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ENCODE cell lines, expression (Ernst 2011)

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Results for HMGA2

Z-value: 0.63

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Transcription factors associated with HMGA2

Gene Symbol Gene ID Gene Info
HMGA2
ENSG00000149948.9 HMGA2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HMGA2hg19_v2_chr12_+_66218598_662186780.792.7e-04Click!

Activity profile of HMGA2 motif

Sorted Z-values of HMGA2 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HMGA2

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr10_-_5046042 2.35 ENST00000421196.3
ENST00000455190.1
 AKR1C2
 aldo-keto reductase family 1, member C2
chr15_+_58702742 2.35 ENST00000356113.6
ENST00000414170.3
 LIPC
 lipase, hepatic
chr14_-_65409438 1.84 ENST00000557049.1
 GPX2
 glutathione peroxidase 2 (gastrointestinal)
chr14_-_65409502 1.61 ENST00000389614.5
 GPX2
 glutathione peroxidase 2 (gastrointestinal)
chr2_-_216257849 1.46 ENST00000456923.1
 FN1
 fibronectin 1
chrY_+_22918021 1.22 ENST00000288666.5
 RPS4Y2
 ribosomal protein S4, Y-linked 2
chr19_-_36297632 1.18 ENST00000588266.2
 PRODH2
 proline dehydrogenase (oxidase) 2
chr3_+_193853927 1.02 ENST00000232424.3
 HES1
 hes family bHLH transcription factor 1
chr14_-_94759595 1.00 ENST00000261994.4
 SERPINA10
 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr14_-_94759361 0.98 ENST00000393096.1
 SERPINA10
 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr14_-_94759408 0.97 ENST00000554723.1
 SERPINA10
 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr2_+_235887329 0.79 ENST00000409212.1
ENST00000344528.4
ENST00000444916.1
 SH3BP4
 SH3-domain binding protein 4
chr11_+_69455855 0.71 ENST00000227507.2
ENST00000536559.1
 CCND1
 cyclin D1
chr15_+_84904525 0.68 ENST00000510439.2
 GOLGA6L4
 golgin A6 family-like 4
chr9_-_115480303 0.51 ENST00000374234.1
ENST00000374238.1
ENST00000374236.1
ENST00000374242.4
 INIP
 INTS3 and NABP interacting protein
chr6_-_52705641 0.50 ENST00000370989.2
 GSTA5
 glutathione S-transferase alpha 5
chr6_+_123110302 0.44 ENST00000368440.4
 SMPDL3A
 sphingomyelin phosphodiesterase, acid-like 3A
chr20_+_48884002 0.44 ENST00000425497.1
ENST00000445003.1
 RP11-290F20.3
 RP11-290F20.3
chr2_+_220143989 0.41 ENST00000336576.5
 DNAJB2
 DnaJ (Hsp40) homolog, subfamily B, member 2
chr2_+_120436733 0.39 ENST00000401466.1
ENST00000424086.1
ENST00000272521.6
 TMEM177
 transmembrane protein 177
chr19_-_12267524 0.38 ENST00000455799.1
ENST00000355738.1
ENST00000439556.2
ENST00000542938.1
 ZNF625
 zinc finger protein 625
chr11_+_73661364 0.37 ENST00000339764.1
 DNAJB13
 DnaJ (Hsp40) homolog, subfamily B, member 13
chr6_+_111580508 0.36 ENST00000368847.4
 KIAA1919
 KIAA1919
chr1_+_55464600 0.36 ENST00000371265.4
 BSND
 Bartter syndrome, infantile, with sensorineural deafness (Barttin)
chr2_+_220144052 0.34 ENST00000425450.1
ENST00000392086.4
ENST00000421532.1
 DNAJB2
 DnaJ (Hsp40) homolog, subfamily B, member 2
chr15_+_83098710 0.30 ENST00000561062.1
ENST00000358583.3
 GOLGA6L9
 golgin A6 family-like 20
chr3_-_106959424 0.27 ENST00000607801.1
ENST00000479612.2
ENST00000484698.1
ENST00000477210.2
ENST00000473636.1
 LINC00882
 long intergenic non-protein coding RNA 882
chr15_+_82722225 0.27 ENST00000300515.8
 GOLGA6L9
 golgin A6 family-like 9
chr18_-_21017817 0.26 ENST00000542162.1
ENST00000383233.3
ENST00000582336.1
ENST00000450466.2
ENST00000578520.1
ENST00000399707.1
 TMEM241
 transmembrane protein 241
chr12_+_21207503 0.26 ENST00000545916.1
 SLCO1B7
 solute carrier organic anion transporter family, member 1B7 (non-functional)
chr17_-_4607335 0.25 ENST00000570571.1
ENST00000575101.1
ENST00000436683.2
ENST00000574876.1
 PELP1
 proline, glutamate and leucine rich protein 1
chr15_+_43985084 0.24 ENST00000434505.1
ENST00000411750.1
 CKMT1A
 creatine kinase, mitochondrial 1A
chr17_-_48785216 0.22 ENST00000285243.6
 ANKRD40
 ankyrin repeat domain 40
chr12_-_122751002 0.22 ENST00000267199.4
 VPS33A
 vacuolar protein sorting 33 homolog A (S. cerevisiae)
chr5_+_150827143 0.22 ENST00000243389.3
ENST00000517945.1
ENST00000521925.1
 SLC36A1
 solute carrier family 36 (proton/amino acid symporter), member 1
chr15_+_43885252 0.22 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
 CKMT1B
 creatine kinase, mitochondrial 1B
chr20_+_46130619 0.21 ENST00000372004.3
 NCOA3
 nuclear receptor coactivator 3
chr20_+_46130601 0.20 ENST00000341724.6
 NCOA3
 nuclear receptor coactivator 3
chr4_+_40058411 0.19 ENST00000261435.6
ENST00000515550.1
 N4BP2
 NEDD4 binding protein 2
chr14_+_45553296 0.19 ENST00000355765.6
ENST00000553605.1
 PRPF39
 pre-mRNA processing factor 39
chr18_+_11851383 0.16 ENST00000526991.2
 CHMP1B
 charged multivesicular body protein 1B
chr20_+_46130671 0.16 ENST00000371998.3
ENST00000371997.3
 NCOA3
 nuclear receptor coactivator 3
chr6_-_52926539 0.16 ENST00000350082.5
ENST00000356971.3
 ICK
 intestinal cell (MAK-like) kinase
chr3_+_186501336 0.16 ENST00000323963.5
ENST00000440191.2
ENST00000356531.5
 EIF4A2
 eukaryotic translation initiation factor 4A2
chr1_-_226374373 0.15 ENST00000366812.5
 ACBD3
 acyl-CoA binding domain containing 3
chr2_-_89266286 0.14 ENST00000464162.1
 IGKV1-6
 immunoglobulin kappa variable 1-6
chr19_-_38146289 0.13 ENST00000392144.1
ENST00000591444.1
ENST00000351218.2
ENST00000587809.1
 ZFP30
 ZFP30 zinc finger protein
chr20_-_31989307 0.13 ENST00000473997.1
ENST00000544843.1
ENST00000346416.2
ENST00000357886.4
ENST00000339269.5
 CDK5RAP1
 CDK5 regulatory subunit associated protein 1
chr9_+_42704004 0.11 ENST00000457288.1
 CBWD7
 COBW domain containing 7
chr7_-_102985035 0.11 ENST00000426036.2
ENST00000249270.7
ENST00000454277.1
ENST00000412522.1
 DNAJC2
 DnaJ (Hsp40) homolog, subfamily C, member 2
chr12_+_18414446 0.10 ENST00000433979.1
 PIK3C2G
 phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
chr7_-_102985288 0.07 ENST00000379263.3
 DNAJC2
 DnaJ (Hsp40) homolog, subfamily C, member 2
chrX_-_135962876 0.06 ENST00000431446.3
ENST00000570135.1
ENST00000320676.7
ENST00000562646.1
 RBMX
 RNA binding motif protein, X-linked
chrX_-_77150985 0.05 ENST00000358075.6
 MAGT1
 magnesium transporter 1
chr13_+_50656307 0.05 ENST00000378180.4
 DLEU1
 deleted in lymphocytic leukemia 1 (non-protein coding)
chr11_+_67250490 0.04 ENST00000528641.2
ENST00000279146.3
 AIP
 aryl hydrocarbon receptor interacting protein
chr3_+_137728842 0.04 ENST00000183605.5
 CLDN18
 claudin 18
chr9_+_108463234 0.03 ENST00000374688.1
 TMEM38B
 transmembrane protein 38B
chr12_-_10324716 0.02 ENST00000545927.1
ENST00000432556.2
ENST00000309539.3
ENST00000544577.1
 OLR1
 oxidized low density lipoprotein (lectin-like) receptor 1
chr19_+_44455368 0.02 ENST00000591168.1
ENST00000587682.1
ENST00000251269.5
 ZNF221
 zinc finger protein 221
chr17_-_50236039 0.02 ENST00000451037.2
 CA10
 carbonic anhydrase X
chr12_-_10573149 0.01 ENST00000381904.2
ENST00000381903.2
ENST00000396439.2
 KLRC3
 killer cell lectin-like receptor subfamily C, member 3
chr15_+_28623784 0.01 ENST00000526619.2
ENST00000337838.7
ENST00000532622.2
 GOLGA8F
 golgin A8 family, member F
chr5_+_36608422 0.00 ENST00000381918.3
 SLC1A3
 solute carrier family 1 (glial high affinity glutamate transporter), member 3

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.5 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
0.4 3.0 GO:0008218 bioluminescence(GO:0008218)
0.3 1.0 GO:0021558 midbrain-hindbrain boundary morphogenesis(GO:0021555) trochlear nerve development(GO:0021558) regulation of timing of neuron differentiation(GO:0060164)
0.3 2.4 GO:0009753 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.2 1.2 GO:0010133 proline catabolic process to glutamate(GO:0010133)
0.2 0.7 GO:1903644 regulation of chaperone-mediated protein folding(GO:1903644)
0.2 2.4 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372) phosphatidylcholine catabolic process(GO:0034638)
0.1 0.3 GO:0015783 GDP-fucose transport(GO:0015783) purine nucleotide-sugar transport(GO:0036079)
0.1 0.6 GO:0035624 receptor transactivation(GO:0035624)
0.1 0.7 GO:0070141 response to UV-A(GO:0070141)
0.1 0.2 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
0.1 0.2 GO:0015808 L-alanine transport(GO:0015808)
0.0 0.4 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 0.2 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.0 0.1 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
0.0 3.2 GO:0098869 cellular oxidant detoxification(GO:0098869)
0.0 0.2 GO:0006600 creatine metabolic process(GO:0006600)
0.0 0.8 GO:0043090 amino acid import(GO:0043090)
0.0 0.2 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.0 0.2 GO:0035751 regulation of lysosomal lumen pH(GO:0035751)
0.0 0.2 GO:1904903 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.0 0.4 GO:0035082 axoneme assembly(GO:0035082)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0070876 SOSS complex(GO:0070876)
0.1 1.5 GO:0005577 fibrinogen complex(GO:0005577)
0.0 1.7 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.2 GO:0071439 clathrin complex(GO:0071439)
0.0 1.2 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.2 GO:0000243 commitment complex(GO:0000243)
0.0 0.1 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.2 GO:0000815 ESCRT III complex(GO:0000815)
0.0 0.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.4 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 1.5 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0 0.7 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 1.0 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.6 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.4 GO:0018636 phenanthrene 9,10-monooxygenase activity(GO:0018636) ketosteroid monooxygenase activity(GO:0047086) trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity(GO:0047115)
0.3 1.2 GO:0004657 proline dehydrogenase activity(GO:0004657)
0.1 3.4 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 2.4 GO:0034185 apolipoprotein binding(GO:0034185)
0.1 0.3 GO:0005457 GDP-fucose transmembrane transporter activity(GO:0005457) purine nucleotide-sugar transmembrane transporter activity(GO:0036080)
0.1 0.2 GO:0030627 pre-mRNA 5'-splice site binding(GO:0030627)
0.1 0.2 GO:0022858 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.0 0.2 GO:0051734 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734)
0.0 0.4 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.8 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 0.2 GO:0004111 creatine kinase activity(GO:0004111)
0.0 0.2 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.0 3.2 GO:0051087 chaperone binding(GO:0051087)
0.0 3.0 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.7 GO:0070064 proline-rich region binding(GO:0070064)
0.0 0.6 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 1.2 GO:0019843 rRNA binding(GO:0019843)
0.0 0.4 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.5 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.3 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 4.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.5 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.7 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 0.6 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.0 3.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix