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ENCODE cell lines, expression (Ernst 2011)

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Results for GRHL1

Z-value: 0.94

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Transcription factors associated with GRHL1

Gene Symbol Gene ID Gene Info
GRHL1
ENSG00000134317.13 GRHL1

Activity profile of GRHL1 motif

Sorted Z-values of GRHL1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of GRHL1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr1_+_35247859 3.67 ENST00000373362.3
 GJB3
 gap junction protein, beta 3, 31kDa
chr7_-_80551671 2.06 ENST00000419255.2
ENST00000544525.1
 SEMA3C
 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr1_-_201368707 1.91 ENST00000391967.2
 LAD1
 ladinin 1
chr5_+_125758865 1.90 ENST00000542322.1
ENST00000544396.1
 GRAMD3
 GRAM domain containing 3
chr5_+_125758813 1.82 ENST00000285689.3
ENST00000515200.1
 GRAMD3
 GRAM domain containing 3
chr1_-_201368653 1.80 ENST00000367313.3
 LAD1
 ladinin 1
chr13_+_48807334 1.40 ENST00000378549.5
 ITM2B
 integral membrane protein 2B
chr19_-_291133 1.35 ENST00000327790.3
 PPAP2C
 phosphatidic acid phosphatase type 2C
chr13_+_48807288 1.33 ENST00000378565.5
 ITM2B
 integral membrane protein 2B
chr2_-_85641162 1.16 ENST00000447219.2
ENST00000409670.1
ENST00000409724.1
 CAPG
 capping protein (actin filament), gelsolin-like
chr20_-_18038521 1.12 ENST00000278780.6
 OVOL2
 ovo-like zinc finger 2
chr1_-_153113927 1.06 ENST00000368752.4
 SPRR2B
 small proline-rich protein 2B
chr3_+_101568349 1.00 ENST00000326151.5
ENST00000326172.5
 NFKBIZ
 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta
chrX_-_119603138 0.71 ENST00000200639.4
ENST00000371335.4
ENST00000538785.1
ENST00000434600.2
 LAMP2
 lysosomal-associated membrane protein 2
chr2_-_209118974 0.61 ENST00000415913.1
ENST00000415282.1
ENST00000446179.1
 IDH1
 isocitrate dehydrogenase 1 (NADP+), soluble
chr5_-_132299313 0.54 ENST00000265343.5
 AFF4
 AF4/FMR2 family, member 4
chr4_-_99850243 0.46 ENST00000280892.6
ENST00000511644.1
ENST00000504432.1
ENST00000505992.1
 EIF4E
 eukaryotic translation initiation factor 4E
chr1_+_44440575 0.40 ENST00000532642.1
ENST00000236067.4
ENST00000471859.2
 ATP6V0B
 ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b
chr16_+_2564254 0.39 ENST00000565223.1
 ATP6V0C
 ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr19_+_45312347 0.37 ENST00000270233.6
ENST00000591520.1
 BCAM
 basal cell adhesion molecule (Lutheran blood group)
chr3_-_172241250 0.34 ENST00000420541.2
ENST00000241261.2
 TNFSF10
 tumor necrosis factor (ligand) superfamily, member 10
chr7_+_76139741 0.33 ENST00000334348.3
ENST00000419923.2
ENST00000448265.3
ENST00000443097.2
 UPK3B
 uroplakin 3B
chr9_-_77703115 0.32 ENST00000361092.4
ENST00000376808.4
 NMRK1
 nicotinamide riboside kinase 1
chr9_+_130565487 0.30 ENST00000373225.3
ENST00000431857.1
 FPGS
 folylpolyglutamate synthase
chr10_+_81838792 0.28 ENST00000372273.3
 TMEM254
 transmembrane protein 254
chr2_+_113816215 0.24 ENST00000346807.3
 IL36RN
 interleukin 36 receptor antagonist
chr19_-_40596767 0.23 ENST00000599972.1
ENST00000450241.2
ENST00000595687.2
 ZNF780A
 zinc finger protein 780A
chr1_+_155023757 0.23 ENST00000356955.2
ENST00000449910.2
ENST00000359280.4
ENST00000360674.4
ENST00000368412.3
ENST00000355956.2
ENST00000368410.2
ENST00000271836.6
ENST00000368413.1
ENST00000531455.1
ENST00000447332.3
 ADAM15
 ADAM metallopeptidase domain 15
chr9_+_71736177 0.21 ENST00000606364.1
ENST00000453658.2
 TJP2
 tight junction protein 2
chr10_+_105036909 0.21 ENST00000369849.4
 INA
 internexin neuronal intermediate filament protein, alpha
chr12_-_10959892 0.21 ENST00000240615.2
 TAS2R8
 taste receptor, type 2, member 8
chr1_+_40723779 0.20 ENST00000372759.3
 ZMPSTE24
 zinc metallopeptidase STE24
chr1_-_24469602 0.18 ENST00000270800.1
 IL22RA1
 interleukin 22 receptor, alpha 1
chr10_+_81838411 0.16 ENST00000372281.3
ENST00000372277.3
ENST00000372275.1
ENST00000372274.1
 TMEM254
 transmembrane protein 254
chr11_+_15095108 0.13 ENST00000324229.6
ENST00000533448.1
 CALCB
 calcitonin-related polypeptide beta
chr19_+_12035913 0.13 ENST00000591944.1
 ZNF763
 Uncharacterized protein; Zinc finger protein 763
chr3_+_186383741 0.13 ENST00000232003.4
 HRG
 histidine-rich glycoprotein
chr19_-_17356697 0.12 ENST00000291442.3
 NR2F6
 nuclear receptor subfamily 2, group F, member 6
chr15_+_49170083 0.12 ENST00000530028.2
 EID1
 EP300 interacting inhibitor of differentiation 1
chr14_+_23938891 0.12 ENST00000408901.3
ENST00000397154.3
ENST00000555128.1
 NGDN
 neuroguidin, EIF4E binding protein
chr12_+_18414446 0.11 ENST00000433979.1
 PIK3C2G
 phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
chr14_-_23540826 0.11 ENST00000357481.2
 ACIN1
 apoptotic chromatin condensation inducer 1
chr4_+_110736659 0.10 ENST00000394631.3
ENST00000226796.6
 GAR1
 GAR1 ribonucleoprotein
chr7_-_138794081 0.10 ENST00000464606.1
 ZC3HAV1
 zinc finger CCCH-type, antiviral 1
chr7_-_102184083 0.09 ENST00000379357.5
 POLR2J3
 polymerase (RNA) II (DNA directed) polypeptide J3
chr14_-_80677815 0.08 ENST00000557125.1
ENST00000555750.1
 DIO2
 deiodinase, iodothyronine, type II
chr7_-_102283238 0.08 ENST00000340457.8
 UPK3BL
 uroplakin 3B-like
chr14_-_80677613 0.07 ENST00000556811.1
 DIO2
 deiodinase, iodothyronine, type II
chr14_-_23540747 0.06 ENST00000555566.1
ENST00000338631.6
ENST00000557515.1
ENST00000397341.3
 ACIN1
 apoptotic chromatin condensation inducer 1
chr6_-_31107127 0.05 ENST00000259845.4
 PSORS1C2
 psoriasis susceptibility 1 candidate 2
chr1_-_28384598 0.05 ENST00000373864.1
 EYA3
 eyes absent homolog 3 (Drosophila)
chr10_+_96443204 0.04 ENST00000339022.5
 CYP2C18
 cytochrome P450, family 2, subfamily C, polypeptide 18
chr7_+_76139925 0.03 ENST00000394849.1
 UPK3B
 uroplakin 3B
chrX_+_146993449 0.03 ENST00000218200.8
ENST00000370471.3
ENST00000370477.1
 FMR1
 fragile X mental retardation 1
chr19_+_58038683 0.03 ENST00000240719.3
ENST00000376233.3
ENST00000594943.1
ENST00000602149.1
 ZNF549
 zinc finger protein 549
chr11_+_119039414 0.03 ENST00000409991.1
ENST00000292199.2
ENST00000409265.4
ENST00000409109.1
 NLRX1
 NLR family member X1
chr1_+_206643787 0.02 ENST00000367120.3
 IKBKE
 inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr7_+_76139833 0.02 ENST00000257632.5
 UPK3B
 uroplakin 3B
chr3_-_3152031 0.00 ENST00000383846.1
ENST00000427088.1
ENST00000446632.2
ENST00000438560.1
 IL5RA
 interleukin 5 receptor, alpha

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.7 GO:0005922 connexon complex(GO:0005922)
0.2 0.7 GO:0031166 integral component of vacuolar membrane(GO:0031166)
0.1 0.8 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.1 1.2 GO:0008290 F-actin capping protein complex(GO:0008290) Flemming body(GO:0090543)
0.1 2.7 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.0 0.5 GO:0033391 chromatoid body(GO:0033391)
0.0 3.7 GO:0005604 basement membrane(GO:0005604)
0.0 1.1 GO:0001533 cornified envelope(GO:0001533)
0.0 0.5 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 0.2 GO:0061574 ASAP complex(GO:0061574)
0.0 0.1 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.0 0.0 GO:0019034 viral replication complex(GO:0019034)
0.0 0.2 GO:0005883 neurofilament(GO:0005883)
0.0 0.6 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 2.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.7 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.0 1.3 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 2.7 REACTOME AMYLOIDS Genes involved in Amyloids
0.0 0.8 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 0.5 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.0 0.6 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 0.2 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.7 GO:0005243 gap junction channel activity(GO:0005243)
0.2 0.6 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.1 2.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 0.3 GO:0050262 ribosylnicotinamide kinase activity(GO:0050262) ribosylnicotinate kinase activity(GO:0061769)
0.1 0.2 GO:0042015 interleukin-20 binding(GO:0042015)
0.1 0.5 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.2 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.0 2.7 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.8 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0 0.1 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.2 GO:0033038 bitter taste receptor activity(GO:0033038)
0.0 0.1 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.3 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.0 0.4 GO:0043236 laminin binding(GO:0043236)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.1 GO:0003350 pulmonary myocardium development(GO:0003350)
0.3 2.7 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.2 1.1 GO:0060214 endocardium formation(GO:0060214)
0.2 0.6 GO:0006097 glyoxylate cycle(GO:0006097)
0.1 0.3 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
0.1 0.2 GO:0030327 prenylated protein catabolic process(GO:0030327)
0.1 0.7 GO:1905146 protein targeting to lysosome involved in chaperone-mediated autophagy(GO:0061740) lysosomal protein catabolic process(GO:1905146)
0.1 1.2 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.0 0.4 GO:0007042 lysosomal lumen acidification(GO:0007042)
0.0 0.2 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
0.0 3.7 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 0.1 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)
0.0 0.2 GO:0071847 TNFSF11-mediated signaling pathway(GO:0071847)
0.0 0.2 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.0 0.4 GO:0007035 vacuolar acidification(GO:0007035)
0.0 1.1 GO:0018149 peptide cross-linking(GO:0018149)
0.0 0.1 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.2 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.1 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.0 0.3 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.0 0.2 GO:1900121 negative regulation of receptor binding(GO:1900121)
0.0 0.1 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.3 GO:0009435 NAD biosynthetic process(GO:0009435)