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ENCODE cell lines, expression (Ernst 2011)

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Results for GATA6

Z-value: 1.00

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Transcription factors associated with GATA6

Gene Symbol Gene ID Gene Info
GATA6
ENSG00000141448.4 GATA6

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
GATA6hg19_v2_chr18_+_19749386_197494040.204.5e-01Click!

Activity profile of GATA6 motif

Sorted Z-values of GATA6 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GATA6

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr17_-_62084241 4.01 ENST00000449662.2
 ICAM2
 intercellular adhesion molecule 2
chr16_+_202686 3.34 ENST00000252951.2
 HBZ
 hemoglobin, zeta
chr12_-_54689532 3.20 ENST00000540264.2
ENST00000312156.4
 NFE2
 nuclear factor, erythroid 2
chr19_-_13213662 2.62 ENST00000264824.4
 LYL1
 lymphoblastic leukemia derived sequence 1
chr19_+_10397621 2.17 ENST00000380770.3
 ICAM4
 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr19_+_10397648 2.15 ENST00000340992.4
ENST00000393717.2
 ICAM4
 intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr7_-_100239132 2.04 ENST00000223051.3
ENST00000431692.1
 TFR2
 transferrin receptor 2
chr11_-_116708302 1.60 ENST00000375320.1
ENST00000359492.2
ENST00000375329.2
ENST00000375323.1
 APOA1
 apolipoprotein A-I
chr11_+_118958689 1.51 ENST00000535253.1
ENST00000392841.1
 HMBS
 hydroxymethylbilane synthase
chr2_+_102928009 1.43 ENST00000404917.2
ENST00000447231.1
 IL1RL1
 interleukin 1 receptor-like 1
chr13_-_46716969 1.40 ENST00000435666.2
 LCP1
 lymphocyte cytosolic protein 1 (L-plastin)
chr8_-_38008783 1.38 ENST00000276449.4
 STAR
 steroidogenic acute regulatory protein
chr12_-_6233828 1.20 ENST00000572068.1
ENST00000261405.5
 VWF
 von Willebrand factor
chr1_-_158656488 1.20 ENST00000368147.4
 SPTA1
 spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr15_-_64126084 1.17 ENST00000560316.1
ENST00000443617.2
ENST00000560462.1
ENST00000558532.1
ENST00000561400.1
 HERC1
 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
chr8_+_21823726 1.16 ENST00000433566.4
 XPO7
 exportin 7
chr11_-_66206260 1.11 ENST00000329819.4
ENST00000310999.7
ENST00000430466.2
 MRPL11
 mitochondrial ribosomal protein L11
chr3_+_69812877 1.04 ENST00000457080.1
ENST00000328528.6
 MITF
 microphthalmia-associated transcription factor
chr1_+_25598989 1.04 ENST00000454452.2
 RHD
 Rh blood group, D antigen
chr17_+_74381343 1.03 ENST00000392496.3
 SPHK1
 sphingosine kinase 1
chr2_+_3642545 0.97 ENST00000382062.2
ENST00000236693.7
ENST00000349077.4
 COLEC11
 collectin sub-family member 11
chr1_+_161136180 0.94 ENST00000352210.5
ENST00000367999.4
ENST00000544598.1
ENST00000535223.1
ENST00000432542.2
 PPOX
 protoporphyrinogen oxidase
chr2_+_138722028 0.93 ENST00000280096.5
 HNMT
 histamine N-methyltransferase
chr1_-_27240455 0.76 ENST00000254227.3
 NR0B2
 nuclear receptor subfamily 0, group B, member 2
chr4_+_100495864 0.69 ENST00000265517.5
ENST00000422897.2
 MTTP
 microsomal triglyceride transfer protein
chr18_+_19749386 0.69 ENST00000269216.3
 GATA6
 GATA binding protein 6
chr21_-_39870339 0.67 ENST00000429727.2
ENST00000398905.1
ENST00000398907.1
ENST00000453032.2
ENST00000288319.7
 ERG
 v-ets avian erythroblastosis virus E26 oncogene homolog
chr1_+_25598872 0.61 ENST00000328664.4
 RHD
 Rh blood group, D antigen
chr1_-_24469602 0.61 ENST00000270800.1
 IL22RA1
 interleukin 22 receptor, alpha 1
chr3_+_148583043 0.55 ENST00000296046.3
 CPA3
 carboxypeptidase A3 (mast cell)
chr8_-_95449155 0.55 ENST00000481490.2
 FSBP
 fibrinogen silencer binding protein
chr1_+_25599018 0.54 ENST00000417538.2
ENST00000357542.4
ENST00000568195.1
ENST00000342055.5
ENST00000423810.2
 RHD
 Rh blood group, D antigen
chr2_-_44065889 0.53 ENST00000543989.1
ENST00000405322.1
 ABCG5
 ATP-binding cassette, sub-family G (WHITE), member 5
chr17_+_4675175 0.53 ENST00000270560.3
 TM4SF5
 transmembrane 4 L six family member 5
chr4_-_103266355 0.53 ENST00000424970.2
 SLC39A8
 solute carrier family 39 (zinc transporter), member 8
chr2_-_44065946 0.51 ENST00000260645.1
 ABCG5
 ATP-binding cassette, sub-family G (WHITE), member 5
chr1_+_12524965 0.50 ENST00000471923.1
 VPS13D
 vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr20_-_30795511 0.46 ENST00000246229.4
 PLAGL2
 pleiomorphic adenoma gene-like 2
chr18_-_28742813 0.45 ENST00000257197.3
ENST00000257198.5
 DSC1
 desmocollin 1
chr6_+_12290586 0.38 ENST00000379375.5
 EDN1
 endothelin 1
chr19_-_11494975 0.37 ENST00000222139.6
ENST00000592375.2
 EPOR
 erythropoietin receptor
chr20_-_54967187 0.33 ENST00000422322.1
ENST00000371356.2
ENST00000451915.1
ENST00000347343.2
ENST00000395911.1
ENST00000395907.1
ENST00000441357.1
ENST00000456249.1
ENST00000420474.1
ENST00000395909.4
ENST00000395914.1
ENST00000312783.6
ENST00000395915.3
ENST00000395913.3
 AURKA
 aurora kinase A
chr5_+_159848807 0.32 ENST00000352433.5
 PTTG1
 pituitary tumor-transforming 1
chr19_-_55549624 0.30 ENST00000417454.1
ENST00000310373.3
ENST00000333884.2
 GP6
 glycoprotein VI (platelet)
chr14_+_75988851 0.29 ENST00000555504.1
 BATF
 basic leucine zipper transcription factor, ATF-like
chr6_-_30128657 0.28 ENST00000449742.2
ENST00000376704.3
 TRIM10
 tripartite motif containing 10
chr12_+_53818855 0.26 ENST00000550839.1
 AMHR2
 anti-Mullerian hormone receptor, type II
chr12_+_111843749 0.25 ENST00000341259.2
 SH2B3
 SH2B adaptor protein 3
chr7_+_155090271 0.24 ENST00000476756.1
 INSIG1
 insulin induced gene 1
chr2_-_219850277 0.23 ENST00000295727.1
 FEV
 FEV (ETS oncogene family)
chr4_-_103266219 0.21 ENST00000394833.2
 SLC39A8
 solute carrier family 39 (zinc transporter), member 8
chr17_-_4806369 0.21 ENST00000293780.4
 CHRNE
 cholinergic receptor, nicotinic, epsilon (muscle)
chr2_+_169757750 0.20 ENST00000375363.3
ENST00000429379.2
ENST00000421979.1
 G6PC2
 glucose-6-phosphatase, catalytic, 2
chr10_+_118350468 0.19 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
 PNLIPRP1
 pancreatic lipase-related protein 1
chr3_+_69812701 0.19 ENST00000472437.1
 MITF
 microphthalmia-associated transcription factor
chr6_-_86099898 0.19 ENST00000455071.1
 RP11-30P6.6
 RP11-30P6.6
chr4_-_186697044 0.18 ENST00000437304.2
 SORBS2
 sorbin and SH3 domain containing 2
chr9_-_117692697 0.17 ENST00000223795.2
 TNFSF8
 tumor necrosis factor (ligand) superfamily, member 8
chr2_+_220436917 0.16 ENST00000243786.2
 INHA
 inhibin, alpha
chr14_+_53173910 0.16 ENST00000606149.1
ENST00000555339.1
ENST00000556813.1
 PSMC6
 proteasome (prosome, macropain) 26S subunit, ATPase, 6
chr1_+_171217677 0.16 ENST00000402921.2
 FMO1
 flavin containing monooxygenase 1
chr15_-_43513187 0.15 ENST00000540029.1
ENST00000441366.2
 EPB42
 erythrocyte membrane protein band 4.2
chr16_+_71560154 0.15 ENST00000539698.3
 CHST4
 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
chr10_+_118350522 0.15 ENST00000530319.1
ENST00000527980.1
ENST00000471549.1
ENST00000534537.1
 PNLIPRP1
 pancreatic lipase-related protein 1
chr14_+_53173890 0.13 ENST00000445930.2
 PSMC6
 proteasome (prosome, macropain) 26S subunit, ATPase, 6
chr11_-_47374246 0.13 ENST00000545968.1
ENST00000399249.2
ENST00000256993.4
 MYBPC3
 myosin binding protein C, cardiac
chr5_-_33984741 0.12 ENST00000382102.3
ENST00000509381.1
ENST00000342059.3
ENST00000345083.5
 SLC45A2
 solute carrier family 45, member 2
chr1_+_50574585 0.10 ENST00000371824.1
ENST00000371823.4
 ELAVL4
 ELAV like neuron-specific RNA binding protein 4
chr18_-_45663666 0.09 ENST00000535628.2
 ZBTB7C
 zinc finger and BTB domain containing 7C
chr20_+_43029911 0.08 ENST00000443598.2
ENST00000316099.4
ENST00000415691.2
 HNF4A
 hepatocyte nuclear factor 4, alpha
chr2_-_214014959 0.07 ENST00000442445.1
ENST00000457361.1
ENST00000342002.2
 IKZF2
 IKAROS family zinc finger 2 (Helios)
chr5_-_33984786 0.07 ENST00000296589.4
 SLC45A2
 solute carrier family 45, member 2
chr7_-_107880508 0.06 ENST00000425651.2
 NRCAM
 neuronal cell adhesion molecule
chr1_+_171217622 0.05 ENST00000433267.1
ENST00000367750.3
 FMO1
 flavin containing monooxygenase 1
chr16_+_71560023 0.04 ENST00000572450.1
 CHST4
 carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
chr8_-_20040638 0.03 ENST00000519026.1
ENST00000276373.5
ENST00000440926.1
ENST00000437980.1
 SLC18A1
 solute carrier family 18 (vesicular monoamine transporter), member 1
chr14_+_21945335 0.03 ENST00000262709.3
ENST00000457430.2
ENST00000448790.2
 TOX4
 TOX high mobility group box family member 4
chr8_-_93107443 0.02 ENST00000360348.2
ENST00000520428.1
ENST00000518992.1
ENST00000520556.1
ENST00000518317.1
ENST00000521319.1
ENST00000521375.1
ENST00000518449.1
 RUNX1T1
 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr14_+_75988768 0.01 ENST00000286639.6
 BATF
 basic leucine zipper transcription factor, ATF-like
chr14_-_21945057 0.01 ENST00000397762.1
 RAB2B
 RAB2B, member RAS oncogene family
chr2_+_87565634 0.01 ENST00000421835.2
 IGKV3OR2-268
 immunoglobulin kappa variable 3/OR2-268 (non-functional)
chr2_-_90538397 0.00 ENST00000443397.3
 RP11-685N3.1
 Uncharacterized protein
chr9_+_125796806 0.00 ENST00000373642.1
 GPR21
 G protein-coupled receptor 21

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.2 3.3 GO:0005833 hemoglobin complex(GO:0005833)
0.2 1.4 GO:0030061 mitochondrial crista(GO:0030061)
0.2 4.0 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.2 1.2 GO:0032437 cuticular plate(GO:0032437)
0.2 2.0 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 1.6 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 1.0 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.1 1.4 GO:0001891 phagocytic cup(GO:0001891)
0.1 0.2 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 0.2 GO:0043512 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.0 0.3 GO:0032133 chromosome passenger complex(GO:0032133)
0.0 0.9 GO:0031305 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 0.3 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.0 0.1 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.0 1.1 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.3 GO:0031595 nuclear proteasome complex(GO:0031595)
0.0 3.0 GO:0016605 PML body(GO:0016605)
0.0 0.2 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.5 GO:0005921 gap junction(GO:0005921)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0004998 transferrin receptor activity(GO:0004998)
0.4 1.6 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.3 0.9 GO:0002113 interleukin-33 binding(GO:0002113)
0.3 3.3 GO:0005344 oxygen transporter activity(GO:0005344)
0.2 0.6 GO:0042015 interleukin-20 binding(GO:0042015)
0.2 1.0 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 2.4 GO:0017127 cholesterol transporter activity(GO:0017127)
0.1 1.2 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 0.9 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.1 0.4 GO:0031708 endothelin B receptor binding(GO:0031708)
0.1 3.2 GO:0050699 WW domain binding(GO:0050699)
0.1 2.2 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.1 0.3 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.1 0.8 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 9.5 GO:0005178 integrin binding(GO:0005178)
0.0 0.2 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 1.0 GO:0005537 mannose binding(GO:0005537)
0.0 1.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.3 GO:0035174 histone serine kinase activity(GO:0035174)
0.0 0.2 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 0.3 GO:0036402 proteasome-activating ATPase activity(GO:0036402)
0.0 0.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 1.2 GO:0070888 E-box binding(GO:0070888)
0.0 0.2 GO:0034711 inhibin binding(GO:0034711)
0.0 0.1 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.7 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 1.1 GO:0019843 rRNA binding(GO:0019843)
0.0 0.7 GO:0005548 phospholipid transporter activity(GO:0005548)
0.0 1.2 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 0.2 GO:0005351 sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402)
0.0 2.7 GO:0051015 actin filament binding(GO:0051015)
0.0 0.3 GO:0004806 triglyceride lipase activity(GO:0004806)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 8.3 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.0 0.8 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 1.0 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 1.7 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.9 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.7 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.2 PID ALK2 PATHWAY ALK2 signaling events

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0018894 dibenzo-p-dioxin metabolic process(GO:0018894)
0.4 2.6 GO:1904729 regulation of intestinal cholesterol absorption(GO:0030300) regulation of intestinal lipid absorption(GO:1904729)
0.3 1.0 GO:0046521 sphingoid catabolic process(GO:0046521)
0.3 2.0 GO:0098707 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.3 3.5 GO:0043249 erythrocyte maturation(GO:0043249)
0.3 2.6 GO:0001955 blood vessel maturation(GO:0001955)
0.2 0.7 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
0.2 0.4 GO:0038162 erythropoietin-mediated signaling pathway(GO:0038162)
0.2 0.9 GO:0001692 histamine metabolic process(GO:0001692)
0.1 0.9 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
0.1 0.7 GO:2000504 positive regulation of blood vessel remodeling(GO:2000504)
0.1 0.4 GO:0060585 regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.1 3.2 GO:0006337 nucleosome disassembly(GO:0006337)
0.1 0.3 GO:1900195 spindle assembly involved in female meiosis I(GO:0007057) positive regulation of oocyte maturation(GO:1900195)
0.1 1.1 GO:0034378 chylomicron assembly(GO:0034378)
0.1 1.3 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.1 1.4 GO:0051639 actin filament network formation(GO:0051639)
0.1 0.2 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.1 1.2 GO:0021694 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.1 1.0 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.1 0.7 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.1 2.2 GO:0015695 organic cation transport(GO:0015695)
0.1 0.3 GO:1902612 regulation of anti-Mullerian hormone signaling pathway(GO:1902612) negative regulation of anti-Mullerian hormone signaling pathway(GO:1902613) anti-Mullerian hormone signaling pathway(GO:1990262)
0.1 1.2 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.0 1.2 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.0 0.2 GO:0046882 negative regulation of B cell differentiation(GO:0045578) negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.0 0.6 GO:0002003 angiotensin maturation(GO:0002003)
0.0 1.1 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 1.5 GO:2000144 positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.0 0.2 GO:0070995 NADPH oxidation(GO:0070995)
0.0 0.1 GO:0032971 regulation of muscle filament sliding(GO:0032971)
0.0 3.8 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.0 0.2 GO:0006477 protein sulfation(GO:0006477)
0.0 0.3 GO:0072540 T-helper 17 cell lineage commitment(GO:0072540)
0.0 1.2 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.3 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.0 0.2 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0 0.1 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.6 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 8.3 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.2 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 1.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.0 0.7 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 1.4 REACTOME STEROID HORMONES Genes involved in Steroid hormones
0.0 1.3 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.7 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.0 1.0 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 4.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.2 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.0 0.2 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors