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ENCODE cell lines, expression (Ernst 2011)

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Results for HDX

Z-value: 0.73

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Transcription factors associated with HDX

Gene Symbol Gene ID Gene Info
HDX
ENSG00000165259.9 HDX

Activity profile of HDX motif

Sorted Z-values of HDX motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HDX

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr2_-_113594279 3.57 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
 IL1B
 interleukin 1, beta
chr1_-_153363452 3.36 ENST00000368732.1
ENST00000368733.3
 S100A8
 S100 calcium binding protein A8
chr1_-_209825674 2.97 ENST00000367030.3
ENST00000356082.4
 LAMB3
 laminin, beta 3
chr18_+_29027696 1.97 ENST00000257189.4
 DSG3
 desmoglein 3
chr12_+_54422142 1.18 ENST00000243108.4
 HOXC6
 homeobox C6
chr2_+_113735575 0.37 ENST00000376489.2
ENST00000259205.4
 IL36G
 interleukin 36, gamma
chr5_+_140165876 0.33 ENST00000504120.2
ENST00000394633.3
ENST00000378133.3
 PCDHA1
 protocadherin alpha 1
chr5_-_35230771 0.26 ENST00000342362.5
 PRLR
 prolactin receptor
chr5_-_41213607 0.22 ENST00000337836.5
ENST00000433294.1
 C6
 complement component 6
chr22_+_40440804 0.20 ENST00000441751.1
ENST00000301923.9
 TNRC6B
 trinucleotide repeat containing 6B
chr5_-_35230649 0.17 ENST00000382002.5
 PRLR
 prolactin receptor
chr11_+_9685604 0.16 ENST00000447399.2
ENST00000318950.6
 SWAP70
 SWAP switching B-cell complex 70kDa subunit
chr1_+_117602925 0.14 ENST00000369466.4
 TTF2
 transcription termination factor, RNA polymerase II
chr19_+_36602104 0.13 ENST00000585332.1
ENST00000262637.4
 OVOL3
 ovo-like zinc finger 3
chr5_+_140625147 0.12 ENST00000231173.3
 PCDHB15
 protocadherin beta 15
chr1_-_48866517 0.11 ENST00000371841.1
 SPATA6
 spermatogenesis associated 6
chr1_-_159684371 0.10 ENST00000255030.5
ENST00000437342.1
ENST00000368112.1
ENST00000368111.1
ENST00000368110.1
ENST00000343919.2
 CRP
 C-reactive protein, pentraxin-related
chr1_+_84630053 0.09 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
 PRKACB
 protein kinase, cAMP-dependent, catalytic, beta
chr12_-_118797475 0.09 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
 TAOK3
 TAO kinase 3
chr12_+_10460549 0.09 ENST00000543420.1
ENST00000543777.1
 KLRD1
 killer cell lectin-like receptor subfamily D, member 1
chr8_+_24151620 0.08 ENST00000437154.2
 ADAM28
 ADAM metallopeptidase domain 28
chr11_-_66675371 0.05 ENST00000393955.2
 PC
 pyruvate carboxylase
chr3_+_54157480 0.05 ENST00000490478.1
 CACNA2D3
 calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr5_-_135290705 0.04 ENST00000274507.1
 LECT2
 leukocyte cell-derived chemotaxin 2
chr8_+_110098850 0.04 ENST00000518632.1
 TRHR
 thyrotropin-releasing hormone receptor
chr12_+_10460417 0.03 ENST00000381908.3
ENST00000336164.4
ENST00000350274.5
 KLRD1
 killer cell lectin-like receptor subfamily D, member 1
chr6_-_116381918 0.03 ENST00000606080.1
 FRK
 fyn-related kinase
chr1_+_197237352 0.02 ENST00000538660.1
ENST00000367400.3
ENST00000367399.2
 CRB1
 crumbs homolog 1 (Drosophila)

Gene Ontology Analysis

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.6 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 3.0 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 3.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.5 3.4 GO:0032119 sequestering of zinc ion(GO:0032119)
0.1 3.0 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.2 GO:0001970 positive regulation of activation of membrane attack complex(GO:0001970)
0.1 0.2 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0 0.2 GO:0038161 prolactin signaling pathway(GO:0038161)
0.0 0.1 GO:0097338 response to clozapine(GO:0097338)
0.0 0.1 GO:0019072 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.0 2.0 GO:0070268 cornification(GO:0070268)
0.0 0.2 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.4 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.2 3.9 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.2 GO:0004925 prolactin receptor activity(GO:0004925)
0.0 0.1 GO:0023024 MHC class I protein complex binding(GO:0023024)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 3.0 GO:0005610 laminin-5 complex(GO:0005610)
0.1 2.0 GO:0030057 desmosome(GO:0030057)
0.0 0.1 GO:0097224 sperm connecting piece(GO:0097224)
0.0 0.2 GO:0005579 membrane attack complex(GO:0005579)
0.0 3.4 GO:0045111 intermediate filament cytoskeleton(GO:0045111)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.0 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.1 3.6 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 3.0 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.2 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling