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ENCODE cell lines, expression (Ernst 2011)

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Results for EVX2

Z-value: 0.61

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Transcription factors associated with EVX2

Gene Symbol Gene ID Gene Info
EVX2
ENSG00000174279.4 EVX2

Activity profile of EVX2 motif

Sorted Z-values of EVX2 motif

Network of associatons between targets according to the STRING database.

Top targets:

Promoter Score Transcript Gene Gene Info
chr15_-_55562479 1.95 ENST00000564609.1
 RAB27A
 RAB27A, member RAS oncogene family
chr15_-_55563072 1.87 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
 RAB27A
 RAB27A, member RAS oncogene family
chr15_-_55562582 1.34 ENST00000396307.2
 RAB27A
 RAB27A, member RAS oncogene family
chr11_-_115375107 0.90 ENST00000545380.1
ENST00000452722.3
ENST00000537058.1
ENST00000536727.1
ENST00000542447.2
ENST00000331581.6
 CADM1
 cell adhesion molecule 1
chr4_-_41884620 0.69 ENST00000504870.1
 LINC00682
 long intergenic non-protein coding RNA 682
chr15_+_41057818 0.60 ENST00000558467.1
 GCHFR
 GTP cyclohydrolase I feedback regulator
chr3_+_111718173 0.49 ENST00000494932.1
 TAGLN3
 transgelin 3
chr12_+_28410128 0.46 ENST00000381259.1
ENST00000381256.1
 CCDC91
 coiled-coil domain containing 91
chr3_+_111718036 0.30 ENST00000455401.2
 TAGLN3
 transgelin 3
chr17_-_27418537 0.25 ENST00000408971.2
 TIAF1
 TGFB1-induced anti-apoptotic factor 1
chr1_+_28261533 0.25 ENST00000411604.1
ENST00000373888.4
 SMPDL3B
 sphingomyelin phosphodiesterase, acid-like 3B
chr6_-_111927062 0.24 ENST00000359831.4
 TRAF3IP2
 TRAF3 interacting protein 2
chr3_+_111717600 0.23 ENST00000273368.4
 TAGLN3
 transgelin 3
chr3_+_111717511 0.20 ENST00000478951.1
ENST00000393917.2
 TAGLN3
 transgelin 3
chr17_-_40337470 0.20 ENST00000293330.1
 HCRT
 hypocretin (orexin) neuropeptide precursor
chr17_-_9929581 0.19 ENST00000437099.2
ENST00000396115.2
 GAS7
 growth arrest-specific 7
chr18_-_33709268 0.11 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
 SLC39A6
 solute carrier family 39 (zinc transporter), member 6
chr1_+_28261492 0.10 ENST00000373894.3
 SMPDL3B
 sphingomyelin phosphodiesterase, acid-like 3B
chr1_+_28261621 0.09 ENST00000549094.1
 SMPDL3B
 sphingomyelin phosphodiesterase, acid-like 3B
chr1_+_160160346 0.08 ENST00000368078.3
 CASQ1
 calsequestrin 1 (fast-twitch, skeletal muscle)
chr3_+_115342349 0.07 ENST00000393780.3
 GAP43
 growth associated protein 43
chr1_-_151431647 0.06 ENST00000368863.2
ENST00000409503.1
ENST00000491586.1
ENST00000533351.1
ENST00000540984.1
 POGZ
 pogo transposable element with ZNF domain
chr1_+_160160283 0.06 ENST00000368079.3
 CASQ1
 calsequestrin 1 (fast-twitch, skeletal muscle)
chr6_-_62996066 0.01 ENST00000281156.4
 KHDRBS2
 KH domain containing, RNA binding, signal transduction associated 2

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.1 GO:0014802 terminal cisterna(GO:0014802)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 5.2 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
0.2 0.9 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.2 0.6 GO:0043105 regulation of GTP cyclohydrolase I activity(GO:0043095) negative regulation of GTP cyclohydrolase I activity(GO:0043105)
0.0 0.4 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.5 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 0.2 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.1 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.1 GO:0071578 zinc II ion transmembrane import(GO:0071578)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0044549 GTP cyclohydrolase binding(GO:0044549)
0.2 5.2 GO:0031489 myosin V binding(GO:0031489)
0.0 0.4 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.1 GO:0035727 lysophosphatidic acid binding(GO:0035727)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.2 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.0 0.9 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.6 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation