1
chr21_-_36421626 0.47 ENST00000300305.3
 RUNX1
 runt-related transcription factor 1
chr11_+_18343800 0.47 ENST00000453096.2
 GTF2H1
 general transcription factor IIH, polypeptide 1, 62kDa
chr5_-_137878887 0.43 ENST00000507939.1
ENST00000572514.1
ENST00000499810.2
ENST00000360541.5
 ETF1
 eukaryotic translation termination factor 1
chr11_-_58343319 0.43 ENST00000395074.2
 LPXN
 leupaxin
chr4_+_74347400 0.42 ENST00000226355.3
 AFM
 afamin
chr10_-_29811456 0.39 ENST00000535393.1
 SVIL
 supervillin
chr12_-_68553512 0.34 ENST00000229135.3
 IFNG
 interferon, gamma
chr1_+_209859510 0.31 ENST00000367028.2
ENST00000261465.1
 HSD11B1
 hydroxysteroid (11-beta) dehydrogenase 1
chr2_-_87248975 0.29 ENST00000409310.2
ENST00000355705.3
 PLGLB1
 plasminogen-like B1
chr20_+_54987168 0.29 ENST00000360314.3
 CASS4
 Cas scaffolding protein family member 4
chr15_+_49715293 0.26 ENST00000267843.4
ENST00000560270.1
 FGF7
 fibroblast growth factor 7
chr7_+_120628731 0.24 ENST00000310396.5
 CPED1
 cadherin-like and PC-esterase domain containing 1
chr20_+_54987305 0.23 ENST00000371336.3
ENST00000434344.1
 CASS4
 Cas scaffolding protein family member 4
chr21_-_36421401 0.22 ENST00000486278.2
 RUNX1
 runt-related transcription factor 1
chr12_-_14849470 0.21 ENST00000261170.3
 GUCY2C
 guanylate cyclase 2C (heat stable enterotoxin receptor)
chr9_+_15422702 0.18 ENST00000380821.3
ENST00000421710.1
 SNAPC3
 small nuclear RNA activating complex, polypeptide 3, 50kDa
chr11_-_66103867 0.18 ENST00000424433.2
 RIN1
 Ras and Rab interactor 1
chr1_-_184723942 0.16 ENST00000318130.8
 EDEM3
 ER degradation enhancer, mannosidase alpha-like 3
chr16_+_53088885 0.15 ENST00000566029.1
ENST00000447540.1
 CHD9
 chromodomain helicase DNA binding protein 9
chr5_+_131409476 0.13 ENST00000296871.2
 CSF2
 colony stimulating factor 2 (granulocyte-macrophage)
chr9_-_35080013 0.13 ENST00000378643.3
 FANCG
 Fanconi anemia, complementation group G
chrX_-_153718988 0.12 ENST00000263512.4
ENST00000393587.4
ENST00000453912.1
 SLC10A3
 solute carrier family 10, member 3
chrX_+_68048803 0.10 ENST00000204961.4
 EFNB1
 ephrin-B1
chr5_+_131396222 0.10 ENST00000296870.2
 IL3
 interleukin 3 (colony-stimulating factor, multiple)
chr11_-_18343669 0.09 ENST00000396253.3
ENST00000349215.3
ENST00000438420.2
 HPS5
 Hermansky-Pudlak syndrome 5
chr8_-_60031762 0.08 ENST00000361421.1
 TOX
 thymocyte selection-associated high mobility group box
chr11_-_64885111 0.08 ENST00000528598.1
ENST00000310597.4
 ZNHIT2
 zinc finger, HIT-type containing 2
chr2_+_207024306 0.07 ENST00000236957.5
ENST00000392221.1
ENST00000392222.2
ENST00000445505.1
 EEF1B2
 eukaryotic translation elongation factor 1 beta 2
chr1_-_179112189 0.06 ENST00000512653.1
ENST00000344730.3
 ABL2
 c-abl oncogene 2, non-receptor tyrosine kinase
chr14_+_22919081 0.05 ENST00000390473.1
 TRDJ1
 T cell receptor delta joining 1
chr6_+_27925019 0.04 ENST00000244623.1
 OR2B6
 olfactory receptor, family 2, subfamily B, member 6
chr15_+_64386261 0.04 ENST00000560829.1
 SNX1
 sorting nexin 1
chr14_-_24977457 0.03 ENST00000250378.3
ENST00000206446.4
 CMA1
 chymase 1, mast cell
chr6_+_29068386 0.03 ENST00000377171.3
 OR2J1
 olfactory receptor, family 2, subfamily J, member 1 (gene/pseudogene)
chr9_-_123342415 0.02 ENST00000349780.4
ENST00000360190.4
ENST00000360822.3
ENST00000359309.3
 CDK5RAP2
 CDK5 regulatory subunit associated protein 2
chr13_-_28674693 0.00 ENST00000537084.1
ENST00000241453.7
ENST00000380982.4
 FLT3
 fms-related tyrosine kinase 3
chr1_+_89246647 0.00 ENST00000544045.1
 PKN2
 protein kinase N2

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0036449 microtubule minus-end(GO:0036449)
0.1 0.6 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
0.1 5.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.5 GO:0000439 core TFIIH complex(GO:0000439)
0.0 2.4 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.1 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 2.4 GO:0072562 blood microparticle(GO:0072562)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.8 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 2.0 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.0 0.8 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.5 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 0.6 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 0.3 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.3 REACTOME ACTIVATED POINT MUTANTS OF FGFR2 Genes involved in Activated point mutants of FGFR2

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.3 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.0 1.0 PID GMCSF PATHWAY GMCSF-mediated signaling events
0.0 1.2 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.5 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.4 2.5 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
0.3 0.3 GO:2000309 positive regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000309)
0.3 0.8 GO:1901624 negative regulation of lymphocyte chemotaxis(GO:1901624)
0.2 0.6 GO:0061055 myotome development(GO:0061055) positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.2 0.6 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.2 1.8 GO:0033089 positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400)
0.1 5.3 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.1 0.3 GO:0060437 lung growth(GO:0060437)
0.1 2.0 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 1.2 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.1 0.6 GO:1902412 regulation of mitotic cytokinesis(GO:1902412)
0.1 0.4 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0 0.2 GO:0035977 protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) glycoprotein ERAD pathway(GO:0097466) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.0 0.4 GO:0006449 regulation of translational termination(GO:0006449)
0.0 0.1 GO:0045918 neutrophil differentiation(GO:0030223) negative regulation of cytolysis(GO:0045918)
0.0 0.5 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 0.2 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 0.1 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.0 0.3 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.8 GO:0004917 interleukin-7 receptor activity(GO:0004917)
0.3 2.5 GO:0001849 complement component C1q binding(GO:0001849)
0.3 0.8 GO:0031727 CCR2 chemokine receptor binding(GO:0031727)
0.2 2.5 GO:0045499 chemorepellent activity(GO:0045499)
0.1 5.3 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.1 0.3 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1 0.4 GO:0008431 vitamin E binding(GO:0008431)
0.1 2.0 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 0.4 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.6 GO:0036122 BMP binding(GO:0036122)
0.0 0.5 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.1 GO:0008508 bile acid:sodium symporter activity(GO:0008508)
0.0 0.6 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.5 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.6 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 0.2 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0 0.3 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)