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ENCODE cell lines, expression (Ernst 2011)

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Results for HNF1A_HNF1B

Z-value: 4.44

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Transcription factors associated with HNF1A_HNF1B

Gene Symbol Gene ID Gene Info
HNF1A
ENSG00000135100.13 HNF1A
HNF1B
ENSG00000108753.8 HNF1B

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HNF1Ahg19_v2_chr12_+_121416489_1214165520.971.6e-10Click!

Activity profile of HNF1A_HNF1B motif

Sorted Z-values of HNF1A_HNF1B motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HNF1A_HNF1B

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr4_+_74301880 66.80 ENST00000395792.2
ENST00000226359.2
 AFP
 alpha-fetoprotein
chr17_-_64225508 41.88 ENST00000205948.6
 APOH
 apolipoprotein H (beta-2-glycoprotein I)
chrX_-_105282712 27.11 ENST00000372563.1
 SERPINA7
 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr9_-_123812542 25.50 ENST00000223642.1
 C5
 complement component 5
chr4_-_110723335 22.70 ENST00000394634.2
 CFI
 complement factor I
chr4_-_155511887 22.56 ENST00000302053.3
ENST00000403106.3
 FGA
 fibrinogen alpha chain
chr4_-_110723194 22.18 ENST00000394635.3
 CFI
 complement factor I
chr4_-_110723134 22.14 ENST00000510800.1
ENST00000512148.1
 CFI
 complement factor I
chr14_-_94854926 18.80 ENST00000402629.1
ENST00000556091.1
ENST00000554720.1
 SERPINA1
 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr10_+_5135981 17.37 ENST00000380554.3
 AKR1C3
 aldo-keto reductase family 1, member C3
chr4_+_155484155 16.66 ENST00000509493.1
 FGB
 fibrinogen beta chain
chr4_+_74269956 16.55 ENST00000295897.4
ENST00000415165.2
ENST00000503124.1
ENST00000509063.1
ENST00000401494.3
 ALB
 albumin
chr19_-_36304201 16.52 ENST00000301175.3
 PRODH2
 proline dehydrogenase (oxidase) 2
chr7_+_45927956 16.16 ENST00000275525.3
ENST00000457280.1
 IGFBP1
 insulin-like growth factor binding protein 1
chr19_+_11350278 15.64 ENST00000252453.8
 C19orf80
 chromosome 19 open reading frame 80
chr7_+_45928079 15.50 ENST00000468955.1
 IGFBP1
 insulin-like growth factor binding protein 1
chr1_+_207277590 15.30 ENST00000367070.3
 C4BPA
 complement component 4 binding protein, alpha
chr15_+_58724184 15.22 ENST00000433326.2
 LIPC
 lipase, hepatic
chr10_+_101542462 14.70 ENST00000370449.4
ENST00000370434.1
 ABCC2
 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr4_-_69817481 13.71 ENST00000251566.4
 UGT2A3
 UDP glucuronosyltransferase 2 family, polypeptide A3
chr14_-_94759595 13.66 ENST00000261994.4
 SERPINA10
 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr5_+_176513868 13.45 ENST00000292408.4
 FGFR4
 fibroblast growth factor receptor 4
chr14_-_94759361 13.28 ENST00000393096.1
 SERPINA10
 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr14_-_94759408 13.06 ENST00000554723.1
 SERPINA10
 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr2_-_88427568 12.75 ENST00000393750.3
ENST00000295834.3
 FABP1
 fatty acid binding protein 1, liver
chr8_-_17752996 12.71 ENST00000381841.2
ENST00000427924.1
 FGL1
 fibrinogen-like 1
chr4_+_155484103 12.59 ENST00000302068.4
 FGB
 fibrinogen beta chain
chr5_+_176513895 12.06 ENST00000503708.1
ENST00000393648.2
ENST00000514472.1
ENST00000502906.1
ENST00000292410.3
ENST00000510911.1
 FGFR4
 fibroblast growth factor receptor 4
chr4_+_100495864 11.63 ENST00000265517.5
ENST00000422897.2
 MTTP
 microsomal triglyceride transfer protein
chr14_+_21156915 11.38 ENST00000397990.4
ENST00000555597.1
 ANG
RNASE4
 angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr1_+_207262170 9.86 ENST00000367078.3
 C4BPB
 complement component 4 binding protein, beta
chr6_+_7541845 8.95 ENST00000418664.2
 DSP
 desmoplakin
chr7_-_50633078 8.80 ENST00000444124.2
 DDC
 dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr12_+_100867486 8.67 ENST00000548884.1
 NR1H4
 nuclear receptor subfamily 1, group H, member 4
chr6_-_25930819 8.61 ENST00000360488.3
 SLC17A2
 solute carrier family 17, member 2
chr19_+_50016610 8.40 ENST00000596975.1
 FCGRT
 Fc fragment of IgG, receptor, transporter, alpha
chr6_-_25930904 8.02 ENST00000377850.3
 SLC17A2
 solute carrier family 17, member 2
chr11_+_46740730 7.87 ENST00000311907.5
ENST00000530231.1
ENST00000442468.1
 F2
 coagulation factor II (thrombin)
chr17_+_1646130 7.65 ENST00000453066.1
ENST00000324015.3
ENST00000450523.2
ENST00000453723.1
ENST00000382061.4
 SERPINF2
 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2
chr1_+_207262881 7.58 ENST00000451804.2
 C4BPB
 complement component 4 binding protein, beta
chr17_+_41052808 6.86 ENST00000592383.1
ENST00000253801.2
ENST00000585489.1
 G6PC
 glucose-6-phosphatase, catalytic subunit
chr14_-_65409438 6.70 ENST00000557049.1
 GPX2
 glutathione peroxidase 2 (gastrointestinal)
chr1_+_207262627 6.64 ENST00000391923.1
 C4BPB
 complement component 4 binding protein, beta
chr22_-_30970560 6.63 ENST00000402369.1
ENST00000406361.1
 GAL3ST1
 galactose-3-O-sulfotransferase 1
chr6_+_167704798 6.58 ENST00000230256.3
 UNC93A
 unc-93 homolog A (C. elegans)
chr19_+_50016411 6.51 ENST00000426395.3
ENST00000600273.1
ENST00000599988.1
 FCGRT
 Fc fragment of IgG, receptor, transporter, alpha
chr6_+_167704838 6.50 ENST00000366829.2
 UNC93A
 unc-93 homolog A (C. elegans)
chr1_+_207262578 6.39 ENST00000243611.5
ENST00000367076.3
 C4BPB
 complement component 4 binding protein, beta
chr17_+_79953310 6.34 ENST00000582355.2
 ASPSCR1
 alveolar soft part sarcoma chromosome region, candidate 1
chr10_-_52645379 6.27 ENST00000395489.2
 A1CF
 APOBEC1 complementation factor
chr12_+_100867694 6.26 ENST00000392986.3
ENST00000549996.1
 NR1H4
 nuclear receptor subfamily 1, group H, member 4
chr10_-_52645416 6.12 ENST00000374001.2
ENST00000373997.3
ENST00000373995.3
ENST00000282641.2
ENST00000395495.1
ENST00000414883.1
 A1CF
 APOBEC1 complementation factor
chr14_-_65409502 5.96 ENST00000389614.5
 GPX2
 glutathione peroxidase 2 (gastrointestinal)
chr14_+_95027772 5.86 ENST00000555095.1
ENST00000298841.5
ENST00000554220.1
ENST00000553780.1
 SERPINA4
SERPINA5
 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr4_+_187187098 5.79 ENST00000403665.2
ENST00000264692.4
 F11
 coagulation factor XI
chr2_+_27719697 5.42 ENST00000264717.2
ENST00000424318.2
 GCKR
 glucokinase (hexokinase 4) regulator
chr8_+_21911054 5.42 ENST00000519850.1
ENST00000381470.3
 DMTN
 dematin actin binding protein
chr7_-_44580861 5.30 ENST00000546276.1
ENST00000289547.4
ENST00000381160.3
ENST00000423141.1
 NPC1L1
 NPC1-like 1
chr16_-_87970122 5.22 ENST00000309893.2
 CA5A
 carbonic anhydrase VA, mitochondrial
chr20_+_35973080 5.14 ENST00000445403.1
 SRC
 v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr5_+_175976324 5.05 ENST00000261944.5
 CDHR2
 cadherin-related family member 2
chr14_+_39703084 4.96 ENST00000553728.1
 RP11-407N17.3
 cTAGE family member 5 isoform 4
chr17_-_202579 4.86 ENST00000577079.1
ENST00000331302.7
ENST00000536489.2
 RPH3AL
 rabphilin 3A-like (without C2 domains)
chr1_+_17906970 4.35 ENST00000375415.1
 ARHGEF10L
 Rho guanine nucleotide exchange factor (GEF) 10-like
chr12_+_100897130 4.17 ENST00000551379.1
ENST00000188403.7
ENST00000551184.1
 NR1H4
 nuclear receptor subfamily 1, group H, member 4
chr12_+_70132632 3.67 ENST00000378815.6
ENST00000483530.2
ENST00000325555.9
 RAB3IP
 RAB3A interacting protein
chr16_+_20775358 3.58 ENST00000440284.2
 ACSM3
 acyl-CoA synthetase medium-chain family member 3
chr11_-_117695449 3.53 ENST00000292079.2
 FXYD2
 FXYD domain containing ion transport regulator 2
chr2_-_55920952 3.31 ENST00000447944.2
 PNPT1
 polyribonucleotide nucleotidyltransferase 1
chr7_-_47579188 3.30 ENST00000398879.1
ENST00000355730.3
ENST00000442536.2
ENST00000458317.2
 TNS3
 tensin 3
chr2_-_162931052 3.29 ENST00000360534.3
 DPP4
 dipeptidyl-peptidase 4
chr6_+_161123270 3.26 ENST00000366924.2
ENST00000308192.9
ENST00000418964.1
 PLG
 plasminogen
chr16_+_20775024 3.22 ENST00000289416.5
 ACSM3
 acyl-CoA synthetase medium-chain family member 3
chr21_-_47575481 3.15 ENST00000291670.5
ENST00000397748.1
ENST00000359679.2
ENST00000355384.2
ENST00000397746.3
ENST00000397743.1
 FTCD
 formimidoyltransferase cyclodeaminase
chr14_+_24590560 3.10 ENST00000558325.1
 RP11-468E2.6
 RP11-468E2.6
chr4_+_8201091 3.06 ENST00000382521.3
ENST00000245105.3
ENST00000457650.2
ENST00000539824.1
 SH3TC1
 SH3 domain and tetratricopeptide repeats 1
chr22_-_30968813 3.01 ENST00000443111.2
ENST00000443136.1
ENST00000426220.1
 GAL3ST1
 galactose-3-O-sulfotransferase 1
chr16_+_20462783 2.86 ENST00000574251.1
ENST00000576361.1
ENST00000417235.2
ENST00000573854.1
ENST00000424070.1
ENST00000536134.1
ENST00000219054.6
ENST00000575690.1
ENST00000571894.1
 ACSM2A
 acyl-CoA synthetase medium-chain family member 2A
chr2_-_169104651 2.84 ENST00000355999.4
 STK39
 serine threonine kinase 39
chr16_-_20587599 2.75 ENST00000566384.1
ENST00000565232.1
ENST00000567001.1
ENST00000565322.1
ENST00000569344.1
ENST00000329697.6
ENST00000414188.2
ENST00000568882.1
 ACSM2B
 acyl-CoA synthetase medium-chain family member 2B
chr16_-_57831914 2.64 ENST00000421376.2
 KIFC3
 kinesin family member C3
chr6_-_52628271 2.54 ENST00000493422.1
 GSTA2
 glutathione S-transferase alpha 2
chr12_-_24102576 2.40 ENST00000537393.1
ENST00000309359.1
ENST00000381381.2
ENST00000451604.2
 SOX5
 SRY (sex determining region Y)-box 5
chr4_-_1166954 2.36 ENST00000514490.1
ENST00000431380.1
ENST00000503765.1
 SPON2
 spondin 2, extracellular matrix protein
chr17_+_41363854 2.26 ENST00000588693.1
ENST00000588659.1
ENST00000541594.1
ENST00000536052.1
ENST00000331615.3
 TMEM106A
 transmembrane protein 106A
chrX_+_107288197 2.21 ENST00000415430.3
 VSIG1
 V-set and immunoglobulin domain containing 1
chr10_-_72648541 2.21 ENST00000299299.3
 PCBD1
 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
chr1_-_110284384 2.16 ENST00000540225.1
 GSTM3
 glutathione S-transferase mu 3 (brain)
chr1_+_36789335 2.11 ENST00000373137.2
 RP11-268J15.5
 RP11-268J15.5
chr4_+_3443614 2.09 ENST00000382774.3
ENST00000511533.1
 HGFAC
 HGF activator
chr16_+_89696692 2.08 ENST00000261615.4
 DPEP1
 dipeptidase 1 (renal)
chr6_-_25874440 2.07 ENST00000361703.6
ENST00000397060.4
 SLC17A3
 solute carrier family 17 (organic anion transporter), member 3
chr16_-_15474904 2.02 ENST00000534094.1
 NPIPA5
 nuclear pore complex interacting protein family, member A5
chr12_+_70133152 1.90 ENST00000550536.1
ENST00000362025.5
 RAB3IP
 RAB3A interacting protein
chrX_+_107288239 1.83 ENST00000217957.5
 VSIG1
 V-set and immunoglobulin domain containing 1
chr1_+_57320437 1.69 ENST00000361249.3
 C8A
 complement component 8, alpha polypeptide
chr11_-_128894053 1.69 ENST00000392657.3
 ARHGAP32
 Rho GTPase activating protein 32
chr17_-_36904437 1.63 ENST00000585100.1
ENST00000360797.2
ENST00000578109.1
ENST00000579882.1
 PCGF2
 polycomb group ring finger 2
chr7_+_120629653 1.54 ENST00000450913.2
ENST00000340646.5
 CPED1
 cadherin-like and PC-esterase domain containing 1
chr4_-_166034029 1.46 ENST00000306480.6
 TMEM192
 transmembrane protein 192
chr1_+_229406847 1.33 ENST00000366690.4
 RAB4A
 RAB4A, member RAS oncogene family
chr16_-_57831676 1.30 ENST00000465878.2
ENST00000539578.1
ENST00000561524.1
 KIFC3
 kinesin family member C3
chrX_+_120181457 1.24 ENST00000328078.1
 GLUD2
 glutamate dehydrogenase 2
chr5_+_67586465 1.22 ENST00000336483.5
 PIK3R1
 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr1_-_20141763 1.21 ENST00000375121.2
 RNF186
 ring finger protein 186
chr9_-_98079965 1.07 ENST00000289081.3
 FANCC
 Fanconi anemia, complementation group C
chr3_-_49466686 1.00 ENST00000273598.3
ENST00000436744.2
 NICN1
 nicolin 1
chr20_+_62371206 1.00 ENST00000266077.2
 SLC2A4RG
 SLC2A4 regulator
chr17_+_48823896 0.97 ENST00000511974.1
 LUC7L3
 LUC7-like 3 (S. cerevisiae)
chr6_+_144904334 0.96 ENST00000367526.4
 UTRN
 utrophin
chr3_-_192445289 0.94 ENST00000430714.1
ENST00000418610.1
ENST00000448795.1
ENST00000445105.2
 FGF12
 fibroblast growth factor 12
chr4_+_39408470 0.83 ENST00000257408.4
 KLB
 klotho beta
chr19_+_54466179 0.80 ENST00000270458.2
 CACNG8
 calcium channel, voltage-dependent, gamma subunit 8
chr16_-_66952779 0.80 ENST00000570262.1
ENST00000394055.3
ENST00000299752.4
 CDH16
 cadherin 16, KSP-cadherin
chr11_+_20620946 0.78 ENST00000525748.1
 SLC6A5
 solute carrier family 6 (neurotransmitter transporter), member 5
chr11_+_1860200 0.72 ENST00000381911.1
 TNNI2
 troponin I type 2 (skeletal, fast)
chr20_+_45947246 0.66 ENST00000599904.1
 AL031666.2
 HCG2018772; Uncharacterized protein; cDNA FLJ31609 fis, clone NT2RI2002852
chr7_-_6098770 0.66 ENST00000536084.1
ENST00000446699.1
ENST00000199389.6
 EIF2AK1
 eukaryotic translation initiation factor 2-alpha kinase 1
chr2_-_47572105 0.63 ENST00000419035.1
ENST00000448713.1
ENST00000450550.1
ENST00000413185.2
 AC073283.4
 AC073283.4
chr16_-_66952742 0.60 ENST00000565235.2
ENST00000568632.1
ENST00000565796.1
 CDH16
 cadherin 16, KSP-cadherin
chr10_-_38146510 0.60 ENST00000395867.3
 ZNF248
 zinc finger protein 248
chr15_+_48498480 0.54 ENST00000380993.3
ENST00000396577.3
 SLC12A1
 solute carrier family 12 (sodium/potassium/chloride transporter), member 1
chr5_-_111093167 0.54 ENST00000446294.2
ENST00000419114.2
 NREP
 neuronal regeneration related protein
chr7_+_130126012 0.54 ENST00000341441.5
 MEST
 mesoderm specific transcript
chr20_+_57414743 0.52 ENST00000313949.7
 GNAS
 GNAS complex locus
chr9_-_215744 0.44 ENST00000382387.2
 C9orf66
 chromosome 9 open reading frame 66
chr2_-_228244013 0.40 ENST00000304568.3
 TM4SF20
 transmembrane 4 L six family member 20
chr19_-_11639931 0.38 ENST00000592312.1
ENST00000590480.1
ENST00000585318.1
ENST00000252440.7
ENST00000417981.2
ENST00000270517.7
 ECSIT
 ECSIT signalling integrator
chr19_-_11639910 0.37 ENST00000588998.1
ENST00000586149.1
 ECSIT
 ECSIT signalling integrator
chr7_+_130126165 0.29 ENST00000427521.1
ENST00000416162.2
ENST00000378576.4
 MEST
 mesoderm specific transcript
chr8_-_124749609 0.21 ENST00000262219.6
ENST00000419625.1
 ANXA13
 annexin A13
chr5_+_6714718 0.18 ENST00000230859.6
ENST00000515721.1
 PAPD7
 PAP associated domain containing 7
chr3_+_38307293 0.17 ENST00000311856.4
 SLC22A13
 solute carrier family 22 (organic anion/urate transporter), member 13
chr4_-_70518941 0.16 ENST00000286604.4
ENST00000505512.1
ENST00000514019.1
 UGT2A1
UGT2A1
 UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
chr20_+_57414795 0.16 ENST00000371098.2
ENST00000371075.3
 GNAS
 GNAS complex locus
chr7_+_152456904 0.15 ENST00000537264.1
 ACTR3B
 ARP3 actin-related protein 3 homolog B (yeast)
chr5_-_77844974 0.13 ENST00000515007.2
 LHFPL2
 lipoma HMGIC fusion partner-like 2
chr12_-_18243119 0.11 ENST00000538724.1
ENST00000229002.2
 RERGL
 RERG/RAS-like
chr10_+_115312766 0.11 ENST00000351270.3
 HABP2
 hyaluronan binding protein 2
chr13_+_96085847 0.07 ENST00000376873.3
 CLDN10
 claudin 10
chr13_-_41593425 0.05 ENST00000239882.3
 ELF1
 E74-like factor 1 (ets domain transcription factor)
chr7_+_152456829 0.05 ENST00000377776.3
ENST00000256001.8
ENST00000397282.2
 ACTR3B
 ARP3 actin-related protein 3 homolog B (yeast)
chr6_+_106534192 0.04 ENST00000369091.2
ENST00000369096.4
 PRDM1
 PR domain containing 1, with ZNF domain

Gene Ontology Analysis

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
8.4 41.9 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
6.4 19.1 GO:1902122 chenodeoxycholic acid binding(GO:1902122)
4.3 17.4 GO:0047718 enone reductase activity(GO:0035671) androsterone dehydrogenase activity(GO:0047023) indanol dehydrogenase activity(GO:0047718)
4.1 16.5 GO:0004657 proline dehydrogenase activity(GO:0004657)
3.7 14.9 GO:0019770 IgG receptor activity(GO:0019770)
2.9 31.7 GO:0031995 insulin-like growth factor II binding(GO:0031995)
2.6 25.5 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
2.0 7.9 GO:0070053 thrombospondin receptor activity(GO:0070053)
1.9 11.4 GO:0004522 ribonuclease A activity(GO:0004522)
1.8 12.8 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
1.7 6.9 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
1.6 14.1 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
1.5 18.2 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
1.4 12.4 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
1.4 9.6 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
1.2 14.7 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
1.1 5.4 GO:0070095 fructose-6-phosphate binding(GO:0070095)
1.0 64.8 GO:0005044 scavenger receptor activity(GO:0005044)
1.0 16.5 GO:0015643 toxic substance binding(GO:0015643)
1.0 9.0 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.9 97.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.8 3.1 GO:0016841 ammonia-lyase activity(GO:0016841)
0.7 5.1 GO:0071253 connexin binding(GO:0071253)
0.7 3.3 GO:0034046 poly(G) binding(GO:0034046)
0.6 2.2 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.5 24.7 GO:0008009 chemokine activity(GO:0008009)
0.4 4.9 GO:0030274 LIM domain binding(GO:0030274)
0.4 12.7 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.4 3.3 GO:1990405 protein antigen binding(GO:1990405)
0.3 3.5 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.3 1.2 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.3 5.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.3 2.1 GO:0070573 metallodipeptidase activity(GO:0070573)
0.3 29.3 GO:0051087 chaperone binding(GO:0051087)
0.3 5.8 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.2 3.9 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.2 0.7 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.2 0.8 GO:0008422 beta-glucosidase activity(GO:0008422)
0.2 11.6 GO:0005548 phospholipid transporter activity(GO:0005548)
0.2 5.3 GO:0031489 myosin V binding(GO:0031489)
0.2 1.2 GO:0043559 insulin binding(GO:0043559)
0.2 0.8 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.2 3.3 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.2 8.8 GO:0016831 carboxy-lyase activity(GO:0016831)
0.2 2.2 GO:0043295 glutathione binding(GO:0043295)
0.1 12.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 5.4 GO:0030507 spectrin binding(GO:0030507)
0.1 5.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 2.4 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.1 1.3 GO:0001671 ATPase activator activity(GO:0001671)
0.1 2.5 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 20.5 GO:0030674 protein binding, bridging(GO:0030674)
0.1 0.7 GO:0051430 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.1 1.7 GO:0001848 complement binding(GO:0001848)
0.1 0.7 GO:0031014 troponin T binding(GO:0031014)
0.0 1.0 GO:0017166 vinculin binding(GO:0017166)
0.0 0.5 GO:0015377 cation:chloride symporter activity(GO:0015377)
0.0 2.8 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 0.2 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.8 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 0.2 GO:0015101 organic cation transmembrane transporter activity(GO:0015101)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 72.2 GO:0005577 fibrinogen complex(GO:0005577)
4.1 12.4 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
3.0 27.2 GO:0005579 membrane attack complex(GO:0005579)
2.7 47.7 GO:0031089 platelet dense granule lumen(GO:0031089)
2.6 18.0 GO:0046581 intercellular canaliculus(GO:0046581)
1.9 11.4 GO:0032311 angiogenin-PRI complex(GO:0032311)
1.6 12.8 GO:0045179 apical cortex(GO:0045179)
1.0 5.1 GO:0089717 spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.7 3.3 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.6 9.0 GO:0005916 fascia adherens(GO:0005916)
0.6 208.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.5 19.1 GO:0005719 nuclear euchromatin(GO:0005719)
0.4 3.9 GO:0005915 zonula adherens(GO:0005915)
0.4 40.3 GO:0044215 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.4 3.3 GO:0042788 polysomal ribosome(GO:0042788)
0.3 3.1 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.3 5.4 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.3 1.2 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.3 1.3 GO:0098837 postsynaptic recycling endosome(GO:0098837)
0.2 2.2 GO:0035686 sperm fibrous sheath(GO:0035686)
0.2 3.5 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.2 1.6 GO:0001739 sex chromatin(GO:0001739)
0.2 6.3 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.2 1.1 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.1 1.0 GO:0070938 contractile ring(GO:0070938)
0.1 7.1 GO:0031526 brush border membrane(GO:0031526)
0.1 2.1 GO:0031528 microvillus membrane(GO:0031528)
0.1 5.1 GO:0002102 podosome(GO:0002102)
0.1 37.4 GO:0030133 transport vesicle(GO:0030133)
0.1 6.9 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 14.8 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 0.8 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.0 0.8 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 50.6 GO:0005615 extracellular space(GO:0005615)
0.0 0.7 GO:0005861 troponin complex(GO:0005861)
0.0 1.5 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 13.4 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 5.6 GO:0030027 lamellipodium(GO:0030027)
0.0 10.7 GO:0000139 Golgi membrane(GO:0000139)
0.0 0.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.0 3.5 GO:0019898 extrinsic component of membrane(GO:0019898)
0.0 1.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.5 GO:0005770 late endosome(GO:0005770)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 129.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
1.0 54.2 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.7 49.3 PID HNF3A PATHWAY FOXA1 transcription factor network
0.4 19.1 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.4 32.7 PID FGF PATHWAY FGF signaling pathway
0.3 15.3 PID CD40 PATHWAY CD40/CD40L signaling
0.3 69.8 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 12.7 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 9.0 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 4.4 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 10.8 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 2.2 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.3 PID TCPTP PATHWAY Signaling events mediated by TCPTP
0.0 2.8 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.0 1.7 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 1.1 PID BARD1 PATHWAY BARD1 signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 112.8 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
3.4 50.5 REACTOME COMMON PATHWAY Genes involved in Common Pathway
1.8 25.5 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
1.4 34.9 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
1.2 26.8 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
1.2 26.1 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.9 16.5 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.5 9.0 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.4 14.7 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.4 8.8 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.3 5.2 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.3 5.8 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.3 5.1 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.2 12.3 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
0.2 9.6 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.2 3.3 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 20.5 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 3.9 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 12.8 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 2.5 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 1.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.1 3.5 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 12.4 REACTOME MRNA PROCESSING Genes involved in mRNA Processing
0.1 0.8 REACTOME FGFR LIGAND BINDING AND ACTIVATION Genes involved in FGFR ligand binding and activation
0.0 1.1 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.8 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.7 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0 0.7 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
8.5 25.5 GO:0010760 negative regulation of macrophage chemotaxis(GO:0010760)
6.4 19.1 GO:2000213 nitrogen catabolite regulation of transcription from RNA polymerase II promoter(GO:0001079) nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) regulation of urea metabolic process(GO:0034255) intracellular bile acid receptor signaling pathway(GO:0038185) interleukin-17 secretion(GO:0072615) nitrogen catabolite regulation of transcription(GO:0090293) nitrogen catabolite activation of transcription(GO:0090294) regulation of nitrogen cycle metabolic process(GO:1903314) positive regulation of glutamate metabolic process(GO:2000213) regulation of ammonia assimilation cycle(GO:2001248) positive regulation of ammonia assimilation cycle(GO:2001250)
5.8 17.4 GO:0016095 polyprenol catabolic process(GO:0016095)
5.7 40.0 GO:0008218 bioluminescence(GO:0008218)
5.6 16.8 GO:0016999 antibiotic metabolic process(GO:0016999)
5.5 16.5 GO:0019836 hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
5.4 54.2 GO:0043152 induction of bacterial agglutination(GO:0043152)
5.4 59.1 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
5.1 25.5 GO:1903412 response to bile acid(GO:1903412)
5.1 45.8 GO:0045959 regulation of complement activation, classical pathway(GO:0030450) negative regulation of complement activation, classical pathway(GO:0045959) regulation of opsonization(GO:1903027)
4.5 66.8 GO:0001542 ovulation from ovarian follicle(GO:0001542)
2.9 8.8 GO:0052314 serotonin biosynthetic process(GO:0042427) phytoalexin metabolic process(GO:0052314)
2.8 16.5 GO:0010133 proline catabolic process to glutamate(GO:0010133)
2.3 11.4 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
2.2 26.4 GO:0070327 thyroid hormone transport(GO:0070327)
2.1 14.9 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
2.1 12.4 GO:0016554 cytidine to uridine editing(GO:0016554)
1.9 5.8 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
1.7 5.1 GO:0090675 intermicrovillar adhesion(GO:0090675)
1.4 5.4 GO:1903300 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
1.3 5.1 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
1.3 9.0 GO:0071896 protein localization to adherens junction(GO:0071896)
1.3 8.9 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
1.3 12.8 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
1.2 5.9 GO:0061107 seminal vesicle development(GO:0061107)
1.2 15.2 GO:0034372 very-low-density lipoprotein particle remodeling(GO:0034372)
1.2 11.6 GO:0034197 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
1.1 3.3 GO:0000965 mitochondrial RNA 3'-end processing(GO:0000965) rRNA import into mitochondrion(GO:0035928)
1.1 9.6 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
1.0 3.1 GO:0019557 histidine catabolic process to glutamate and formamide(GO:0019556) histidine catabolic process to glutamate and formate(GO:0019557) formamide metabolic process(GO:0043606)
1.0 3.9 GO:0045218 zonula adherens maintenance(GO:0045218)
0.9 2.8 GO:0023016 signal transduction by trans-phosphorylation(GO:0023016) negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.9 5.4 GO:0070560 protein secretion by platelet(GO:0070560)
0.9 16.1 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.9 31.7 GO:0036499 PERK-mediated unfolded protein response(GO:0036499)
0.8 3.3 GO:0036343 psychomotor behavior(GO:0036343)
0.5 5.3 GO:0098856 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.5 68.7 GO:0006958 complement activation, classical pathway(GO:0006958)
0.4 2.2 GO:0008065 establishment of blood-nerve barrier(GO:0008065)
0.4 2.4 GO:0055059 asymmetric neuroblast division(GO:0055059)
0.4 0.4 GO:0045861 negative regulation of proteolysis(GO:0045861)
0.3 2.9 GO:0036112 medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
0.2 2.2 GO:0046146 tetrahydrobiopterin biosynthetic process(GO:0006729) tetrahydrobiopterin metabolic process(GO:0046146)
0.2 3.5 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.2 4.0 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.2 18.8 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.2 0.7 GO:0006447 regulation of translational initiation by iron(GO:0006447)
0.2 1.3 GO:0032482 Rab protein signal transduction(GO:0032482)
0.2 2.5 GO:1901687 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.1 13.7 GO:0098869 cellular oxidant detoxification(GO:0098869)
0.1 1.2 GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103)
0.1 6.3 GO:0055092 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
0.1 0.8 GO:0090080 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.1 5.2 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 0.8 GO:0015816 glycine transport(GO:0015816)
0.1 0.7 GO:2000828 post-embryonic body morphogenesis(GO:0040032) regulation of parathyroid hormone secretion(GO:2000828)
0.1 1.0 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.1 1.2 GO:0006538 glutamate catabolic process(GO:0006538)
0.1 4.9 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.1 3.3 GO:0048286 lung alveolus development(GO:0048286)
0.1 4.5 GO:0046324 regulation of glucose import(GO:0046324)
0.0 0.4 GO:0098908 regulation of neuronal action potential(GO:0098908)
0.0 0.8 GO:2000311 regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000311)
0.0 2.8 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.0 0.8 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.8 GO:0007498 mesoderm development(GO:0007498)
0.0 4.9 GO:0006612 protein targeting to membrane(GO:0006612)
0.0 0.2 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.0 1.6 GO:0070301 cellular response to hydrogen peroxide(GO:0070301)
0.0 0.7 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 0.2 GO:0007076 mitotic chromosome condensation(GO:0007076)