ISMARA results: ETV4

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ENCODE cell lines, expression (Ernst 2011)

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Results for ETV4_ETS2

Z-value: 0.85

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Transcription factors associated with ETV4_ETS2

Gene Symbol	Gene ID	Gene Info
ETV4 Ensembl NCBI GeneCards UniProt	ENSG00000175832.8	ETV4
ETS2 Ensembl NCBI GeneCards UniProt	ENSG00000157557.7	ETS2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ETS2	hg19_v2_chr21_+_40177755_40177875, hg19_v2_chr21_+_40177143_40177231	0.81	1.3e-04	Click!
ETV4	hg19_v2_chr17_-_41623691_41623715, hg19_v2_chr17_-_41623075_41623101	0.79	3.1e-04	Click!

Activity profile of ETV4_ETS2 motif

Sorted Z-values of ETV4_ETS2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ETV4_ETS2

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Top targets:

Promoter	Score	Transcript	Gene	Gene Info
chr6_+_31620191	3.48	ENST00000375918.2 ENST00000375920.4	APOM	apolipoprotein M
chr2_+_138721850	2.39	ENST00000329366.4 ENST00000280097.3	HNMT	histamine N-methyltransferase
chr2_+_110371905	1.98	ENST00000356454.3	SOWAHC	sosondowah ankyrin repeat domain family member C
chr6_-_31620403	1.74	ENST00000451898.1 ENST00000439687.2 ENST00000362049.6 ENST00000424480.1	BAG6	BCL2-associated athanogene 6
chr6_-_31620455	1.69	ENST00000437771.1 ENST00000404765.2 ENST00000375964.6 ENST00000211379.5	BAG6	BCL2-associated athanogene 6
chr11_-_46722117	1.66	ENST00000311956.4	ARHGAP1	Rho GTPase activating protein 1
chr2_+_138722028	1.61	ENST00000280096.5	HNMT	histamine N-methyltransferase
chr3_-_149095652	1.43	ENST00000305366.3	TM4SF1	transmembrane 4 L six family member 1
chr4_-_187644930	1.28	ENST00000441802.2	FAT1	FAT atypical cadherin 1
chr6_-_33267101	1.26	ENST00000497454.1	RGL2	ral guanine nucleotide dissociation stimulator-like 2
chr11_+_46722368	1.25	ENST00000311764.2	ZNF408	zinc finger protein 408
chr6_-_11382478	1.24	ENST00000397378.3 ENST00000513989.1 ENST00000508546.1 ENST00000504387.1	NEDD9	neural precursor cell expressed, developmentally down-regulated 9
chr19_-_4559814	1.24	ENST00000586582.1	SEMA6B	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chr16_-_30125177	1.16	ENST00000406256.3	GDPD3	glycerophosphodiester phosphodiesterase domain containing 3
chr17_+_1674982	1.14	ENST00000572048.1 ENST00000573763.1	SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr14_-_53417732	1.13	ENST00000399304.3 ENST00000395631.2 ENST00000341590.3 ENST00000343279.4	FERMT2	fermitin family member 2
chr8_-_134309335	1.11	ENST00000522890.1 ENST00000323851.7 ENST00000518176.1 ENST00000354944.5 ENST00000537882.1 ENST00000522476.1 ENST00000518066.1 ENST00000521544.1 ENST00000518480.1 ENST00000523892.1	NDRG1	N-myc downstream regulated 1
chr2_+_228678550	1.08	ENST00000409189.3 ENST00000358813.4	CCL20	chemokine (C-C motif) ligand 20
chr2_-_220435963	1.07	ENST00000373876.1 ENST00000404537.1 ENST00000603926.1 ENST00000373873.4 ENST00000289656.3	OBSL1	obscurin-like 1
chr18_+_55862622	1.06	ENST00000456173.2	NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr11_-_70507901	1.05	ENST00000449833.2 ENST00000357171.3 ENST00000449116.2	SHANK2	SH3 and multiple ankyrin repeat domains 2
chr6_-_31620149	1.03	ENST00000435080.1 ENST00000375976.4 ENST00000441054.1	BAG6	BCL2-associated athanogene 6
chr12_-_44200146	1.03	ENST00000395510.2 ENST00000325127.4	TWF1	twinfilin actin-binding protein 1
chr19_-_4338783	1.00	ENST00000601482.1 ENST00000600324.1	STAP2	signal transducing adaptor family member 2
chr3_-_50340996	0.99	ENST00000266031.4 ENST00000395143.2 ENST00000457214.2 ENST00000447605.2 ENST00000418723.1 ENST00000395144.2	HYAL1	hyaluronoglucosaminidase 1
chr8_+_22438009	0.99	ENST00000409417.1	PDLIM2	PDZ and LIM domain 2 (mystique)
chr2_-_188419078	0.98	ENST00000437725.1 ENST00000409676.1 ENST00000339091.4 ENST00000420747.1	TFPI	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr16_-_10652993	0.96	ENST00000536829.1	EMP2	epithelial membrane protein 2
chr6_-_138428613	0.95	ENST00000421351.3	PERP	PERP, TP53 apoptosis effector
chr7_-_107642348	0.95	ENST00000393561.1	LAMB1	laminin, beta 1
chr17_-_79269067	0.91	ENST00000288439.5 ENST00000374759.3	SLC38A10	solute carrier family 38, member 10
chr6_+_53659746	0.89	ENST00000370888.1	LRRC1	leucine rich repeat containing 1
chr19_-_4338838	0.86	ENST00000594605.1	STAP2	signal transducing adaptor family member 2
chr16_+_56485402	0.86	ENST00000566157.1 ENST00000562150.1 ENST00000561646.1 ENST00000568397.1	OGFOD1	2-oxoglutarate and iron-dependent oxygenase domain containing 1
chr17_-_39093672	0.85	ENST00000209718.3 ENST00000436344.3 ENST00000485751.1	KRT23	keratin 23 (histone deacetylase inducible)
chr2_-_188419200	0.83	ENST00000233156.3 ENST00000426055.1 ENST00000453013.1 ENST00000417013.1	TFPI	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr20_-_2451395	0.82	ENST00000339610.6 ENST00000381342.2 ENST00000438552.2	SNRPB	small nuclear ribonucleoprotein polypeptides B and B1
chr4_-_140005341	0.81	ENST00000379549.2 ENST00000512627.1	ELF2	E74-like factor 2 (ets domain transcription factor)
chr8_+_22437965	0.81	ENST00000409141.1 ENST00000265810.4	PDLIM2	PDZ and LIM domain 2 (mystique)
chr14_-_45431091	0.81	ENST00000579157.1 ENST00000396128.4 ENST00000556500.1	KLHL28	kelch-like family member 28
chr17_+_37844331	0.81	ENST00000578199.1 ENST00000406381.2	ERBB2	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
chr15_+_77287426	0.80	ENST00000558012.1 ENST00000267939.5 ENST00000379595.3	PSTPIP1	proline-serine-threonine phosphatase interacting protein 1
chr2_-_242556900	0.79	ENST00000402545.1 ENST00000402136.1	THAP4	THAP domain containing 4
chr2_+_32502952	0.79	ENST00000238831.4	YIPF4	Yip1 domain family, member 4
chr16_+_66968343	0.78	ENST00000417689.1 ENST00000561697.1 ENST00000317091.4 ENST00000566182.1	CES2	carboxylesterase 2
chr12_-_103310987	0.78	ENST00000307000.2	PAH	phenylalanine hydroxylase
chr4_-_39529049	0.77	ENST00000501493.2 ENST00000509391.1 ENST00000507089.1	UGDH	UDP-glucose 6-dehydrogenase
chr1_+_160313062	0.76	ENST00000294785.5 ENST00000368063.1 ENST00000437169.1	NCSTN	nicastrin
chr6_+_142622991	0.75	ENST00000230173.6 ENST00000367608.2	GPR126	G protein-coupled receptor 126
chr14_+_24702073	0.74	ENST00000399440.2	GMPR2	guanosine monophosphate reductase 2
chr2_+_118846008	0.74	ENST00000245787.4	INSIG2	insulin induced gene 2
chr1_-_146696901	0.73	ENST00000369272.3 ENST00000441068.2	FMO5	flavin containing monooxygenase 5
chr11_+_19799327	0.73	ENST00000540292.1	NAV2	neuron navigator 2
chr7_-_100860851	0.73	ENST00000223127.3	PLOD3	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr14_+_24702127	0.73	ENST00000557854.1 ENST00000348719.7 ENST00000559104.1 ENST00000456667.3	GMPR2	guanosine monophosphate reductase 2
chr4_-_110723335	0.73	ENST00000394634.2	CFI	complement factor I
chr1_+_228353495	0.72	ENST00000366711.3	IBA57	IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
chr14_+_21156915	0.71	ENST00000397990.4 ENST00000555597.1	ANG RNASE4	angiogenin, ribonuclease, RNase A family, 5 ribonuclease, RNase A family, 4
chr14_-_23504087	0.70	ENST00000493471.2 ENST00000460922.2	PSMB5	proteasome (prosome, macropain) subunit, beta type, 5
chr1_-_146697185	0.69	ENST00000533174.1 ENST00000254090.4	FMO5	flavin containing monooxygenase 5
chr9_+_115983808	0.69	ENST00000374210.6 ENST00000374212.4	SLC31A1	solute carrier family 31 (copper transporter), member 1
chr15_+_90808919	0.69	ENST00000379095.3	NGRN	neugrin, neurite outgrowth associated
chrX_+_115567767	0.69	ENST00000371900.4	SLC6A14	solute carrier family 6 (amino acid transporter), member 14
chr11_+_2421718	0.68	ENST00000380996.5 ENST00000333256.6 ENST00000380992.1 ENST00000437110.1 ENST00000435795.1	TSSC4	tumor suppressing subtransferable candidate 4
chr17_+_79935464	0.68	ENST00000581647.1 ENST00000580534.1 ENST00000579684.1	ASPSCR1	alveolar soft part sarcoma chromosome region, candidate 1
chr4_-_140005443	0.67	ENST00000510408.1 ENST00000420916.2 ENST00000358635.3	ELF2	E74-like factor 2 (ets domain transcription factor)
chr14_-_38064198	0.67	ENST00000250448.2	FOXA1	forkhead box A1
chr14_-_23504432	0.66	ENST00000425762.2	PSMB5	proteasome (prosome, macropain) subunit, beta type, 5
chr1_+_154300217	0.66	ENST00000368489.3	ATP8B2	ATPase, aminophospholipid transporter, class I, type 8B, member 2
chr8_-_134309823	0.65	ENST00000414097.2	NDRG1	N-myc downstream regulated 1
chr14_-_23504337	0.65	ENST00000361611.6	PSMB5	proteasome (prosome, macropain) subunit, beta type, 5
chrX_-_128657457	0.64	ENST00000371121.3 ENST00000371123.1 ENST00000371122.4	SMARCA1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
chr8_+_95565947	0.64	ENST00000523011.1	RP11-267M23.4	RP11-267M23.4
chr3_-_128879875	0.63	ENST00000418265.1 ENST00000393292.3 ENST00000273541.8	ISY1-RAB43 ISY1	ISY1-RAB43 readthrough ISY1 splicing factor homolog (S. cerevisiae)
chr3_+_15468862	0.63	ENST00000396842.2	EAF1	ELL associated factor 1
chr14_+_77924373	0.63	ENST00000216479.3 ENST00000535854.2 ENST00000555517.1	AHSA1	AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
chr4_-_10023095	0.63	ENST00000264784.3	SLC2A9	solute carrier family 2 (facilitated glucose transporter), member 9
chr14_+_24702099	0.62	ENST00000420554.2	GMPR2	guanosine monophosphate reductase 2
chr14_+_24701819	0.62	ENST00000560139.1 ENST00000559910.1	GMPR2	guanosine monophosphate reductase 2
chr20_-_22565101	0.61	ENST00000419308.2	FOXA2	forkhead box A2
chr2_-_161349909	0.61	ENST00000392753.3	RBMS1	RNA binding motif, single stranded interacting protein 1
chr6_-_32143828	0.60	ENST00000412465.2 ENST00000375107.3	AGPAT1	1-acylglycerol-3-phosphate O-acyltransferase 1
chr7_+_134464414	0.60	ENST00000361901.2	CALD1	caldesmon 1
chr20_-_54967187	0.60	ENST00000422322.1 ENST00000371356.2 ENST00000451915.1 ENST00000347343.2 ENST00000395911.1 ENST00000395907.1 ENST00000441357.1 ENST00000456249.1 ENST00000420474.1 ENST00000395909.4 ENST00000395914.1 ENST00000312783.6 ENST00000395915.3 ENST00000395913.3	AURKA	aurora kinase A
chr2_-_28113965	0.59	ENST00000302188.3	RBKS	ribokinase
chr16_+_31085714	0.59	ENST00000300850.5 ENST00000564189.1 ENST00000428260.1	ZNF646	zinc finger protein 646
chr15_+_58702742	0.59	ENST00000356113.6 ENST00000414170.3	LIPC	lipase, hepatic
chr16_-_57513657	0.58	ENST00000566936.1 ENST00000568617.1 ENST00000567276.1 ENST00000569548.1 ENST00000569250.1 ENST00000564378.1	DOK4	docking protein 4
chr6_-_155635583	0.58	ENST00000367166.4	TFB1M	transcription factor B1, mitochondrial
chr21_-_36421535	0.58	ENST00000416754.1 ENST00000437180.1 ENST00000455571.1	RUNX1	runt-related transcription factor 1
chr16_-_28506840	0.57	ENST00000569430.1	CLN3	ceroid-lipofuscinosis, neuronal 3
chr6_+_36853607	0.57	ENST00000480824.2 ENST00000355190.3 ENST00000373685.1	C6orf89	chromosome 6 open reading frame 89
chr14_+_32546274	0.57	ENST00000396582.2	ARHGAP5	Rho GTPase activating protein 5
chr20_+_44044717	0.56	ENST00000279036.6 ENST00000279035.9 ENST00000372689.5 ENST00000545755.1 ENST00000341555.5 ENST00000535404.1 ENST00000543458.2 ENST00000432270.1	PIGT	phosphatidylinositol glycan anchor biosynthesis, class T
chr3_-_50360192	0.56	ENST00000442581.1 ENST00000447092.1 ENST00000357750.4	HYAL2	hyaluronoglucosaminidase 2
chr14_+_24701628	0.56	ENST00000355299.4 ENST00000559836.1	GMPR2	guanosine monophosphate reductase 2
chr12_+_132195617	0.56	ENST00000261674.4 ENST00000535236.1 ENST00000541286.1	SFSWAP	splicing factor, suppressor of white-apricot homolog (Drosophila)
chr14_+_74004051	0.56	ENST00000557556.1	ACOT1	acyl-CoA thioesterase 1
chr7_-_139876812	0.55	ENST00000397560.2	JHDM1D	lysine (K)-specific demethylase 7A
chr14_+_77924204	0.54	ENST00000555133.1	AHSA1	AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
chr2_+_109237717	0.54	ENST00000409441.1	LIMS1	LIM and senescent cell antigen-like domains 1
chr1_+_156698234	0.54	ENST00000368218.4 ENST00000368216.4	RRNAD1	ribosomal RNA adenine dimethylase domain containing 1
chr19_+_35739782	0.54	ENST00000347609.4	LSR	lipolysis stimulated lipoprotein receptor
chr4_-_89152474	0.54	ENST00000515655.1	ABCG2	ATP-binding cassette, sub-family G (WHITE), member 2
chr11_-_72433346	0.54	ENST00000334211.8	ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr2_-_9563575	0.54	ENST00000488451.1 ENST00000238091.4 ENST00000355346.4	ITGB1BP1	integrin beta 1 binding protein 1
chr19_+_35739897	0.53	ENST00000605618.1 ENST00000427250.1 ENST00000601623.1	LSR	lipolysis stimulated lipoprotein receptor
chrX_-_10851762	0.53	ENST00000380785.1 ENST00000380787.1	MID1	midline 1 (Opitz/BBB syndrome)
chr12_+_53443680	0.53	ENST00000314250.6 ENST00000451358.1	TENC1	tensin like C1 domain containing phosphatase (tensin 2)
chr21_-_36421626	0.52	ENST00000300305.3	RUNX1	runt-related transcription factor 1
chr8_+_117778736	0.52	ENST00000309822.2 ENST00000357148.3 ENST00000517814.1 ENST00000517820.1	UTP23	UTP23, small subunit (SSU) processome component, homolog (yeast)
chr11_-_62389449	0.52	ENST00000534026.1	B3GAT3	beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)
chr20_-_48532019	0.52	ENST00000289431.5	SPATA2	spermatogenesis associated 2
chr2_-_220436248	0.51	ENST00000265318.4	OBSL1	obscurin-like 1
chr17_+_21191341	0.51	ENST00000526076.2 ENST00000361818.5 ENST00000316920.6	MAP2K3	mitogen-activated protein kinase kinase 3
chr11_+_47270475	0.51	ENST00000481889.2 ENST00000436778.1 ENST00000531660.1 ENST00000407404.1	NR1H3	nuclear receptor subfamily 1, group H, member 3
chr11_-_61197480	0.51	ENST00000439958.3 ENST00000394888.4	CPSF7	cleavage and polyadenylation specific factor 7, 59kDa
chr1_+_40505891	0.51	ENST00000372797.3 ENST00000372802.1 ENST00000449311.1	CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)
chr16_+_28875126	0.51	ENST00000359285.5 ENST00000538342.1	SH2B1	SH2B adaptor protein 1
chr11_-_72432950	0.50	ENST00000426523.1 ENST00000429686.1	ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr19_+_15218180	0.50	ENST00000342784.2 ENST00000597977.1 ENST00000600440.1	SYDE1	synapse defective 1, Rho GTPase, homolog 1 (C. elegans)
chr17_-_7155274	0.50	ENST00000318988.6 ENST00000575783.1 ENST00000573600.1	CTDNEP1	CTD nuclear envelope phosphatase 1
chr11_+_47270436	0.50	ENST00000395397.3 ENST00000405576.1	NR1H3	nuclear receptor subfamily 1, group H, member 3
chr17_+_15848231	0.49	ENST00000304222.2	ADORA2B	adenosine A2b receptor
chr10_-_15902449	0.49	ENST00000277632.3	FAM188A	family with sequence similarity 188, member A
chr9_+_120466610	0.49	ENST00000394487.4	TLR4	toll-like receptor 4
chr9_+_120466650	0.49	ENST00000355622.6	TLR4	toll-like receptor 4
chrX_+_54834791	0.49	ENST00000218439.4 ENST00000375058.1 ENST00000375060.1	MAGED2	melanoma antigen family D, 2
chr19_+_35940486	0.49	ENST00000246549.2	FFAR2	free fatty acid receptor 2
chr8_+_9413410	0.48	ENST00000520408.1 ENST00000310430.6 ENST00000522110.1	TNKS	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
chr1_+_17944832	0.48	ENST00000167825.4	ARHGEF10L	Rho guanine nucleotide exchange factor (GEF) 10-like
chr16_+_29465822	0.48	ENST00000330181.5 ENST00000351581.4	SLX1B	SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)
chr11_+_844406	0.48	ENST00000397404.1	TSPAN4	tetraspanin 4
chr3_-_178984759	0.48	ENST00000349697.2 ENST00000497599.1	KCNMB3	potassium large conductance calcium-activated channel, subfamily M beta member 3
chr7_+_99613212	0.48	ENST00000426572.1 ENST00000535170.1	ZKSCAN1	zinc finger with KRAB and SCAN domains 1
chr17_+_41561317	0.47	ENST00000540306.1 ENST00000262415.3 ENST00000605777.1	DHX8	DEAH (Asp-Glu-Ala-His) box polypeptide 8
chr16_+_30205225	0.47	ENST00000345535.4 ENST00000251303.6	SLX1A	SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)
chr17_+_39969183	0.47	ENST00000321562.4	FKBP10	FK506 binding protein 10, 65 kDa
chr1_+_17944806	0.47	ENST00000375408.3	ARHGEF10L	Rho guanine nucleotide exchange factor (GEF) 10-like
chr14_-_24780573	0.47	ENST00000336557.5 ENST00000258807.5	CIDEB	cell death-inducing DFFA-like effector b
chr1_-_92351769	0.47	ENST00000212355.4	TGFBR3	transforming growth factor, beta receptor III
chr17_-_56494882	0.47	ENST00000584437.1	RNF43	ring finger protein 43
chr9_+_103204553	0.47	ENST00000502978.1 ENST00000334943.6	MSANTD3-TMEFF1 TMEFF1	MSANTD3-TMEFF1 readthrough transmembrane protein with EGF-like and two follistatin-like domains 1
chr5_+_68530697	0.46	ENST00000256443.3 ENST00000514676.1	CDK7	cyclin-dependent kinase 7
chr4_-_10686475	0.46	ENST00000226951.6	CLNK	cytokine-dependent hematopoietic cell linker
chr17_-_74722672	0.46	ENST00000397625.4 ENST00000445478.2	JMJD6	jumonji domain containing 6
chr16_+_69373323	0.46	ENST00000254940.5	NIP7	NIP7, nucleolar pre-rRNA processing protein
chr17_-_37844267	0.46	ENST00000579146.1 ENST00000378011.4 ENST00000429199.2 ENST00000300658.4	PGAP3	post-GPI attachment to proteins 3
chr19_-_16653325	0.46	ENST00000546361.2	CHERP	calcium homeostasis endoplasmic reticulum protein
chr2_-_9563319	0.46	ENST00000497105.1 ENST00000360635.3 ENST00000359712.3	ITGB1BP1	integrin beta 1 binding protein 1
chr17_-_56494908	0.46	ENST00000577716.1	RNF43	ring finger protein 43
chr12_+_53443963	0.46	ENST00000546602.1 ENST00000552570.1 ENST00000549700.1	TENC1	tensin like C1 domain containing phosphatase (tensin 2)
chr6_+_33168597	0.45	ENST00000374675.3	SLC39A7	solute carrier family 39 (zinc transporter), member 7
chr11_+_9406169	0.45	ENST00000379719.3 ENST00000527431.1	IPO7	importin 7
chr11_+_46402583	0.45	ENST00000359803.3	MDK	midkine (neurite growth-promoting factor 2)
chr17_-_56065484	0.45	ENST00000581208.1	VEZF1	vascular endothelial zinc finger 1
chr19_-_4723761	0.45	ENST00000597849.1 ENST00000598800.1 ENST00000602161.1 ENST00000597726.1 ENST00000601130.1 ENST00000262960.9	DPP9	dipeptidyl-peptidase 9
chr1_+_16083154	0.45	ENST00000375771.1	FBLIM1	filamin binding LIM protein 1
chr6_+_33168637	0.45	ENST00000374677.3	SLC39A7	solute carrier family 39 (zinc transporter), member 7
chr9_-_139268068	0.45	ENST00000371734.3 ENST00000371732.5 ENST00000315908.7	CARD9	caspase recruitment domain family, member 9
chr1_-_20987982	0.45	ENST00000375048.3	DDOST	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
chr2_+_187454749	0.44	ENST00000261023.3 ENST00000374907.3	ITGAV	integrin, alpha V
chr10_-_79789291	0.44	ENST00000372371.3	POLR3A	polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
chr1_-_20987851	0.44	ENST00000464364.1 ENST00000602624.2	DDOST	dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)
chr12_-_110888103	0.44	ENST00000426440.1 ENST00000228825.7	ARPC3	actin related protein 2/3 complex, subunit 3, 21kDa
chr17_-_56494713	0.44	ENST00000407977.2	RNF43	ring finger protein 43
chr16_-_30122717	0.44	ENST00000566613.1	GDPD3	glycerophosphodiester phosphodiesterase domain containing 3
chr3_+_52812523	0.44	ENST00000540715.1	ITIH1	inter-alpha-trypsin inhibitor heavy chain 1
chr19_+_16296191	0.43	ENST00000589852.1 ENST00000263384.7 ENST00000588367.1 ENST00000587351.1	FAM32A	family with sequence similarity 32, member A
chr20_+_56136136	0.43	ENST00000319441.4 ENST00000543666.1	PCK1	phosphoenolpyruvate carboxykinase 1 (soluble)
chr11_+_46402744	0.43	ENST00000533952.1	MDK	midkine (neurite growth-promoting factor 2)
chr14_-_35099315	0.43	ENST00000396526.3 ENST00000396534.3 ENST00000355110.5 ENST00000557265.1	SNX6	sorting nexin 6
chr5_+_141303373	0.43	ENST00000432126.2 ENST00000194118.4	KIAA0141	KIAA0141
chr19_+_54694119	0.43	ENST00000456872.1 ENST00000302937.4 ENST00000429671.2	TSEN34	TSEN34 tRNA splicing endonuclease subunit
chr6_+_43739697	0.43	ENST00000230480.6	VEGFA	vascular endothelial growth factor A
chr2_-_101767715	0.43	ENST00000376840.4 ENST00000409318.1	TBC1D8	TBC1 domain family, member 8 (with GRAM domain)
chr17_-_74722536	0.42	ENST00000585429.1	JMJD6	jumonji domain containing 6
chr13_+_113633620	0.42	ENST00000421756.1 ENST00000375601.3	MCF2L	MCF.2 cell line derived transforming sequence-like
chr16_+_69458428	0.42	ENST00000512062.1 ENST00000307892.8	CYB5B	cytochrome b5 type B (outer mitochondrial membrane)
chr11_-_57282349	0.41	ENST00000528450.1	SLC43A1	solute carrier family 43 (amino acid system L transporter), member 1
chr3_+_57541975	0.41	ENST00000487257.1 ENST00000311180.8	PDE12	phosphodiesterase 12
chr14_-_77923897	0.41	ENST00000343765.2 ENST00000327028.4 ENST00000556412.1 ENST00000557466.1 ENST00000448935.2 ENST00000553888.1 ENST00000557658.1	VIPAS39	VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog
chr16_-_31085514	0.41	ENST00000300849.4	ZNF668	zinc finger protein 668
chr19_-_16653226	0.41	ENST00000198939.6	CHERP	calcium homeostasis endoplasmic reticulum protein
chr1_-_118472216	0.41	ENST00000369443.5	GDAP2	ganglioside induced differentiation associated protein 2
chr7_+_99613195	0.41	ENST00000324306.6	ZKSCAN1	zinc finger with KRAB and SCAN domains 1
chr7_+_134464376	0.41	ENST00000454108.1 ENST00000361675.2	CALD1	caldesmon 1
chr3_-_15469006	0.41	ENST00000443029.1 ENST00000383790.3 ENST00000383789.5	METTL6	methyltransferase like 6
chr11_-_47270341	0.40	ENST00000529444.1 ENST00000530453.1 ENST00000537863.1 ENST00000529788.1 ENST00000444355.2 ENST00000527256.1 ENST00000529663.1 ENST00000256997.3	ACP2	acid phosphatase 2, lysosomal
chr17_+_37856299	0.40	ENST00000269571.5	ERBB2	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2
chr11_+_63655987	0.40	ENST00000509502.2 ENST00000512060.1	MARK2	MAP/microtubule affinity-regulating kinase 2
chrX_+_153775821	0.40	ENST00000263518.6 ENST00000470142.1 ENST00000393549.2 ENST00000455588.2 ENST00000369602.3	IKBKG	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
chr14_-_24701539	0.40	ENST00000534348.1 ENST00000524927.1 ENST00000250495.5	NEDD8-MDP1 NEDD8	NEDD8-MDP1 readthrough neural precursor cell expressed, developmentally down-regulated 8
chr14_-_21979428	0.40	ENST00000538267.1 ENST00000298717.4	METTL3	methyltransferase like 3
chr4_-_17812309	0.40	ENST00000382247.1 ENST00000536863.1	DCAF16	DDB1 and CUL4 associated factor 16
chr21_-_33984888	0.40	ENST00000382549.4 ENST00000540881.1	C21orf59	chromosome 21 open reading frame 59
chr20_-_45984401	0.40	ENST00000311275.7	ZMYND8	zinc finger, MYND-type containing 8
chr18_-_812517	0.39	ENST00000584307.1	YES1	v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
chr8_+_104427581	0.39	ENST00000521716.1 ENST00000521971.1 ENST00000519682.1	DCAF13	DDB1 and CUL4 associated factor 13
chr2_-_106013400	0.39	ENST00000409807.1	FHL2	four and a half LIM domains 2

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.2	3.5	GO:0034365	discoidal high-density lipoprotein particle(GO:0034365)
1.1	4.3	GO:0072379	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.5	3.3	GO:1902560	GMP reductase complex(GO:1902560)
0.3	1.6	GO:1990393	3M complex(GO:1990393)
0.3	0.9	GO:0005607	laminin-2 complex(GO:0005607)
0.2	0.7	GO:0071595	Nem1-Spo7 phosphatase complex(GO:0071595)
0.2	0.6	GO:0045293	MIS complex(GO:0036396) mRNA editing complex(GO:0045293)
0.2	0.8	GO:0070985	TFIIK complex(GO:0070985)
0.2	0.6	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.2	0.7	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)
0.2	1.1	GO:0061689	tricellular tight junction(GO:0061689)
0.1	0.4	GO:0033185	dolichol-phosphate-mannose synthase complex(GO:0033185)
0.1	1.6	GO:0097443	sorting endosome(GO:0097443)
0.1	0.4	GO:0034685	integrin alphav-beta6 complex(GO:0034685) integrin alphav-beta8 complex(GO:0034686)
0.1	1.7	GO:0043203	axon hillock(GO:0043203)
0.1	0.4	GO:0061673	cortical microtubule(GO:0055028) mitotic spindle astral microtubule(GO:0061673)
0.1	1.4	GO:0005883	neurofilament(GO:0005883)
0.1	0.4	GO:0005944	phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
0.1	1.0	GO:0071204	histone pre-mRNA 3'end processing complex(GO:0071204)
0.1	0.4	GO:0071020	post-spliceosomal complex(GO:0071020)
0.1	0.5	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.1	0.7	GO:0032311	angiogenin-PRI complex(GO:0032311)
0.1	0.3	GO:0016222	procollagen-proline 4-dioxygenase complex(GO:0016222)
0.1	0.4	GO:0032044	DSIF complex(GO:0032044)
0.1	0.5	GO:0045272	plasma membrane respiratory chain complex I(GO:0045272)
0.1	0.4	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.1	0.5	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.1	0.5	GO:0071797	LUBAC complex(GO:0071797)
0.1	0.7	GO:0097427	microtubule bundle(GO:0097427)
0.1	0.4	GO:0033596	TSC1-TSC2 complex(GO:0033596)
0.1	0.4	GO:1990745	EARP complex(GO:1990745)
0.1	0.6	GO:0071817	MMXD complex(GO:0071817)
0.1	0.6	GO:0016589	NURF complex(GO:0016589)
0.1	1.4	GO:0019774	proteasome core complex, beta-subunit complex(GO:0019774)
0.1	0.5	GO:0070435	Shc-EGFR complex(GO:0070435)
0.1	1.0	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.1	0.4	GO:0097422	tubular endosome(GO:0097422)
0.1	0.4	GO:0031313	extrinsic component of endosome membrane(GO:0031313)
0.1	0.3	GO:0036449	microtubule minus-end(GO:0036449)
0.1	0.7	GO:0005614	interstitial matrix(GO:0005614)
0.1	0.2	GO:0071159	NF-kappaB complex(GO:0071159)
0.1	0.6	GO:0031209	SCAR complex(GO:0031209)
0.1	0.2	GO:0030981	cortical microtubule cytoskeleton(GO:0030981)
0.1	0.3	GO:1990357	terminal web(GO:1990357)
0.1	0.5	GO:0033588	Elongator holoenzyme complex(GO:0033588)
0.1	0.3	GO:1990130	Iml1 complex(GO:1990130)
0.1	0.4	GO:0000813	ESCRT I complex(GO:0000813)
0.1	0.2	GO:0030689	Noc complex(GO:0030689)
0.1	0.3	GO:0034388	Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0	0.5	GO:0070765	gamma-secretase complex(GO:0070765)
0.0	0.7	GO:0030478	actin cap(GO:0030478)
0.0	0.1	GO:0019034	viral replication complex(GO:0019034)
0.0	0.8	GO:0071782	endoplasmic reticulum tubular network(GO:0071782)
0.0	0.2	GO:1990037	Lewy body core(GO:1990037)
0.0	0.4	GO:0044233	ER-mitochondrion membrane contact site(GO:0044233)
0.0	1.9	GO:0031941	filamentous actin(GO:0031941)
0.0	0.3	GO:1903439	calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.0	0.3	GO:0036056	filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0	1.2	GO:0030057	desmosome(GO:0030057)
0.0	0.4	GO:0044615	nuclear pore nuclear basket(GO:0044615)
0.0	0.2	GO:0033269	internode region of axon(GO:0033269)
0.0	0.3	GO:0061574	ASAP complex(GO:0061574)
0.0	0.4	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.0	0.3	GO:0097425	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0	0.5	GO:0031362	anchored component of external side of plasma membrane(GO:0031362)
0.0	0.4	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	0.0	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0	0.4	GO:0033018	sarcoplasmic reticulum lumen(GO:0033018)
0.0	0.4	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.0	0.2	GO:0033553	rDNA heterochromatin(GO:0033553)
0.0	0.4	GO:0035102	PRC1 complex(GO:0035102)
0.0	0.6	GO:0097225	sperm midpiece(GO:0097225)
0.0	0.9	GO:0080008	Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0	0.1	GO:1990796	photoreceptor cell terminal bouton(GO:1990796)
0.0	0.1	GO:1902636	kinociliary basal body(GO:1902636)
0.0	0.1	GO:0042382	paraspeckles(GO:0042382)
0.0	0.3	GO:0071014	post-mRNA release spliceosomal complex(GO:0071014)
0.0	0.4	GO:0030914	STAGA complex(GO:0030914)
0.0	3.1	GO:0005901	caveola(GO:0005901)
0.0	0.3	GO:0030126	COPI vesicle coat(GO:0030126)
0.0	0.2	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	0.2	GO:0070938	dystroglycan complex(GO:0016011) contractile ring(GO:0070938)
0.0	0.2	GO:0008024	cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.0	2.1	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.0	0.1	GO:0070847	core mediator complex(GO:0070847)
0.0	0.6	GO:0030867	rough endoplasmic reticulum membrane(GO:0030867)
0.0	0.2	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.2	GO:0097165	nuclear stress granule(GO:0097165)
0.0	0.1	GO:0005726	perichromatin fibrils(GO:0005726) pre-snoRNP complex(GO:0070761)
0.0	0.3	GO:0005833	hemoglobin complex(GO:0005833)
0.0	0.4	GO:0097038	perinuclear endoplasmic reticulum(GO:0097038)
0.0	0.0	GO:0031501	mannosyltransferase complex(GO:0031501)
0.0	0.3	GO:0000346	transcription export complex(GO:0000346)
0.0	0.3	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.8	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.0	0.2	GO:0097431	mitotic spindle pole(GO:0097431)
0.0	1.5	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.0	0.6	GO:0005685	U1 snRNP(GO:0005685)
0.0	0.1	GO:0097013	phagocytic vesicle lumen(GO:0097013)
0.0	0.6	GO:0042629	mast cell granule(GO:0042629)
0.0	0.3	GO:0008091	spectrin(GO:0008091)
0.0	0.5	GO:0030687	preribosome, large subunit precursor(GO:0030687)
0.0	0.3	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.3	GO:0030014	CCR4-NOT complex(GO:0030014)
0.0	0.4	GO:0034706	sodium channel complex(GO:0034706)
0.0	0.8	GO:0005801	cis-Golgi network(GO:0005801)
0.0	0.2	GO:0030897	HOPS complex(GO:0030897)
0.0	0.1	GO:0044232	organelle membrane contact site(GO:0044232)
0.0	0.8	GO:0031430	M band(GO:0031430)
0.0	0.1	GO:0030427	site of polarized growth(GO:0030427)
0.0	0.1	GO:0071438	invadopodium membrane(GO:0071438)
0.0	0.6	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.0	0.1	GO:0030991	intraciliary transport particle A(GO:0030991)
0.0	0.1	GO:0061617	MICOS complex(GO:0061617)
0.0	0.1	GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0	0.2	GO:0000815	ESCRT III complex(GO:0000815)
0.0	0.1	GO:0055087	Ski complex(GO:0055087)
0.0	1.0	GO:0055038	recycling endosome membrane(GO:0055038)
0.0	2.1	GO:0031225	anchored component of membrane(GO:0031225)
0.0	0.0	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.3	GO:0031105	septin complex(GO:0031105)
0.0	0.0	GO:0070110	ciliary neurotrophic factor receptor complex(GO:0070110)
0.0	0.2	GO:0000812	Swr1 complex(GO:0000812)
0.0	0.2	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.2	GO:0005790	smooth endoplasmic reticulum(GO:0005790)
0.0	1.3	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.0	0.1	GO:0008537	proteasome activator complex(GO:0008537)
0.0	0.8	GO:0033116	endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0	0.7	GO:0010494	cytoplasmic stress granule(GO:0010494)
0.0	0.0	GO:0090568	nuclear transcriptional repressor complex(GO:0090568)
0.0	0.1	GO:0035061	Smc5-Smc6 complex(GO:0030915) interchromatin granule(GO:0035061)
0.0	0.8	GO:0005811	lipid particle(GO:0005811)
0.0	0.1	GO:0002116	semaphorin receptor complex(GO:0002116)
0.0	1.3	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.0	0.4	GO:0016327	apicolateral plasma membrane(GO:0016327)
0.0	0.1	GO:0005610	laminin-5 complex(GO:0005610)
0.0	0.3	GO:0071141	SMAD protein complex(GO:0071141)
0.0	0.1	GO:0097346	INO80-type complex(GO:0097346)
0.0	0.3	GO:0000421	autophagosome membrane(GO:0000421)
0.0	0.1	GO:0005638	lamin filament(GO:0005638)
0.0	0.3	GO:0035577	azurophil granule membrane(GO:0035577)
0.0	0.2	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0	0.1	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	0.0	GO:0071437	invadopodium(GO:0071437)
0.0	0.1	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.0	0.0	GO:0072536	interleukin-23 receptor complex(GO:0072536)
0.0	0.3	GO:0009925	basal plasma membrane(GO:0009925)
0.0	0.1	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.0	0.2	GO:0035371	microtubule plus-end(GO:0035371)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.0	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.1	0.8	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1	0.9	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.1	0.7	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.1	4.0	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.0	2.9	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.0	2.0	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	0.7	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	0.8	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	1.2	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.0	2.4	SIG CHEMOTAXIS	Genes related to chemotaxis
0.0	0.3	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.0	0.5	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.0	0.3	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.0	0.4	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	1.0	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.0	0.8	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	2.0	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	1.9	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.0	0.1	PID VEGFR1 PATHWAY	VEGFR1 specific signals
0.0	2.2	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	0.5	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.0	0.5	PID S1P S1P1 PATHWAY	S1P1 pathway
0.0	0.4	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	1.0	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.0	1.3	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	0.4	PID ARF 3PATHWAY	Arf1 pathway
0.0	0.5	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.0	0.5	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.0	0.3	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.0	0.3	ST GAQ PATHWAY	G alpha q Pathway
0.0	4.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	0.1	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	0.1	PID S1P S1P2 PATHWAY	S1P2 pathway
0.0	0.3	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.0	0.2	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	0.1	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0	0.4	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.0	0.4	PID IL1 PATHWAY	IL1-mediated signaling events
0.0	0.2	SIG IL4RECEPTOR IN B LYPHOCYTES	Genes related to IL4 rceptor signaling in B lymphocytes
0.0	0.4	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.0	0.2	PID BETA CATENIN NUC PATHWAY	Regulation of nuclear beta catenin signaling and target gene transcription
0.0	0.3	PID PS1 PATHWAY	Presenilin action in Notch and Wnt signaling
0.0	0.2	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
0.0	0.1	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	3.3	GO:0016657	GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.4	1.1	GO:0031731	CCR6 chemokine receptor binding(GO:0031731)
0.3	1.0	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.3	1.6	GO:0070815	peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.3	4.5	GO:0015643	toxic substance binding(GO:0015643)
0.3	1.0	GO:0032810	sterol response element binding(GO:0032810)
0.2	1.0	GO:0000179	rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179)
0.2	0.2	GO:0071209	U7 snRNA binding(GO:0071209)
0.2	0.6	GO:0016422	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity(GO:0016422)
0.2	1.4	GO:0030160	GKAP/Homer scaffold activity(GO:0030160)
0.2	2.2	GO:0001042	RNA polymerase I core binding(GO:0001042)
0.2	0.8	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.2	0.6	GO:0003923	GPI-anchor transamidase activity(GO:0003923)
0.2	0.6	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.2	0.8	GO:0071208	histone pre-mRNA DCP binding(GO:0071208)
0.2	1.3	GO:0019871	sodium channel inhibitor activity(GO:0019871)
0.2	1.4	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.2	0.5	GO:0017108	5'-flap endonuclease activity(GO:0017108)
0.2	0.2	GO:0005294	neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.2	0.8	GO:0047374	methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.1	0.4	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.1	0.4	GO:0004611	phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.1	0.4	GO:0000213	tRNA-intron endonuclease activity(GO:0000213)
0.1	0.6	GO:0033906	protein tyrosine kinase inhibitor activity(GO:0030292) hyaluronoglucuronidase activity(GO:0033906)
0.1	0.4	GO:0036487	nitric-oxide synthase inhibitor activity(GO:0036487)
0.1	0.1	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.1	1.1	GO:0070181	small ribosomal subunit rRNA binding(GO:0070181)
0.1	0.6	GO:0019798	procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.1	1.0	GO:0031543	peptidyl-proline dioxygenase activity(GO:0031543)
0.1	1.2	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1	0.7	GO:0004522	ribonuclease A activity(GO:0004522)
0.1	0.4	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.1	0.3	GO:0070699	type II activin receptor binding(GO:0070699)
0.1	0.1	GO:0004821	histidine-tRNA ligase activity(GO:0004821)
0.1	1.3	GO:0030215	semaphorin receptor binding(GO:0030215)
0.1	0.4	GO:1990430	extracellular matrix protein binding(GO:1990430)
0.1	0.3	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1	0.3	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.1	0.3	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.1	0.9	GO:0050542	icosanoid binding(GO:0050542) arachidonic acid binding(GO:0050544) fatty acid derivative binding(GO:1901567)
0.1	0.1	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.1	0.6	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.1	0.3	GO:0043515	kinetochore binding(GO:0043515)
0.1	0.8	GO:0016290	palmitoyl-CoA hydrolase activity(GO:0016290)
0.1	0.5	GO:0048408	epidermal growth factor binding(GO:0048408)
0.1	0.4	GO:0043183	vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1	1.6	GO:0097493	structural molecule activity conferring elasticity(GO:0097493)
0.1	0.4	GO:0051011	microtubule minus-end binding(GO:0051011)
0.1	0.5	GO:0042910	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.1	0.2	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.1	0.6	GO:0035174	histone serine kinase activity(GO:0035174)
