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ENCODE cell lines, expression (Ernst 2011)

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Results for HAND1

Z-value: 0.94

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Transcription factors associated with HAND1

Gene Symbol Gene ID Gene Info
HAND1
ENSG00000113196.2 HAND1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HAND1hg19_v2_chr5_-_153857819_153857824-0.601.4e-02Click!

Activity profile of HAND1 motif

Sorted Z-values of HAND1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HAND1

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr17_-_64216748 4.30 ENST00000585162.1
 APOH
 apolipoprotein H (beta-2-glycoprotein I)
chr2_+_228678550 3.53 ENST00000409189.3
ENST00000358813.4
 CCL20
 chemokine (C-C motif) ligand 20
chr14_-_65409438 2.75 ENST00000557049.1
 GPX2
 glutathione peroxidase 2 (gastrointestinal)
chr14_-_65409502 2.45 ENST00000389614.5
 GPX2
 glutathione peroxidase 2 (gastrointestinal)
chr16_-_28621353 2.16 ENST00000567512.1
 SULT1A1
 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr17_+_53342311 2.06 ENST00000226067.5
 HLF
 hepatic leukemia factor
chr1_+_207262540 2.02 ENST00000452902.2
 C4BPB
 complement component 4 binding protein, beta
chr16_-_28621312 1.98 ENST00000314752.7
 SULT1A1
 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr1_+_207262627 1.91 ENST00000391923.1
 C4BPB
 complement component 4 binding protein, beta
chr1_+_207262170 1.89 ENST00000367078.3
 C4BPB
 complement component 4 binding protein, beta
chr1_+_207262578 1.87 ENST00000243611.5
ENST00000367076.3
 C4BPB
 complement component 4 binding protein, beta
chr16_-_28621298 1.80 ENST00000566189.1
 SULT1A1
 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
chr16_-_28608364 1.63 ENST00000533150.1
 SULT1A2
 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr22_+_25003626 1.32 ENST00000451366.1
ENST00000406383.2
ENST00000428855.1
 GGT1
 gamma-glutamyltransferase 1
chr16_-_28608424 1.25 ENST00000335715.4
 SULT1A2
 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 2
chr3_-_114035026 1.24 ENST00000570269.1
 RP11-553L6.5
 RP11-553L6.5
chr22_+_24999114 1.21 ENST00000412658.1
ENST00000445029.1
ENST00000419133.1
ENST00000400382.1
ENST00000438643.2
ENST00000452551.1
ENST00000400383.1
ENST00000412898.1
ENST00000400380.1
ENST00000455483.1
ENST00000430289.1
 GGT1
 gamma-glutamyltransferase 1
chr19_-_36304201 0.96 ENST00000301175.3
 PRODH2
 proline dehydrogenase (oxidase) 2
chr19_-_55866061 0.83 ENST00000588572.2
ENST00000593184.1
ENST00000589467.1
 COX6B2
 cytochrome c oxidase subunit VIb polypeptide 2 (testis)
chr12_+_53848505 0.70 ENST00000552819.1
ENST00000455667.3
 PCBP2
 poly(rC) binding protein 2
chr11_+_101785727 0.70 ENST00000263468.8
 KIAA1377
 KIAA1377
chr2_+_201997595 0.67 ENST00000470178.2
 CFLAR
 CASP8 and FADD-like apoptosis regulator
chr3_+_123813543 0.65 ENST00000360013.3
 KALRN
 kalirin, RhoGEF kinase
chr1_+_174846570 0.59 ENST00000392064.2
 RABGAP1L
 RAB GTPase activating protein 1-like
chr3_-_9811595 0.57 ENST00000256460.3
 CAMK1
 calcium/calmodulin-dependent protein kinase I
chr1_-_155904187 0.57 ENST00000368321.3
ENST00000368320.3
 KIAA0907
 KIAA0907
chr2_+_3642545 0.54 ENST00000382062.2
ENST00000236693.7
ENST00000349077.4
 COLEC11
 collectin sub-family member 11
chr6_+_6588902 0.51 ENST00000230568.4
 LY86
 lymphocyte antigen 86
chrX_+_49832231 0.49 ENST00000376108.3
 CLCN5
 chloride channel, voltage-sensitive 5
chr6_+_6588316 0.48 ENST00000379953.2
 LY86
 lymphocyte antigen 86
chr16_-_10652993 0.46 ENST00000536829.1
 EMP2
 epithelial membrane protein 2
chr2_+_201997492 0.43 ENST00000494258.1
 CFLAR
 CASP8 and FADD-like apoptosis regulator
chr12_-_7261772 0.43 ENST00000545280.1
ENST00000543933.1
ENST00000545337.1
ENST00000544702.1
ENST00000266542.4
 C1RL
 complement component 1, r subcomponent-like
chr1_+_52870227 0.42 ENST00000257181.9
 PRPF38A
 pre-mRNA processing factor 38A
chr3_+_148415571 0.41 ENST00000497524.1
ENST00000349243.3
ENST00000542281.1
ENST00000418473.2
ENST00000404754.2
 AGTR1
 angiotensin II receptor, type 1
chr1_+_215747118 0.39 ENST00000448333.1
 KCTD3
 potassium channel tetramerization domain containing 3
chr17_-_43025005 0.39 ENST00000587309.1
ENST00000593135.1
ENST00000339151.4
 KIF18B
 kinesin family member 18B
chr2_-_197791441 0.37 ENST00000409475.1
ENST00000354764.4
ENST00000374738.3
 PGAP1
 post-GPI attachment to proteins 1
chr12_+_53848549 0.37 ENST00000439930.3
ENST00000548933.1
ENST00000562264.1
 PCBP2
 poly(rC) binding protein 2
chr20_-_1165117 0.37 ENST00000381894.3
 TMEM74B
 transmembrane protein 74B
chr21_+_34602377 0.36 ENST00000342101.3
ENST00000413881.1
ENST00000443073.1
 IFNAR2
 interferon (alpha, beta and omega) receptor 2
chr12_+_121131970 0.36 ENST00000535656.1
 MLEC
 malectin
chr7_-_20256965 0.35 ENST00000400331.5
ENST00000332878.4
 MACC1
 metastasis associated in colon cancer 1
chr3_+_112051994 0.33 ENST00000473539.1
ENST00000315711.8
ENST00000383681.3
 CD200
 CD200 molecule
chr2_-_128784846 0.33 ENST00000259235.3
ENST00000357702.5
ENST00000424298.1
 SAP130
 Sin3A-associated protein, 130kDa
chr2_-_89597542 0.32 ENST00000465170.1
 IGKV1-37
 immunoglobulin kappa variable 1-37 (non-functional)
chr1_-_205601064 0.32 ENST00000357992.4
ENST00000289703.4
 ELK4
 ELK4, ETS-domain protein (SRF accessory protein 1)
chr16_+_6069586 0.30 ENST00000547372.1
 RBFOX1
 RNA binding protein, fox-1 homolog (C. elegans) 1
chr4_-_40631859 0.30 ENST00000295971.7
ENST00000319592.4
 RBM47
 RNA binding motif protein 47
chr2_+_204732666 0.29 ENST00000295854.6
ENST00000472206.1
 CTLA4
 cytotoxic T-lymphocyte-associated protein 4
chr11_-_72432950 0.29 ENST00000426523.1
ENST00000429686.1
 ARAP1
 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
chr12_+_49717019 0.27 ENST00000549275.1
ENST00000551245.1
ENST00000380327.5
ENST00000548311.1
ENST00000550346.1
ENST00000550709.1
ENST00000549534.1
ENST00000257909.3
 TROAP
 trophinin associated protein
chr4_+_41614720 0.26 ENST00000509277.1
 LIMCH1
 LIM and calponin homology domains 1
chr21_+_34602200 0.25 ENST00000382264.3
ENST00000382241.3
ENST00000404220.3
ENST00000342136.4
 IFNAR2
 interferon (alpha, beta and omega) receptor 2
chr2_+_98262497 0.24 ENST00000258424.2
 COX5B
 cytochrome c oxidase subunit Vb
chr16_+_56969284 0.23 ENST00000568358.1
 HERPUD1
 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr2_-_25475120 0.23 ENST00000380746.4
ENST00000402667.1
 DNMT3A
 DNA (cytosine-5-)-methyltransferase 3 alpha
chr16_+_90089008 0.21 ENST00000268699.4
 GAS8
 growth arrest-specific 8
chr2_-_228582709 0.21 ENST00000541617.1
ENST00000409456.2
ENST00000409287.1
ENST00000258403.3
 SLC19A3
 solute carrier family 19 (thiamine transporter), member 3
chr5_-_150466692 0.21 ENST00000315050.7
ENST00000523338.1
ENST00000522100.1
 TNIP1
 TNFAIP3 interacting protein 1
chr2_-_42588338 0.20 ENST00000234301.2
 COX7A2L
 cytochrome c oxidase subunit VIIa polypeptide 2 like
chr1_+_28261533 0.20 ENST00000411604.1
ENST00000373888.4
 SMPDL3B
 sphingomyelin phosphodiesterase, acid-like 3B
chr7_+_96634850 0.20 ENST00000518156.2
 DLX6
 distal-less homeobox 6
chr16_+_6069664 0.19 ENST00000422070.4
 RBFOX1
 RNA binding protein, fox-1 homolog (C. elegans) 1
chr4_+_41614909 0.19 ENST00000509454.1
ENST00000396595.3
ENST00000381753.4
 LIMCH1
 LIM and calponin homology domains 1
chrX_+_15767971 0.19 ENST00000479740.1
ENST00000454127.2
 CA5B
 carbonic anhydrase VB, mitochondrial
chr19_+_47421933 0.19 ENST00000404338.3
 ARHGAP35
 Rho GTPase activating protein 35
chr2_+_201997676 0.18 ENST00000462763.1
ENST00000479953.2
 CFLAR
 CASP8 and FADD-like apoptosis regulator
chr19_+_12862486 0.16 ENST00000549706.1
 BEST2
 bestrophin 2
chr16_+_70328680 0.16 ENST00000563206.1
ENST00000451014.3
ENST00000568625.1
 DDX19B
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 19B
chr10_+_118350522 0.16 ENST00000530319.1
ENST00000527980.1
ENST00000471549.1
ENST00000534537.1
 PNLIPRP1
 pancreatic lipase-related protein 1
chr2_+_90153696 0.15 ENST00000417279.2
 IGKV3D-15
 immunoglobulin kappa variable 3D-15 (gene/pseudogene)
chr1_-_32210275 0.14 ENST00000440175.2
 BAI2
 brain-specific angiogenesis inhibitor 2
chr10_+_118350468 0.14 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
 PNLIPRP1
 pancreatic lipase-related protein 1
chr11_-_2323290 0.13 ENST00000381153.3
 C11orf21
 chromosome 11 open reading frame 21
chr11_-_102496063 0.12 ENST00000260228.2
 MMP20
 matrix metallopeptidase 20
chr1_+_27719148 0.12 ENST00000374024.3
 GPR3
 G protein-coupled receptor 3
chr10_+_72972281 0.10 ENST00000335350.6
 UNC5B
 unc-5 homolog B (C. elegans)
chr11_+_2323236 0.10 ENST00000182290.4
 TSPAN32
 tetraspanin 32
chr14_+_24422795 0.09 ENST00000313250.5
ENST00000558263.1
ENST00000543741.2
ENST00000421831.1
ENST00000397073.2
ENST00000308178.8
ENST00000382761.3
ENST00000397075.3
ENST00000397074.3
ENST00000559632.1
ENST00000558581.1
 DHRS4
 dehydrogenase/reductase (SDR family) member 4
chr17_-_36358166 0.09 ENST00000537432.1
 TBC1D3
 TBC1 domain family, member 3
chr19_+_36359341 0.09 ENST00000221891.4
 APLP1
 amyloid beta (A4) precursor-like protein 1
chr17_+_66624280 0.09 ENST00000585484.1
 RP11-118B18.1
 RP11-118B18.1
chr17_-_10372875 0.08 ENST00000255381.2
 MYH4
 myosin, heavy chain 4, skeletal muscle
chr12_+_54379569 0.07 ENST00000513209.1
 RP11-834C11.12
 RP11-834C11.12
chr19_+_12862604 0.07 ENST00000553030.1
 BEST2
 bestrophin 2
chr1_+_44444865 0.07 ENST00000372324.1
 B4GALT2
 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2
chr20_+_1115821 0.06 ENST00000435720.1
 PSMF1
 proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
chr2_+_204732487 0.05 ENST00000302823.3
 CTLA4
 cytotoxic T-lymphocyte-associated protein 4
chr17_-_40337470 0.05 ENST00000293330.1
 HCRT
 hypocretin (orexin) neuropeptide precursor
chr16_-_70729496 0.05 ENST00000567648.1
 VAC14
 Vac14 homolog (S. cerevisiae)
chr16_-_89556942 0.04 ENST00000301030.4
 ANKRD11
 ankyrin repeat domain 11
chr12_+_98909260 0.03 ENST00000556029.1
 TMPO
 thymopoietin
chr7_+_76139833 0.02 ENST00000257632.5
 UPK3B
 uroplakin 3B
chr1_+_11249398 0.02 ENST00000376819.3
 ANGPTL7
 angiopoietin-like 7
chr1_+_173446405 0.01 ENST00000340385.5
 PRDX6
 peroxiredoxin 6
chr14_+_96722539 0.01 ENST00000553356.1
 BDKRB1
 bradykinin receptor B1
chr11_-_64527425 0.01 ENST00000377432.3
 PYGM
 phosphorylase, glycogen, muscle
chr12_-_110271178 0.00 ENST00000261740.2
ENST00000392719.2
ENST00000346520.2
 TRPV4
 transient receptor potential cation channel, subfamily V, member 4

Gene Ontology Analysis

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 8.8 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.3 7.7 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.1 2.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 3.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 1.3 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.0 1.1 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.6 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.0 0.4 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.0 0.2 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.0 0.4 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.7 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 5.2 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.3 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0 0.4 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 8.8 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894)
1.2 3.5 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.9 4.3 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
0.2 1.0 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.2 2.5 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.2 1.1 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
0.2 5.2 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 0.4 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.1 0.6 GO:0004905 type I interferon receptor activity(GO:0004905)
0.1 0.2 GO:0015403 thiamine transmembrane transporter activity(GO:0015234) thiamine uptake transmembrane transporter activity(GO:0015403)
0.0 1.3 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0 0.2 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
0.0 0.1 GO:0000253 3-keto sterol reductase activity(GO:0000253)
0.0 0.5 GO:0005537 mannose binding(GO:0005537)
0.0 0.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.1 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.0 0.4 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0004461 lactose synthase activity(GO:0004461)
0.0 0.3 GO:0031702 type 1 angiotensin receptor binding(GO:0031702)
0.0 0.6 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.3 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.2 GO:0004089 carbonate dehydratase activity(GO:0004089)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.3 GO:0031089 platelet dense granule lumen(GO:0031089)
0.1 0.8 GO:0030061 mitochondrial crista(GO:0030061)
0.1 1.3 GO:0097342 ripoptosome(GO:0097342)
0.1 7.1 GO:0044215 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0 0.4 GO:0005818 astral microtubule(GO:0000235) aster(GO:0005818)
0.0 0.2 GO:1990037 Lewy body core(GO:1990037)
0.0 0.4 GO:0071011 precatalytic spliceosome(GO:0071011)
0.0 0.2 GO:0001741 XY body(GO:0001741)
0.0 0.3 GO:0070822 Sin3-type complex(GO:0070822)

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0045362 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.9 7.7 GO:0045959 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027)
0.4 4.3 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.4 2.5 GO:0019344 cysteine biosynthetic process(GO:0019344)
0.4 8.8 GO:0006068 ethanol catabolic process(GO:0006068)
0.2 1.0 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.1 0.6 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.1 1.3 GO:1903944 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
0.1 1.0 GO:0031666 positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.1 0.4 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.1 0.4 GO:0060125 negative regulation of growth hormone secretion(GO:0060125)
0.1 0.3 GO:0030037 actin filament reorganization involved in cell cycle(GO:0030037)
0.1 0.2 GO:0015888 thiamine transport(GO:0015888) thiamine transmembrane transport(GO:0071934)
0.1 0.2 GO:0085032 modulation of signal transduction in other organism(GO:0044501) modulation by symbiont of host signal transduction pathway(GO:0052027) modulation of signal transduction in other organism involved in symbiotic interaction(GO:0052250) modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade(GO:0085032)
0.1 0.3 GO:0045590 negative regulation of regulatory T cell differentiation(GO:0045590)
0.1 1.1 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.1 0.4 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.1 0.3 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.5 GO:0070836 caveola assembly(GO:0070836)
0.0 0.5 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 5.1 GO:0098869 cellular oxidant detoxification(GO:0098869)
0.0 0.2 GO:0090116 C-5 methylation of cytosine(GO:0090116)
0.0 0.2 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0 0.2 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.2 GO:0060294 cilium movement involved in cell motility(GO:0060294) regulation of microtubule binding(GO:1904526)
0.0 2.1 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 0.3 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.0 0.6 GO:0035455 response to interferon-alpha(GO:0035455)
0.0 0.4 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 0.1 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.0 0.1 GO:0071874 cellular response to norepinephrine stimulus(GO:0071874)
0.0 0.1 GO:0070166 enamel mineralization(GO:0070166)
0.0 0.0 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
0.0 0.3 GO:0070932 histone H3 deacetylation(GO:0070932)