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ENCODE cell lines, expression (Ernst 2011)

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Results for DDIT3

Z-value: 0.63

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Transcription factors associated with DDIT3

Gene Symbol Gene ID Gene Info
DDIT3
ENSG00000175197.6 DDIT3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DDIT3hg19_v2_chr12_-_57914275_57914304-0.243.8e-01Click!

Activity profile of DDIT3 motif

Sorted Z-values of DDIT3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of DDIT3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_-_216300784 3.22 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
 FN1
 fibronectin 1
chr3_+_157154578 2.91 ENST00000295927.3
 PTX3
 pentraxin 3, long
chr10_-_17659357 1.88 ENST00000326961.6
ENST00000361271.3
 PTPLA
 protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr2_-_161350305 1.87 ENST00000348849.3
 RBMS1
 RNA binding motif, single stranded interacting protein 1
chr10_-_92681033 1.75 ENST00000371697.3
 ANKRD1
 ankyrin repeat domain 1 (cardiac muscle)
chr4_-_99578789 1.53 ENST00000511651.1
ENST00000505184.1
 TSPAN5
 tetraspanin 5
chr2_+_192141611 1.44 ENST00000392316.1
 MYO1B
 myosin IB
chr10_-_17659234 1.36 ENST00000466335.1
 PTPLA
 protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr8_-_18744528 1.26 ENST00000523619.1
 PSD3
 pleckstrin and Sec7 domain containing 3
chr9_+_112542591 0.96 ENST00000483909.1
ENST00000314527.4
ENST00000413420.1
ENST00000302798.7
ENST00000555236.1
ENST00000510514.5
 PALM2
PALM2-AKAP2
AKAP2
 paralemmin 2
PALM2-AKAP2 readthrough
A kinase (PRKA) anchor protein 2
chr2_-_179672142 0.94 ENST00000342992.6
ENST00000360870.5
ENST00000460472.2
ENST00000589042.1
ENST00000591111.1
ENST00000342175.6
ENST00000359218.5
 TTN
 titin
chr9_+_112542572 0.93 ENST00000374530.3
 PALM2-AKAP2
 PALM2-AKAP2 readthrough
chr3_+_38017264 0.81 ENST00000436654.1
 CTDSPL
 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr12_-_52867569 0.79 ENST00000252250.6
 KRT6C
 keratin 6C
chr5_-_54281407 0.75 ENST00000381403.4
 ESM1
 endothelial cell-specific molecule 1
chr16_+_56965960 0.70 ENST00000439977.2
ENST00000344114.4
ENST00000300302.5
ENST00000379792.2
 HERPUD1
 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr15_+_85923797 0.69 ENST00000559362.1
 AKAP13
 A kinase (PRKA) anchor protein 13
chr1_+_169079823 0.61 ENST00000367813.3
 ATP1B1
 ATPase, Na+/K+ transporting, beta 1 polypeptide
chr2_-_208030647 0.57 ENST00000309446.6
 KLF7
 Kruppel-like factor 7 (ubiquitous)
chr4_+_157997273 0.54 ENST00000541722.1
ENST00000512619.1
 GLRB
 glycine receptor, beta
chr16_+_56970567 0.53 ENST00000563911.1
 HERPUD1
 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr10_-_116444371 0.53 ENST00000533213.2
ENST00000369252.4
 ABLIM1
 actin binding LIM protein 1
chr4_+_157997209 0.48 ENST00000264428.4
 GLRB
 glycine receptor, beta
chr17_+_4855053 0.43 ENST00000518175.1
 ENO3
 enolase 3 (beta, muscle)
chr7_-_56101826 0.41 ENST00000421626.1
 PSPH
 phosphoserine phosphatase
chr3_-_45883558 0.38 ENST00000445698.1
ENST00000296135.6
 LZTFL1
 leucine zipper transcription factor-like 1
chr15_+_41245160 0.37 ENST00000444189.2
ENST00000446533.3
 CHAC1
 ChaC, cation transport regulator homolog 1 (E. coli)
chr8_-_93029865 0.36 ENST00000422361.2
 RUNX1T1
 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr17_+_56315936 0.35 ENST00000543544.1
 LPO
 lactoperoxidase
chr17_+_56315787 0.27 ENST00000262290.4
ENST00000421678.2
 LPO
 lactoperoxidase
chr7_-_44530479 0.25 ENST00000355451.7
 NUDCD3
 NudC domain containing 3
chr20_+_24929866 0.23 ENST00000480798.1
ENST00000376835.2
 CST7
 cystatin F (leukocystatin)
chr5_-_137878887 0.22 ENST00000507939.1
ENST00000572514.1
ENST00000499810.2
ENST00000360541.5
 ETF1
 eukaryotic translation termination factor 1
chr12_-_53074182 0.22 ENST00000252244.3
 KRT1
 keratin 1
chr11_+_62495541 0.20 ENST00000530625.1
ENST00000513247.2
 TTC9C
 tetratricopeptide repeat domain 9C
chr2_-_32390801 0.19 ENST00000608489.1
 RP11-563N4.1
 RP11-563N4.1
chr20_+_48807351 0.19 ENST00000303004.3
 CEBPB
 CCAAT/enhancer binding protein (C/EBP), beta
chr13_-_24007815 0.17 ENST00000382298.3
 SACS
 spastic ataxia of Charlevoix-Saguenay (sacsin)
chr16_-_68269971 0.17 ENST00000565858.1
 ESRP2
 epithelial splicing regulatory protein 2
chr14_-_92413727 0.16 ENST00000267620.10
 FBLN5
 fibulin 5
chr14_-_92413353 0.16 ENST00000556154.1
 FBLN5
 fibulin 5
chr3_+_15643476 0.16 ENST00000436193.1
ENST00000383778.4
 BTD
 biotinidase
chr6_+_31895254 0.15 ENST00000299367.5
ENST00000442278.2
 C2
 complement component 2
chr15_+_85923856 0.12 ENST00000560302.1
ENST00000394518.2
ENST00000361243.2
ENST00000560256.1
 AKAP13
 A kinase (PRKA) anchor protein 13
chr3_+_186330712 0.12 ENST00000411641.2
ENST00000273784.5
 AHSG
 alpha-2-HS-glycoprotein
chr10_+_86004802 0.09 ENST00000359452.4
ENST00000358110.5
ENST00000372092.3
 RGR
 retinal G protein coupled receptor
chr1_+_150954493 0.08 ENST00000368947.4
 ANXA9
 annexin A9
chr14_+_21387508 0.08 ENST00000555624.1
 RP11-84C10.2
 RP11-84C10.2
chr5_+_72143988 0.07 ENST00000506351.2
 TNPO1
 transportin 1
chrX_-_40506766 0.07 ENST00000378421.1
ENST00000440784.2
ENST00000327877.5
ENST00000378426.1
ENST00000378418.2
 CXorf38
 chromosome X open reading frame 38
chr3_+_130569429 0.06 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
 ATP2C1
 ATPase, Ca++ transporting, type 2C, member 1
chr17_-_34257731 0.06 ENST00000431884.2
ENST00000425909.3
ENST00000394528.3
ENST00000430160.2
 RDM1
 RAD52 motif 1
chr6_-_157744531 0.05 ENST00000400788.4
ENST00000367144.4
 TMEM242
 transmembrane protein 242
chr1_-_161277210 0.05 ENST00000491222.2
 MPZ
 myelin protein zero
chr9_-_95056010 0.05 ENST00000443024.2
 IARS
 isoleucyl-tRNA synthetase
chr6_+_168399772 0.04 ENST00000443060.2
 KIF25
 kinesin family member 25
chr22_-_30901637 0.04 ENST00000381982.3
ENST00000255858.7
ENST00000540456.1
ENST00000392772.2
 SEC14L4
 SEC14-like 4 (S. cerevisiae)
chr17_-_46691990 0.04 ENST00000576562.1
 HOXB8
 homeobox B8
chr4_-_2935674 0.04 ENST00000514800.1
 MFSD10
 major facilitator superfamily domain containing 10
chr11_+_61976137 0.03 ENST00000244930.4
 SCGB2A1
 secretoglobin, family 2A, member 1
chr12_-_25102252 0.03 ENST00000261192.7
 BCAT1
 branched chain amino-acid transaminase 1, cytosolic
chr4_-_119274121 0.02 ENST00000296498.3
 PRSS12
 protease, serine, 12 (neurotrypsin, motopsin)
chr2_-_63815628 0.01 ENST00000409562.3
 WDPCP
 WD repeat containing planar cell polarity effector
chrX_-_100129128 0.01 ENST00000372960.4
ENST00000372964.1
ENST00000217885.5
 NOX1
 NADPH oxidase 1
chr8_-_21669826 0.01 ENST00000517328.1
 GFRA2
 GDNF family receptor alpha 2
chr7_-_99006443 0.00 ENST00000350498.3
 PDAP1
 PDGFA associated protein 1

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0016935 glycine-gated chloride channel complex(GO:0016935)
0.2 3.2 GO:0005577 fibrinogen complex(GO:0005577)
0.2 1.2 GO:1990037 Lewy body core(GO:1990037)
0.1 0.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.3 GO:0071953 elastic fiber(GO:0071953)
0.0 2.9 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 0.6 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.9 GO:0005859 muscle myosin complex(GO:0005859)
0.0 0.2 GO:0070852 cell body fiber(GO:0070852)
0.0 1.4 GO:0016459 myosin complex(GO:0016459)
0.0 1.0 GO:0045095 keratin filament(GO:0045095)
0.0 1.7 GO:0001650 fibrillar center(GO:0001650)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.6 2.9 GO:0052199 negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.3 1.0 GO:0097112 gamma-aminobutyric acid receptor clustering(GO:0097112)
0.3 0.9 GO:0030241 skeletal muscle myosin thick filament assembly(GO:0030241)
0.3 0.8 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.2 0.6 GO:1903288 protein transport into plasma membrane raft(GO:0044861) positive regulation of potassium ion import(GO:1903288)
0.1 1.7 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.1 0.8 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.1 1.2 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.1 0.4 GO:1903564 regulation of protein localization to cilium(GO:1903564)
0.1 1.3 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 1.5 GO:0045747 positive regulation of Notch signaling pathway(GO:0045747)
0.0 0.3 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.4 GO:0006751 glutathione catabolic process(GO:0006751)
0.0 0.6 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.8 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.0 0.2 GO:0006449 regulation of translational termination(GO:0006449)
0.0 0.2 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 1.4 GO:0006892 post-Golgi vesicle-mediated transport(GO:0006892)
0.0 0.2 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.2 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 0.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:0032468 Golgi calcium ion homeostasis(GO:0032468)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.2 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 1.2 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 0.5 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 1.0 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.6 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.7 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.4 2.9 GO:0001849 complement component C1q binding(GO:0001849)
0.3 0.8 GO:0005171 hepatocyte growth factor receptor binding(GO:0005171)
0.2 1.0 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 0.9 GO:0031433 telethonin binding(GO:0031433)
0.1 0.4 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.1 0.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 0.8 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 1.4 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 3.1 GO:0016504 peptidase activator activity(GO:0016504)
0.0 0.2 GO:0047708 biotinidase activity(GO:0047708)
0.0 1.0 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.6 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.2 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.4 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.0 0.2 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.6 GO:0004601 peroxidase activity(GO:0004601)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.2 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 2.6 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.8 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.8 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 0.8 PID THROMBIN PAR1 PATHWAY PAR1-mediated thrombin signaling events