0.1	0.3	GO:0015137	citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.1	0.6	GO:0015143	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1	0.4	GO:0035614	snRNA stem-loop binding(GO:0035614)
0.1	0.4	GO:0015057	thrombin receptor activity(GO:0015057)
0.1	0.7	GO:0051525	NFAT protein binding(GO:0051525)
0.1	0.1	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1	1.0	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.1	0.2	GO:0005150	interleukin-1, Type I receptor binding(GO:0005150)
0.1	1.1	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.1	0.2	GO:0004958	prostaglandin F receptor activity(GO:0004958)
0.1	0.5	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.1	1.7	GO:0043015	gamma-tubulin binding(GO:0043015)
0.1	0.2	GO:0055077	gap junction hemi-channel activity(GO:0055077)
0.1	0.2	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.1	1.6	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1	0.5	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.1	0.4	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.1	0.3	GO:0043023	ribosomal large subunit binding(GO:0043023)
0.1	0.5	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
0.0	0.2	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.3	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.2	GO:0035243	protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.0	0.1	GO:0035374	chondroitin sulfate binding(GO:0035374)
0.0	0.3	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.1	GO:0016019	peptidoglycan receptor activity(GO:0016019)
0.0	0.2	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.2	GO:0004532	3'-5'-exoribonuclease activity(GO:0000175) exoribonuclease activity(GO:0004532) exoribonuclease activity, producing 5'-phosphomonoesters(GO:0016896)
0.0	0.2	GO:0052827	inositol pentakisphosphate phosphatase activity(GO:0052827)
0.0	0.1	GO:0005330	dopamine:sodium symporter activity(GO:0005330)
0.0	0.3	GO:0015186	L-glutamine transmembrane transporter activity(GO:0015186)
0.0	0.2	GO:0047237	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237)
0.0	0.3	GO:0035500	MH2 domain binding(GO:0035500)
0.0	1.8	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0	0.9	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0	0.7	GO:0016783	sulfurtransferase activity(GO:0016783)
0.0	0.3	GO:0050733	RS domain binding(GO:0050733)
0.0	0.3	GO:0008109	N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0	0.5	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.2	GO:0043237	laminin-1 binding(GO:0043237)
0.0	0.2	GO:0070051	fibrinogen binding(GO:0070051)
0.0	0.2	GO:0035368	selenocysteine insertion sequence binding(GO:0035368)
0.0	0.1	GO:0003845	11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.0	0.8	GO:0034185	apolipoprotein binding(GO:0034185)
0.0	0.1	GO:0031727	CCR2 chemokine receptor binding(GO:0031727)
0.0	0.1	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0	0.5	GO:0042975	peroxisome proliferator activated receptor binding(GO:0042975)
0.0	3.7	GO:0008170	N-methyltransferase activity(GO:0008170)
0.0	0.7	GO:0005328	neurotransmitter:sodium symporter activity(GO:0005328)
0.0	1.3	GO:0005109	frizzled binding(GO:0005109)
0.0	0.2	GO:0022889	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.3	GO:0034452	dynactin binding(GO:0034452)
0.0	0.3	GO:0097643	amylin receptor activity(GO:0097643)
0.0	0.2	GO:0004925	prolactin receptor activity(GO:0004925)
0.0	0.3	GO:0046923	ER retention sequence binding(GO:0046923)
0.0	1.0	GO:0005523	tropomyosin binding(GO:0005523)
0.0	0.2	GO:0003998	acylphosphatase activity(GO:0003998)
0.0	0.6	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	0.4	GO:0039706	co-receptor binding(GO:0039706)
0.0	0.5	GO:0008179	adenylate cyclase binding(GO:0008179)
0.0	0.5	GO:0008236	serine-type peptidase activity(GO:0008236)
0.0	0.1	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
0.0	0.3	GO:0038085	vascular endothelial growth factor binding(GO:0038085)
0.0	1.2	GO:0001671	ATPase activator activity(GO:0001671)
0.0	0.4	GO:0097016	L27 domain binding(GO:0097016)
0.0	0.2	GO:0004815	aspartate-tRNA ligase activity(GO:0004815)
0.0	0.7	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.4	GO:0042809	vitamin D receptor binding(GO:0042809)
0.0	0.2	GO:0008430	selenium binding(GO:0008430)
0.0	0.4	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.1	GO:0035650	AP-1 adaptor complex binding(GO:0035650)
0.0	0.4	GO:0046790	virion binding(GO:0046790)
0.0	3.2	GO:0016209	antioxidant activity(GO:0016209)
0.0	0.3	GO:0016312	inositol bisphosphate phosphatase activity(GO:0016312)
0.0	0.6	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	0.2	GO:0044729	hemi-methylated DNA-binding(GO:0044729)
0.0	0.9	GO:0017134	fibroblast growth factor binding(GO:0017134)
0.0	0.1	GO:0001031	RNA polymerase III type 1 promoter DNA binding(GO:0001030) RNA polymerase III type 2 promoter DNA binding(GO:0001031) 5S rDNA binding(GO:0080084)
0.0	0.5	GO:0031698	beta-2 adrenergic receptor binding(GO:0031698)
0.0	0.3	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.2	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
0.0	0.7	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.4	GO:0070300	phosphatidic acid binding(GO:0070300)
0.0	0.1	GO:0004345	glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.0	0.2	GO:0070891	lipoteichoic acid binding(GO:0070891)
0.0	0.2	GO:0045159	myosin II binding(GO:0045159)
0.0	2.9	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	0.2	GO:0008474	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.3	GO:0042731	PH domain binding(GO:0042731)
0.0	0.1	GO:0015319	sodium:inorganic phosphate symporter activity(GO:0015319)
0.0	0.2	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0	0.3	GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.0	0.4	GO:0004535	poly(A)-specific ribonuclease activity(GO:0004535)
0.0	0.5	GO:0051537	2 iron, 2 sulfur cluster binding(GO:0051537)
0.0	0.5	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.3	GO:0035612	AP-2 adaptor complex binding(GO:0035612)
0.0	0.8	GO:0001972	retinoic acid binding(GO:0001972)
0.0	0.1	GO:0001588	dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
0.0	0.3	GO:0005161	platelet-derived growth factor receptor binding(GO:0005161)
0.0	1.0	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.4	GO:0015175	neutral amino acid transmembrane transporter activity(GO:0015175)
0.0	0.4	GO:0019864	IgG binding(GO:0019864)
0.0	0.1	GO:0097322	7SK snRNA binding(GO:0097322)
0.0	0.1	GO:0010859	calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.0	0.1	GO:0000702	oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.0	0.1	GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.0	0.1	GO:0034038	deoxyhypusine synthase activity(GO:0034038)
0.0	0.3	GO:0001222	transcription corepressor binding(GO:0001222)
0.0	0.3	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	3.8	GO:0017137	Rab GTPase binding(GO:0017137)
0.0	2.2	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	0.5	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0	0.1	GO:0008097	5S rRNA binding(GO:0008097)
0.0	0.0	GO:0035473	lipase binding(GO:0035473)
0.0	0.5	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.0	0.1	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.5	GO:0070403	NAD+ binding(GO:0070403)
0.0	0.7	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.4	GO:0031005	filamin binding(GO:0031005)
0.0	0.1	GO:0015254	glycerol channel activity(GO:0015254)
0.0	0.0	GO:0035529	NADH pyrophosphatase activity(GO:0035529)
0.0	0.2	GO:0016868	intramolecular transferase activity, phosphotransferases(GO:0016868)
0.0	0.1	GO:0004449	isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0	0.4	GO:0050811	GABA receptor binding(GO:0050811)
0.0	0.3	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	0.4	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	0.1	GO:0016603	glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.0	0.2	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0	0.1	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0	0.1	GO:0052851	cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0	0.1	GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.0	0.5	GO:0005528	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.1	GO:0000990	transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0	0.1	GO:0004064	arylesterase activity(GO:0004064)
0.0	0.4	GO:1990841	promoter-specific chromatin binding(GO:1990841)
0.0	0.2	GO:0004969	histamine receptor activity(GO:0004969)
0.0	0.1	GO:0050613	delta14-sterol reductase activity(GO:0050613)
0.0	0.2	GO:0017127	cholesterol transporter activity(GO:0017127)
0.0	0.1	GO:0004376	glycolipid mannosyltransferase activity(GO:0004376)
0.0	0.2	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.0	GO:0001034	RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.0	0.3	GO:0097602	cullin family protein binding(GO:0097602)
0.0	0.3	GO:0016500	protein-hormone receptor activity(GO:0016500)
0.0	0.1	GO:0070095	fructose-6-phosphate binding(GO:0070095)
0.0	0.2	GO:0019789	SUMO transferase activity(GO:0019789)
0.0	0.9	GO:0005044	scavenger receptor activity(GO:0005044)
0.0	0.1	GO:0008276	protein methyltransferase activity(GO:0008276)
0.0	0.1	GO:0008310	single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.0	0.3	GO:0000062	fatty-acyl-CoA binding(GO:0000062)
0.0	2.0	GO:0008201	heparin binding(GO:0008201)
0.0	0.1	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.8	GO:0051287	NAD binding(GO:0051287)
0.0	0.1	GO:0001135	transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0	0.2	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.1	GO:1904264	ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0	0.0	GO:0019981	interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.0	0.1	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.0	0.1	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.2	GO:0008494	translation activator activity(GO:0008494)
0.0	0.6	GO:0008536	Ran GTPase binding(GO:0008536)
0.0	0.0	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.1	GO:0005412	glucose:sodium symporter activity(GO:0005412)
0.0	0.2	GO:0017049	GTP-Rho binding(GO:0017049)
0.0	0.2	GO:0102391	decanoate--CoA ligase activity(GO:0102391)
0.0	1.1	GO:0008081	phosphoric diester hydrolase activity(GO:0008081)
0.0	0.1	GO:0019865	immunoglobulin binding(GO:0019865)
0.0	0.1	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.1	GO:0043422	protein kinase B binding(GO:0043422)
0.0	0.1	GO:0061133	endopeptidase activator activity(GO:0061133)
0.0	0.5	GO:0005080	protein kinase C binding(GO:0005080)
0.0	0.9	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.0	GO:0042019	interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020)
0.0	0.2	GO:0008417	fucosyltransferase activity(GO:0008417)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	3.5	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.1	1.3	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.1	2.4	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.1	1.6	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.1	1.0	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.1	1.7	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.1	0.4	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.1	0.2	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.1	1.4	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.1	1.4	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.1	1.0	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.1	2.0	REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE	Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0	0.7	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0	0.7	REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0	0.9	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	0.6	REACTOME PROCESSING OF INTRONLESS PRE MRNAS	Genes involved in Processing of Intronless Pre-mRNAs
0.0	0.9	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.0	0.7	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0	0.7	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.8	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0	0.0	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0	0.4	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0	0.5	REACTOME SIGNALING BY NOTCH2	Genes involved in Signaling by NOTCH2
0.0	0.8	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.0	0.4	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0	0.5	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	0.3	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.0	0.5	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.0	0.4	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	0.8	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	2.1	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	0.6	REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS	Genes involved in Nucleotide-like (purinergic) receptors
0.0	0.5	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.0	0.5	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.0	0.2	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0	0.6	REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS	Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0	0.5	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	0.2	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.0	0.7	REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS	Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0	0.5	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.0	0.5	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.4	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.7	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.0	0.1	REACTOME G ALPHA1213 SIGNALLING EVENTS	Genes involved in G alpha (12/13) signalling events
0.0	2.9	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.0	0.8	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.0	0.5	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	0.4	REACTOME FATTY ACYL COA BIOSYNTHESIS	Genes involved in Fatty Acyl-CoA Biosynthesis
0.0	0.4	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	0.5	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0	0.5	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.0	0.2	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.3	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	0.3	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.1	REACTOME SIGNALING BY SCF KIT	Genes involved in Signaling by SCF-KIT
0.0	0.1	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0	0.4	REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE	Genes involved in Synthesis of PIPs at the plasma membrane

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.1	4.5	GO:1904379	maintenance of unfolded protein(GO:0036506) protein localization to cytosolic proteasome complex(GO:1904327) maintenance of unfolded protein involved in ERAD pathway(GO:1904378) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.9	3.5	GO:0034444	regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445)
0.7	4.0	GO:0001692	histamine metabolic process(GO:0001692)
0.6	1.7	GO:1903336	negative regulation of vacuolar transport(GO:1903336)
0.5	1.9	GO:0042509	tyrosine phosphorylation of STAT protein(GO:0007260) regulation of tyrosine phosphorylation of STAT protein(GO:0042509) positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.4	1.2	GO:0045360	regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.4	1.6	GO:0035752	lysosomal lumen pH elevation(GO:0035752)
0.3	1.4	GO:0038018	Wnt receptor catabolic process(GO:0038018)
0.3	1.0	GO:0090341	negative regulation of secretion of lysosomal enzymes(GO:0090341)
0.3	1.0	GO:1900106	hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.3	1.0	GO:0070428	negative regulation of interleukin-23 production(GO:0032707) regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070428)
0.3	1.2	GO:0030037	actin filament reorganization involved in cell cycle(GO:0030037)
0.2	0.7	GO:0046946	hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.2	1.2	GO:0030047	actin modification(GO:0030047)
0.2	0.9	GO:0021812	neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
0.2	0.7	GO:0051697	protein delipidation(GO:0051697)
0.2	1.8	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.2	1.8	GO:0033088	negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.2	0.7	GO:0070213	protein auto-ADP-ribosylation(GO:0070213)
0.2	1.1	GO:0017185	peptidyl-lysine hydroxylation(GO:0017185)
0.2	0.6	GO:0006711	estrogen catabolic process(GO:0006711)
0.2	1.1	GO:1904274	tricellular tight junction assembly(GO:1904274)
0.2	0.2	GO:0051683	establishment of Golgi localization(GO:0051683)
0.2	0.2	GO:1901873	regulation of post-translational protein modification(GO:1901873)
0.2	1.1	GO:2001288	positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.2	0.6	GO:0045013	carbon catabolite repression of transcription(GO:0045013) negative regulation of transcription by glucose(GO:0045014)
0.2	0.2	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.2	1.2	GO:0030421	defecation(GO:0030421)
0.2	0.6	GO:1900195	spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195)
0.2	1.0	GO:0071279	cellular response to cobalt ion(GO:0071279)
0.2	0.7	GO:0021564	vagus nerve development(GO:0021564)
0.2	1.9	GO:0090232	positive regulation of spindle checkpoint(GO:0090232)
0.2	0.7	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.2	0.2	GO:0032607	interferon-alpha production(GO:0032607)
0.2	0.5	GO:0006014	D-ribose metabolic process(GO:0006014)
0.2	0.5	GO:0002752	leukocyte chemotaxis involved in inflammatory response(GO:0002232) cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.2	0.5	GO:0050748	negative regulation of lipoprotein metabolic process(GO:0050748)
0.2	0.5	GO:0000412	histone peptidyl-prolyl isomerization(GO:0000412)
0.2	0.5	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.2	0.6	GO:2000230	negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.2	0.3	GO:0043011	myeloid dendritic cell differentiation(GO:0043011)
0.2	0.5	GO:0060265	positive regulation of respiratory burst involved in inflammatory response(GO:0060265)
0.1	0.7	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.1	0.4	GO:0000379	tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.1	0.4	GO:1903570	regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.1	1.8	GO:0010764	negative regulation of fibroblast migration(GO:0010764)
0.1	0.4	GO:1900081	regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283)
0.1	0.4	GO:1902365	regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
0.1	0.4	GO:0018283	metal incorporation into metallo-sulfur cluster(GO:0018282) iron incorporation into metallo-sulfur cluster(GO:0018283)
0.1	0.3	GO:0003221	right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.1	0.1	GO:0002467	germinal center formation(GO:0002467)
0.1	3.5	GO:0043101	purine-containing compound salvage(GO:0043101)
0.1	0.4	GO:0048611	ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
0.1	0.8	GO:0006065	UDP-glucuronate biosynthetic process(GO:0006065)
0.1	0.8	GO:0015677	copper ion import(GO:0015677)
0.1	0.6	GO:0080009	mRNA methylation(GO:0080009)
0.1	0.4	GO:0003285	septum secundum development(GO:0003285)
0.1	0.5	GO:0002880	chronic inflammatory response to non-antigenic stimulus(GO:0002545) regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002880)
0.1	0.5	GO:2000402	negative regulation of lymphocyte migration(GO:2000402)
0.1	0.4	GO:0072092	ureteric bud invasion(GO:0072092)
0.1	0.1	GO:0014029	neural crest formation(GO:0014029)
0.1	0.5	GO:1901165	positive regulation of trophoblast cell migration(GO:1901165)
0.1	0.4	GO:0070086	ubiquitin-dependent endocytosis(GO:0070086) regulation of ubiquitin-dependent endocytosis(GO:2000395) positive regulation of ubiquitin-dependent endocytosis(GO:2000397)
0.1	0.3	GO:0034144	negative regulation of toll-like receptor 4 signaling pathway(GO:0034144) circadian temperature homeostasis(GO:0060086)
0.1	0.6	GO:1901727	positive regulation of histone deacetylase activity(GO:1901727)
0.1	1.6	GO:0071688	striated muscle myosin thick filament assembly(GO:0071688)
0.1	0.3	GO:0002590	regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440) response to iron ion starvation(GO:1990641)
0.1	0.4	GO:0009226	nucleotide-sugar biosynthetic process(GO:0009226)
0.1	1.7	GO:0019511	peptidyl-proline hydroxylation(GO:0019511)
0.1	0.2	GO:0044111	development involved in symbiotic interaction(GO:0044111)
0.1	0.4	GO:0006114	glycerol biosynthetic process(GO:0006114) response to methionine(GO:1904640)
0.1	0.9	GO:0051533	positive regulation of NFAT protein import into nucleus(GO:0051533)
0.1	0.9	GO:0003096	renal sodium ion transport(GO:0003096)
0.1	0.2	GO:0030223	neutrophil differentiation(GO:0030223)
0.1	1.0	GO:0070836	caveola assembly(GO:0070836)
0.1	0.2	GO:0036344	platelet formation(GO:0030220) platelet morphogenesis(GO:0036344)
0.1	0.1	GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.1	0.9	GO:0002098	tRNA wobble uridine modification(GO:0002098)
0.1	0.9	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)
0.1	0.4	GO:0055014	atrial cardiac muscle cell differentiation(GO:0055011) atrial cardiac muscle cell development(GO:0055014)
0.1	0.8	GO:0051388	positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.1	0.5	GO:0045626	negative regulation of T-helper 1 cell differentiation(GO:0045626)
0.1	0.7	GO:0023035	CD40 signaling pathway(GO:0023035)
0.1	0.8	GO:0060363	cranial suture morphogenesis(GO:0060363)
0.1	0.4	GO:0000350	generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.1	0.3	GO:2000439	positive regulation of monocyte extravasation(GO:2000439)
0.1	1.2	GO:0046415	urate metabolic process(GO:0046415)
0.1	0.4	GO:0019348	dolichol metabolic process(GO:0019348)
0.1	0.4	GO:1902626	assembly of large subunit precursor of preribosome(GO:1902626)
0.1	0.8	GO:2000270	negative regulation of fibroblast apoptotic process(GO:2000270)
0.1	0.3	GO:0045658	regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.1	0.4	GO:0051941	regulation of amino acid uptake involved in synaptic transmission(GO:0051941) regulation of glutamate uptake involved in transmission of nerve impulse(GO:0051946) regulation of L-glutamate import(GO:1900920)
0.1	0.4	GO:0008625	extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.1	0.3	GO:0061394	regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.1	0.3	GO:0044375	regulation of peroxisome size(GO:0044375)
0.1	0.2	GO:0002456	T cell mediated immunity(GO:0002456)
0.1	0.3	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.1	0.9	GO:0002934	desmosome organization(GO:0002934)
0.1	0.2	GO:0006624	vacuolar protein processing(GO:0006624)
0.1	0.6	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.1	1.5	GO:0016226	iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1	0.3	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
0.1	0.3	GO:0036229	glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
0.1	0.3	GO:0044027	hypermethylation of CpG island(GO:0044027)
0.1	0.4	GO:1903361	protein localization to basolateral plasma membrane(GO:1903361)
0.1	0.1	GO:0031344	regulation of cell projection organization(GO:0031344)
0.1	0.3	GO:0003402	planar cell polarity pathway involved in axis elongation(GO:0003402)
0.1	0.6	GO:0071649	regulation of chemokine (C-C motif) ligand 5 production(GO:0071649)
0.1	0.3	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1	0.2	GO:0043006	activation of phospholipase A2 activity by calcium-mediated signaling(GO:0043006)
0.1	0.4	GO:1903756	regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.1	0.2	GO:0048294	negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.1	0.2	GO:0035606	peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.1	0.2	GO:0019323	pentose catabolic process(GO:0019323)
0.1	0.5	GO:0035897	proteolysis in other organism(GO:0035897)
0.1	1.1	GO:0031167	rRNA methylation(GO:0031167)
0.1	0.3	GO:0006842	tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
0.1	0.3	GO:1903691	positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.1	0.6	GO:0000395	mRNA 5'-splice site recognition(GO:0000395)
0.1	0.3	GO:1902378	vestibulocochlear nerve structural organization(GO:0021649) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) endothelial tip cell fate specification(GO:0097102) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.1	0.3	GO:1905098	negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
0.1	0.3	GO:1903564	regulation of protein localization to cilium(GO:1903564)
0.1	0.1	GO:0034427	nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5'(GO:0034427)
0.1	0.2	GO:2000660	negative regulation of interleukin-1-mediated signaling pathway(GO:2000660)
0.1	0.2	GO:0035927	RNA import into mitochondrion(GO:0035927)
0.1	0.2	GO:0009298	GDP-mannose biosynthetic process(GO:0009298)
0.1	1.4	GO:0033622	integrin activation(GO:0033622)
0.1	0.2	GO:2000645	negative regulation of receptor catabolic process(GO:2000645)
0.1	0.7	GO:0000479	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000479)
0.1	0.2	GO:0098904	regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652) regulation of AV node cell action potential(GO:0098904) regulation of bundle of His cell action potential(GO:0098905)
0.1	0.2	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.1	0.2	GO:0002669	positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.1	0.2	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.1	0.3	GO:0035105	sterol regulatory element binding protein import into nucleus(GO:0035105)
0.1	0.2	GO:0018242	protein O-linked glycosylation via serine(GO:0018242)
0.1	0.2	GO:0045053	protein retention in Golgi apparatus(GO:0045053) asymmetric Golgi ribbon formation(GO:0090164)
0.1	0.2	GO:2000870	regulation of progesterone secretion(GO:2000870)
0.1	0.6	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.1	0.7	GO:0010867	positive regulation of triglyceride biosynthetic process(GO:0010867)
0.1	0.3	GO:1904431	positive regulation of t-circle formation(GO:1904431)
0.1	0.5	GO:2000622	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.1	0.8	GO:1902222	L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.1	0.2	GO:0002725	negative regulation of T cell cytokine production(GO:0002725)
0.1	0.3	GO:2001270	regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001270)
0.1	0.8	GO:0070831	basement membrane assembly(GO:0070831)
0.1	0.2	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.1	0.2	GO:0051083	'de novo' cotranslational protein folding(GO:0051083)
0.1	0.3	GO:0070092	regulation of glucagon secretion(GO:0070092)
0.0	0.2	GO:0045872	positive regulation of rhodopsin gene expression(GO:0045872)
0.0	0.2	GO:0019918	peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918)
0.0	0.4	GO:0060155	platelet dense granule organization(GO:0060155)
0.0	0.1	GO:0051710	regulation of cytolysis in other organism(GO:0051710)
0.0	0.2	GO:0003322	pancreatic A cell development(GO:0003322)
0.0	0.4	GO:0032494	response to peptidoglycan(GO:0032494)
0.0	0.3	GO:0061469	regulation of type B pancreatic cell proliferation(GO:0061469)
0.0	0.5	GO:0038092	nodal signaling pathway(GO:0038092)
0.0	0.1	GO:1990637	response to prolactin(GO:1990637)
0.0	0.0	GO:1902229	regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902229) negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902230)
0.0	0.3	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0	0.3	GO:0033211	adiponectin-activated signaling pathway(GO:0033211)
0.0	0.3	GO:0097094	craniofacial suture morphogenesis(GO:0097094)
0.0	0.2	GO:0060010	Sertoli cell fate commitment(GO:0060010)
0.0	0.2	GO:0002084	protein depalmitoylation(GO:0002084)
0.0	0.1	GO:0048203	vesicle targeting, trans-Golgi to endosome(GO:0048203)
0.0	0.3	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.0	1.4	GO:0071625	vocalization behavior(GO:0071625)
0.0	0.3	GO:0036438	maintenance of lens transparency(GO:0036438)
0.0	0.5	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0	0.3	GO:0010454	negative regulation of cell fate commitment(GO:0010454) lung goblet cell differentiation(GO:0060480)
0.0	0.3	GO:0006701	progesterone biosynthetic process(GO:0006701)
0.0	0.3	GO:0070164	negative regulation of adiponectin secretion(GO:0070164)
0.0	0.1	GO:0097325	melanocyte proliferation(GO:0097325)
0.0	0.7	GO:0007220	Notch receptor processing(GO:0007220)
0.0	0.3	GO:1901525	negative regulation of macromitophagy(GO:1901525)
0.0	0.7	GO:0090110	cargo loading into COPII-coated vesicle(GO:0090110)
0.0	0.2	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.2	GO:0017196	N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0	0.7	GO:0034315	regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.0	0.2	GO:1903237	negative regulation of leukocyte tethering or rolling(GO:1903237)
0.0	0.3	GO:1902715	positive regulation of interferon-gamma secretion(GO:1902715)
0.0	0.1	GO:0039513	modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148)
0.0	0.8	GO:0035024	negative regulation of Rho protein signal transduction(GO:0035024)
0.0	0.1	GO:0046726	positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.0	0.1	GO:0035880	embryonic nail plate morphogenesis(GO:0035880)
0.0	0.1	GO:1903935	response to sodium arsenite(GO:1903935) cellular response to sodium arsenite(GO:1903936)
0.0	0.3	GO:0006621	protein retention in ER lumen(GO:0006621)
0.0	0.2	GO:2000255	negative regulation of male germ cell proliferation(GO:2000255)
0.0	0.1	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.0	0.2	GO:0090309	positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.0	0.4	GO:0048505	regulation of development, heterochronic(GO:0040034) regulation of timing of cell differentiation(GO:0048505)
0.0	0.1	GO:0021886	hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888)
0.0	0.2	GO:0042631	cellular response to water deprivation(GO:0042631)
0.0	1.1	GO:0010667	negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.0	0.4	GO:0050703	interleukin-1 alpha secretion(GO:0050703)
0.0	0.1	GO:1902473	regulation of protein localization to synapse(GO:1902473) positive regulation of protein localization to synapse(GO:1902474)
0.0	0.1	GO:0098907	protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371) regulation of SA node cell action potential(GO:0098907)
0.0	0.2	GO:0098535	de novo centriole assembly(GO:0098535)
0.0	0.1	GO:0060971	embryonic heart tube left/right pattern formation(GO:0060971)
0.0	0.2	GO:1903527	positive regulation of membrane tubulation(GO:1903527)
0.0	0.1	GO:0007173	epidermal growth factor receptor signaling pathway(GO:0007173)
0.0	1.0	GO:2000810	regulation of bicellular tight junction assembly(GO:2000810)
0.0	0.2	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.0	1.0	GO:0051894	positive regulation of focal adhesion assembly(GO:0051894)
0.0	0.1	GO:0046504	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.0	0.2	GO:0038161	prolactin signaling pathway(GO:0038161)
0.0	0.0	GO:1903625	negative regulation of DNA catabolic process(GO:1903625)
0.0	0.0	GO:0032347	regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.0	0.1	GO:0000729	DNA double-strand break processing(GO:0000729)
0.0	0.3	GO:0032286	central nervous system myelin maintenance(GO:0032286)
0.0	0.1	GO:0035694	mitochondrial protein catabolic process(GO:0035694)
0.0	0.1	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.0	0.2	GO:0007000	nucleolus organization(GO:0007000)
0.0	0.1	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.4	GO:0009650	UV protection(GO:0009650)
0.0	0.3	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.1	GO:0060335	positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.0	0.3	GO:0060325	face morphogenesis(GO:0060325)
0.0	0.4	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0	0.1	GO:0061051	regulation of cell growth involved in cardiac muscle cell development(GO:0061050) positive regulation of cell growth involved in cardiac muscle cell development(GO:0061051)
0.0	0.2	GO:1904262	negative regulation of TORC1 signaling(GO:1904262)
0.0	0.0	GO:0098927	early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.0	0.4	GO:0035372	protein localization to microtubule(GO:0035372)
0.0	0.2	GO:0018095	protein polyglutamylation(GO:0018095)
0.0	0.3	GO:0071670	smooth muscle cell chemotaxis(GO:0071670)
0.0	0.3	GO:0036066	protein O-linked fucosylation(GO:0036066)
0.0	0.1	GO:1902723	negative regulation of skeletal muscle cell proliferation(GO:0014859) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.0	0.5	GO:0005513	detection of calcium ion(GO:0005513)
0.0	0.1	GO:0015747	urate transport(GO:0015747)
0.0	0.1	GO:0048213	Golgi vesicle prefusion complex stabilization(GO:0048213)
0.0	1.0	GO:0070884	regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0	0.1	GO:1900220	semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.0	0.4	GO:0032785	negative regulation of DNA-templated transcription, elongation(GO:0032785)
0.0	0.1	GO:1904398	positive regulation of neuromuscular junction development(GO:1904398)
0.0	0.6	GO:0006622	protein targeting to lysosome(GO:0006622)
0.0	0.1	GO:1903465	vacuolar phosphate transport(GO:0007037) positive regulation of mitotic cell cycle DNA replication(GO:1903465) positive regulation of parathyroid hormone secretion(GO:2000830)
0.0	0.3	GO:1904778	regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0	0.2	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.2	GO:0070345	negative regulation of fat cell proliferation(GO:0070345)
0.0	0.2	GO:0015825	L-serine transport(GO:0015825)
0.0	0.1	GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.0	0.1	GO:0002276	basophil activation involved in immune response(GO:0002276) basophil activation(GO:0045575)
0.0	0.2	GO:2000389	regulation of neutrophil extravasation(GO:2000389)
0.0	0.8	GO:0030182	neuron differentiation(GO:0030182)
0.0	0.1	GO:0014816	skeletal muscle satellite cell differentiation(GO:0014816)
0.0	0.4	GO:0036120	cellular response to platelet-derived growth factor stimulus(GO:0036120)
0.0	0.4	GO:0000028	ribosomal small subunit assembly(GO:0000028)
0.0	0.1	GO:0010793	regulation of mRNA export from nucleus(GO:0010793)
0.0	0.2	GO:0002903	negative regulation of B cell apoptotic process(GO:0002903)
0.0	0.6	GO:0015012	heparan sulfate proteoglycan biosynthetic process(GO:0015012)
0.0	0.2	GO:1900028	negative regulation of ruffle assembly(GO:1900028)
0.0	0.2	GO:0031087	deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0	0.0	GO:0002384	hepatic immune response(GO:0002384)
0.0	0.1	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0	0.3	GO:1901862	negative regulation of striated muscle tissue development(GO:0045843) negative regulation of muscle tissue development(GO:1901862)
0.0	1.0	GO:0051646	mitochondrion localization(GO:0051646)
0.0	0.1	GO:0090527	actin filament reorganization(GO:0090527)
0.0	0.6	GO:0006491	N-glycan processing(GO:0006491)
0.0	0.0	GO:0031119	tRNA pseudouridine synthesis(GO:0031119)
0.0	0.1	GO:0043321	regulation of natural killer cell degranulation(GO:0043321) positive regulation of natural killer cell degranulation(GO:0043323)
0.0	0.3	GO:0034447	very-low-density lipoprotein particle clearance(GO:0034447)
0.0	0.1	GO:0090038	negative regulation of protein kinase C signaling(GO:0090038)
0.0	0.0	GO:0060715	syncytiotrophoblast cell differentiation involved in labyrinthine layer development(GO:0060715)
0.0	0.4	GO:0010801	negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.0	0.1	GO:0060037	pharyngeal system development(GO:0060037)
0.0	0.4	GO:0003197	endocardial cushion development(GO:0003197)
0.0	0.8	GO:0006692	prostanoid metabolic process(GO:0006692) prostaglandin metabolic process(GO:0006693)
0.0	0.0	GO:0036369	transcription factor catabolic process(GO:0036369)
0.0	0.1	GO:0010499	proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0	1.0	GO:0018279	protein N-linked glycosylation via asparagine(GO:0018279)
0.0	0.5	GO:0006506	GPI anchor metabolic process(GO:0006505) GPI anchor biosynthetic process(GO:0006506)
0.0	0.3	GO:0031998	regulation of fatty acid beta-oxidation(GO:0031998)
0.0	0.4	GO:0001946	lymphangiogenesis(GO:0001946)
0.0	0.1	GO:0042710	biofilm formation(GO:0042710) single-species biofilm formation(GO:0044010) single-species biofilm formation in or on host organism(GO:0044407) regulation of single-species biofilm formation(GO:1900190) negative regulation of single-species biofilm formation(GO:1900191) regulation of single-species biofilm formation in or on host organism(GO:1900228) negative regulation of single-species biofilm formation in or on host organism(GO:1900229)
0.0	0.1	GO:0090362	positive regulation of platelet-derived growth factor production(GO:0090362)
0.0	0.1	GO:0097010	eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.0	0.1	GO:0017186	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.0	0.1	GO:0000492	box C/D snoRNP assembly(GO:0000492)
0.0	0.3	GO:0036342	post-anal tail morphogenesis(GO:0036342)
0.0	0.1	GO:0007296	vitellogenesis(GO:0007296)
0.0	0.1	GO:0006307	DNA dealkylation involved in DNA repair(GO:0006307)
0.0	0.2	GO:1904896	ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.0	0.6	GO:0090200	positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0	0.1	GO:0048050	post-embryonic eye morphogenesis(GO:0048050)
0.0	0.1	GO:0008627	intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.0	0.2	GO:0018026	peptidyl-lysine monomethylation(GO:0018026)
0.0	1.3	GO:0031338	regulation of vesicle fusion(GO:0031338)
0.0	0.2	GO:0034723	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.5	GO:0048025	negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.0	0.3	GO:0043562	cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0	0.1	GO:0060136	embryonic process involved in female pregnancy(GO:0060136)
0.0	0.1	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.0	0.1	GO:0042670	retinal cone cell differentiation(GO:0042670) retinal cone cell development(GO:0046549)
0.0	0.2	GO:0051665	membrane raft localization(GO:0051665)
0.0	0.1	GO:0033133	positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.0	0.5	GO:0051457	maintenance of protein location in nucleus(GO:0051457)
0.0	0.1	GO:2000675	negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.0	0.1	GO:0016127	cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0	0.1	GO:0032351	negative regulation of glucocorticoid metabolic process(GO:0031944) regulation of glucocorticoid biosynthetic process(GO:0031946) negative regulation of glucocorticoid biosynthetic process(GO:0031947) negative regulation of hormone metabolic process(GO:0032351) negative regulation of hormone biosynthetic process(GO:0032353) negative regulation of steroid hormone biosynthetic process(GO:0090032)
0.0	0.1	GO:0098881	exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
0.0	0.0	GO:0060632	regulation of microtubule-based movement(GO:0060632)
0.0	0.2	GO:0000963	mitochondrial RNA processing(GO:0000963)
0.0	0.4	GO:0015804	neutral amino acid transport(GO:0015804)
0.0	0.1	GO:0048702	embryonic neurocranium morphogenesis(GO:0048702)
0.0	0.1	GO:0045919	positive regulation of cytolysis(GO:0045919)
0.0	0.1	GO:0031063	regulation of histone deacetylation(GO:0031063)
0.0	0.1	GO:0046831	regulation of RNA export from nucleus(GO:0046831)
0.0	0.4	GO:0042059	negative regulation of epidermal growth factor receptor signaling pathway(GO:0042059)
0.0	0.1	GO:1901409	positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0	0.2	GO:0089711	L-glutamate transmembrane transport(GO:0089711)
0.0	1.0	GO:0006369	termination of RNA polymerase II transcription(GO:0006369)
0.0	0.5	GO:0001961	positive regulation of cytokine-mediated signaling pathway(GO:0001961)
0.0	0.0	GO:0043983	histone H4-K12 acetylation(GO:0043983) response to sorbitol(GO:0072708)
0.0	0.1	GO:0014877	response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0	0.2	GO:0000183	chromatin silencing at rDNA(GO:0000183)
0.0	0.1	GO:0046203	spermidine catabolic process(GO:0046203)
0.0	0.1	GO:0045714	regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045714) positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716)
0.0	0.1	GO:0034088	maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088)
0.0	0.4	GO:0070207	protein homotrimerization(GO:0070207)
0.0	0.3	GO:1902591	single-organism membrane budding(GO:1902591)
0.0	0.2	GO:0043508	negative regulation of JUN kinase activity(GO:0043508)
0.0	0.5	GO:0043276	anoikis(GO:0043276)
0.0	0.0	GO:0009078	alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080)
0.0	0.0	GO:0045409	negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.0	0.1	GO:0035845	photoreceptor cell outer segment organization(GO:0035845)
0.0	0.6	GO:1990090	cellular response to nerve growth factor stimulus(GO:1990090)
0.0	0.1	GO:0086024	adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0	0.1	GO:0015793	glycerol transport(GO:0015793)
0.0	0.1	GO:0002032	desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
0.0	0.1	GO:0044341	sodium-dependent phosphate transport(GO:0044341)
0.0	0.2	GO:0048820	hair follicle maturation(GO:0048820)
0.0	0.1	GO:0060004	reflex(GO:0060004)
0.0	0.1	GO:0010626	regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626)
0.0	0.3	GO:0045747	positive regulation of Notch signaling pathway(GO:0045747)
0.0	0.1	GO:0045023	G0 to G1 transition(GO:0045023)
0.0	0.2	GO:0036109	alpha-linolenic acid metabolic process(GO:0036109)
0.0	0.2	GO:0007597	blood coagulation, intrinsic pathway(GO:0007597)
0.0	0.0	GO:0045113	regulation of integrin biosynthetic process(GO:0045113) positive regulation of integrin biosynthetic process(GO:0045726)
0.0	1.7	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0	0.0	GO:0021562	vestibulocochlear nerve development(GO:0021562)
0.0	0.2	GO:0008535	respiratory chain complex IV assembly(GO:0008535)
0.0	0.1	GO:0017062	respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0	0.1	GO:0021942	radial glia guided migration of Purkinje cell(GO:0021942)
0.0	0.0	GO:0014807	regulation of somitogenesis(GO:0014807)
0.0	0.6	GO:0045840	positive regulation of mitotic nuclear division(GO:0045840)
0.0	0.1	GO:0002933	lipid hydroxylation(GO:0002933)
0.0	0.1	GO:0001867	complement activation, lectin pathway(GO:0001867)
0.0	0.3	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0	0.1	GO:0000733	DNA strand renaturation(GO:0000733)
0.0	0.1	GO:0044253	positive regulation of collagen metabolic process(GO:0010714) positive regulation of collagen biosynthetic process(GO:0032967) positive regulation of multicellular organismal metabolic process(GO:0044253)
0.0	0.1	GO:0035811	negative regulation of urine volume(GO:0035811)
0.0	0.1	GO:0006704	glucocorticoid biosynthetic process(GO:0006704)
0.0	0.1	GO:1900112	regulation of histone H3-K9 trimethylation(GO:1900112)
0.0	0.1	GO:1902187	negative regulation of viral release from host cell(GO:1902187)
0.0	0.3	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0	0.0	GO:0038155	interleukin-23-mediated signaling pathway(GO:0038155)
0.0	0.2	GO:1902857	positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.0	0.7	GO:0032781	positive regulation of ATPase activity(GO:0032781)
0.0	0.1	GO:0072733	response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)

Results for ETV4_ETS2

Z-value: 0.85

Motif logo

Transcription factors associated with ETV4_ETS2

Activity-expression correlation:

Activity profile of ETV4_ETS2 motif

Sorted Z-values of ETV4_ETS2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of ETV4_ETS2

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in biological_process category: