ISMARA results: GFI1

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ENCODE cell lines, expression (Ernst 2011)

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Results for GFI1

Z-value: 0.91

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Transcription factors associated with GFI1

Gene Symbol	Gene ID	Gene Info
GFI1 Ensembl NCBI GeneCards UniProt	ENSG00000162676.7	GFI1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
GFI1	hg19_v2_chr1_-_92951607_92951661, hg19_v2_chr1_-_92949505_92949543, hg19_v2_chr1_-_92952433_92952489	0.62	1.0e-02	Click!

Activity profile of GFI1 motif

Sorted Z-values of GFI1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GFI1

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Top targets:

Promoter	Score	Transcript	Gene	Gene Info
chr17_+_47448102	2.59	ENST00000576461.1	RP11-81K2.1	Uncharacterized protein
chr4_-_155533787	2.45	ENST00000407946.1 ENST00000405164.1 ENST00000336098.3 ENST00000393846.2 ENST00000404648.3 ENST00000443553.1	FGG	fibrinogen gamma chain
chr2_+_11696464	2.34	ENST00000234142.5	GREB1	growth regulation by estrogen in breast cancer 1
chr17_-_26694979	2.30	ENST00000438614.1	VTN	vitronectin
chr17_-_26695013	2.23	ENST00000555059.2	CTB-96E2.2	Homeobox protein SEBOX
chr14_-_22005062	1.91	ENST00000317492.5	SALL2	spalt-like transcription factor 2
chr6_+_31982539	1.73	ENST00000435363.2 ENST00000425700.2	C4B	complement component 4B (Chido blood group)
chr6_+_31949801	1.69	ENST00000428956.2 ENST00000498271.1	C4A	complement component 4A (Rodgers blood group)
chr14_-_22005343	1.55	ENST00000327430.3	SALL2	spalt-like transcription factor 2
chr17_+_1665253	1.49	ENST00000254722.4	SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chrX_+_49294472	1.48	ENST00000361446.5	GAGE12B	G antigen 12B
chr17_-_7018128	1.41	ENST00000380952.2 ENST00000254850.7	ASGR2	asialoglycoprotein receptor 2
chr17_-_7017968	1.40	ENST00000355035.5	ASGR2	asialoglycoprotein receptor 2
chr17_+_1665345	1.37	ENST00000576406.1 ENST00000571149.1	SERPINF1	serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr8_-_145642267	1.35	ENST00000301305.3	SLC39A4	solute carrier family 39 (zinc transporter), member 4
chr11_+_22689648	1.24	ENST00000278187.3	GAS2	growth arrest-specific 2
chr8_-_145641864	1.20	ENST00000276833.5	SLC39A4	solute carrier family 39 (zinc transporter), member 4
chr17_+_4675175	1.10	ENST00000270560.3	TM4SF5	transmembrane 4 L six family member 5
chr17_-_79895097	1.06	ENST00000402252.2 ENST00000583564.1 ENST00000585244.1 ENST00000337943.5 ENST00000579698.1	PYCR1	pyrroline-5-carboxylate reductase 1
chr11_+_22688150	0.98	ENST00000454584.2	GAS2	growth arrest-specific 2
chr5_-_78809950	0.97	ENST00000334082.6	HOMER1	homer homolog 1 (Drosophila)
chr12_+_71833550	0.95	ENST00000266674.5	LGR5	leucine-rich repeat containing G protein-coupled receptor 5
chr20_-_33999766	0.91	ENST00000349714.5 ENST00000438533.1 ENST00000359226.2 ENST00000374384.2 ENST00000374377.5 ENST00000407996.2 ENST00000424405.1 ENST00000542501.1 ENST00000397554.1 ENST00000540457.1 ENST00000374380.2 ENST00000374385.5	UQCC1	ubiquinol-cytochrome c reductase complex assembly factor 1
chr1_-_110306562	0.89	ENST00000369805.3	EPS8L3	EPS8-like 3
chr7_-_87104963	0.89	ENST00000359206.3 ENST00000358400.3 ENST00000265723.4	ABCB4	ATP-binding cassette, sub-family B (MDR/TAP), member 4
chr12_+_100867486	0.89	ENST00000548884.1	NR1H4	nuclear receptor subfamily 1, group H, member 4
chr16_+_82090028	0.86	ENST00000568090.1	HSD17B2	hydroxysteroid (17-beta) dehydrogenase 2
chr17_-_56595196	0.82	ENST00000579921.1 ENST00000579925.1 ENST00000323456.5	MTMR4	myotubularin related protein 4
chr14_-_22005018	0.78	ENST00000546363.1	SALL2	spalt-like transcription factor 2
chr15_-_52587945	0.77	ENST00000443683.2 ENST00000558479.1 ENST00000261839.7	MYO5C	myosin VC
chr4_-_144940477	0.77	ENST00000513128.1 ENST00000429670.2 ENST00000502664.1	GYPB	glycophorin B (MNS blood group)
chr5_+_133451254	0.76	ENST00000517851.1 ENST00000521639.1 ENST00000522375.1 ENST00000378560.4 ENST00000432532.2 ENST00000520958.1 ENST00000518915.1 ENST00000395023.1	TCF7	transcription factor 7 (T-cell specific, HMG-box)
chr10_-_82049424	0.73	ENST00000372213.3	MAT1A	methionine adenosyltransferase I, alpha
chr4_-_145061788	0.73	ENST00000512064.1 ENST00000512789.1 ENST00000504786.1 ENST00000503627.1 ENST00000535709.1 ENST00000324022.10 ENST00000360771.4 ENST00000283126.7	GYPA GYPB	glycophorin A (MNS blood group) glycophorin B (MNS blood group)
chr6_+_42984723	0.71	ENST00000332245.8	KLHDC3	kelch domain containing 3
chr18_+_55711575	0.70	ENST00000356462.6 ENST00000400345.3 ENST00000589054.1 ENST00000256832.7	NEDD4L	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr2_+_54683419	0.69	ENST00000356805.4	SPTBN1	spectrin, beta, non-erythrocytic 1
chr6_+_42584847	0.68	ENST00000372883.3	UBR2	ubiquitin protein ligase E3 component n-recognin 2
chr10_-_13523073	0.68	ENST00000440282.1	BEND7	BEN domain containing 7
chr13_-_46756351	0.68	ENST00000323076.2	LCP1	lymphocyte cytosolic protein 1 (L-plastin)
chr10_+_94451574	0.65	ENST00000492654.2	HHEX	hematopoietically expressed homeobox
chr10_-_11574274	0.64	ENST00000277575.5	USP6NL	USP6 N-terminal like
chr17_-_79895154	0.63	ENST00000405481.4 ENST00000585215.1 ENST00000577624.1 ENST00000403172.4	PYCR1	pyrroline-5-carboxylate reductase 1
chr12_+_100867694	0.63	ENST00000392986.3 ENST00000549996.1	NR1H4	nuclear receptor subfamily 1, group H, member 4
chr2_-_111291587	0.63	ENST00000437167.1	RGPD6	RANBP2-like and GRIP domain containing 6
chr2_+_17721920	0.63	ENST00000295156.4	VSNL1	visinin-like 1
chr7_-_71912046	0.59	ENST00000395276.2 ENST00000431984.1	CALN1	calneuron 1
chr1_-_25291475	0.59	ENST00000338888.3 ENST00000399916.1	RUNX3	runt-related transcription factor 3
chr1_+_46713404	0.58	ENST00000371975.4 ENST00000469835.1	RAD54L	RAD54-like (S. cerevisiae)
chr2_-_89157161	0.58	ENST00000390237.2	IGKC	immunoglobulin kappa constant
chr1_+_46713357	0.57	ENST00000442598.1	RAD54L	RAD54-like (S. cerevisiae)
chrX_+_48681768	0.57	ENST00000430858.1	HDAC6	histone deacetylase 6
chr19_-_13227534	0.56	ENST00000588229.1 ENST00000357720.4	TRMT1	tRNA methyltransferase 1 homolog (S. cerevisiae)
chr6_-_31704282	0.55	ENST00000375784.3 ENST00000375779.2	CLIC1	chloride intracellular channel 1
chr7_-_23510086	0.54	ENST00000258729.3	IGF2BP3	insulin-like growth factor 2 mRNA binding protein 3
chr19_-_13227463	0.53	ENST00000437766.1 ENST00000221504.8	TRMT1	tRNA methyltransferase 1 homolog (S. cerevisiae)
chr1_+_156338993	0.53	ENST00000368249.1 ENST00000368246.2 ENST00000537040.1 ENST00000400992.2 ENST00000255013.3 ENST00000451864.2	RHBG	Rh family, B glycoprotein (gene/pseudogene)
chr7_-_1980128	0.53	ENST00000437877.1	MAD1L1	MAD1 mitotic arrest deficient-like 1 (yeast)
chr5_+_118690466	0.53	ENST00000503646.1	TNFAIP8	tumor necrosis factor, alpha-induced protein 8
chrX_-_48056199	0.52	ENST00000311798.1 ENST00000347757.1	SSX5	synovial sarcoma, X breakpoint 5
chr16_-_70323422	0.52	ENST00000261772.8	AARS	alanyl-tRNA synthetase
chr3_-_66024213	0.52	ENST00000483466.1	MAGI1	membrane associated guanylate kinase, WW and PDZ domain containing 1
chr17_-_56494908	0.52	ENST00000577716.1	RNF43	ring finger protein 43
chr3_-_178976996	0.52	ENST00000485523.1	KCNMB3	potassium large conductance calcium-activated channel, subfamily M beta member 3
chr4_-_144826682	0.51	ENST00000358615.4 ENST00000437468.2	GYPE	glycophorin E (MNS blood group)
chr16_+_12059050	0.51	ENST00000396495.3	TNFRSF17	tumor necrosis factor receptor superfamily, member 17
chr17_-_56494882	0.51	ENST00000584437.1	RNF43	ring finger protein 43
chr16_+_12059091	0.51	ENST00000562385.1	TNFRSF17	tumor necrosis factor receptor superfamily, member 17
chr2_-_96874553	0.50	ENST00000337288.5 ENST00000443962.1	STARD7	StAR-related lipid transfer (START) domain containing 7
chr2_+_62900986	0.49	ENST00000405015.3 ENST00000413434.1 ENST00000426940.1 ENST00000449820.1	EHBP1	EH domain binding protein 1
chr1_-_67142710	0.48	ENST00000502413.2	AL139147.1	Uncharacterized protein
chr6_-_41040268	0.47	ENST00000373154.2 ENST00000244558.9 ENST00000464633.1 ENST00000424266.2 ENST00000479950.1 ENST00000482515.1	OARD1	O-acyl-ADP-ribose deacylase 1
chrX_-_102319092	0.46	ENST00000372728.3	BEX1	brain expressed, X-linked 1
chr5_+_157158205	0.46	ENST00000231198.7	THG1L	tRNA-histidine guanylyltransferase 1-like (S. cerevisiae)
chr16_+_12058961	0.46	ENST00000053243.1	TNFRSF17	tumor necrosis factor receptor superfamily, member 17
chr19_+_6772710	0.45	ENST00000304076.2 ENST00000602142.1 ENST00000596764.1	VAV1	vav 1 guanine nucleotide exchange factor
chr6_+_45296048	0.45	ENST00000465038.2 ENST00000352853.5 ENST00000541979.1 ENST00000371438.1	RUNX2	runt-related transcription factor 2
chr3_-_33686743	0.45	ENST00000333778.6 ENST00000539981.1	CLASP2	cytoplasmic linker associated protein 2
chr2_+_17721230	0.44	ENST00000457525.1	VSNL1	visinin-like 1
chrX_-_52683950	0.44	ENST00000298181.5	SSX7	synovial sarcoma, X breakpoint 7
chr17_-_56494713	0.42	ENST00000407977.2	RNF43	ring finger protein 43
chr14_-_95623607	0.42	ENST00000531162.1 ENST00000529720.1 ENST00000343455.3	DICER1	dicer 1, ribonuclease type III
chr2_-_27938593	0.42	ENST00000379677.2	AC074091.13	Uncharacterized protein
chr14_-_95624227	0.42	ENST00000526495.1	DICER1	dicer 1, ribonuclease type III
chr4_-_89744457	0.41	ENST00000395002.2	FAM13A	family with sequence similarity 13, member A
chr1_-_173793246	0.41	ENST00000345664.6 ENST00000367710.3	CENPL	centromere protein L
chrX_+_12885183	0.41	ENST00000380659.3	TLR7	toll-like receptor 7
chr9_+_108456800	0.41	ENST00000434214.1 ENST00000374692.3	TMEM38B	transmembrane protein 38B
chr1_-_173793458	0.41	ENST00000356198.2	CENPL	centromere protein L
chr7_+_112063192	0.41	ENST00000005558.4	IFRD1	interferon-related developmental regulator 1
chr1_-_160681593	0.41	ENST00000368045.3 ENST00000368046.3	CD48	CD48 molecule
chr6_+_6588902	0.41	ENST00000230568.4	LY86	lymphocyte antigen 86
chr8_+_40010989	0.41	ENST00000315792.3	C8orf4	chromosome 8 open reading frame 4
chr17_+_76311791	0.40	ENST00000586321.1	AC061992.2	AC061992.2
chr11_-_66675371	0.40	ENST00000393955.2	PC	pyruvate carboxylase
chr10_-_65028938	0.40	ENST00000402544.1	JMJD1C	jumonji domain containing 1C
chr11_+_117049854	0.40	ENST00000278951.7	SIDT2	SID1 transmembrane family, member 2
chr2_+_47630108	0.39	ENST00000233146.2 ENST00000454849.1 ENST00000543555.1	MSH2	mutS homolog 2
chr21_+_44313375	0.39	ENST00000354250.2 ENST00000340344.4	NDUFV3	NADH dehydrogenase (ubiquinone) flavoprotein 3, 10kDa
chr17_-_18266660	0.39	ENST00000582653.1 ENST00000352886.6	SHMT1	serine hydroxymethyltransferase 1 (soluble)
chr6_-_25930904	0.38	ENST00000377850.3	SLC17A2	solute carrier family 17, member 2
chr17_-_18266765	0.38	ENST00000354098.3	SHMT1	serine hydroxymethyltransferase 1 (soluble)
chr4_-_89744365	0.37	ENST00000513837.1 ENST00000503556.1	FAM13A	family with sequence similarity 13, member A
chr9_+_133710453	0.37	ENST00000318560.5	ABL1	c-abl oncogene 1, non-receptor tyrosine kinase
chr17_-_18266797	0.37	ENST00000316694.3 ENST00000539052.1	SHMT1	serine hydroxymethyltransferase 1 (soluble)
chr10_-_65028817	0.37	ENST00000542921.1	JMJD1C	jumonji domain containing 1C
chr5_+_59783941	0.37	ENST00000506884.1 ENST00000504876.2	PART1	prostate androgen-regulated transcript 1 (non-protein coding)
chr3_-_142166904	0.37	ENST00000264951.4	XRN1	5'-3' exoribonuclease 1
chr12_-_56756553	0.37	ENST00000398189.3 ENST00000541105.1	APOF	apolipoprotein F
chr1_-_155947951	0.36	ENST00000313695.7 ENST00000497907.1	ARHGEF2	Rho/Rac guanine nucleotide exchange factor (GEF) 2
chr19_+_50353944	0.36	ENST00000594151.1 ENST00000600603.1 ENST00000601638.1 ENST00000221557.9	PTOV1	prostate tumor overexpressed 1
chr8_+_21823726	0.36	ENST00000433566.4	XPO7	exportin 7
chr3_+_51575596	0.36	ENST00000409535.2	RAD54L2	RAD54-like 2 (S. cerevisiae)
chr1_+_32739733	0.36	ENST00000333070.4	LCK	lymphocyte-specific protein tyrosine kinase
chr7_-_148581251	0.36	ENST00000478654.1 ENST00000460911.1 ENST00000350995.2	EZH2	enhancer of zeste homolog 2 (Drosophila)
chr20_+_36373032	0.36	ENST00000373473.1	CTNNBL1	catenin, beta like 1
chrX_+_37639302	0.36	ENST00000545017.1 ENST00000536160.1	CYBB	cytochrome b-245, beta polypeptide
chr12_+_56732658	0.36	ENST00000228534.4	IL23A	interleukin 23, alpha subunit p19
chr11_-_72432950	0.36	ENST00000426523.1 ENST00000429686.1	ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr6_-_41040195	0.36	ENST00000463088.1 ENST00000469104.1 ENST00000486443.1	OARD1	O-acyl-ADP-ribose deacylase 1
chr7_+_55980331	0.35	ENST00000429591.2	ZNF713	zinc finger protein 713
chr14_-_37642016	0.35	ENST00000331299.5	SLC25A21	solute carrier family 25 (mitochondrial oxoadipate carrier), member 21
chr7_+_130020932	0.35	ENST00000484324.1	CPA1	carboxypeptidase A1 (pancreatic)
chr7_+_100136811	0.35	ENST00000300176.4 ENST00000262935.4	AGFG2	ArfGAP with FG repeats 2
chr3_+_63898275	0.35	ENST00000538065.1	ATXN7	ataxin 7
chr12_-_56843161	0.34	ENST00000554616.1 ENST00000553532.1 ENST00000229201.4	TIMELESS	timeless circadian clock
chr6_-_135271260	0.34	ENST00000265605.2	ALDH8A1	aldehyde dehydrogenase 8 family, member A1
chr11_+_117049445	0.34	ENST00000324225.4 ENST00000532960.1	SIDT2	SID1 transmembrane family, member 2
chr6_-_32920794	0.34	ENST00000395305.3 ENST00000395303.3 ENST00000374843.4 ENST00000429234.1	HLA-DMA XXbac-BPG181M17.5	major histocompatibility complex, class II, DM alpha Uncharacterized protein
chr8_-_27115903	0.33	ENST00000350889.4 ENST00000519997.1 ENST00000519614.1 ENST00000522908.1 ENST00000265770.7	STMN4	stathmin-like 4
chr5_+_59783540	0.33	ENST00000515734.2	PART1	prostate androgen-regulated transcript 1 (non-protein coding)
chr2_+_152214098	0.33	ENST00000243347.3	TNFAIP6	tumor necrosis factor, alpha-induced protein 6
chr2_-_153574480	0.33	ENST00000410080.1	PRPF40A	PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
chr4_-_89744314	0.32	ENST00000508369.1	FAM13A	family with sequence similarity 13, member A
chr6_+_167704838	0.32	ENST00000366829.2	UNC93A	unc-93 homolog A (C. elegans)
chr4_+_41937131	0.32	ENST00000504986.1 ENST00000508448.1 ENST00000513702.1 ENST00000325094.5	TMEM33	transmembrane protein 33
chr12_+_117176113	0.32	ENST00000319176.7	RNFT2	ring finger protein, transmembrane 2
chr8_-_27115931	0.31	ENST00000523048.1	STMN4	stathmin-like 4
chr19_+_50354430	0.31	ENST00000599732.1	PTOV1	prostate tumor overexpressed 1
chr5_+_176784837	0.31	ENST00000408923.3	RGS14	regulator of G-protein signaling 14
chr20_+_45338126	0.31	ENST00000359271.2	SLC2A10	solute carrier family 2 (facilitated glucose transporter), member 10
chr7_-_140482926	0.31	ENST00000496384.2	BRAF	v-raf murine sarcoma viral oncogene homolog B
chr17_-_40761375	0.31	ENST00000543197.1 ENST00000309428.5	FAM134C	family with sequence similarity 134, member C
chr20_-_34252759	0.31	ENST00000414711.1 ENST00000416778.1 ENST00000397442.1 ENST00000440240.1 ENST00000412056.1 ENST00000352393.4 ENST00000458038.1 ENST00000420363.1 ENST00000434795.1 ENST00000437100.1 ENST00000414664.1 ENST00000359646.1 ENST00000424458.1 ENST00000374104.3 ENST00000374114.3	CPNE1 RBM12	copine I RNA binding motif protein 12
chr7_+_150758304	0.31	ENST00000482950.1 ENST00000463414.1 ENST00000310317.5	SLC4A2	solute carrier family 4 (anion exchanger), member 2
chr19_-_15529790	0.30	ENST00000596195.1 ENST00000595067.1 ENST00000595465.2 ENST00000397410.5 ENST00000600247.1	AKAP8L	A kinase (PRKA) anchor protein 8-like
chr1_+_168250194	0.30	ENST00000367821.3	TBX19	T-box 19
chr3_+_52017454	0.30	ENST00000476854.1 ENST00000476351.1 ENST00000494103.1 ENST00000404366.2 ENST00000469863.1	ACY1	aminoacylase 1
chr19_+_50354462	0.30	ENST00000601675.1	PTOV1	prostate tumor overexpressed 1
chr5_-_147162078	0.30	ENST00000507386.1	JAKMIP2	janus kinase and microtubule interacting protein 2
chr2_-_68479614	0.29	ENST00000234310.3	PPP3R1	protein phosphatase 3, regulatory subunit B, alpha
chr2_-_238499725	0.29	ENST00000264601.3	RAB17	RAB17, member RAS oncogene family
chr4_+_106631966	0.29	ENST00000360505.5 ENST00000510865.1 ENST00000509336.1	GSTCD	glutathione S-transferase, C-terminal domain containing
chr2_-_158300556	0.29	ENST00000264192.3	CYTIP	cytohesin 1 interacting protein
chr10_-_74385811	0.28	ENST00000603011.1 ENST00000401998.3 ENST00000361114.5 ENST00000604238.1	MICU1	mitochondrial calcium uptake 1
chr19_+_3880581	0.28	ENST00000450849.2 ENST00000301260.6 ENST00000398448.3	ATCAY	ataxia, cerebellar, Cayman type
chr5_-_111091948	0.28	ENST00000447165.2	NREP	neuronal regeneration related protein
chr6_+_6588316	0.28	ENST00000379953.2	LY86	lymphocyte antigen 86
chr15_+_84115868	0.28	ENST00000427482.2	SH3GL3	SH3-domain GRB2-like 3
chr7_-_148581360	0.27	ENST00000320356.2 ENST00000541220.1 ENST00000483967.1 ENST00000536783.1	EZH2	enhancer of zeste homolog 2 (Drosophila)
chr18_-_19283649	0.27	ENST00000584464.1 ENST00000578270.1	ABHD3	abhydrolase domain containing 3
chr11_-_72433346	0.27	ENST00000334211.8	ARAP1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr6_+_111195973	0.27	ENST00000368885.3 ENST00000368882.3 ENST00000451850.2 ENST00000368877.5	AMD1	adenosylmethionine decarboxylase 1
chr16_+_31366536	0.26	ENST00000562522.1	ITGAX	integrin, alpha X (complement component 3 receptor 4 subunit)
chr2_+_171785012	0.26	ENST00000234160.4	GORASP2	golgi reassembly stacking protein 2, 55kDa
chr6_-_135271219	0.26	ENST00000367847.2 ENST00000367845.2	ALDH8A1	aldehyde dehydrogenase 8 family, member A1
chr14_+_72052983	0.26	ENST00000358550.2	SIPA1L1	signal-induced proliferation-associated 1 like 1
chr17_+_34171081	0.26	ENST00000585577.1	TAF15	TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa
chr2_+_202122703	0.26	ENST00000447616.1 ENST00000358485.4	CASP8	caspase 8, apoptosis-related cysteine peptidase
chr10_+_31610064	0.25	ENST00000446923.2 ENST00000559476.1	ZEB1	zinc finger E-box binding homeobox 1
chr6_-_32908792	0.25	ENST00000418107.2	HLA-DMB	major histocompatibility complex, class II, DM beta
chr7_+_123488124	0.25	ENST00000476325.1	HYAL4	hyaluronoglucosaminidase 4
chr12_+_7941989	0.24	ENST00000229307.4	NANOG	Nanog homeobox
chr19_-_16045220	0.24	ENST00000326742.8	CYP4F11	cytochrome P450, family 4, subfamily F, polypeptide 11
chrX_-_48216101	0.24	ENST00000298396.2 ENST00000376893.3	SSX3	synovial sarcoma, X breakpoint 3
chr5_+_37379314	0.24	ENST00000265107.4 ENST00000504564.1	WDR70	WD repeat domain 70
chr2_+_32853093	0.24	ENST00000448773.1 ENST00000317907.4	TTC27	tetratricopeptide repeat domain 27
chr15_+_84116106	0.24	ENST00000535412.1 ENST00000324537.5	SH3GL3	SH3-domain GRB2-like 3
chr19_-_46088068	0.23	ENST00000263275.4 ENST00000323060.3	OPA3	optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr12_+_96252706	0.23	ENST00000266735.5 ENST00000553192.1 ENST00000552085.1	SNRPF	small nuclear ribonucleoprotein polypeptide F
chr5_-_88179302	0.23	ENST00000504921.2	MEF2C	myocyte enhancer factor 2C
chr11_+_117049910	0.23	ENST00000431081.2 ENST00000524842.1	SIDT2	SID1 transmembrane family, member 2
chr17_+_45728427	0.23	ENST00000540627.1	KPNB1	karyopherin (importin) beta 1
chr16_+_19183671	0.22	ENST00000562711.2	SYT17	synaptotagmin XVII
chr9_+_2159850	0.22	ENST00000416751.1	SMARCA2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr19_+_47813110	0.22	ENST00000355085.3	C5AR1	complement component 5a receptor 1
chr17_-_3539558	0.21	ENST00000225519.3	SHPK	sedoheptulokinase
chr1_+_12524965	0.21	ENST00000471923.1	VPS13D	vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr16_-_67517716	0.21	ENST00000290953.2	AGRP	agouti related protein homolog (mouse)
chr8_+_75736761	0.21	ENST00000260113.2	PI15	peptidase inhibitor 15
chr19_+_50354393	0.20	ENST00000391842.1	PTOV1	prostate tumor overexpressed 1
chr6_+_28092338	0.20	ENST00000340487.4	ZSCAN16	zinc finger and SCAN domain containing 16
chr19_-_51875523	0.20	ENST00000593572.1 ENST00000595157.1	NKG7	natural killer cell group 7 sequence
chr14_-_106069247	0.20	ENST00000479229.1	RP11-731F5.1	RP11-731F5.1
chr8_+_145192672	0.20	ENST00000347708.4	FAM203A	family with sequence similarity 203, member A
chr16_-_19729502	0.20	ENST00000219837.7	KNOP1	lysine-rich nucleolar protein 1
chr14_+_35591858	0.20	ENST00000603544.1	KIAA0391	KIAA0391
chr20_-_33732952	0.20	ENST00000541621.1	EDEM2	ER degradation enhancer, mannosidase alpha-like 2
chr2_-_153573887	0.20	ENST00000493468.2 ENST00000545856.1	PRPF40A	PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
chr11_-_11374904	0.19	ENST00000528848.2	CSNK2A3	casein kinase 2, alpha 3 polypeptide

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.9	5.7	GO:0061357	positive regulation of Wnt protein secretion(GO:0061357)
1.8	5.5	GO:0006624	vacuolar protein processing(GO:0006624)
1.7	5.1	GO:0060585	regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
1.6	4.9	GO:0070563	negative regulation of vitamin D receptor signaling pathway(GO:0070563)
1.6	6.5	GO:0050928	negative regulation of positive chemotaxis(GO:0050928)
1.3	4.0	GO:0093001	glycolysis from storage polysaccharide through glucose-1-phosphate(GO:0093001)
1.3	3.8	GO:1990108	protein linear deubiquitination(GO:1990108)
1.1	12.8	GO:1900028	negative regulation of ruffle assembly(GO:1900028)
1.1	5.3	GO:0060718	chorionic trophoblast cell differentiation(GO:0060718)
1.0	2.9	GO:0003241	growth involved in heart morphogenesis(GO:0003241)
0.9	4.5	GO:0003289	atrial septum primum morphogenesis(GO:0003289)
0.9	6.1	GO:2000795	trigeminal sensory nucleus development(GO:0021730) principal sensory nucleus of trigeminal nerve development(GO:0021740) negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.8	3.1	GO:1903224	regulation of endodermal cell differentiation(GO:1903224)
0.7	4.4	GO:0000821	regulation of arginine metabolic process(GO:0000821)
0.6	1.8	GO:1901491	negative regulation of lymphangiogenesis(GO:1901491)
0.6	5.3	GO:0008090	retrograde axonal transport(GO:0008090)
0.6	1.7	GO:1905205	positive regulation of connective tissue replacement(GO:1905205)
0.5	2.9	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.5	1.4	GO:0061055	myotome development(GO:0061055)
0.5	2.3	GO:0051534	negative regulation of NFAT protein import into nucleus(GO:0051534)
0.5	5.1	GO:0060020	Bergmann glial cell differentiation(GO:0060020)
0.4	2.7	GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.4	1.2	GO:0032679	antigen processing and presentation of endogenous peptide antigen via MHC class Ib(GO:0002476) TRAIL production(GO:0032639) regulation of TRAIL production(GO:0032679) positive regulation of TRAIL production(GO:0032759) protection from natural killer cell mediated cytotoxicity(GO:0042270) positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.4	2.2	GO:0002175	protein localization to paranode region of axon(GO:0002175)
0.4	1.1	GO:0021763	subthalamic nucleus development(GO:0021763) prolactin secreting cell differentiation(GO:0060127) left lung development(GO:0060459) left lung morphogenesis(GO:0060460) pulmonary vein morphogenesis(GO:0060577) superior vena cava morphogenesis(GO:0060578)
0.3	3.7	GO:1904321	response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.3	0.9	GO:0014016	neuroblast differentiation(GO:0014016)
0.3	2.1	GO:0006880	intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.3	0.9	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.3	2.0	GO:0042426	choline catabolic process(GO:0042426)
0.3	0.8	GO:0002101	tRNA wobble cytosine modification(GO:0002101)
0.3	2.3	GO:0045617	negative regulation of keratinocyte differentiation(GO:0045617)
0.2	2.5	GO:0010265	SCF complex assembly(GO:0010265)
0.2	6.2	GO:0033622	integrin activation(GO:0033622)
0.2	1.3	GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.2	1.3	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.2	1.7	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.2	1.7	GO:0045602	negative regulation of endothelial cell differentiation(GO:0045602)
0.2	1.3	GO:0006537	glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.2	2.5	GO:0001973	adenosine receptor signaling pathway(GO:0001973)
0.2	1.4	GO:0006013	mannose metabolic process(GO:0006013)
0.2	1.2	GO:0060011	Sertoli cell proliferation(GO:0060011)
0.2	0.7	GO:0097368	histone H4-K20 trimethylation(GO:0034773) establishment of Sertoli cell barrier(GO:0097368)
0.2	1.7	GO:0033327	Leydig cell differentiation(GO:0033327)
0.2	1.8	GO:0051665	membrane raft localization(GO:0051665)
0.1	0.4	GO:0072137	condensed mesenchymal cell proliferation(GO:0072137)
0.1	1.0	GO:0044800	fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.1	0.6	GO:1903597	negative regulation of gap junction assembly(GO:1903597)
0.1	0.6	GO:0050717	positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.1	0.4	GO:0098923	retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.1	3.3	GO:0030208	dermatan sulfate biosynthetic process(GO:0030208)
0.1	1.3	GO:1903943	regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.1	0.6	GO:1903243	negative regulation of cardiac muscle adaptation(GO:0010616) negative regulation of lung blood pressure(GO:0061767) negative regulation of cardiac muscle hypertrophy in response to stress(GO:1903243)
0.1	0.3	GO:0046967	cytosol to ER transport(GO:0046967)
0.1	0.3	GO:0015920	leukocyte chemotaxis involved in inflammatory response(GO:0002232) lipopolysaccharide transport(GO:0015920)
0.1	1.4	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.1	1.2	GO:1901223	negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.1	1.0	GO:0061299	retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.1	0.3	GO:0006788	heme oxidation(GO:0006788)
0.1	0.4	GO:0008582	regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.1	0.6	GO:0070294	renal sodium ion absorption(GO:0070294)
0.1	0.9	GO:0006451	selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.1	0.5	GO:0003415	chondrocyte hypertrophy(GO:0003415)
0.1	0.7	GO:0035873	lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.1	1.2	GO:0007220	Notch receptor processing(GO:0007220)
0.1	2.4	GO:0061049	physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1	0.3	GO:1902774	late endosome to lysosome transport(GO:1902774)
0.1	0.8	GO:0002315	marginal zone B cell differentiation(GO:0002315)
0.1	0.6	GO:1904424	regulation of GTP binding(GO:1904424)
0.1	0.2	GO:0002188	translation reinitiation(GO:0002188)
0.1	0.2	GO:1900114	positive regulation of histone H3-K9 trimethylation(GO:1900114)
0.1	0.4	GO:0045359	negative regulation of MyD88-independent toll-like receptor signaling pathway(GO:0034128) positive regulation of interferon-beta biosynthetic process(GO:0045359)
0.1	0.8	GO:0052697	flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.1	0.5	GO:0016127	cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.1	1.3	GO:0007250	activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.1	0.2	GO:0006428	isoleucyl-tRNA aminoacylation(GO:0006428)
0.1	0.6	GO:0006621	protein retention in ER lumen(GO:0006621)
0.1	0.3	GO:0007185	transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185)
0.1	0.2	GO:0006524	alanine metabolic process(GO:0006522) alanine catabolic process(GO:0006524) pyruvate family amino acid metabolic process(GO:0009078) pyruvate family amino acid catabolic process(GO:0009080)
0.1	0.2	GO:0045658	regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.1	0.5	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1	2.0	GO:0016486	peptide hormone processing(GO:0016486)
0.0	0.1	GO:0032887	regulation of spindle elongation(GO:0032887) regulation of mitotic spindle elongation(GO:0032888) anastral spindle assembly(GO:0055048) protein localization to spindle pole body(GO:0071988) regulation of protein localization to spindle pole body(GO:1902363) positive regulation of protein localization to spindle pole body(GO:1902365) positive regulation of mitotic spindle elongation(GO:1902846)
0.0	2.0	GO:0045668	negative regulation of osteoblast differentiation(GO:0045668)
0.0	1.7	GO:0016577	histone demethylation(GO:0016577)
0.0	0.8	GO:0043374	CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	1.1	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.0	0.4	GO:0032510	endosome to lysosome transport via multivesicular body sorting pathway(GO:0032510)
0.0	2.0	GO:0048488	synaptic vesicle endocytosis(GO:0048488)
0.0	0.6	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.8	GO:0006706	steroid catabolic process(GO:0006706)
0.0	0.7	GO:0090129	positive regulation of synapse maturation(GO:0090129)
0.0	0.5	GO:0030321	transepithelial chloride transport(GO:0030321)
0.0	0.3	GO:1904776	regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.0	0.8	GO:1900745	positive regulation of p38MAPK cascade(GO:1900745)
0.0	0.7	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.0	1.3	GO:0043001	Golgi to plasma membrane protein transport(GO:0043001)
0.0	0.7	GO:0007191	adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.0	0.6	GO:0003351	epithelial cilium movement(GO:0003351)
0.0	0.1	GO:0002125	maternal aggressive behavior(GO:0002125)
0.0	0.2	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.1	GO:0003220	left ventricular cardiac muscle tissue morphogenesis(GO:0003220) cell proliferation involved in heart valve morphogenesis(GO:0003249) regulation of cell proliferation involved in heart valve morphogenesis(GO:0003250) formation of anatomical boundary(GO:0048859) cell proliferation involved in heart valve development(GO:2000793)
0.0	0.2	GO:0001951	intestinal D-glucose absorption(GO:0001951)
0.0	1.1	GO:1903959	regulation of anion transmembrane transport(GO:1903959)
0.0	0.2	GO:0006578	amino-acid betaine biosynthetic process(GO:0006578)
0.0	0.4	GO:0010457	centriole-centriole cohesion(GO:0010457)
0.0	1.6	GO:0001895	retina homeostasis(GO:0001895)
0.0	0.4	GO:2000369	regulation of clathrin-mediated endocytosis(GO:2000369)
0.0	2.7	GO:0007224	smoothened signaling pathway(GO:0007224)
0.0	0.3	GO:0044241	lipid digestion(GO:0044241)
0.0	1.4	GO:0010507	negative regulation of autophagy(GO:0010507)
0.0	0.4	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	1.4	GO:1902017	regulation of cilium assembly(GO:1902017)
0.0	0.3	GO:0034656	nucleobase-containing small molecule catabolic process(GO:0034656)
0.0	0.2	GO:0060117	auditory receptor cell development(GO:0060117)
0.0	0.9	GO:0043277	apoptotic cell clearance(GO:0043277)
0.0	1.0	GO:0008593	regulation of Notch signaling pathway(GO:0008593)
0.0	0.3	GO:0018214	peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0	0.1	GO:0033353	S-adenosylmethionine cycle(GO:0033353)
0.0	0.1	GO:0043353	enucleate erythrocyte differentiation(GO:0043353)
0.0	0.3	GO:0030252	growth hormone secretion(GO:0030252)
0.0	0.4	GO:0050687	negative regulation of defense response to virus(GO:0050687)
0.0	1.1	GO:0031532	actin cytoskeleton reorganization(GO:0031532)
0.0	6.9	GO:0006936	muscle contraction(GO:0006936)
0.0	1.8	GO:0034605	cellular response to heat(GO:0034605)
0.0	0.3	GO:0071526	semaphorin-plexin signaling pathway(GO:0071526)
0.0	0.3	GO:0031639	plasminogen activation(GO:0031639)
0.0	0.3	GO:0000413	protein peptidyl-prolyl isomerization(GO:0000413)
0.0	0.3	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.6	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.2	2.5	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.1	0.8	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.1	1.7	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.1	1.7	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.0	0.8	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	0.4	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.8	REACTOME MICRORNA MIRNA BIOGENESIS	Genes involved in MicroRNA (miRNA) Biogenesis
0.0	0.2	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.0	0.7	REACTOME NEPHRIN INTERACTIONS	Genes involved in Nephrin interactions
0.0	0.4	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0	2.9	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.0	0.7	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.0	0.3	REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES	Genes involved in Recruitment of NuMA to mitotic centrosomes
0.0	0.3	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.0	0.3	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.0	0.3	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.1	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0	1.1	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
0.0	0.3	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	0.3	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0	0.2	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0	0.1	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.3	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.0	0.5	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.0	0.3	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.1	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	0.2	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	0.4	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0	0.7	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0	0.2	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0	0.2	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.0	0.4	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.0	0.8	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0	1.0	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	5.5	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.4	6.6	REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	Genes involved in Adenylate cyclase inhibitory pathway
0.2	12.6	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.2	1.0	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.2	6.5	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.2	6.1	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.2	4.9	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.2	10.4	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	1.3	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.1	2.0	REACTOME SIGNALING BY NOTCH2	Genes involved in Signaling by NOTCH2
0.1	4.5	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1	1.8	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.1	4.2	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.1	2.6	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.1	4.3	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.1	3.8	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.1	2.6	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.1	0.4	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.1	0.6	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.1	0.8	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.1	1.7	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.1	3.3	REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM	Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.1	1.3	REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS	Genes involved in Amino acid and oligopeptide SLC transporters
0.1	0.9	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0	3.1	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.0	0.8	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.0	1.1	REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0	1.7	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.7	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.0	5.4	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.0	0.8	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.0	0.5	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.0	1.1	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.0	4.7	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors
0.0	0.4	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0	0.8	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.0	2.2	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.0	0.3	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0	2.0	REACTOME MHC CLASS II ANTIGEN PRESENTATION	Genes involved in MHC class II antigen presentation
0.0	0.3	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	0.2	REACTOME PEPTIDE HORMONE BIOSYNTHESIS	Genes involved in Peptide hormone biosynthesis
0.0	0.8	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.0	0.3	REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D	Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0	0.3	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	1.1	REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	Genes involved in Antiviral mechanism by IFN-stimulated genes

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	2.5	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	2.9	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	1.6	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	2.7	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.0	1.0	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.0	0.5	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	2.5	PID P73PATHWAY	p73 transcription factor network
0.0	0.5	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0	0.2	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.4	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	0.3	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	0.4	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.0	0.1	ST STAT3 PATHWAY	STAT3 Pathway

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.2	3.5	GO:0047757	chondroitin-glucuronate 5-epimerase activity(GO:0047757)
1.0	5.1	GO:0031708	endothelin B receptor binding(GO:0031708)
0.9	5.1	GO:1990254	keratin filament binding(GO:1990254)
0.7	4.0	GO:0003872	6-phosphofructokinase activity(GO:0003872)
0.4	5.7	GO:0031852	mu-type opioid receptor binding(GO:0031852)
0.4	4.2	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.4	3.8	GO:1990380	Lys63-specific deubiquitinase activity(GO:0061578) Lys48-specific deubiquitinase activity(GO:1990380)
0.4	3.7	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.3	8.9	GO:0005523	tropomyosin binding(GO:0005523)
0.3	2.1	GO:0017002	activin-activated receptor activity(GO:0017002)
0.3	1.4	GO:0038062	protein tyrosine kinase collagen receptor activity(GO:0038062)
0.3	12.8	GO:0003785	actin monomer binding(GO:0003785)
0.2	2.9	GO:0046625	sphingosine-1-phosphate receptor activity(GO:0038036) sphingolipid binding(GO:0046625)
0.2	0.9	GO:0003990	acetylcholinesterase activity(GO:0003990)
0.2	2.9	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.2	1.3	GO:0045569	TRAIL binding(GO:0045569)
0.2	0.8	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.2	0.6	GO:0055077	gap junction hemi-channel activity(GO:0055077)
0.2	1.3	GO:0015501	glutamate:sodium symporter activity(GO:0015501)
0.2	2.7	GO:0017160	Ral GTPase binding(GO:0017160)
0.2	1.7	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)
0.2	2.9	GO:0031683	G-protein beta/gamma-subunit complex binding(GO:0031683)
0.2	4.2	GO:0051010	microtubule plus-end binding(GO:0051010)
0.2	0.8	GO:0016427	tRNA (cytosine) methyltransferase activity(GO:0016427)
0.1	1.3	GO:0008158	hedgehog receptor activity(GO:0008158)
0.1	1.2	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1	0.9	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.1	5.3	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.1	1.2	GO:0046703	natural killer cell lectin-like receptor binding(GO:0046703)
0.1	1.7	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1	0.6	GO:0031962	mineralocorticoid receptor binding(GO:0031962)
0.1	0.5	GO:0052795	exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
0.1	0.2	GO:0016206	catechol O-methyltransferase activity(GO:0016206)
0.1	1.4	GO:0015924	mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.1	4.9	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1	0.6	GO:0008240	tripeptidyl-peptidase activity(GO:0008240) peptidyl-dipeptidase activity(GO:0008241)
0.1	2.0	GO:0070064	proline-rich region binding(GO:0070064)
0.1	0.4	GO:0061769	ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769)
0.1	1.0	GO:0016494	C-X-C chemokine receptor activity(GO:0016494)
0.1	0.3	GO:0004618	phosphoglycerate kinase activity(GO:0004618)
0.1	0.3	GO:0004392	heme oxygenase (decyclizing) activity(GO:0004392)
0.1	2.0	GO:0050321	tau-protein kinase activity(GO:0050321)
0.1	2.4	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.1	6.5	GO:0030971	receptor tyrosine kinase binding(GO:0030971)
0.1	2.0	GO:0004029	aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.1	4.5	GO:0001105	RNA polymerase II transcription coactivator activity(GO:0001105)
0.1	0.7	GO:0015129	lactate transmembrane transporter activity(GO:0015129)
0.1	10.0	GO:0004197	cysteine-type endopeptidase activity(GO:0004197)
0.1	0.6	GO:0046923	ER retention sequence binding(GO:0046923)
0.1	1.7	GO:0070888	E-box binding(GO:0070888)
0.1	0.6	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.1	1.3	GO:0004707	MAP kinase activity(GO:0004707)
0.1	0.2	GO:0008336	gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.1	0.2	GO:0036487	nitric-oxide synthase inhibitor activity(GO:0036487)
0.1	0.5	GO:0008233	peptidase activity(GO:0008233)
0.1	0.2	GO:0004822	isoleucine-tRNA ligase activity(GO:0004822)
0.1	1.7	GO:0032452	histone demethylase activity(GO:0032452)
0.1	1.1	GO:0000339	RNA cap binding(GO:0000339)
0.1	0.2	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.1	4.9	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1	1.1	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.0	0.9	GO:0016864	protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0	1.2	GO:0005092	GDP-dissociation inhibitor activity(GO:0005092)
0.0	0.3	GO:0070891	lipoteichoic acid binding(GO:0070891)
0.0	0.2	GO:0005412	glucose:sodium symporter activity(GO:0005412)
0.0	0.7	GO:0097109	neuroligin family protein binding(GO:0097109)
0.0	0.3	GO:0046979	TAP2 binding(GO:0046979)
0.0	0.5	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.0	1.1	GO:0070182	DNA polymerase binding(GO:0070182)
0.0	0.8	GO:0008484	sulfuric ester hydrolase activity(GO:0008484)
0.0	14.0	GO:0001077	transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0	0.3	GO:0042731	PH domain binding(GO:0042731)
0.0	1.7	GO:0005504	fatty acid binding(GO:0005504)
0.0	2.5	GO:0030165	PDZ domain binding(GO:0030165)
0.0	0.6	GO:0004550	nucleoside diphosphate kinase activity(GO:0004550)
0.0	0.5	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	1.9	GO:0019003	GDP binding(GO:0019003)
0.0	2.7	GO:0005201	extracellular matrix structural constituent(GO:0005201)
0.0	0.6	GO:0016832	aldehyde-lyase activity(GO:0016832)
0.0	8.6	GO:0005525	GTP binding(GO:0005525)
0.0	0.3	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.3	GO:0016831	carbon-carbon lyase activity(GO:0016830) carboxy-lyase activity(GO:0016831)
0.0	2.7	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.0	0.3	GO:0017110	nucleoside-diphosphatase activity(GO:0017110)
0.0	0.8	GO:0015020	glucuronosyltransferase activity(GO:0015020)
0.0	1.7	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	0.1	GO:0031893	vasopressin receptor binding(GO:0031893)
0.0	0.1	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.3	GO:0005024	transforming growth factor beta-activated receptor activity(GO:0005024)
0.0	0.5	GO:0008395	steroid hydroxylase activity(GO:0008395)
0.0	0.2	GO:0008569	ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0	0.4	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.0	0.7	GO:0004407	histone deacetylase activity(GO:0004407)
0.0	0.9	GO:0017048	Rho GTPase binding(GO:0017048)
0.0	0.1	GO:0099583	neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.3	5.3	GO:0031673	H zone(GO:0031673)
1.0	3.1	GO:0005588	collagen type V trimer(GO:0005588)
0.8	4.0	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.8	5.5	GO:0036021	endolysosome lumen(GO:0036021)
0.7	3.0	GO:0048237	rough endoplasmic reticulum lumen(GO:0048237)
0.7	10.4	GO:0030478	actin cap(GO:0030478)
0.7	2.7	GO:0045160	myosin I complex(GO:0045160)
0.5	6.1	GO:0044300	cerebellar mossy fiber(GO:0044300)
0.3	1.4	GO:0005797	Golgi medial cisterna(GO:0005797)
0.3	1.3	GO:1990075	periciliary membrane compartment(GO:1990075)
0.3	2.1	GO:0044326	dendritic spine neck(GO:0044326)
0.3	1.0	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.2	1.4	GO:0030991	intraciliary transport particle A(GO:0030991)
0.2	5.7	GO:0032839	dendrite cytoplasm(GO:0032839)
0.2	1.7	GO:0005955	calcineurin complex(GO:0005955)
0.2	2.7	GO:0036038	MKS complex(GO:0036038)
0.2	1.8	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
0.2	2.9	GO:0043194	axon initial segment(GO:0043194)
0.1	2.2	GO:0033270	paranode region of axon(GO:0033270)
0.1	4.9	GO:0031258	lamellipodium membrane(GO:0031258)
0.1	12.8	GO:0043195	terminal bouton(GO:0043195)
0.1	1.3	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.1	6.6	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.1	1.2	GO:0042612	MHC class I protein complex(GO:0042612)
0.1	1.2	GO:0070765	gamma-secretase complex(GO:0070765)
0.1	3.8	GO:0097542	ciliary tip(GO:0097542)
0.1	1.0	GO:1990909	Wnt signalosome(GO:1990909)
0.1	0.9	GO:0005641	nuclear envelope lumen(GO:0005641)
0.1	0.6	GO:0000322	storage vacuole(GO:0000322)
0.1	0.6	GO:0071144	SMAD2-SMAD3 protein complex(GO:0071144)
0.1	2.5	GO:0016010	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1	0.3	GO:0012507	ER to Golgi transport vesicle membrane(GO:0012507)
0.1	0.4	GO:0070436	Grb2-EGFR complex(GO:0070436)
0.1	0.8	GO:0097433	dense body(GO:0097433)
0.1	1.1	GO:0097342	ripoptosome(GO:0097342)
0.1	1.1	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.1	GO:0061673	cortical microtubule(GO:0055028) mitotic spindle astral microtubule(GO:0061673)
0.0	0.3	GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)
0.0	2.5	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	0.3	GO:0042825	TAP complex(GO:0042825)
0.0	4.8	GO:0005882	intermediate filament(GO:0005882)
0.0	0.2	GO:0016514	SWI/SNF complex(GO:0016514)
0.0	0.1	GO:0005826	actomyosin contractile ring(GO:0005826) GID complex(GO:0034657)
0.0	0.6	GO:0032059	bleb(GO:0032059)
0.0	0.4	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.4	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.3	GO:0030123	AP-3 adaptor complex(GO:0030123)
0.0	0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.8	GO:0017053	transcriptional repressor complex(GO:0017053)
0.0	5.1	GO:0030027	lamellipodium(GO:0030027)
0.0	0.2	GO:1990111	spermatoproteasome complex(GO:1990111)
0.0	1.8	GO:0097610	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0	0.5	GO:0034451	centriolar satellite(GO:0034451)
0.0	0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.7	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.0	0.8	GO:0005720	nuclear heterochromatin(GO:0005720)
0.0	0.6	GO:0036126	sperm flagellum(GO:0036126) sperm part(GO:0097223)
0.0	2.9	GO:0005667	transcription factor complex(GO:0005667)
0.0	0.2	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0	0.1	GO:0038038	G-protein coupled receptor homodimeric complex(GO:0038038)
0.0	2.7	GO:0044798	nuclear transcription factor complex(GO:0044798)
0.0	0.2	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.0	1.3	GO:0016605	PML body(GO:0016605)
0.0	0.9	GO:0042641	actomyosin(GO:0042641)
0.0	3.3	GO:0000790	nuclear chromatin(GO:0000790)
0.0	3.4	GO:0005788	endoplasmic reticulum lumen(GO:0005788)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.5	GO:1902122	chenodeoxycholic acid binding(GO:1902122)
0.4	1.7	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)
0.4	2.8	GO:0004873	asialoglycoprotein receptor activity(GO:0004873)
0.3	1.1	GO:0004809	tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
0.2	1.1	GO:0070905	serine binding(GO:0070905)
0.2	0.9	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.2	0.8	GO:0004530	deoxyribonuclease I activity(GO:0004530)
0.2	0.9	GO:0090554	phosphatidylcholine-translocating ATPase activity(GO:0090554)
0.2	0.5	GO:0004813	alanine-tRNA ligase activity(GO:0004813)
0.2	1.0	GO:0051032	nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.2	1.2	GO:0001849	complement component C1q binding(GO:0001849)
0.2	0.5	GO:0008192	RNA guanylyltransferase activity(GO:0008192)
0.2	2.3	GO:0001871	pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1	0.6	GO:0042903	tubulin deacetylase activity(GO:0042903)
0.1	0.7	GO:0070728	leucine binding(GO:0070728)
0.1	2.6	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.1	0.4	GO:0000404	heteroduplex DNA loop binding(GO:0000404) double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181)
0.1	0.4	GO:0004515	nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.1	0.4	GO:0042610	CD8 receptor binding(GO:0042610)
0.1	1.2	GO:0036310	annealing helicase activity(GO:0036310)
0.1	0.7	GO:0019871	sodium channel inhibitor activity(GO:0019871)
0.1	0.2	GO:0004878	complement component C5a receptor activity(GO:0004878)
0.1	1.7	GO:0001848	complement binding(GO:0001848)
0.1	1.0	GO:0035256	G-protein coupled glutamate receptor binding(GO:0035256)
0.1	0.8	GO:0052629	phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.1	0.2	GO:0099580	ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.1	0.2	GO:0030305	heparanase activity(GO:0030305)
0.1	0.3	GO:0052740	1-acyl-2-lysophosphatidylserine acylhydrolase activity(GO:0052740)
0.1	0.4	GO:0051880	G-quadruplex DNA binding(GO:0051880)
0.1	0.3	GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.1	0.6	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.7	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	1.2	GO:0030506	ankyrin binding(GO:0030506)
0.0	1.7	GO:0005109	frizzled binding(GO:0005109)
0.0	0.3	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.4	GO:0046976	histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0	0.2	GO:0061649	ubiquitinated histone binding(GO:0061649)
0.0	0.1	GO:0016314	phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0	0.8	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.4	GO:0004075	biotin carboxylase activity(GO:0004075) biotin binding(GO:0009374)
0.0	0.1	GO:0004951	cholecystokinin receptor activity(GO:0004951)
0.0	0.1	GO:0008267	poly-glutamine tract binding(GO:0008267)
0.0	0.6	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.9	GO:0015269	calcium-activated potassium channel activity(GO:0015269)
0.0	0.4	GO:0035197	siRNA binding(GO:0035197)
0.0	0.8	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.4	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.1	GO:0004074	biliverdin reductase activity(GO:0004074)
0.0	0.1	GO:0019981	interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.0	0.2	GO:0016802	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.9	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.0	0.3	GO:0015143	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0	0.1	GO:0008422	beta-glucosidase activity(GO:0008422)
0.0	0.4	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.3	GO:0005351	sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402)
0.0	0.4	GO:0004526	ribonuclease P activity(GO:0004526)
0.0	0.1	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.2	GO:0004415	hyalurononglucosaminidase activity(GO:0004415)
0.0	2.4	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	0.1	GO:0055131	C3HC4-type RING finger domain binding(GO:0055131)
0.0	0.1	GO:0005171	hepatocyte growth factor receptor binding(GO:0005171)
0.0	0.1	GO:0003845	11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.0	0.3	GO:0016018	calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) cyclosporin A binding(GO:0016018)
0.0	0.4	GO:0016175	superoxide-generating NADPH oxidase activity(GO:0016175)
0.0	0.5	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.3	GO:0005310	dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.0	0.2	GO:0005436	sodium:phosphate symporter activity(GO:0005436)
0.0	0.1	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.5	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.2	GO:0022841	potassium ion leak channel activity(GO:0022841)
0.0	0.2	GO:0001042	RNA polymerase I core binding(GO:0001042)
0.0	0.4	GO:0005112	Notch binding(GO:0005112)
0.0	0.3	GO:0008510	sodium:bicarbonate symporter activity(GO:0008510)
0.0	0.2	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.1	GO:0019158	glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0	0.2	GO:0030274	LIM domain binding(GO:0030274)
0.0	0.5	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.0	0.1	GO:0004126	cytidine deaminase activity(GO:0004126)
0.0	0.1	GO:0004447	iodide peroxidase activity(GO:0004447)
0.0	0.3	GO:0032794	GTPase activating protein binding(GO:0032794)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.1	GO:0004995	tachykinin receptor activity(GO:0004995)
0.0	0.1	GO:0016929	SUMO-specific protease activity(GO:0016929)
0.0	0.5	GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0	0.5	GO:0051393	alpha-actinin binding(GO:0051393)
0.0	0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.4	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.9	GO:0019213	deacetylase activity(GO:0019213)
0.0	0.3	GO:0005521	lamin binding(GO:0005521) protein kinase A regulatory subunit binding(GO:0034237)
0.0	0.1	GO:0031893	vasopressin receptor binding(GO:0031893)
0.0	0.3	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.3	GO:0005540	hyaluronic acid binding(GO:0005540)
0.0	0.2	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.2	GO:0005229	intracellular calcium activated chloride channel activity(GO:0005229)
0.0	0.0	GO:0097001	ceramide binding(GO:0097001)
0.0	0.1	GO:0030621	U4 snRNA binding(GO:0030621)
0.0	0.1	GO:0004996	thyroid-stimulating hormone receptor activity(GO:0004996)
0.0	0.2	GO:0032451	demethylase activity(GO:0032451)
0.0	0.0	GO:0070568	guanylyltransferase activity(GO:0070568)
0.0	0.1	GO:0030249	cyclase regulator activity(GO:0010851) guanylate cyclase regulator activity(GO:0030249)
0.0	0.6	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.0	0.9	GO:0001618	virus receptor activity(GO:0001618)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.3	GO:0046875	ephrin receptor binding(GO:0046875)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.6	2.3	GO:0071062	rough endoplasmic reticulum lumen(GO:0048237) alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.2	2.9	GO:0043203	axon hillock(GO:0043203)
0.2	2.5	GO:0005577	fibrinogen complex(GO:0005577)
0.1	4.3	GO:0016581	NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.1	0.4	GO:0032302	MutSbeta complex(GO:0032302)
0.1	0.9	GO:0046581	intercellular canaliculus(GO:0046581)
0.1	0.7	GO:0032437	cuticular plate(GO:0032437)
0.1	0.4	GO:0030678	mitochondrial ribonuclease P complex(GO:0030678)
0.1	0.3	GO:1990246	uniplex complex(GO:1990246)
0.1	0.1	GO:0033186	CAF-1 complex(GO:0033186)
0.1	0.8	GO:0070578	RISC-loading complex(GO:0070578)
0.1	2.2	GO:0005719	nuclear euchromatin(GO:0005719)
0.0	0.2	GO:0005683	U7 snRNP(GO:0005683)
0.0	0.4	GO:0032009	early phagosome(GO:0032009)
0.0	0.5	GO:0045180	basal cortex(GO:0045180)
0.0	0.2	GO:0034669	integrin alpha4-beta7 complex(GO:0034669)
0.0	0.9	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.7	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.3	GO:0005955	calcineurin complex(GO:0005955)
0.0	2.5	GO:0055038	recycling endosome membrane(GO:0055038)
0.0	0.7	GO:0071004	U2-type prespliceosome(GO:0071004)
0.0	0.1	GO:0055028	cortical microtubule(GO:0055028) mitotic spindle astral microtubule(GO:0061673)
0.0	0.5	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.4	GO:0045120	pronucleus(GO:0045120)
0.0	0.2	GO:0005827	polar microtubule(GO:0005827)
0.0	0.4	GO:0000974	Prp19 complex(GO:0000974)
0.0	0.1	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	1.3	GO:0005771	multivesicular body(GO:0005771)
0.0	0.4	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	0.4	GO:0097342	ripoptosome(GO:0097342)
0.0	0.1	GO:0002189	ribose phosphate diphosphokinase complex(GO:0002189)
0.0	0.1	GO:0035976	AP1 complex(GO:0035976)
0.0	4.2	GO:0072562	blood microparticle(GO:0072562)
0.0	0.8	GO:0043034	costamere(GO:0043034)
0.0	0.2	GO:0061574	ASAP complex(GO:0061574)
0.0	0.4	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.4	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.2	GO:0042575	DNA polymerase complex(GO:0042575)
0.0	0.1	GO:0005687	U4 snRNP(GO:0005687)
0.0	0.5	GO:0005911	cell-cell junction(GO:0005911)
0.0	0.2	GO:0071782	endoplasmic reticulum tubular network(GO:0071782)
0.0	0.5	GO:0043198	dendritic shaft(GO:0043198)
0.0	0.7	GO:0032588	trans-Golgi network membrane(GO:0032588)

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.6	2.9	GO:0071279	cellular response to cobalt ion(GO:0071279)
0.5	1.5	GO:0072615	nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
0.4	1.1	GO:1904481	response to tetrahydrofolate(GO:1904481) cellular response to tetrahydrofolate(GO:1904482)
0.4	1.4	GO:0038018	Wnt receptor catabolic process(GO:0038018)
0.3	1.0	GO:0007206	phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206)
0.3	0.9	GO:0097327	response to antineoplastic agent(GO:0097327) glycoside transport(GO:1901656) cellular response to bile acid(GO:1903413)
0.3	1.7	GO:0055129	proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
0.3	0.3	GO:2000211	regulation of glutamate metabolic process(GO:2000211)
0.3	0.8	GO:0032290	peripheral nervous system myelin formation(GO:0032290)
0.3	1.1	GO:1900042	positive regulation of interleukin-2 secretion(GO:1900042)
0.3	3.4	GO:2000427	positive regulation of apoptotic cell clearance(GO:2000427)
0.3	2.6	GO:0071578	zinc II ion transmembrane import(GO:0071578)
0.3	2.3	GO:0061302	smooth muscle cell-matrix adhesion(GO:0061302)
0.2	0.7	GO:0061010	negative regulation of transcription by transcription factor localization(GO:0010621) gall bladder development(GO:0061010)
0.2	0.6	GO:1904772	hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
0.2	0.6	GO:0090035	regulation of chaperone-mediated protein complex assembly(GO:0090034) positive regulation of chaperone-mediated protein complex assembly(GO:0090035)
0.2	0.8	GO:0002503	peptide antigen assembly with MHC class II protein complex(GO:0002503)
0.2	0.7	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.2	0.9	GO:0070131	positive regulation of mitochondrial translation(GO:0070131)
0.2	0.5	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.2	0.5	GO:0006419	alanyl-tRNA aminoacylation(GO:0006419)
0.2	0.6	GO:0030037	actin filament reorganization involved in cell cycle(GO:0030037)
0.2	0.8	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.1	0.7	GO:2001288	positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1	0.4	GO:0034154	toll-like receptor 7 signaling pathway(GO:0034154)
0.1	0.4	GO:0007518	myoblast fate determination(GO:0007518)
0.1	0.4	GO:0019074	viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.1	2.5	GO:0090331	negative regulation of platelet aggregation(GO:0090331)
0.1	1.4	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.1	0.4	GO:0071409	cellular response to cycloheximide(GO:0071409)
0.1	0.7	GO:0071233	cellular response to leucine(GO:0071233)
0.1	0.1	GO:1901657	glycosyl compound metabolic process(GO:1901657)
0.1	0.6	GO:0015742	alpha-ketoglutarate transport(GO:0015742)
0.1	0.3	GO:1903371	regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.1	1.2	GO:0000733	DNA strand renaturation(GO:0000733)
0.1	0.6	GO:0090235	regulation of metaphase plate congression(GO:0090235)
0.1	0.4	GO:0071802	negative regulation of podosome assembly(GO:0071802)
0.1	0.3	GO:0006597	spermine biosynthetic process(GO:0006597)
0.1	1.0	GO:0033227	dsRNA transport(GO:0033227)
0.1	0.3	GO:0039507	modulation by virus of host molecular function(GO:0039506) suppression by virus of host molecular function(GO:0039507) suppression by virus of host catalytic activity(GO:0039513) modulation by virus of host catalytic activity(GO:0039516) suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process(GO:0039650) negative regulation by symbiont of host catalytic activity(GO:0052053) negative regulation by symbiont of host molecular function(GO:0052056) modulation by symbiont of host catalytic activity(GO:0052148)
0.1	0.4	GO:0010520	regulation of reciprocal meiotic recombination(GO:0010520)
0.1	0.8	GO:0014877	response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1	0.2	GO:0051083	'de novo' cotranslational protein folding(GO:0051083)
0.1	0.1	GO:0035992	tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
0.1	0.3	GO:2000301	negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.1	0.7	GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.1	0.3	GO:0042377	menaquinone catabolic process(GO:0042361) vitamin K catabolic process(GO:0042377)
0.1	0.2	GO:0038178	complement component C5a signaling pathway(GO:0038178)
0.1	0.2	GO:0035963	cellular response to interleukin-13(GO:0035963)
0.1	0.4	GO:1904844	response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.1	0.4	GO:0051140	regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
0.1	0.4	GO:1900020	regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.1	0.2	GO:0036512	trimming of terminal mannose on B branch(GO:0036509) trimming of first mannose on A branch(GO:0036511) trimming of second mannose on A branch(GO:0036512)
0.1	0.4	GO:0090646	mitochondrial tRNA processing(GO:0090646)
0.1	0.3	GO:0010793	regulation of mRNA export from nucleus(GO:0010793)
0.1	0.3	GO:0002415	immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.1	0.9	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.1	0.3	GO:0072719	cellular response to hydroxyurea(GO:0072711) cellular response to cisplatin(GO:0072719)
0.1	0.2	GO:0031291	Ran protein signal transduction(GO:0031291)
0.1	0.5	GO:1903690	negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1	0.6	GO:0042904	9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.1	0.4	GO:0002051	osteoblast fate commitment(GO:0002051)
0.1	0.2	GO:2000253	positive regulation of feeding behavior(GO:2000253)
0.1	0.3	GO:0031914	negative regulation of synaptic plasticity(GO:0031914)
0.0	0.6	GO:0048227	plasma membrane to endosome transport(GO:0048227)
0.0	1.2	GO:0030488	tRNA methylation(GO:0030488)
0.0	0.2	GO:0001714	endodermal cell fate specification(GO:0001714)
0.0	2.8	GO:0018279	protein N-linked glycosylation via asparagine(GO:0018279)
0.0	0.3	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0	0.1	GO:0061074	regulation of neural retina development(GO:0061074) regulation of retina development in camera-type eye(GO:1902866)
0.0	0.2	GO:0003366	cell-matrix adhesion involved in ameboidal cell migration(GO:0003366)
0.0	0.7	GO:0051639	actin filament network formation(GO:0051639)
0.0	0.2	GO:0035752	lysosomal lumen pH elevation(GO:0035752)
0.0	0.1	GO:0002581	negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581)
0.0	0.4	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0	0.1	GO:0045658	regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
0.0	0.1	GO:0046101	hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101)
0.0	0.1	GO:0070940	dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.0	0.1	GO:0038188	cholecystokinin signaling pathway(GO:0038188)
0.0	0.8	GO:0033169	histone H3-K9 demethylation(GO:0033169)
0.0	0.2	GO:0070432	regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070432)
0.0	0.1	GO:0039003	pronephric field specification(GO:0039003) pattern specification involved in pronephros development(GO:0039017) kidney rudiment formation(GO:0072003) kidney field specification(GO:0072004) regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis(GO:0072304) negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis(GO:0072305) mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis(GO:0072309) mesenchymal cell apoptotic process involved in metanephros development(GO:1900200) apoptotic process involved in metanephric collecting duct development(GO:1900204) apoptotic process involved in metanephric nephron tubule development(GO:1900205) regulation of mesenchymal cell apoptotic process involved in metanephros development(GO:1900211) negative regulation of mesenchymal cell apoptotic process involved in metanephros development(GO:1900212) regulation of apoptotic process involved in metanephric collecting duct development(GO:1900214) negative regulation of apoptotic process involved in metanephric collecting duct development(GO:1900215) regulation of apoptotic process involved in metanephric nephron tubule development(GO:1900217) negative regulation of apoptotic process involved in metanephric nephron tubule development(GO:1900218) mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis(GO:1901147) regulation of metanephric DCT cell differentiation(GO:2000592) positive regulation of metanephric DCT cell differentiation(GO:2000594)
0.0	0.1	GO:0002384	hepatic immune response(GO:0002384)
0.0	0.2	GO:0038031	non-canonical Wnt signaling pathway via JNK cascade(GO:0038031)
0.0	0.1	GO:0097156	fasciculation of motor neuron axon(GO:0097156)
0.0	0.5	GO:0005513	detection of calcium ion(GO:0005513)
0.0	0.8	GO:0048935	peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0	0.3	GO:0048752	semicircular canal morphogenesis(GO:0048752)
0.0	0.1	GO:0021691	cerebellar Purkinje cell layer maturation(GO:0021691)
0.0	1.1	GO:0046676	negative regulation of insulin secretion(GO:0046676)
0.0	0.4	GO:0050862	positive regulation of T cell receptor signaling pathway(GO:0050862)
0.0	0.2	GO:0033353	S-adenosylmethionine cycle(GO:0033353)
0.0	0.2	GO:0033088	negative regulation of immature T cell proliferation in thymus(GO:0033088)
0.0	0.3	GO:1901223	negative regulation of NIK/NF-kappaB signaling(GO:1901223)
0.0	0.2	GO:0098735	positive regulation of the force of heart contraction(GO:0098735)
0.0	0.1	GO:0008628	hormone-mediated apoptotic signaling pathway(GO:0008628)
0.0	0.1	GO:1990502	dense core granule maturation(GO:1990502)
0.0	0.1	GO:0045590	negative regulation of regulatory T cell differentiation(GO:0045590)
0.0	0.1	GO:2001280	maternal aggressive behavior(GO:0002125) positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.0	1.5	GO:0002260	lymphocyte homeostasis(GO:0002260)
0.0	0.7	GO:0007131	reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825)
0.0	0.6	GO:0034080	CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0	0.1	GO:0016554	cytidine to uridine editing(GO:0016554)
0.0	0.2	GO:0030322	stabilization of membrane potential(GO:0030322)
0.0	0.2	GO:0086024	adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0	0.6	GO:0007019	microtubule depolymerization(GO:0007019)
0.0	0.1	GO:0006335	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.2	GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity(GO:0051091)
0.0	0.4	GO:0045954	positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.0	0.1	GO:0021764	amygdala development(GO:0021764)
0.0	0.8	GO:0006656	phosphatidylcholine biosynthetic process(GO:0006656)
0.0	0.0	GO:0035621	ER to Golgi ceramide transport(GO:0035621)
0.0	0.1	GO:0061198	fungiform papilla formation(GO:0061198)
0.0	0.2	GO:0050962	detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)
0.0	0.1	GO:0016926	protein desumoylation(GO:0016926)
0.0	0.1	GO:0014067	negative regulation of phosphatidylinositol 3-kinase signaling(GO:0014067)
0.0	0.1	GO:0090005	negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.0	0.5	GO:0006400	tRNA modification(GO:0006400)
0.0	0.1	GO:0035372	protein localization to microtubule(GO:0035372)
0.0	0.2	GO:0000212	meiotic spindle organization(GO:0000212)
0.0	0.1	GO:0048194	Golgi vesicle budding(GO:0048194)
0.0	0.3	GO:0030728	ovulation(GO:0030728)
0.0	0.1	GO:0060684	epithelial-mesenchymal cell signaling(GO:0060684)
0.0	0.1	GO:0002084	protein depalmitoylation(GO:0002084)
0.0	0.2	GO:0070584	mitochondrion morphogenesis(GO:0070584)
0.0	0.3	GO:0035428	hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.0	0.1	GO:2000507	positive regulation of energy homeostasis(GO:2000507)
0.0	2.5	GO:0008360	regulation of cell shape(GO:0008360)
0.0	0.1	GO:0016559	peroxisome fission(GO:0016559)
0.0	0.1	GO:0030903	notochord development(GO:0030903)
0.0	0.1	GO:1903943	regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.0	0.0	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	9.1	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.2	13.6	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.1	3.8	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.1	2.6	PID TRAIL PATHWAY	TRAIL signaling pathway
0.1	1.0	PID S1P S1P3 PATHWAY	S1P3 pathway
0.1	6.5	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.1	6.0	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1	5.8	PID ENDOTHELIN PATHWAY	Endothelins
0.1	2.6	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.1	3.1	NABA COLLAGENS	Genes encoding collagen proteins
0.1	2.0	PID EPHB FWD PATHWAY	EPHB forward signaling
0.1	1.1	PID ALK2 PATHWAY	ALK2 signaling events
0.1	1.3	ST GA12 PATHWAY	G alpha 12 Pathway
0.1	4.0	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.1	4.8	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.1	5.0	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.1	1.0	PID EPHA FWDPATHWAY	EPHA forward signaling
0.0	1.1	SIG CHEMOTAXIS	Genes related to chemotaxis
0.0	1.9	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
0.0	1.2	PID PI3KCI PATHWAY	Class I PI3K signaling events
0.0	1.2	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.0	5.5	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.0	1.0	PID ALK1 PATHWAY	ALK1 signaling events
0.0	2.3	PID ILK PATHWAY	Integrin-linked kinase signaling
0.0	3.1	PID CMYB PATHWAY	C-MYB transcription factor network
0.0	7.4	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	0.4	PID NECTIN PATHWAY	Nectin adhesion pathway
0.0	0.6	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	1.1	ST FAS SIGNALING PATHWAY	Fas Signaling Pathway
0.0	0.5	ST WNT BETA CATENIN PATHWAY	Wnt/beta-catenin Pathway
0.0	0.4	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	1.3	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	1.1	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.0	0.3	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.0	0.2	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.0	0.3	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.0	0.3	PID NETRIN PATHWAY	Netrin-mediated signaling events
0.0	0.4	ST INTEGRIN SIGNALING PATHWAY	Integrin Signaling Pathway
0.0	0.4	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes

Results for GFI1

Z-value: 0.91

Motif logo

Transcription factors associated with GFI1

Activity-expression correlation:

Activity profile of GFI1 motif

Sorted Z-values of GFI1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GFI1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in C2:CP category: