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ENCODE cell lines, expression (Ernst 2011)

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Results for GLIS3

Z-value: 0.64

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Transcription factors associated with GLIS3

Gene Symbol Gene ID Gene Info
GLIS3
ENSG00000107249.17 GLIS3

Activity profile of GLIS3 motif

Sorted Z-values of GLIS3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GLIS3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr11_+_68451943 2.01 ENST00000265643.3
 GAL
 galanin/GMAP prepropeptide
chr6_+_24495067 1.76 ENST00000357578.3
ENST00000546278.1
ENST00000491546.1
 ALDH5A1
 aldehyde dehydrogenase 5 family, member A1
chr7_+_150758304 1.01 ENST00000482950.1
ENST00000463414.1
ENST00000310317.5
 SLC4A2
 solute carrier family 4 (anion exchanger), member 2
chr6_+_24495185 0.89 ENST00000348925.2
 ALDH5A1
 aldehyde dehydrogenase 5 family, member A1
chr19_-_41859814 0.83 ENST00000221930.5
 TGFB1
 transforming growth factor, beta 1
chr15_+_84116106 0.82 ENST00000535412.1
ENST00000324537.5
 SH3GL3
 SH3-domain GRB2-like 3
chr3_-_25824925 0.70 ENST00000396649.3
ENST00000428257.1
ENST00000280700.5
 NGLY1
 N-glycanase 1
chr3_-_25824872 0.59 ENST00000308710.5
 NGLY1
 N-glycanase 1
chr6_+_44191507 0.57 ENST00000371724.1
ENST00000371713.1
 SLC29A1
 solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr6_+_44191290 0.57 ENST00000371755.3
ENST00000371740.5
ENST00000371731.1
ENST00000393841.1
 SLC29A1
 solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr1_-_92371839 0.49 ENST00000370399.2
 TGFBR3
 transforming growth factor, beta receptor III
chr6_+_33172407 0.47 ENST00000374662.3
 HSD17B8
 hydroxysteroid (17-beta) dehydrogenase 8
chr1_-_53018654 0.45 ENST00000257177.4
ENST00000355809.4
ENST00000528642.1
ENST00000470626.1
ENST00000371544.3
 ZCCHC11
 zinc finger, CCHC domain containing 11
chr19_+_46850320 0.43 ENST00000391919.1
 PPP5C
 protein phosphatase 5, catalytic subunit
chr19_+_46850251 0.41 ENST00000012443.4
 PPP5C
 protein phosphatase 5, catalytic subunit
chr17_-_5015129 0.37 ENST00000575898.1
ENST00000416429.2
 ZNF232
 zinc finger protein 232
chr15_+_91478493 0.37 ENST00000418476.2
 UNC45A
 unc-45 homolog A (C. elegans)
chr12_-_57400227 0.34 ENST00000300101.2
 ZBTB39
 zinc finger and BTB domain containing 39
chr19_-_48673552 0.34 ENST00000536218.1
ENST00000596549.1
 LIG1
 ligase I, DNA, ATP-dependent
chr2_+_220379052 0.33 ENST00000347842.3
ENST00000358078.4
 ASIC4
 acid-sensing (proton-gated) ion channel family member 4
chr22_+_50628999 0.32 ENST00000395827.1
 TRABD
 TraB domain containing
chr3_+_173116225 0.30 ENST00000457714.1
 NLGN1
 neuroligin 1
chr12_+_132312931 0.26 ENST00000360564.1
ENST00000545671.1
ENST00000545790.1
 MMP17
 matrix metallopeptidase 17 (membrane-inserted)
chr20_-_30310693 0.25 ENST00000307677.4
ENST00000420653.1
 BCL2L1
 BCL2-like 1
chr3_+_38029462 0.25 ENST00000283713.6
 VILL
 villin-like
chr1_-_45988542 0.25 ENST00000424390.1
 PRDX1
 peroxiredoxin 1
chr19_-_10613421 0.24 ENST00000393623.2
 KEAP1
 kelch-like ECH-associated protein 1
chr19_+_40697514 0.22 ENST00000253055.3
 MAP3K10
 mitogen-activated protein kinase kinase kinase 10
chr3_+_127348005 0.22 ENST00000342480.6
 PODXL2
 podocalyxin-like 2
chr11_-_8680383 0.20 ENST00000299550.6
 TRIM66
 tripartite motif containing 66
chr20_-_62103862 0.19 ENST00000344462.4
ENST00000357249.2
ENST00000359125.2
ENST00000360480.3
ENST00000370224.1
ENST00000344425.5
ENST00000354587.3
ENST00000359689.1
 KCNQ2
 potassium voltage-gated channel, KQT-like subfamily, member 2
chr20_-_30310656 0.19 ENST00000376055.4
 BCL2L1
 BCL2-like 1
chr4_-_74904398 0.18 ENST00000296026.4
 CXCL3
 chemokine (C-X-C motif) ligand 3
chr9_-_130742792 0.18 ENST00000373095.1
 FAM102A
 family with sequence similarity 102, member A
chr14_+_22931924 0.17 ENST00000390477.2
 TRDC
 T cell receptor delta constant
chr2_-_241759622 0.17 ENST00000320389.7
ENST00000498729.2
 KIF1A
 kinesin family member 1A
chr1_+_110527308 0.16 ENST00000369799.5
 AHCYL1
 adenosylhomocysteinase-like 1
chr16_-_3285144 0.15 ENST00000431561.3
ENST00000396870.4
 ZNF200
 zinc finger protein 200
chr22_-_21482352 0.15 ENST00000329949.3
 POM121L7
 POM121 transmembrane nucleoporin-like 7
chr17_+_46018872 0.15 ENST00000583599.1
ENST00000434554.2
ENST00000225573.4
ENST00000544840.1
ENST00000534893.1
 PNPO
 pyridoxamine 5'-phosphate oxidase
chr3_+_120626919 0.15 ENST00000273666.6
ENST00000471454.1
ENST00000472879.1
ENST00000497029.1
ENST00000492541.1
 STXBP5L
 syntaxin binding protein 5-like
chr21_+_38071430 0.14 ENST00000290399.6
 SIM2
 single-minded family bHLH transcription factor 2
chr10_+_105314881 0.13 ENST00000437579.1
 NEURL
 neuralized E3 ubiquitin protein ligase 1
chr17_+_7792101 0.12 ENST00000358181.4
ENST00000330494.7
 CHD3
 chromodomain helicase DNA binding protein 3
chr5_-_137090028 0.12 ENST00000314940.4
 HNRNPA0
 heterogeneous nuclear ribonucleoprotein A0
chr11_+_1463728 0.12 ENST00000544817.1
 BRSK2
 BR serine/threonine kinase 2
chr1_+_1950763 0.10 ENST00000378585.4
 GABRD
 gamma-aminobutyric acid (GABA) A receptor, delta
chr8_+_27183033 0.10 ENST00000420218.2
 PTK2B
 protein tyrosine kinase 2 beta
chr9_-_98279241 0.09 ENST00000437951.1
ENST00000375274.2
ENST00000430669.2
ENST00000468211.2
 PTCH1
 patched 1
chr19_+_13875316 0.08 ENST00000319545.8
ENST00000593245.1
ENST00000040663.6
 MRI1
 methylthioribose-1-phosphate isomerase 1
chrX_+_118370288 0.08 ENST00000535419.1
 PGRMC1
 progesterone receptor membrane component 1
chr1_-_42801540 0.08 ENST00000372573.1
 FOXJ3
 forkhead box J3
chr1_-_42800860 0.07 ENST00000445886.1
ENST00000361346.1
ENST00000361776.1
 FOXJ3
 forkhead box J3
chr21_-_46330545 0.06 ENST00000320216.6
ENST00000397852.1
 ITGB2
 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr17_-_73178599 0.06 ENST00000578238.1
 SUMO2
 small ubiquitin-like modifier 2
chr2_-_241737128 0.05 ENST00000404283.3
 KIF1A
 kinesin family member 1A
chr1_-_160254913 0.05 ENST00000440949.3
ENST00000368072.5
ENST00000608310.1
ENST00000556710.1
 PEX19
DCAF8
DCAF8
 peroxisomal biogenesis factor 19
DDB1 and CUL4 associated factor 8
DDB1- and CUL4-associated factor 8
chr14_+_77228532 0.05 ENST00000167106.4
ENST00000554237.1
 VASH1
 vasohibin 1
chr1_+_16062820 0.05 ENST00000294454.5
 SLC25A34
 solute carrier family 25, member 34
chr17_-_3819751 0.05 ENST00000225538.3
 P2RX1
 purinergic receptor P2X, ligand-gated ion channel, 1
chr22_+_18834324 0.04 ENST00000342005.4
 AC008132.13
 Uncharacterized protein
chr12_-_48152611 0.04 ENST00000389212.3
 RAPGEF3
 Rap guanine nucleotide exchange factor (GEF) 3
chrX_+_64887512 0.03 ENST00000360270.5
 MSN
 moesin
chr2_+_219824357 0.03 ENST00000302625.4
 CDK5R2
 cyclin-dependent kinase 5, regulatory subunit 2 (p39)
chr8_-_74791051 0.03 ENST00000453587.2
ENST00000602969.1
ENST00000602593.1
ENST00000419880.3
ENST00000517608.1
 UBE2W
 ubiquitin-conjugating enzyme E2W (putative)
chr22_-_50964849 0.02 ENST00000543927.1
ENST00000423348.1
 SCO2
 SCO2 cytochrome c oxidase assembly protein
chr15_-_43882353 0.02 ENST00000453080.1
ENST00000360301.4
ENST00000360135.4
ENST00000417085.1
ENST00000431962.1
ENST00000334933.4
ENST00000381879.4
ENST00000420765.1
 PPIP5K1
 diphosphoinositol pentakisphosphate kinase 1
chr20_+_18447771 0.01 ENST00000377603.4
 POLR3F
 polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
chr16_+_89686991 0.01 ENST00000393092.3
 DPEP1
 dipeptidase 1 (renal)
chrX_+_118370211 0.01 ENST00000217971.7
 PGRMC1
 progesterone receptor membrane component 1
chr4_+_164265035 0.01 ENST00000338566.3
 NPY5R
 neuropeptide Y receptor Y5
chr1_-_157108266 0.01 ENST00000326786.4
 ETV3
 ets variant 3
chr20_-_23969416 0.00 ENST00000335694.4
 GGTLC1
 gamma-glutamyltransferase light chain 1
chr17_+_5389605 0.00 ENST00000576988.1
ENST00000576570.1
ENST00000573759.1
 MIS12
 MIS12 kinetochore complex component

Gene Ontology Analysis

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0 0.4 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.1 0.8 GO:1990635 proximal dendrite(GO:1990635)
0.0 0.4 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 0.4 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.0 0.1 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
0.0 0.1 GO:0044294 dendritic growth cone(GO:0044294)
0.0 0.2 GO:0043194 axon initial segment(GO:0043194)
0.0 0.9 GO:0005902 microvillus(GO:0005902)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.6 REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION Genes involved in GABA synthesis, release, reuptake and degradation
0.0 0.8 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 1.1 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 0.3 REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND Genes involved in Processive synthesis on the lagging strand
0.0 0.4 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.0 2.2 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.0 GO:0051795 cortisol secretion(GO:0043400) regulation of cortisol secretion(GO:0051462) positive regulation of catagen(GO:0051795)
0.4 2.6 GO:0006540 glutamate decarboxylation to succinate(GO:0006540) gamma-aminobutyric acid catabolic process(GO:0009450)
0.3 0.8 GO:0060364 induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) frontal suture morphogenesis(GO:0060364) modulation by virus of host immune response(GO:0075528)
0.2 1.1 GO:0015862 uridine transport(GO:0015862)
0.2 0.5 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.1 0.8 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.1 0.3 GO:0010841 positive regulation of circadian sleep/wake cycle, wakefulness(GO:0010841) retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.1 0.5 GO:0010587 miRNA catabolic process(GO:0010587)
0.1 0.3 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
0.1 0.4 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.1 1.2 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.1 0.2 GO:0042823 pyridoxal phosphate metabolic process(GO:0042822) pyridoxal phosphate biosynthetic process(GO:0042823)
0.0 0.2 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.5 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.2 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.3 GO:0042756 drinking behavior(GO:0042756)
0.0 0.1 GO:2000537 regulation of cGMP-mediated signaling(GO:0010752) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
0.0 0.1 GO:0021997 response to chlorate(GO:0010157) neural plate axis specification(GO:0021997)
0.0 0.2 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 1.0 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.1 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.0 0.0 GO:0021722 superior olivary nucleus development(GO:0021718) superior olivary nucleus maturation(GO:0021722)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0004966 galanin receptor activity(GO:0004966)
0.3 0.8 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.1 0.5 GO:0050265 RNA uridylyltransferase activity(GO:0050265)
0.1 0.5 GO:0070404 NADH binding(GO:0070404)
0.1 0.5 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.1 1.0 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510)
0.1 0.2 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.1 1.1 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 2.6 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.0 0.4 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.3 GO:0003910 DNA ligase (ATP) activity(GO:0003910)
0.0 0.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.8 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.2 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.0 0.1 GO:0097108 hedgehog family protein binding(GO:0097108)
0.0 1.4 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.0 0.2 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.3 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 0.0 GO:0016534 cyclin-dependent protein kinase 5 activator activity(GO:0016534)