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ENCODE cell lines, expression (Ernst 2011)

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Results for EN2_GBX2_LBX2

Z-value: 0.76

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Transcription factors associated with EN2_GBX2_LBX2

Gene Symbol Gene ID Gene Info
EN2
ENSG00000164778.4 EN2
GBX2
ENSG00000168505.6 GBX2
LBX2
ENSG00000179528.11 LBX2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GBX2hg19_v2_chr2_-_237076992_237077012-0.485.8e-02Click!
EN2hg19_v2_chr7_+_155250824_155250824-0.391.3e-01Click!

Activity profile of EN2_GBX2_LBX2 motif

Sorted Z-values of EN2_GBX2_LBX2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of EN2_GBX2_LBX2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr15_-_55562479 1.74 ENST00000564609.1
 RAB27A
 RAB27A, member RAS oncogene family
chr15_-_55563072 1.61 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
 RAB27A
 RAB27A, member RAS oncogene family
chr6_+_26199737 1.40 ENST00000359985.1
 HIST1H2BF
 histone cluster 1, H2bf
chr4_-_105416039 1.34 ENST00000394767.2
 CXXC4
 CXXC finger protein 4
chr15_-_55562582 1.22 ENST00000396307.2
 RAB27A
 RAB27A, member RAS oncogene family
chr7_+_138145076 1.09 ENST00000343526.4
 TRIM24
 tripartite motif containing 24
chr15_-_37393406 1.06 ENST00000338564.5
ENST00000558313.1
ENST00000340545.5
 MEIS2
 Meis homeobox 2
chr13_-_41593425 1.04 ENST00000239882.3
 ELF1
 E74-like factor 1 (ets domain transcription factor)
chr2_-_61697862 0.99 ENST00000398571.2
 USP34
 ubiquitin specific peptidase 34
chr6_-_39693111 0.95 ENST00000373215.3
ENST00000538893.1
ENST00000287152.7
ENST00000373216.3
 KIF6
 kinesin family member 6
chr9_+_2159850 0.91 ENST00000416751.1
 SMARCA2
 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr6_-_26199499 0.86 ENST00000377831.5
 HIST1H3D
 histone cluster 1, H3d
chr6_+_135502501 0.85 ENST00000527615.1
ENST00000420123.2
ENST00000525369.1
ENST00000528774.1
ENST00000534121.1
ENST00000534044.1
ENST00000533624.1
 MYB
 v-myb avian myeloblastosis viral oncogene homolog
chr6_-_32157947 0.84 ENST00000375050.4
 PBX2
 pre-B-cell leukemia homeobox 2
chr16_-_29910853 0.75 ENST00000308713.5
 SEZ6L2
 seizure related 6 homolog (mouse)-like 2
chr6_-_111927062 0.73 ENST00000359831.4
 TRAF3IP2
 TRAF3 interacting protein 2
chr3_+_167453493 0.62 ENST00000295777.5
ENST00000472747.2
 SERPINI1
 serpin peptidase inhibitor, clade I (neuroserpin), member 1
chr2_-_242089677 0.61 ENST00000405260.1
 PASK
 PAS domain containing serine/threonine kinase
chr11_+_67250490 0.60 ENST00000528641.2
ENST00000279146.3
 AIP
 aryl hydrocarbon receptor interacting protein
chr12_+_28410128 0.60 ENST00000381259.1
ENST00000381256.1
 CCDC91
 coiled-coil domain containing 91
chr18_+_59000815 0.59 ENST00000262717.4
 CDH20
 cadherin 20, type 2
chr18_-_31803435 0.58 ENST00000589544.1
ENST00000269185.4
ENST00000261592.5
 NOL4
 nucleolar protein 4
chr3_-_141747950 0.57 ENST00000497579.1
 TFDP2
 transcription factor Dp-2 (E2F dimerization partner 2)
chr18_+_55888767 0.56 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
 NEDD4L
 neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr11_-_33913708 0.56 ENST00000257818.2
 LMO2
 LIM domain only 2 (rhombotin-like 1)
chr13_-_36788718 0.53 ENST00000317764.6
ENST00000379881.3
 SOHLH2
 spermatogenesis and oogenesis specific basic helix-loop-helix 2
chrM_+_12331 0.53 ENST00000361567.2
 MT-ND5
 mitochondrially encoded NADH dehydrogenase 5
chr1_-_190446759 0.52 ENST00000367462.3
 BRINP3
 bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr21_-_43816052 0.50 ENST00000398405.1
 TMPRSS3
 transmembrane protease, serine 3
chr17_-_39191107 0.50 ENST00000344363.5
 KRTAP1-3
 keratin associated protein 1-3
chr6_-_26199471 0.48 ENST00000341023.1
 HIST1H2AD
 histone cluster 1, H2ad
chr10_-_50970322 0.48 ENST00000374103.4
 OGDHL
 oxoglutarate dehydrogenase-like
chr1_+_179923873 0.47 ENST00000367607.3
ENST00000491495.2
 CEP350
 centrosomal protein 350kDa
chr3_+_111718173 0.45 ENST00000494932.1
 TAGLN3
 transgelin 3
chr4_-_39979576 0.45 ENST00000303538.8
ENST00000503396.1
 PDS5A
 PDS5, regulator of cohesion maintenance, homolog A (S. cerevisiae)
chr17_+_47448102 0.44 ENST00000576461.1
 RP11-81K2.1
 Uncharacterized protein
chr6_-_26250835 0.43 ENST00000446824.2
 HIST1H3F
 histone cluster 1, H3f
chr20_-_50722183 0.41 ENST00000371523.4
 ZFP64
 ZFP64 zinc finger protein
chr7_+_77428066 0.41 ENST00000422959.2
ENST00000307305.8
ENST00000424760.1
 PHTF2
 putative homeodomain transcription factor 2
chr10_-_50970382 0.41 ENST00000419399.1
ENST00000432695.1
 OGDHL
 oxoglutarate dehydrogenase-like
chr7_+_77428149 0.37 ENST00000415251.2
ENST00000275575.7
 PHTF2
 putative homeodomain transcription factor 2
chr1_+_101003687 0.37 ENST00000315033.4
 GPR88
 G protein-coupled receptor 88
chr8_+_50824233 0.36 ENST00000522124.1
 SNTG1
 syntrophin, gamma 1
chr2_+_86668464 0.34 ENST00000409064.1
 KDM3A
 lysine (K)-specific demethylase 3A
chr12_-_28123206 0.34 ENST00000542963.1
ENST00000535992.1
 PTHLH
 parathyroid hormone-like hormone
chr18_+_32173276 0.31 ENST00000591816.1
ENST00000588125.1
ENST00000598334.1
ENST00000588684.1
ENST00000554864.3
ENST00000399121.5
ENST00000595022.1
ENST00000269190.7
ENST00000399097.3
 DTNA
 dystrobrevin, alpha
chr2_+_65216462 0.31 ENST00000234256.3
 SLC1A4
 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr14_+_32798462 0.31 ENST00000280979.4
 AKAP6
 A kinase (PRKA) anchor protein 6
chr14_+_32798547 0.31 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
 AKAP6
 A kinase (PRKA) anchor protein 6
chr2_-_77749474 0.31 ENST00000409093.1
ENST00000409088.3
 LRRTM4
 leucine rich repeat transmembrane neuronal 4
chr12_-_28122980 0.29 ENST00000395868.3
ENST00000534890.1
 PTHLH
 parathyroid hormone-like hormone
chr12_-_14133053 0.28 ENST00000609686.1
 GRIN2B
 glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr4_-_116034979 0.28 ENST00000264363.2
 NDST4
 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
chr1_+_171227069 0.28 ENST00000354841.4
 FMO1
 flavin containing monooxygenase 1
chr7_+_100136811 0.28 ENST00000300176.4
ENST00000262935.4
 AGFG2
 ArfGAP with FG repeats 2
chr14_-_51027838 0.28 ENST00000555216.1
 MAP4K5
 mitogen-activated protein kinase kinase kinase kinase 5
chr1_-_156399184 0.27 ENST00000368243.1
ENST00000357975.4
ENST00000310027.5
ENST00000400991.2
 C1orf61
 chromosome 1 open reading frame 61
chr19_+_48949030 0.27 ENST00000253237.5
 GRWD1
 glutamate-rich WD repeat containing 1
chr15_+_58430368 0.27 ENST00000558772.1
ENST00000219919.4
 AQP9
 aquaporin 9
chr6_-_26032288 0.25 ENST00000244661.2
 HIST1H3B
 histone cluster 1, H3b
chr2_+_196313239 0.25 ENST00000413290.1
 AC064834.1
 AC064834.1
chr3_+_115342349 0.25 ENST00000393780.3
 GAP43
 growth associated protein 43
chr19_-_51522955 0.25 ENST00000358789.3
 KLK10
 kallikrein-related peptidase 10
chr17_-_9929581 0.25 ENST00000437099.2
ENST00000396115.2
 GAS7
 growth arrest-specific 7
chr18_-_31803169 0.25 ENST00000590712.1
 NOL4
 nucleolar protein 4
chr12_+_52695617 0.24 ENST00000293525.5
 KRT86
 keratin 86
chr1_+_62901968 0.23 ENST00000452143.1
ENST00000442679.1
ENST00000371146.1
 USP1
 ubiquitin specific peptidase 1
chr1_-_152386732 0.23 ENST00000271835.3
 CRNN
 cornulin
chr11_+_75526212 0.23 ENST00000356136.3
 UVRAG
 UV radiation resistance associated
chr6_-_76203345 0.22 ENST00000393004.2
 FILIP1
 filamin A interacting protein 1
chr1_+_110881945 0.22 ENST00000602849.1
ENST00000487146.2
 RBM15
 RNA binding motif protein 15
chr12_-_52828147 0.22 ENST00000252245.5
 KRT75
 keratin 75
chr6_+_34204642 0.21 ENST00000347617.6
ENST00000401473.3
ENST00000311487.5
ENST00000447654.1
ENST00000395004.3
 HMGA1
 high mobility group AT-hook 1
chr10_-_48416849 0.21 ENST00000249598.1
 GDF2
 growth differentiation factor 2
chr1_+_214161272 0.21 ENST00000498508.2
ENST00000366958.4
 PROX1
 prospero homeobox 1
chrX_+_135730297 0.21 ENST00000370629.2
 CD40LG
 CD40 ligand
chr17_-_74163159 0.21 ENST00000591615.1
 RNF157
 ring finger protein 157
chr19_-_59084647 0.21 ENST00000594234.1
ENST00000596039.1
 MZF1
 myeloid zinc finger 1
chr2_+_171034646 0.20 ENST00000409044.3
ENST00000408978.4
 MYO3B
 myosin IIIB
chr2_+_47630108 0.20 ENST00000233146.2
ENST00000454849.1
ENST00000543555.1
 MSH2
 mutS homolog 2
chr15_+_58430567 0.19 ENST00000536493.1
 AQP9
 aquaporin 9
chr14_+_72052983 0.19 ENST00000358550.2
 SIPA1L1
 signal-induced proliferation-associated 1 like 1
chr9_+_136501478 0.19 ENST00000393056.2
ENST00000263611.2
 DBH
 dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chrX_-_53461305 0.19 ENST00000168216.6
 HSD17B10
 hydroxysteroid (17-beta) dehydrogenase 10
chr4_-_26492076 0.18 ENST00000295589.3
 CCKAR
 cholecystokinin A receptor
chr4_-_120243545 0.18 ENST00000274024.3
 FABP2
 fatty acid binding protein 2, intestinal
chrX_-_53461288 0.18 ENST00000375298.4
ENST00000375304.5
 HSD17B10
 hydroxysteroid (17-beta) dehydrogenase 10
chr2_+_47630255 0.18 ENST00000406134.1
 MSH2
 mutS homolog 2
chr7_-_25268104 0.18 ENST00000222674.2
 NPVF
 neuropeptide VF precursor
chr19_+_4007644 0.18 ENST00000262971.2
 PIAS4
 protein inhibitor of activated STAT, 4
chr17_-_48785216 0.17 ENST00000285243.6
 ANKRD40
 ankyrin repeat domain 40
chr8_+_105235572 0.17 ENST00000523362.1
 RIMS2
 regulating synaptic membrane exocytosis 2
chr12_+_7014064 0.17 ENST00000443597.2
 LRRC23
 leucine rich repeat containing 23
chr7_+_127292234 0.16 ENST00000354725.3
 SND1
 staphylococcal nuclease and tudor domain containing 1
chr16_+_103816 0.16 ENST00000383018.3
ENST00000417493.1
 SNRNP25
 small nuclear ribonucleoprotein 25kDa (U11/U12)
chr7_+_74072288 0.16 ENST00000443166.1
 GTF2I
 general transcription factor IIi
chr9_-_116840728 0.16 ENST00000265132.3
 AMBP
 alpha-1-microglobulin/bikunin precursor
chr19_-_19302931 0.15 ENST00000444486.3
ENST00000514819.3
ENST00000585679.1
ENST00000162023.5
 MEF2BNB-MEF2B
MEF2BNB
MEF2B
 MEF2BNB-MEF2B readthrough
MEF2B neighbor
myocyte enhancer factor 2B
chr15_-_64673665 0.15 ENST00000300035.4
 KIAA0101
 KIAA0101
chr20_-_18447667 0.15 ENST00000262547.5
ENST00000329494.5
ENST00000357236.4
 DZANK1
 double zinc ribbon and ankyrin repeat domains 1
chr17_-_10017864 0.15 ENST00000323816.4
 GAS7
 growth arrest-specific 7
chr8_-_42234745 0.14 ENST00000220812.2
 DKK4
 dickkopf WNT signaling pathway inhibitor 4
chr15_-_64673630 0.13 ENST00000558008.1
ENST00000559519.1
ENST00000380258.2
 KIAA0101
 KIAA0101
chr11_-_71823715 0.13 ENST00000545944.1
ENST00000502597.2
 ANAPC15
 anaphase promoting complex subunit 15
chr12_+_53662073 0.12 ENST00000553219.1
ENST00000257934.4
 ESPL1
 extra spindle pole bodies homolog 1 (S. cerevisiae)
chr3_-_195538728 0.12 ENST00000349607.4
ENST00000346145.4
 MUC4
 mucin 4, cell surface associated
chr11_-_71823796 0.12 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
 ANAPC15
 anaphase promoting complex subunit 15
chr15_+_40733387 0.12 ENST00000416165.1
 BAHD1
 bromo adjacent homology domain containing 1
chr9_+_80912059 0.12 ENST00000347159.2
ENST00000376588.3
 PSAT1
 phosphoserine aminotransferase 1
chr12_-_53171128 0.12 ENST00000332411.2
 KRT76
 keratin 76
chr4_-_174255536 0.12 ENST00000446922.2
 HMGB2
 high mobility group box 2
chr19_+_11485333 0.11 ENST00000312423.2
 SWSAP1
 SWIM-type zinc finger 7 associated protein 1
chr4_-_89205879 0.10 ENST00000608933.1
ENST00000315194.4
ENST00000514204.1
 PPM1K
 protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr3_+_152879985 0.10 ENST00000323534.2
 RAP2B
 RAP2B, member of RAS oncogene family
chr12_-_14849470 0.10 ENST00000261170.3
 GUCY2C
 guanylate cyclase 2C (heat stable enterotoxin receptor)
chr14_-_104181771 0.10 ENST00000554913.1
ENST00000554974.1
ENST00000553361.1
ENST00000555055.1
ENST00000555964.1
ENST00000556682.1
ENST00000445556.1
ENST00000553332.1
ENST00000352127.7
 XRCC3
 X-ray repair complementing defective repair in Chinese hamster cells 3
chr9_+_12693336 0.10 ENST00000381137.2
ENST00000388918.5
 TYRP1
 tyrosinase-related protein 1
chr3_-_52090461 0.09 ENST00000296483.6
ENST00000495880.1
 DUSP7
 dual specificity phosphatase 7
chr12_+_53662110 0.09 ENST00000552462.1
 ESPL1
 extra spindle pole bodies homolog 1 (S. cerevisiae)
chr3_+_173116225 0.09 ENST00000457714.1
 NLGN1
 neuroligin 1
chr4_-_174256276 0.09 ENST00000296503.5
 HMGB2
 high mobility group box 2
chr3_-_195538760 0.09 ENST00000475231.1
 MUC4
 mucin 4, cell surface associated
chr1_+_153747746 0.09 ENST00000368661.3
 SLC27A3
 solute carrier family 27 (fatty acid transporter), member 3
chr3_+_111718036 0.08 ENST00000455401.2
 TAGLN3
 transgelin 3
chr2_-_163008903 0.08 ENST00000418842.2
ENST00000375497.3
 GCG
 glucagon
chr1_+_62439037 0.08 ENST00000545929.1
 INADL
 InaD-like (Drosophila)
chr19_+_51728316 0.08 ENST00000436584.2
ENST00000421133.2
ENST00000391796.3
ENST00000262262.4
 CD33
 CD33 molecule
chr6_-_31088214 0.08 ENST00000376288.2
 CDSN
 corneodesmosin
chr11_-_71823266 0.07 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
 ANAPC15
 anaphase promoting complex subunit 15
chr5_-_95297678 0.07 ENST00000237853.4
 ELL2
 elongation factor, RNA polymerase II, 2
chr17_-_64225508 0.07 ENST00000205948.6
 APOH
 apolipoprotein H (beta-2-glycoprotein I)
chr5_+_179159813 0.07 ENST00000292599.3
 MAML1
 mastermind-like 1 (Drosophila)
chr6_+_26020672 0.07 ENST00000357647.3
 HIST1H3A
 histone cluster 1, H3a
chr19_-_14064114 0.07 ENST00000585607.1
ENST00000538517.2
ENST00000587458.1
ENST00000538371.2
 PODNL1
 podocan-like 1
chr12_+_7013897 0.07 ENST00000007969.8
ENST00000323702.5
 LRRC23
 leucine rich repeat containing 23
chr1_+_160160346 0.07 ENST00000368078.3
 CASQ1
 calsequestrin 1 (fast-twitch, skeletal muscle)
chr5_+_66300446 0.07 ENST00000261569.7
 MAST4
 microtubule associated serine/threonine kinase family member 4
chr1_+_160160283 0.06 ENST00000368079.3
 CASQ1
 calsequestrin 1 (fast-twitch, skeletal muscle)
chr3_+_133292759 0.06 ENST00000431519.2
 CDV3
 CDV3 homolog (mouse)
chr8_-_25281747 0.05 ENST00000421054.2
 GNRH1
 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone)
chr16_+_53164833 0.04 ENST00000564845.1
 CHD9
 chromodomain helicase DNA binding protein 9
chr7_-_73038867 0.04 ENST00000313375.3
ENST00000354613.1
ENST00000395189.1
ENST00000453275.1
 MLXIPL
 MLX interacting protein-like
chr8_+_24298597 0.04 ENST00000380789.1
 ADAM7
 ADAM metallopeptidase domain 7
chr15_-_31393910 0.04 ENST00000397795.2
ENST00000256552.6
ENST00000559179.1
 TRPM1
 transient receptor potential cation channel, subfamily M, member 1
chr12_+_7014126 0.04 ENST00000415834.1
ENST00000436789.1
 LRRC23
 leucine rich repeat containing 23
chr4_-_89205705 0.04 ENST00000295908.7
ENST00000510548.2
ENST00000508256.1
 PPM1K
 protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr15_+_89631647 0.04 ENST00000569550.1
ENST00000565066.1
ENST00000565973.1
 ABHD2
 abhydrolase domain containing 2
chr6_+_131571535 0.03 ENST00000474850.2
 AKAP7
 A kinase (PRKA) anchor protein 7
chr17_+_7792101 0.03 ENST00000358181.4
ENST00000330494.7
 CHD3
 chromodomain helicase DNA binding protein 3
chr9_+_116225999 0.03 ENST00000317613.6
 RGS3
 regulator of G-protein signaling 3
chr17_-_8093471 0.03 ENST00000389017.4
 C17orf59
 chromosome 17 open reading frame 59
chr17_-_47045949 0.03 ENST00000357424.2
 GIP
 gastric inhibitory polypeptide
chr3_-_119813264 0.03 ENST00000264235.8
 GSK3B
 glycogen synthase kinase 3 beta
chr8_+_24298531 0.02 ENST00000175238.6
 ADAM7
 ADAM metallopeptidase domain 7
chr16_+_69345243 0.02 ENST00000254950.11
 VPS4A
 vacuolar protein sorting 4 homolog A (S. cerevisiae)
chr5_+_145826867 0.02 ENST00000296702.5
ENST00000394421.2
 TCERG1
 transcription elongation regulator 1
chr6_-_161695074 0.02 ENST00000457520.2
ENST00000366906.5
ENST00000320285.4
 AGPAT4
 1-acylglycerol-3-phosphate O-acyltransferase 4
chr1_-_23670752 0.01 ENST00000302271.6
ENST00000426846.2
ENST00000427764.2
ENST00000606561.1
ENST00000374616.3
 HNRNPR
 heterogeneous nuclear ribonucleoprotein R
chr12_-_101604185 0.01 ENST00000536262.2
 SLC5A8
 solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
chr6_-_31782813 0.01 ENST00000375654.4
 HSPA1L
 heat shock 70kDa protein 1-like
chr3_+_130569429 0.01 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
 ATP2C1
 ATPase, Ca++ transporting, type 2C, member 1
chr7_-_73038822 0.01 ENST00000414749.2
ENST00000429400.2
ENST00000434326.1
 MLXIPL
 MLX interacting protein-like
chr19_-_41870026 0.01 ENST00000243578.3
 B9D2
 B9 protein domain 2

Gene Ontology Analysis

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.6 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 3.5 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.5 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.1 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.2 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0 0.2 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.3 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.2 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.2 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.7 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.2 1.1 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 0.6 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.1 0.9 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.1 0.4 GO:0032302 MutSbeta complex(GO:0032302)
0.1 0.6 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.1 0.4 GO:0030678 mitochondrial ribonuclease P complex(GO:0030678)
0.1 0.9 GO:0001673 male germ cell nucleus(GO:0001673)
0.0 0.4 GO:0016013 syntrophin complex(GO:0016013)
0.0 0.9 GO:0071564 npBAF complex(GO:0071564)
0.0 0.2 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 1.1 GO:0045095 keratin filament(GO:0045095)
0.0 0.2 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.0 0.2 GO:0042584 chromaffin granule membrane(GO:0042584)
0.0 0.1 GO:0014802 terminal cisterna(GO:0014802)
0.0 0.1 GO:0033063 DNA recombinase mediator complex(GO:0033061) Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 0.2 GO:0030897 HOPS complex(GO:0030897)
0.0 0.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.2 GO:0097433 dense body(GO:0097433)
0.0 0.1 GO:0005677 chromatin silencing complex(GO:0005677)
0.0 0.3 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.6 GO:0000786 nucleosome(GO:0000786)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.9 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.0 2.0 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 1.0 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.5 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.2 4.6 GO:0031489 myosin V binding(GO:0031489)
0.1 0.4 GO:0032181 heteroduplex DNA loop binding(GO:0000404) double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181)
0.1 0.5 GO:0015254 glycerol channel activity(GO:0015254) urea channel activity(GO:0015265)
0.1 1.1 GO:0034056 estrogen response element binding(GO:0034056)
0.1 0.3 GO:0015180 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.1 0.9 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.1 0.6 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 0.2 GO:0005174 CD40 receptor binding(GO:0005174)
0.1 0.2 GO:0004951 cholecystokinin receptor activity(GO:0004951)
0.1 0.2 GO:0030197 extracellular matrix constituent, lubricant activity(GO:0030197)
0.1 0.2 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
0.0 0.3 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0 0.2 GO:0019862 IgA binding(GO:0019862)
0.0 0.6 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.5 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 0.2 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.3 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.0 0.2 GO:0016715 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0 0.3 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.2 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.2 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.4 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0 0.6 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.0 0.3 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 1.5 GO:0001190 transcriptional activator activity, RNA polymerase II transcription factor binding(GO:0001190) transcriptional repressor activity, RNA polymerase II activating transcription factor binding(GO:0098811)
0.0 1.6 GO:0030165 PDZ domain binding(GO:0030165)
0.0 0.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.0 0.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.1 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.0 1.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.1 GO:0008821 crossover junction endodeoxyribonuclease activity(GO:0008821)
0.0 0.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.5 GO:0017080 sodium channel regulator activity(GO:0017080)
0.0 0.9 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.5 GO:0050136 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 4.6 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.3 0.9 GO:1904897 regulation of hepatic stellate cell proliferation(GO:1904897) positive regulation of hepatic stellate cell proliferation(GO:1904899) hepatic stellate cell proliferation(GO:1990922)
0.2 1.3 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.2 1.1 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.2 0.6 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.1 0.4 GO:0070901 mitochondrial tRNA methylation(GO:0070901)
0.1 0.3 GO:0007290 spermatid nucleus elongation(GO:0007290)
0.1 0.6 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 0.6 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.1 0.6 GO:0051344 regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051342) negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.1 0.4 GO:0061743 motor learning(GO:0061743)
0.1 0.5 GO:0015722 canalicular bile acid transport(GO:0015722) pyrimidine nucleobase transport(GO:0015855) urea transmembrane transport(GO:0071918) purine nucleobase transmembrane transport(GO:1904823)
0.1 0.3 GO:0015808 L-alanine transport(GO:0015808)
0.1 0.4 GO:0010520 meiotic gene conversion(GO:0006311) regulation of reciprocal meiotic recombination(GO:0010520)
0.1 0.2 GO:0051684 maintenance of Golgi location(GO:0051684)
0.1 0.2 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.1 0.2 GO:0038188 cholecystokinin signaling pathway(GO:0038188)
0.1 0.2 GO:0090402 oncogene-induced cell senescence(GO:0090402)
0.0 0.6 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 0.3 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 1.0 GO:0050860 negative regulation of T cell receptor signaling pathway(GO:0050860)
0.0 1.0 GO:0071108 protein K48-linked deubiquitination(GO:0071108)
0.0 0.2 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0 0.3 GO:0070995 NADPH oxidation(GO:0070995)
0.0 0.1 GO:0071139 resolution of recombination intermediates(GO:0071139) resolution of mitotic recombination intermediates(GO:0071140)
0.0 0.2 GO:0014886 transition between slow and fast fiber(GO:0014886)
0.0 0.1 GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness(GO:0010841) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.0 0.1 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.0 0.2 GO:0042421 norepinephrine biosynthetic process(GO:0042421)
0.0 0.5 GO:0006883 cellular sodium ion homeostasis(GO:0006883)
0.0 0.8 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.2 GO:0016198 axon choice point recognition(GO:0016198)
0.0 0.6 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.5 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.0 0.1 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.0 0.2 GO:1901970 positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of mitotic sister chromatid separation(GO:1901970) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.0 0.3 GO:0030202 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.0 0.1 GO:0042816 vitamin B6 metabolic process(GO:0042816)
0.0 0.2 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.6 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.0 0.1 GO:0048733 sebaceous gland development(GO:0048733)
0.0 0.8 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.0 0.2 GO:0045654 positive regulation of megakaryocyte differentiation(GO:0045654)
0.0 0.3 GO:0090266 regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
0.0 0.2 GO:0032277 negative regulation of gonadotropin secretion(GO:0032277)
0.0 0.1 GO:0003335 corneocyte development(GO:0003335)
0.0 0.2 GO:0098814 spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0 0.5 GO:0034453 microtubule anchoring(GO:0034453)
0.0 0.1 GO:0048023 positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0 1.1 GO:0008542 visual learning(GO:0008542)
0.0 0.1 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.0 GO:1990637 response to prolactin(GO:1990637)
0.0 0.6 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0 0.3 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.1 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 0.2 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.0 0.2 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.3 GO:0006337 nucleosome disassembly(GO:0006337)
0.0 0.2 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.0 0.2 GO:0042167 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0 0.2 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 0.1 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)