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ENCODE cell lines, expression (Ernst 2011)

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Results for DMC1

Z-value: 0.62

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Transcription factors associated with DMC1

Gene Symbol Gene ID Gene Info
DMC1
ENSG00000100206.5 DMC1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
DMC1hg19_v2_chr22_-_38966172_389662910.638.9e-03Click!

Activity profile of DMC1 motif

Sorted Z-values of DMC1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of DMC1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chrX_-_134305322 1.54 ENST00000276241.6
ENST00000344129.2
 CXorf48
 cancer/testis antigen 55
chrX_+_65382433 1.44 ENST00000374727.3
 HEPH
 hephaestin
chr12_-_8803128 1.02 ENST00000543467.1
 MFAP5
 microfibrillar associated protein 5
chr3_-_141747950 0.97 ENST00000497579.1
 TFDP2
 transcription factor Dp-2 (E2F dimerization partner 2)
chr11_-_85779971 0.85 ENST00000393346.3
 PICALM
 phosphatidylinositol binding clathrin assembly protein
chr11_-_85780086 0.73 ENST00000532317.1
ENST00000528256.1
ENST00000526033.1
 PICALM
 phosphatidylinositol binding clathrin assembly protein
chr14_-_21491477 0.70 ENST00000298684.5
ENST00000557169.1
ENST00000553563.1
 NDRG2
 NDRG family member 2
chr10_+_11047259 0.58 ENST00000379261.4
ENST00000416382.2
 CELF2
 CUGBP, Elav-like family member 2
chr14_-_21492113 0.57 ENST00000554094.1
 NDRG2
 NDRG family member 2
chr5_-_82969405 0.53 ENST00000510978.1
 HAPLN1
 hyaluronan and proteoglycan link protein 1
chr14_-_21492251 0.53 ENST00000554398.1
 NDRG2
 NDRG family member 2
chr3_-_141747459 0.50 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
 TFDP2
 transcription factor Dp-2 (E2F dimerization partner 2)
chr7_+_150758304 0.41 ENST00000482950.1
ENST00000463414.1
ENST00000310317.5
 SLC4A2
 solute carrier family 4 (anion exchanger), member 2
chr21_-_35281399 0.40 ENST00000418933.1
 ATP5O
 ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
chr2_+_233497931 0.38 ENST00000264059.3
 EFHD1
 EF-hand domain family, member D1
chr7_-_22539771 0.37 ENST00000406890.2
ENST00000424363.1
 STEAP1B
 STEAP family member 1B
chr19_-_3600549 0.29 ENST00000589966.1
 TBXA2R
 thromboxane A2 receptor
chr2_+_219247021 0.29 ENST00000539932.1
 SLC11A1
 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
chr2_-_21022818 0.27 ENST00000440866.2
ENST00000541941.1
ENST00000402479.2
ENST00000435420.2
ENST00000432947.1
ENST00000403006.2
ENST00000419825.2
ENST00000381090.3
ENST00000237822.3
ENST00000412261.1
 C2orf43
 chromosome 2 open reading frame 43
chr10_-_62332357 0.26 ENST00000503366.1
 ANK3
 ankyrin 3, node of Ranvier (ankyrin G)
chr18_+_56892724 0.26 ENST00000456142.3
ENST00000530323.1
 GRP
 gastrin-releasing peptide
chrX_+_65382381 0.25 ENST00000519389.1
 HEPH
 hephaestin
chr6_-_150067632 0.25 ENST00000460354.2
ENST00000367404.4
ENST00000543637.1
 NUP43
 nucleoporin 43kDa
chr3_+_101546827 0.24 ENST00000461724.1
ENST00000483180.1
ENST00000394054.2
 NFKBIZ
 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chr5_-_135231516 0.23 ENST00000274520.1
 IL9
 interleukin 9
chr1_-_190446759 0.23 ENST00000367462.3
 BRINP3
 bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr8_+_145438870 0.22 ENST00000527931.1
 FAM203B
 family with sequence similarity 203, member B
chr1_+_12290121 0.21 ENST00000358136.3
ENST00000356315.4
 VPS13D
 vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr1_-_11863571 0.20 ENST00000376583.3
 MTHFR
 methylenetetrahydrofolate reductase (NAD(P)H)
chr16_+_2255710 0.20 ENST00000397124.1
ENST00000565250.1
 MLST8
 MTOR associated protein, LST8 homolog (S. cerevisiae)
chr6_-_150067696 0.19 ENST00000340413.2
ENST00000367403.3
 NUP43
 nucleoporin 43kDa
chr3_+_148457585 0.18 ENST00000402260.1
 AGTR1
 angiotensin II receptor, type 1
chr2_+_219246746 0.17 ENST00000233202.6
 SLC11A1
 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
chr10_+_17851362 0.17 ENST00000331429.2
ENST00000457317.1
 MRC1L1
 cDNA FLJ56855, highly similar to Macrophage mannose receptor 1
chrX_-_49965663 0.16 ENST00000376056.2
ENST00000376058.2
ENST00000358526.2
 AKAP4
 A kinase (PRKA) anchor protein 4
chr17_-_60142609 0.16 ENST00000397786.2
 MED13
 mediator complex subunit 13
chr19_+_1041212 0.14 ENST00000433129.1
 ABCA7
 ATP-binding cassette, sub-family A (ABC1), member 7
chr11_+_71846748 0.12 ENST00000445078.2
 FOLR3
 folate receptor 3 (gamma)
chr2_-_48982857 0.11 ENST00000403273.1
ENST00000401907.1
ENST00000344775.3
 LHCGR
 luteinizing hormone/choriogonadotropin receptor
chr11_+_71846764 0.10 ENST00000456237.1
ENST00000442948.2
ENST00000546166.1
 FOLR3
 folate receptor 3 (gamma)
chr10_+_74870206 0.09 ENST00000357321.4
ENST00000349051.5
 NUDT13
 nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr10_+_62538248 0.08 ENST00000448257.2
 CDK1
 cyclin-dependent kinase 1
chr2_+_136343820 0.08 ENST00000410054.1
 R3HDM1
 R3H domain containing 1
chr12_-_109025849 0.08 ENST00000228463.6
 SELPLG
 selectin P ligand
chr16_-_30122717 0.08 ENST00000566613.1
 GDPD3
 glycerophosphodiester phosphodiesterase domain containing 3
chr10_+_62538089 0.06 ENST00000519078.2
ENST00000395284.3
ENST00000316629.4
 CDK1
 cyclin-dependent kinase 1
chr7_-_15601595 0.06 ENST00000342526.3
 AGMO
 alkylglycerol monooxygenase
chr10_+_74870253 0.06 ENST00000544879.1
ENST00000537969.1
ENST00000372997.3
 NUDT13
 nudix (nucleoside diphosphate linked moiety X)-type motif 13
chr11_+_101785727 0.06 ENST00000263468.8
 KIAA1377
 KIAA1377
chr2_-_163008903 0.05 ENST00000418842.2
ENST00000375497.3
 GCG
 glucagon
chrX_-_49965009 0.05 ENST00000437370.1
ENST00000376064.3
ENST00000448865.1
 AKAP4
 A kinase (PRKA) anchor protein 4
chr2_-_48982708 0.05 ENST00000428232.1
ENST00000405626.1
ENST00000294954.7
 LHCGR
 luteinizing hormone/choriogonadotropin receptor
chr11_+_71238313 0.04 ENST00000398536.4
 KRTAP5-7
 keratin associated protein 5-7
chr18_-_5396271 0.04 ENST00000579951.1
 EPB41L3
 erythrocyte membrane protein band 4.1-like 3
chr10_-_135187193 0.04 ENST00000368547.3
 ECHS1
 enoyl CoA hydratase, short chain, 1, mitochondrial
chr7_+_47694842 0.03 ENST00000408988.2
 C7orf65
 chromosome 7 open reading frame 65
chr6_-_62996066 0.02 ENST00000281156.4
 KHDRBS2
 KH domain containing, RNA binding, signal transduction associated 2
chr11_-_73720122 0.01 ENST00000426995.2
 UCP3
 uncoupling protein 3 (mitochondrial, proton carrier)

Gene Ontology Analysis

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.7 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.2 0.5 GO:0051139 metal ion:proton antiporter activity(GO:0051139)
0.1 1.6 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 0.3 GO:0004960 thromboxane receptor activity(GO:0004960) thromboxane A2 receptor activity(GO:0004961)
0.1 0.4 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.1 0.2 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.0 0.1 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.0 0.2 GO:0004963 follicle-stimulating hormone receptor activity(GO:0004963)
0.0 0.2 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.0 0.4 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.0 0.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.2 GO:0005542 folic acid binding(GO:0005542)
0.0 0.6 GO:0036002 pre-mRNA binding(GO:0036002)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0070381 endosome to plasma membrane transport vesicle(GO:0070381)
0.0 1.0 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.0 0.1 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.0 0.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.2 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.0 0.3 GO:0043194 axon initial segment(GO:0043194)
0.0 0.4 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.0 0.1 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.3 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 1.6 PID E2F PATHWAY E2F transcription factor network
0.0 1.0 PID NOTCH PATHWAY Notch signaling pathway

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.6 GO:1902963 regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963)
0.2 0.5 GO:0055073 cadmium ion homeostasis(GO:0055073)
0.1 1.8 GO:0090361 platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.1 0.3 GO:0038193 thromboxane A2 signaling pathway(GO:0038193)
0.1 2.1 GO:0006825 copper ion transport(GO:0006825)
0.1 0.3 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.1 0.3 GO:0036343 psychomotor behavior(GO:0036343)
0.1 0.2 GO:0042700 luteinizing hormone signaling pathway(GO:0042700)
0.0 0.1 GO:1902995 regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995)
0.0 0.2 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.0 0.2 GO:0070829 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.0 1.5 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.1 GO:0050902 leukocyte adhesive activation(GO:0050902)
0.0 1.0 GO:0060216 definitive hemopoiesis(GO:0060216)
0.0 0.1 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
0.0 0.1 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.0 0.6 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.2 GO:0015884 folic acid transport(GO:0015884)
0.0 0.4 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.1 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.3 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.0 1.6 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.4 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.3 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.4 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 0.1 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.2 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors