ISMARA results: HOXA1

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ENCODE cell lines, expression (Ernst 2011)

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Results for HOXA1

Z-value: 0.91

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Transcription factors associated with HOXA1

Gene Symbol	Gene ID	Gene Info
HOXA1 Ensembl NCBI GeneCards UniProt	ENSG00000105991.7	HOXA1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
HOXA1	hg19_v2_chr7_-_27135591_27135658	-0.13	6.3e-01	Click!

Activity profile of HOXA1 motif

Sorted Z-values of HOXA1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA1

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Top targets:

Promoter	Score	Transcript	Gene	Gene Info
chr5_-_42825983	3.59	ENST00000506577.1	SEPP1	selenoprotein P, plasma, 1
chr20_-_23618582	2.41	ENST00000398411.1 ENST00000376925.3	CST3	cystatin C
chr10_+_7745303	2.22	ENST00000429820.1 ENST00000379587.4	ITIH2	inter-alpha-trypsin inhibitor heavy chain 2
chr8_-_27468842	2.11	ENST00000523500.1	CLU	clusterin
chr11_-_2162162	2.09	ENST00000381389.1	IGF2	insulin-like growth factor 2 (somatomedin A)
chr10_+_7745232	2.07	ENST00000358415.4	ITIH2	inter-alpha-trypsin inhibitor heavy chain 2
chr19_-_10697895	1.86	ENST00000591240.1 ENST00000589684.1 ENST00000591676.1 ENST00000250244.6 ENST00000590923.1	AP1M2	adaptor-related protein complex 1, mu 2 subunit
chr16_-_55867146	1.82	ENST00000422046.2	CES1	carboxylesterase 1
chr8_-_27468945	1.81	ENST00000405140.3	CLU	clusterin
chr3_-_145878954	1.77	ENST00000282903.5 ENST00000360060.3	PLOD2	procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
chr3_-_149688655	1.76	ENST00000461930.1 ENST00000423691.2 ENST00000490975.1 ENST00000461868.1 ENST00000452853.2	PFN2	profilin 2
chr12_+_69742121	1.65	ENST00000261267.2 ENST00000549690.1 ENST00000548839.1	LYZ	lysozyme
chr8_-_27469196	1.65	ENST00000546343.1 ENST00000560566.1	CLU	clusterin
chr8_-_27462822	1.61	ENST00000522098.1	CLU	clusterin
chr4_+_166300084	1.59	ENST00000402744.4	CPE	carboxypeptidase E
chr2_+_24272576	1.55	ENST00000380986.4 ENST00000452109.1	FKBP1B	FK506 binding protein 1B, 12.6 kDa
chr2_+_8822113	1.55	ENST00000396290.1 ENST00000331129.3	ID2	inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
chr6_+_151561506	1.40	ENST00000253332.1	AKAP12	A kinase (PRKA) anchor protein 12
chr6_+_151561085	1.36	ENST00000402676.2	AKAP12	A kinase (PRKA) anchor protein 12
chr17_+_39975455	1.33	ENST00000455106.1	FKBP10	FK506 binding protein 10, 65 kDa
chr17_+_39975544	1.30	ENST00000544340.1	FKBP10	FK506 binding protein 10, 65 kDa
chr12_-_91539918	1.29	ENST00000548218.1	DCN	decorin
chr16_-_21431078	1.18	ENST00000458643.2	NPIPB3	nuclear pore complex interacting protein family, member B3
chr3_-_149093499	1.13	ENST00000472441.1	TM4SF1	transmembrane 4 L six family member 1
chr2_+_24272543	1.09	ENST00000380991.4	FKBP1B	FK506 binding protein 1B, 12.6 kDa
chr16_+_14805546	1.07	ENST00000552140.1	NPIPA3	nuclear pore complex interacting protein family, member A3
chr5_-_125930929	1.06	ENST00000553117.1 ENST00000447989.2 ENST00000409134.3	ALDH7A1	aldehyde dehydrogenase 7 family, member A1
chr16_+_16472912	1.05	ENST00000530217.2	NPIPA7	nuclear pore complex interacting protein family, member A7
chr3_-_129612394	0.95	ENST00000505616.1 ENST00000426664.2	TMCC1	transmembrane and coiled-coil domain family 1
chr16_-_15472151	0.94	ENST00000360151.4 ENST00000543801.1	NPIPA5	nuclear pore complex interacting protein family, member A5
chr8_+_40010989	0.91	ENST00000315792.3	C8orf4	chromosome 8 open reading frame 4
chr1_-_153517473	0.85	ENST00000368715.1	S100A4	S100 calcium binding protein A4
chr20_+_34742650	0.84	ENST00000373945.1 ENST00000338074.2	EPB41L1	erythrocyte membrane protein band 4.1-like 1
chr1_-_92351769	0.78	ENST00000212355.4	TGFBR3	transforming growth factor, beta receptor III
chr11_+_114166536	0.77	ENST00000299964.3	NNMT	nicotinamide N-methyltransferase
chr1_-_45140074	0.73	ENST00000420706.1 ENST00000372235.3 ENST00000372242.3 ENST00000372243.3 ENST00000372244.3	TMEM53	transmembrane protein 53
chr8_-_119124045	0.70	ENST00000378204.2	EXT1	exostosin glycosyltransferase 1
chr13_-_38172863	0.70	ENST00000541481.1 ENST00000379743.4 ENST00000379742.4 ENST00000379749.4 ENST00000541179.1 ENST00000379747.4	POSTN	periostin, osteoblast specific factor
chr7_-_22233442	0.68	ENST00000401957.2	RAPGEF5	Rap guanine nucleotide exchange factor (GEF) 5
chr1_+_2005425	0.68	ENST00000461106.2	PRKCZ	protein kinase C, zeta
chr20_-_3154162	0.67	ENST00000360342.3	LZTS3	Homo sapiens leucine zipper, putative tumor suppressor family member 3 (LZTS3), mRNA.
chr10_+_60272814	0.67	ENST00000373886.3	BICC1	bicaudal C homolog 1 (Drosophila)
chr7_+_94139105	0.65	ENST00000297273.4	CASD1	CAS1 domain containing 1
chr17_-_3499125	0.65	ENST00000399759.3	TRPV1	transient receptor potential cation channel, subfamily V, member 1
chr6_-_52705641	0.65	ENST00000370989.2	GSTA5	glutathione S-transferase alpha 5
chr5_-_133702761	0.64	ENST00000521118.1 ENST00000265334.4 ENST00000435211.1	CDKL3	cyclin-dependent kinase-like 3
chr14_+_24702127	0.64	ENST00000557854.1 ENST00000348719.7 ENST00000559104.1 ENST00000456667.3	GMPR2	guanosine monophosphate reductase 2
chr18_+_3412005	0.64	ENST00000401449.1	TGIF1	TGFB-induced factor homeobox 1
chrX_-_10645773	0.63	ENST00000453318.2	MID1	midline 1 (Opitz/BBB syndrome)
chr1_-_20306909	0.62	ENST00000375111.3 ENST00000400520.3	PLA2G2A	phospholipase A2, group IIA (platelets, synovial fluid)
chr7_-_27170352	0.61	ENST00000428284.2 ENST00000360046.5	HOXA4	homeobox A4
chr1_+_205473720	0.61	ENST00000429964.2 ENST00000506784.1 ENST00000360066.2	CDK18	cyclin-dependent kinase 18
chr1_-_24469602	0.60	ENST00000270800.1	IL22RA1	interleukin 22 receptor, alpha 1
chr20_+_44036620	0.60	ENST00000372710.3	DBNDD2	dysbindin (dystrobrevin binding protein 1) domain containing 2
chr1_-_45140227	0.59	ENST00000372237.3	TMEM53	transmembrane protein 53
chr20_+_8112824	0.59	ENST00000378641.3	PLCB1	phospholipase C, beta 1 (phosphoinositide-specific)
chr20_+_36012051	0.58	ENST00000373567.2	SRC	v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr13_+_102104980	0.56	ENST00000545560.2	ITGBL1	integrin, beta-like 1 (with EGF-like repeat domains)
chr20_+_44036900	0.54	ENST00000443296.1	DBNDD2	dysbindin (dystrobrevin binding protein 1) domain containing 2
chr7_-_137028534	0.52	ENST00000348225.2	PTN	pleiotrophin
chr12_-_71533055	0.51	ENST00000552128.1	TSPAN8	tetraspanin 8
chr7_+_100136811	0.51	ENST00000300176.4 ENST00000262935.4	AGFG2	ArfGAP with FG repeats 2
chrX_-_13835147	0.50	ENST00000493677.1 ENST00000355135.2	GPM6B	glycoprotein M6B
chr15_-_74501310	0.50	ENST00000423167.2 ENST00000432245.2	STRA6	stimulated by retinoic acid 6
chrX_+_54834791	0.49	ENST00000218439.4 ENST00000375058.1 ENST00000375060.1	MAGED2	melanoma antigen family D, 2
chr13_+_102104952	0.48	ENST00000376180.3	ITGBL1	integrin, beta-like 1 (with EGF-like repeat domains)
chrX_+_70443050	0.47	ENST00000361726.6	GJB1	gap junction protein, beta 1, 32kDa
chr7_-_137028498	0.47	ENST00000393083.2	PTN	pleiotrophin
chr15_-_74501360	0.47	ENST00000323940.5	STRA6	stimulated by retinoic acid 6
chr2_-_47142884	0.47	ENST00000409105.1 ENST00000409973.1 ENST00000409913.1 ENST00000319466.4	MCFD2	multiple coagulation factor deficiency 2
chr19_+_5681011	0.43	ENST00000581893.1 ENST00000411793.2 ENST00000301382.4 ENST00000581773.1 ENST00000423665.2 ENST00000583928.1 ENST00000342970.2 ENST00000422535.2 ENST00000581521.1 ENST00000339423.2	HSD11B1L	hydroxysteroid (11-beta) dehydrogenase 1-like
chr19_-_33360647	0.42	ENST00000590341.1 ENST00000587772.1 ENST00000023064.4	SLC7A9	solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9
chr2_-_190044480	0.42	ENST00000374866.3	COL5A2	collagen, type V, alpha 2
chr16_+_66914264	0.40	ENST00000311765.2 ENST00000568869.1 ENST00000561704.1 ENST00000568398.1 ENST00000566776.1	PDP2	pyruvate dehyrogenase phosphatase catalytic subunit 2
chr1_+_10271674	0.40	ENST00000377086.1	KIF1B	kinesin family member 1B
chr1_+_162602244	0.36	ENST00000367922.3 ENST00000367921.3	DDR2	discoidin domain receptor tyrosine kinase 2
chr13_-_36050819	0.35	ENST00000379919.4	MAB21L1	mab-21-like 1 (C. elegans)
chr8_+_104152922	0.35	ENST00000309982.5 ENST00000438105.2 ENST00000297574.6	BAALC	brain and acute leukemia, cytoplasmic
chr14_-_23504432	0.34	ENST00000425762.2	PSMB5	proteasome (prosome, macropain) subunit, beta type, 5
chr12_-_123011476	0.34	ENST00000528279.1 ENST00000344591.4 ENST00000526560.2	RSRC2	arginine/serine-rich coiled-coil 2
chr17_-_1395954	0.33	ENST00000359786.5	MYO1C	myosin IC
chr14_-_23504337	0.32	ENST00000361611.6	PSMB5	proteasome (prosome, macropain) subunit, beta type, 5
chr5_+_125758865	0.31	ENST00000542322.1 ENST00000544396.1	GRAMD3	GRAM domain containing 3
chr10_+_89264625	0.30	ENST00000371996.4 ENST00000371994.4	MINPP1	multiple inositol-polyphosphate phosphatase 1
chr18_-_74207146	0.30	ENST00000443185.2	ZNF516	zinc finger protein 516
chr10_-_126849068	0.30	ENST00000494626.2 ENST00000337195.5	CTBP2	C-terminal binding protein 2
chr7_+_79765071	0.29	ENST00000457358.2	GNAI1	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
chr6_+_43395272	0.29	ENST00000372530.4	ABCC10	ATP-binding cassette, sub-family C (CFTR/MRP), member 10
chr17_-_15502111	0.27	ENST00000354433.3	CDRT1	CMT1A duplicated region transcript 1
chr11_+_7626950	0.27	ENST00000530181.1	PPFIBP2	PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr12_-_23737534	0.25	ENST00000396007.2	SOX5	SRY (sex determining region Y)-box 5
chr14_-_23822061	0.25	ENST00000397260.3	SLC22A17	solute carrier family 22, member 17
chr2_+_27255806	0.24	ENST00000238788.9 ENST00000404032.3	TMEM214	transmembrane protein 214
chr22_-_39190116	0.24	ENST00000406622.1 ENST00000216068.4 ENST00000406199.3	SUN2 DNAL4	Sad1 and UNC84 domain containing 2 dynein, axonemal, light chain 4
chr8_+_37887772	0.22	ENST00000338825.4	EIF4EBP1	eukaryotic translation initiation factor 4E binding protein 1
chr5_+_162864575	0.21	ENST00000512163.1 ENST00000393929.1 ENST00000340828.2 ENST00000511683.2 ENST00000510097.1 ENST00000511490.2 ENST00000510664.1	CCNG1	cyclin G1
chr2_-_79313973	0.21	ENST00000454188.1	REG1B	regenerating islet-derived 1 beta
chr9_-_89562104	0.20	ENST00000298743.7	GAS1	growth arrest-specific 1
chr1_-_111061797	0.20	ENST00000369771.2	KCNA10	potassium voltage-gated channel, shaker-related subfamily, member 10
chr20_+_60174827	0.20	ENST00000543233.1	CDH4	cadherin 4, type 1, R-cadherin (retinal)
chr16_+_15596123	0.19	ENST00000452191.2	C16orf45	chromosome 16 open reading frame 45
chr2_+_162016916	0.19	ENST00000405852.1	TANK	TRAF family member-associated NFKB activator
chr1_-_241520385	0.18	ENST00000366564.1	RGS7	regulator of G-protein signaling 7
chr1_+_2160134	0.18	ENST00000378536.4	SKI	v-ski avian sarcoma viral oncogene homolog
chr1_-_217804377	0.18	ENST00000366935.3 ENST00000366934.3	GPATCH2	G patch domain containing 2
chr2_+_161993412	0.18	ENST00000259075.2 ENST00000432002.1	TANK	TRAF family member-associated NFKB activator
chr2_+_264913	0.18	ENST00000439645.2 ENST00000405233.1	ACP1	acid phosphatase 1, soluble
chr10_-_79397391	0.17	ENST00000286628.8 ENST00000406533.3 ENST00000354353.5 ENST00000404857.1	KCNMA1	potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chr10_-_65028817	0.17	ENST00000542921.1	JMJD1C	jumonji domain containing 1C
chr4_+_71587669	0.17	ENST00000381006.3 ENST00000226328.4	RUFY3	RUN and FYVE domain containing 3
chr17_+_26989109	0.17	ENST00000314616.6 ENST00000347486.4	SUPT6H	suppressor of Ty 6 homolog (S. cerevisiae)
chr1_-_103574024	0.16	ENST00000512756.1 ENST00000370096.3 ENST00000358392.2 ENST00000353414.4	COL11A1	collagen, type XI, alpha 1
chr2_-_50574856	0.16	ENST00000342183.5	NRXN1	neurexin 1
chr11_+_3666335	0.16	ENST00000250693.1	ART1	ADP-ribosyltransferase 1
chr2_+_238600933	0.16	ENST00000420665.1 ENST00000392000.4	LRRFIP1	leucine rich repeat (in FLII) interacting protein 1
chr12_-_101604185	0.15	ENST00000536262.2	SLC5A8	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
chr7_-_99332719	0.15	ENST00000336374.2	CYP3A7	cytochrome P450, family 3, subfamily A, polypeptide 7
chr1_-_7913089	0.15	ENST00000361696.5	UTS2	urotensin 2
chr1_+_12916941	0.14	ENST00000240189.2	PRAMEF2	PRAME family member 2
chr5_+_175792459	0.14	ENST00000310389.5	ARL10	ADP-ribosylation factor-like 10
chr2_+_162016827	0.14	ENST00000429217.1 ENST00000406287.1 ENST00000402568.1	TANK	TRAF family member-associated NFKB activator
chr7_-_100808394	0.14	ENST00000445482.2	VGF	VGF nerve growth factor inducible
chr19_-_39368887	0.14	ENST00000340740.3 ENST00000591812.1	RINL	Ras and Rab interactor-like
chr1_+_3614591	0.14	ENST00000378290.4	TP73	tumor protein p73
chr2_+_161993465	0.13	ENST00000457476.1	TANK	TRAF family member-associated NFKB activator
chr12_-_123011536	0.13	ENST00000331738.7 ENST00000354654.2	RSRC2	arginine/serine-rich coiled-coil 2
chr3_-_113918254	0.13	ENST00000460779.1	DRD3	dopamine receptor D3
chr3_+_148709128	0.13	ENST00000345003.4 ENST00000296048.6 ENST00000483267.1	GYG1	glycogenin 1
chr19_-_40732594	0.13	ENST00000430325.2 ENST00000433940.1	CNTD2	cyclin N-terminal domain containing 2
chr19_+_13875316	0.13	ENST00000319545.8 ENST00000593245.1 ENST00000040663.6	MRI1	methylthioribose-1-phosphate isomerase 1
chr7_-_994302	0.13	ENST00000265846.5	ADAP1	ArfGAP with dual PH domains 1
chr2_+_162016804	0.12	ENST00000392749.2 ENST00000440506.1	TANK	TRAF family member-associated NFKB activator
chr16_+_71660079	0.12	ENST00000565261.1 ENST00000268485.3 ENST00000299952.4	MARVELD3	MARVEL domain containing 3
chr19_+_54371114	0.12	ENST00000448420.1 ENST00000439000.1 ENST00000391770.4 ENST00000391771.1	MYADM	myeloid-associated differentiation marker
chr21_-_46340884	0.11	ENST00000302347.5 ENST00000517819.1	ITGB2	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr8_-_101734907	0.11	ENST00000318607.5 ENST00000521865.1 ENST00000520804.1 ENST00000522720.1 ENST00000521067.1	PABPC1	poly(A) binding protein, cytoplasmic 1
chr9_+_33795533	0.11	ENST00000379405.3	PRSS3	protease, serine, 3
chr10_-_33623310	0.11	ENST00000395995.1 ENST00000374823.5 ENST00000374821.5 ENST00000374816.3	NRP1	neuropilin 1
chr3_-_150920979	0.11	ENST00000309180.5 ENST00000480322.1	GPR171	G protein-coupled receptor 171
chr6_+_32006159	0.10	ENST00000478281.1 ENST00000471671.1 ENST00000435122.2	CYP21A2	cytochrome P450, family 21, subfamily A, polypeptide 2
chr15_-_63674034	0.10	ENST00000344366.3 ENST00000422263.2	CA12	carbonic anhydrase XII
chr22_+_35695793	0.10	ENST00000456128.1 ENST00000449058.2 ENST00000411850.1 ENST00000425375.1 ENST00000436462.2 ENST00000382034.5	TOM1	target of myb1 (chicken)
chr2_-_44588679	0.10	ENST00000409411.1	PREPL	prolyl endopeptidase-like
chr17_+_72270429	0.10	ENST00000311014.6	DNAI2	dynein, axonemal, intermediate chain 2
chr3_+_49059038	0.10	ENST00000451378.2	NDUFAF3	NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
chr19_+_19144384	0.10	ENST00000392335.2 ENST00000535612.1 ENST00000537263.1 ENST00000540707.1 ENST00000541725.1 ENST00000269932.6 ENST00000546344.1 ENST00000540792.1 ENST00000536098.1 ENST00000541898.1 ENST00000543877.1	ARMC6	armadillo repeat containing 6
chr16_+_30080857	0.09	ENST00000565355.1	ALDOA	aldolase A, fructose-bisphosphate
chr1_+_68150744	0.09	ENST00000370986.4 ENST00000370985.3	GADD45A	growth arrest and DNA-damage-inducible, alpha
chr2_-_44588694	0.09	ENST00000409957.1	PREPL	prolyl endopeptidase-like
chr3_+_159557637	0.08	ENST00000445224.2	SCHIP1	schwannomin interacting protein 1
chr17_-_44896047	0.08	ENST00000225512.5	WNT3	wingless-type MMTV integration site family, member 3
chr2_-_71062938	0.08	ENST00000410009.3	CD207	CD207 molecule, langerin
chr17_-_42277203	0.08	ENST00000587097.1	ATXN7L3	ataxin 7-like 3
chr1_-_12958101	0.07	ENST00000235347.4	PRAMEF10	PRAME family member 10
chr7_-_100808843	0.07	ENST00000249330.2	VGF	VGF nerve growth factor inducible
chr6_+_121756809	0.07	ENST00000282561.3	GJA1	gap junction protein, alpha 1, 43kDa
chr19_+_54641444	0.07	ENST00000221232.5 ENST00000358389.3	CNOT3	CCR4-NOT transcription complex, subunit 3
chr1_-_13452656	0.07	ENST00000376132.3	PRAMEF13	PRAME family member 13
chr7_+_139529040	0.07	ENST00000455353.1 ENST00000458722.1 ENST00000411653.1	TBXAS1	thromboxane A synthase 1 (platelet)
chr6_+_32006042	0.07	ENST00000418967.2	CYP21A2	cytochrome P450, family 21, subfamily A, polypeptide 2
chr19_-_42192096	0.07	ENST00000602225.1	CEACAM7	carcinoembryonic antigen-related cell adhesion molecule 7
chr11_+_60739249	0.06	ENST00000542157.1 ENST00000433107.2 ENST00000452451.2 ENST00000352009.5	CD6	CD6 molecule
chr1_+_17634689	0.06	ENST00000375453.1 ENST00000375448.4	PADI4	peptidyl arginine deiminase, type IV
chr3_+_111260856	0.06	ENST00000352690.4	CD96	CD96 molecule
chr1_-_157014865	0.06	ENST00000361409.2	ARHGEF11	Rho guanine nucleotide exchange factor (GEF) 11
chr8_+_22132847	0.06	ENST00000521356.1	PIWIL2	piwi-like RNA-mediated gene silencing 2
chr9_+_35829208	0.06	ENST00000439587.2 ENST00000377991.4	TMEM8B	transmembrane protein 8B
chrM_+_4431	0.06	ENST00000361453.3	MT-ND2	mitochondrially encoded NADH dehydrogenase 2
chr9_-_97402413	0.06	ENST00000414122.1	FBP1	fructose-1,6-bisphosphatase 1
chr7_+_139528952	0.05	ENST00000416849.2 ENST00000436047.2 ENST00000414508.2 ENST00000448866.1	TBXAS1	thromboxane A synthase 1 (platelet)
chr1_+_178062855	0.05	ENST00000448150.3	RASAL2	RAS protein activator like 2
chr19_-_51192661	0.05	ENST00000391813.1	SHANK1	SH3 and multiple ankyrin repeat domains 1
chr12_-_121342170	0.05	ENST00000353487.2	SPPL3	signal peptide peptidase like 3
chr20_+_46130619	0.05	ENST00000372004.3	NCOA3	nuclear receptor coactivator 3
chr1_-_13673511	0.04	ENST00000344998.3 ENST00000334600.6	PRAMEF14	PRAME family member 14
chr8_+_22132810	0.04	ENST00000356766.6	PIWIL2	piwi-like RNA-mediated gene silencing 2
chr7_+_97736197	0.04	ENST00000297293.5	LMTK2	lemur tyrosine kinase 2
chr10_-_103599591	0.04	ENST00000348850.5	KCNIP2	Kv channel interacting protein 2
chr5_+_54398463	0.04	ENST00000274306.6	GZMA	granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr4_+_148402069	0.04	ENST00000358556.4 ENST00000339690.5 ENST00000511804.1 ENST00000324300.5	EDNRA	endothelin receptor type A
chr11_+_118754475	0.04	ENST00000292174.4	CXCR5	chemokine (C-X-C motif) receptor 5
chr22_+_29834572	0.04	ENST00000354373.2	RFPL1	ret finger protein-like 1
chr12_-_21927736	0.04	ENST00000240662.2	KCNJ8	potassium inwardly-rectifying channel, subfamily J, member 8
chr16_+_25228242	0.04	ENST00000219660.5	AQP8	aquaporin 8
chr11_+_63870660	0.04	ENST00000246841.3	FLRT1	fibronectin leucine rich transmembrane protein 1
chr15_-_63674218	0.04	ENST00000178638.3	CA12	carbonic anhydrase XII
chr9_-_21994597	0.03	ENST00000579755.1	CDKN2A	cyclin-dependent kinase inhibitor 2A
chr19_+_1026298	0.03	ENST00000263097.4	CNN2	calponin 2
chr4_+_154178520	0.03	ENST00000433687.1	TRIM2	tripartite motif containing 2
chr5_+_36876833	0.03	ENST00000282516.8 ENST00000448238.2	NIPBL	Nipped-B homolog (Drosophila)
chr2_+_264869	0.03	ENST00000272067.6 ENST00000272065.5 ENST00000407983.3	ACP1	acid phosphatase 1, soluble
chr10_-_98945515	0.03	ENST00000371070.4	SLIT1	slit homolog 1 (Drosophila)
chrX_+_9217932	0.03	ENST00000432442.1	GS1-519E5.1	GS1-519E5.1
chr10_-_134756030	0.03	ENST00000368586.5 ENST00000368582.2	TTC40	tetratricopeptide repeat domain 40
chr16_-_9030515	0.02	ENST00000535863.1 ENST00000381886.4	USP7	ubiquitin specific peptidase 7 (herpes virus-associated)
chr17_+_79495397	0.02	ENST00000417245.2 ENST00000334850.7	FSCN2	fascin homolog 2, actin-bundling protein, retinal (Strongylocentrotus purpuratus)
chr5_-_177210399	0.02	ENST00000510276.1	FAM153A	family with sequence similarity 153, member A
chr19_+_58193337	0.02	ENST00000601064.1 ENST00000282296.5 ENST00000356715.4	ZNF551	zinc finger protein 551
chr2_+_181845074	0.02	ENST00000602959.1 ENST00000602479.1 ENST00000392415.2 ENST00000602291.1	UBE2E3	ubiquitin-conjugating enzyme E2E 3
chr14_+_24779340	0.02	ENST00000533293.1 ENST00000543919.1	LTB4R2	leukotriene B4 receptor 2

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	4.5	GO:0033093	Weibel-Palade body(GO:0033093)
0.3	1.0	GO:1990876	cytoplasmic side of nuclear pore(GO:1990876)
0.2	0.9	GO:0034751	aryl hydrocarbon receptor complex(GO:0034751)
0.2	0.8	GO:1990578	perinuclear endoplasmic reticulum membrane(GO:1990578)
0.2	0.9	GO:0044530	supraspliceosomal complex(GO:0044530)
0.2	0.7	GO:1990423	RZZ complex(GO:1990423)
0.2	1.0	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.1	1.4	GO:0031209	SCAR complex(GO:0031209)
0.1	2.2	GO:0071564	npBAF complex(GO:0071564)
0.1	0.6	GO:0000347	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1	0.5	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1	1.0	GO:0000788	nuclear nucleosome(GO:0000788)
0.1	0.4	GO:0097179	protease inhibitor complex(GO:0097179)
0.1	0.7	GO:0097427	microtubule bundle(GO:0097427)
0.1	0.3	GO:0033186	CAF-1 complex(GO:0033186)
0.1	0.4	GO:1990589	ATF4-CREB1 transcription factor complex(GO:1990589)
0.1	1.1	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1	0.2	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.2	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
0.0	1.2	GO:0000178	exosome (RNase complex)(GO:0000178)
0.0	0.3	GO:1990111	spermatoproteasome complex(GO:1990111)
0.0	3.2	GO:0035577	azurophil granule membrane(GO:0035577)
0.0	1.7	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.0	0.1	GO:0033150	perinuclear theca(GO:0033011) cytoskeletal calyx(GO:0033150)
0.0	0.1	GO:0097679	other organism cytoplasm(GO:0097679)
0.0	0.5	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.0	0.2	GO:0042382	paraspeckles(GO:0042382)
0.0	0.3	GO:0005642	annulate lamellae(GO:0005642)
0.0	0.3	GO:0070531	BRCA1-A complex(GO:0070531)
0.0	0.2	GO:0005750	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0	0.2	GO:0097025	lateral loop(GO:0043219) MPP7-DLG1-LIN7 complex(GO:0097025)
0.0	2.0	GO:0000784	nuclear chromosome, telomeric region(GO:0000784)
0.0	0.6	GO:0001533	cornified envelope(GO:0001533)
0.0	0.7	GO:0001917	photoreceptor inner segment(GO:0001917)
0.0	2.1	GO:0045111	intermediate filament cytoskeleton(GO:0045111)
0.0	0.1	GO:0031595	nuclear proteasome complex(GO:0031595)
0.0	0.6	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	0.1	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.0	1.1	GO:0042734	presynaptic membrane(GO:0042734)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	3.1	GO:0005583	fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.2	1.0	GO:0071148	TEAD-1-YAP complex(GO:0071148)
0.2	2.7	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.2	2.7	GO:0005916	fascia adherens(GO:0005916)
0.2	1.0	GO:1902560	GMP reductase complex(GO:1902560)
0.2	3.5	GO:0001527	microfibril(GO:0001527) fibril(GO:0043205)
0.1	0.6	GO:0070369	beta-catenin-TCF7L2 complex(GO:0070369) catenin-TCF7L2 complex(GO:0071664)
0.1	1.1	GO:0071953	elastic fiber(GO:0071953)
0.1	0.3	GO:0043512	inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.1	3.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.1	0.4	GO:0030991	intraciliary transport particle A(GO:0030991)
0.1	4.4	GO:0097610	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1	0.9	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.9	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.3	GO:1990037	Lewy body core(GO:1990037)
0.0	2.3	GO:0035577	azurophil granule membrane(GO:0035577)
0.0	1.8	GO:0005844	polysome(GO:0005844)
0.0	2.5	GO:0035580	specific granule lumen(GO:0035580)
0.0	0.2	GO:0005784	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0	0.8	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
0.0	0.4	GO:0005652	nuclear lamina(GO:0005652)
0.0	0.3	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.6	GO:0031307	integral component of mitochondrial outer membrane(GO:0031307)
0.0	0.7	GO:0090665	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0	0.8	GO:0005720	nuclear heterochromatin(GO:0005720)
0.0	0.4	GO:0097546	ciliary base(GO:0097546)
0.0	1.6	GO:0016459	myosin complex(GO:0016459)
0.0	0.5	GO:0005868	cytoplasmic dynein complex(GO:0005868)
0.0	0.3	GO:0044295	axonal growth cone(GO:0044295)
0.0	0.7	GO:0031941	filamentous actin(GO:0031941)
0.0	0.3	GO:0097342	ripoptosome(GO:0097342)
0.0	0.1	GO:0005721	pericentric heterochromatin(GO:0005721)

Gene overrepresentation in C2:CP category:

Total log-likelihood	Term	Description
1.0	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
2.1	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.2	ST STAT3 PATHWAY	STAT3 Pathway
0.8	PID IL5 PATHWAY	IL5-mediated signaling events
2.8	PID AR TF PATHWAY	Regulation of Androgen receptor activity
1.7	NABA PROTEOGLYCANS	Genes encoding proteoglycans
2.5	PID NOTCH PATHWAY	Notch signaling pathway
0.5	PID IL27 PATHWAY	IL27-mediated signaling events
0.2	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.4	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
1.2	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.9	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
1.2	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
1.2	PID IL4 2PATHWAY	IL4-mediated signaling events
1.0	PID BMP PATHWAY	BMP receptor signaling
0.3	PID S1P S1P1 PATHWAY	S1P1 pathway
0.3	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.2	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.5	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.4	PID EPHA FWDPATHWAY	EPHA forward signaling
0.6	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.3	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.4	PID TGFBR PATHWAY	TGF-beta receptor signaling

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.7	3.7	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.7	2.2	GO:0016603	glutaminyl-peptide cyclotransferase activity(GO:0016603)
0.7	3.5	GO:0050436	microfibril binding(GO:0050436)
0.5	2.7	GO:0086075	gap junction channel activity involved in cardiac conduction electrical coupling(GO:0086075)
0.5	1.6	GO:0047273	galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273)
0.3	3.1	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.2	0.7	GO:0070538	oleic acid binding(GO:0070538)
0.2	1.0	GO:0003920	GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.1	0.8	GO:0070892	lipoteichoic acid receptor activity(GO:0070892)
0.1	0.6	GO:0047006	17-alpha,20-alpha-dihydroxypregn-4-en-3-one dehydrogenase activity(GO:0047006)
0.1	0.8	GO:0002114	interleukin-33 receptor activity(GO:0002114)
0.1	0.8	GO:0035368	selenocysteine insertion sequence binding(GO:0035368)
0.1	0.3	GO:0070699	type II activin receptor binding(GO:0070699)
0.1	1.1	GO:0045159	myosin II binding(GO:0045159)
0.1	0.3	GO:0000773	phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101)
0.1	0.2	GO:0004947	bradykinin receptor activity(GO:0004947)
0.1	0.6	GO:0035374	chondroitin sulfate binding(GO:0035374)
0.1	0.8	GO:0001011	transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1	0.9	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.1	1.2	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.1	0.3	GO:0097199	cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097199)
0.0	0.3	GO:0035800	deubiquitinase activator activity(GO:0035800)
0.0	0.4	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.0	0.4	GO:0005000	vasopressin receptor activity(GO:0005000)
0.0	1.7	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.8	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0	0.4	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	2.7	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.6	GO:0015643	toxic substance binding(GO:0015643)
0.0	0.6	GO:0045295	gamma-catenin binding(GO:0045295)
0.0	1.0	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.4	GO:1904264	ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0	0.4	GO:0032036	myosin heavy chain binding(GO:0032036)
0.0	0.1	GO:0046848	hydroxyapatite binding(GO:0046848)
0.0	0.1	GO:0070404	NADH binding(GO:0070404)
0.0	0.1	GO:0004958	prostaglandin F receptor activity(GO:0004958)
0.0	0.1	GO:0043515	kinetochore binding(GO:0043515)
0.0	1.8	GO:0019843	rRNA binding(GO:0019843)
0.0	0.5	GO:0045504	dynein heavy chain binding(GO:0045504)
0.0	2.0	GO:0004714	transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.0	0.1	GO:0004741	[pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.0	1.1	GO:0005044	scavenger receptor activity(GO:0005044)
0.0	0.7	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.3	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	2.8	GO:0005178	integrin binding(GO:0005178)
0.0	0.1	GO:0050682	AF-2 domain binding(GO:0050682)
0.0	0.0	GO:0016672	oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
0.0	0.1	GO:0046935	phosphatidylinositol 3-kinase regulator activity(GO:0035014) 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.0	0.2	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.1	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	1.1	GO:0004702	receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0	0.1	GO:0005132	type I interferon receptor binding(GO:0005132)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.6	5.8	GO:0016724	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.2	0.7	GO:0061752	telomeric repeat-containing RNA binding(GO:0061752)
0.2	2.3	GO:0001011	transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.1	0.9	GO:0052655	branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1	0.6	GO:0051373	FATZ binding(GO:0051373)
0.1	0.4	GO:0004819	glutamine-tRNA ligase activity(GO:0004819) valine-tRNA ligase activity(GO:0004832)
0.1	0.3	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1	0.6	GO:0032558	adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.1	1.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.1	0.3	GO:0016749	5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.1	0.5	GO:0070728	leucine binding(GO:0070728)
0.1	0.3	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.1	0.3	GO:0031694	alpha-2A adrenergic receptor binding(GO:0031694)
0.1	0.4	GO:0072320	volume-sensitive chloride channel activity(GO:0072320)
0.1	0.3	GO:0035673	oligopeptide transmembrane transporter activity(GO:0035673)
0.1	0.3	GO:0034988	Fc-gamma receptor I complex binding(GO:0034988)
0.1	0.3	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
0.1	0.2	GO:0004574	oligo-1,6-glucosidase activity(GO:0004574)
0.0	0.2	GO:0004815	aspartate-tRNA ligase activity(GO:0004815)
0.0	0.3	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.4	GO:0004321	fatty-acyl-CoA synthase activity(GO:0004321)
0.0	1.0	GO:0051371	muscle alpha-actinin binding(GO:0051371)
0.0	0.3	GO:0005353	fructose transmembrane transporter activity(GO:0005353)
0.0	0.2	GO:0047708	biotinidase activity(GO:0047708)
0.0	0.4	GO:0036402	proteasome-activating ATPase activity(GO:0036402)
0.0	1.1	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.3	GO:0030621	U4 snRNA binding(GO:0030621)
0.0	1.0	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.2	GO:0051870	methotrexate binding(GO:0051870)
0.0	0.4	GO:1902282	voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1902282)
0.0	0.1	GO:0035276	ethanol binding(GO:0035276)
0.0	0.3	GO:0001849	complement component C1q binding(GO:0001849)
0.0	0.1	GO:0050528	acyloxyacyl hydrolase activity(GO:0050528)
0.0	0.1	GO:0034041	sterol-transporting ATPase activity(GO:0034041)
0.0	0.4	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.3	GO:0035312	5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0	0.1	GO:0005148	prolactin receptor binding(GO:0005148)
0.0	0.4	GO:0005344	oxygen transporter activity(GO:0005344)
0.0	0.1	GO:0070139	ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0	0.1	GO:0003923	GPI-anchor transamidase activity(GO:0003923)
0.0	0.2	GO:0043183	vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0	0.1	GO:0004905	type I interferon receptor activity(GO:0004905)
0.0	0.1	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.2	GO:0003705	transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0	0.2	GO:0043142	single-stranded DNA-dependent ATPase activity(GO:0043142)
0.0	0.5	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.6	GO:0031489	myosin V binding(GO:0031489)
0.0	0.6	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0051120	hepoxilin A3 synthase activity(GO:0051120)
0.0	0.1	GO:0099580	ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.0	0.1	GO:0008934	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.1	GO:0034046	poly(G) binding(GO:0034046)
0.0	0.4	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)
0.0	0.1	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.1	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0	0.7	GO:0004003	ATP-dependent DNA helicase activity(GO:0004003)
0.0	0.6	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.1	GO:0008422	beta-glucosidase activity(GO:0008422)
0.0	0.1	GO:0047237	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237)
0.0	0.3	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.2	GO:0004064	arylesterase activity(GO:0004064)
0.0	0.3	GO:0003691	double-stranded telomeric DNA binding(GO:0003691)
0.0	0.3	GO:0005132	type I interferon receptor binding(GO:0005132)
0.0	0.2	GO:0070915	lysophosphatidic acid receptor activity(GO:0070915)
0.0	0.1	GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.0	0.1	GO:0042296	ISG15 transferase activity(GO:0042296)
0.0	0.3	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.2	GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0	0.2	GO:0004707	MAP kinase activity(GO:0004707)
0.0	0.2	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)
0.0	0.2	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.6	GO:0042605	peptide antigen binding(GO:0042605)
0.0	0.1	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
0.0	0.1	GO:0008172	S-methyltransferase activity(GO:0008172)
0.0	0.2	GO:0005243	gap junction channel activity(GO:0005243)
0.0	0.4	GO:0015269	calcium-activated potassium channel activity(GO:0015269)
0.0	0.2	GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0	0.2	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.1	GO:0001594	trace-amine receptor activity(GO:0001594)
0.0	0.1	GO:0016846	carbon-sulfur lyase activity(GO:0016846)
0.0	0.4	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.0	0.4	GO:0001965	G-protein alpha-subunit binding(GO:0001965)
0.0	1.4	GO:0003707	steroid hormone receptor activity(GO:0003707)
0.0	0.2	GO:0034450	ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0	0.1	GO:1904264	ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0	0.2	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.0	GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.0	0.4	GO:0019865	immunoglobulin binding(GO:0019865)
0.0	0.3	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.0	0.0	GO:0005412	glucose:sodium symporter activity(GO:0005412)
0.0	0.4	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0	0.1	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.1	GO:0042731	PH domain binding(GO:0042731)
0.0	0.2	GO:0017049	GTP-Rho binding(GO:0017049)
0.0	0.1	GO:0001515	opioid peptide activity(GO:0001515)

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.3	GO:0035690	cellular response to drug(GO:0035690)
0.2	0.7	GO:0046098	guanine metabolic process(GO:0046098)
0.2	5.8	GO:0006825	copper ion transport(GO:0006825)
0.2	1.0	GO:1903385	regulation of homophilic cell adhesion(GO:1903385)
0.1	0.7	GO:1990034	calcium ion export from cell(GO:1990034)
0.1	0.9	GO:0009082	branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.1	0.8	GO:0071233	cellular response to leucine(GO:0071233)
0.1	0.5	GO:0031860	telomeric 3' overhang formation(GO:0031860)
0.1	1.1	GO:0035799	ureter maturation(GO:0035799)
0.1	0.4	GO:2000342	negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.1	0.3	GO:0021538	epithalamus development(GO:0021538) habenula development(GO:0021986)
0.1	0.4	GO:1901979	regulation of inward rectifier potassium channel activity(GO:1901979)
0.1	0.6	GO:1903435	positive regulation of constitutive secretory pathway(GO:1903435)
0.1	0.3	GO:0099543	retrograde trans-synaptic signaling by soluble gas(GO:0098923) trans-synaptic signaling by soluble gas(GO:0099543) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.1	0.3	GO:0007412	axon target recognition(GO:0007412)
0.1	0.3	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.1	0.4	GO:0048388	endosomal lumen acidification(GO:0048388)
0.1	0.2	GO:0006422	aspartyl-tRNA aminoacylation(GO:0006422)
0.1	0.6	GO:0002074	extraocular skeletal muscle development(GO:0002074)
0.1	0.5	GO:0035542	regulation of SNARE complex assembly(GO:0035542)
0.1	0.4	GO:0061737	leukotriene signaling pathway(GO:0061737)
0.1	0.3	GO:0090309	positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.1	0.2	GO:0007509	mesoderm migration involved in gastrulation(GO:0007509)
0.1	0.2	GO:0060369	positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.1	0.3	GO:0002314	germinal center B cell differentiation(GO:0002314)
0.1	1.0	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1	0.2	GO:0003331	regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.1	0.3	GO:0052199	negative regulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052199)
0.1	0.4	GO:0098532	histone H3-K27 trimethylation(GO:0098532)
0.1	0.2	GO:0046452	dihydrofolate metabolic process(GO:0046452)
0.1	0.2	GO:0001555	oocyte growth(GO:0001555)
0.0	0.2	GO:0018352	protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.0	0.2	GO:0072658	positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0	0.1	GO:0010430	fatty acid omega-oxidation(GO:0010430)
0.0	0.3	GO:1902894	negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.0	0.2	GO:1903660	negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.0	0.3	GO:0048254	snoRNA localization(GO:0048254)
0.0	0.3	GO:1990539	fructose transport(GO:0015755) fructose import(GO:0032445) carbohydrate import into cell(GO:0097319) carbohydrate import across plasma membrane(GO:0098704) fructose import across plasma membrane(GO:1990539)
0.0	0.1	GO:1990414	replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.0	0.2	GO:0039534	negative regulation of MDA-5 signaling pathway(GO:0039534)
0.0	0.2	GO:0015722	canalicular bile acid transport(GO:0015722)
0.0	0.2	GO:0006574	valine catabolic process(GO:0006574)
0.0	0.3	GO:0051001	negative regulation of nitric-oxide synthase activity(GO:0051001)
0.0	0.1	GO:0010760	negative regulation of macrophage chemotaxis(GO:0010760)
0.0	0.2	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
0.0	0.6	GO:0090360	platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0	0.1	GO:1904751	positive regulation of protein localization to nucleolus(GO:1904751)
0.0	0.2	GO:0002175	protein localization to paranode region of axon(GO:0002175)
0.0	0.1	GO:0032672	response to molecule of fungal origin(GO:0002238) regulation of interleukin-3 production(GO:0032672) positive regulation of interleukin-3 production(GO:0032752) interleukin-3 biosynthetic process(GO:0042223) regulation of interleukin-3 biosynthetic process(GO:0045399) positive regulation of interleukin-3 biosynthetic process(GO:0045401) cellular response to molecule of fungal origin(GO:0071226)
0.0	0.1	GO:1902626	assembly of large subunit precursor of preribosome(GO:1902626)
0.0	0.2	GO:0006611	protein export from nucleus(GO:0006611)
0.0	0.1	GO:0048213	Golgi vesicle prefusion complex stabilization(GO:0048213)
0.0	0.3	GO:0031848	protection from non-homologous end joining at telomere(GO:0031848)
0.0	0.3	GO:0043950	positive regulation of cAMP-mediated signaling(GO:0043950)
0.0	0.5	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
0.0	0.3	GO:0072221	metanephric part of ureteric bud development(GO:0035502) distal convoluted tubule development(GO:0072025) metanephric distal convoluted tubule development(GO:0072221)
0.0	0.1	GO:0002125	maternal aggressive behavior(GO:0002125) positive regulation of female receptivity(GO:0045925)
0.0	0.2	GO:0045876	positive regulation of sister chromatid cohesion(GO:0045876)
0.0	0.1	GO:0033625	positive regulation of integrin activation(GO:0033625)
0.0	0.2	GO:2000676	positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0	0.2	GO:0000393	spliceosomal conformational changes to generate catalytic conformation(GO:0000393)
0.0	0.2	GO:0060754	positive regulation of mast cell chemotaxis(GO:0060754)
0.0	0.3	GO:0036066	protein O-linked fucosylation(GO:0036066)
0.0	0.3	GO:0030263	resolution of meiotic recombination intermediates(GO:0000712) apoptotic chromosome condensation(GO:0030263)
0.0	0.6	GO:0072321	chaperone-mediated protein transport(GO:0072321)
0.0	0.2	GO:0010032	meiotic chromosome condensation(GO:0010032)
0.0	0.1	GO:0002101	tRNA wobble cytosine modification(GO:0002101)
0.0	0.1	GO:2001027	negative regulation of endothelial cell chemotaxis(GO:2001027)
0.0	0.1	GO:0051414	response to cortisol(GO:0051414)
0.0	0.1	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.2	GO:0001554	luteolysis(GO:0001554)
0.0	0.4	GO:0015671	oxygen transport(GO:0015671)
0.0	0.1	GO:0007525	somatic muscle development(GO:0007525)
0.0	0.1	GO:0036015	response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016)
0.0	0.3	GO:0032364	oxygen homeostasis(GO:0032364)
0.0	0.1	GO:0032900	negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804) negative regulation of neurotrophin production(GO:0032900) negative regulation of transforming growth factor beta1 production(GO:0032911)
0.0	0.2	GO:0042276	error-prone translesion synthesis(GO:0042276)
0.0	0.3	GO:0043306	positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
0.0	0.5	GO:0045899	positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
0.0	0.1	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0	0.1	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.2	GO:0090050	positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.1	GO:0019442	tryptophan catabolic process to acetyl-CoA(GO:0019442)
0.0	0.1	GO:0035948	positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.0	0.7	GO:0051894	positive regulation of focal adhesion assembly(GO:0051894)
0.0	0.4	GO:0046602	regulation of mitotic centrosome separation(GO:0046602)
0.0	0.1	GO:0055059	asymmetric neuroblast division(GO:0055059)
0.0	0.2	GO:0071688	striated muscle myosin thick filament assembly(GO:0071688)
0.0	0.2	GO:0016191	synaptic vesicle uncoating(GO:0016191)
0.0	0.1	GO:0032661	regulation of interleukin-18 production(GO:0032661)
0.0	0.2	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383)
0.0	0.1	GO:0006021	inositol biosynthetic process(GO:0006021)
0.0	0.2	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0	0.2	GO:1903830	magnesium ion transmembrane transport(GO:1903830)
0.0	0.1	GO:2000042	negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0	0.1	GO:0070129	regulation of mitochondrial translation(GO:0070129)
0.0	0.1	GO:0070537	histone H2A K63-linked deubiquitination(GO:0070537)
0.0	0.0	GO:0061113	pancreas morphogenesis(GO:0061113)
0.0	0.4	GO:0034389	lipid particle organization(GO:0034389)
0.0	0.3	GO:0021516	dorsal spinal cord development(GO:0021516)
0.0	0.1	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.0	0.2	GO:1903817	negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.0	0.1	GO:0051122	hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0	0.1	GO:0010982	regulation of high-density lipoprotein particle clearance(GO:0010982) positive regulation of lipoprotein particle clearance(GO:0010986)
0.0	0.1	GO:0032000	positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0	0.1	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.3	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0	0.0	GO:0070309	lens fiber cell morphogenesis(GO:0070309)
0.0	0.1	GO:0016926	protein desumoylation(GO:0016926)
0.0	0.0	GO:1900158	positive regulation of osteoclast proliferation(GO:0090290) negative regulation of bone mineralization involved in bone maturation(GO:1900158)
0.0	0.1	GO:0072369	regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
0.0	0.2	GO:1901898	negative regulation of relaxation of cardiac muscle(GO:1901898)
0.0	0.6	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0	0.4	GO:0009954	proximal/distal pattern formation(GO:0009954)
0.0	0.2	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.1	GO:0010578	regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010578) positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway(GO:0010579)
0.0	0.1	GO:0001507	acetylcholine catabolic process in synaptic cleft(GO:0001507) acetylcholine catabolic process(GO:0006581)
0.0	0.1	GO:0060842	arterial endothelial cell differentiation(GO:0060842)
0.0	0.1	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.1	GO:1903690	negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0	0.1	GO:0048023	positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0	0.1	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.0	0.1	GO:0030193	regulation of blood coagulation(GO:0030193) regulation of hemostasis(GO:1900046)
0.0	0.1	GO:0022405	hair follicle development(GO:0001942) molting cycle process(GO:0022404) hair cycle process(GO:0022405)
0.0	0.0	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.0	0.0	GO:0014807	regulation of somitogenesis(GO:0014807)
0.0	0.0	GO:0060474	positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0	0.1	GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.0	0.2	GO:0007597	blood coagulation, intrinsic pathway(GO:0007597)
0.0	0.2	GO:0043923	positive regulation by host of viral transcription(GO:0043923)
0.0	2.7	GO:0065004	protein-DNA complex assembly(GO:0065004)
0.0	0.2	GO:0048026	positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:0006878	cellular copper ion homeostasis(GO:0006878)
0.0	0.2	GO:0048934	peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0	0.1	GO:0044245	polysaccharide digestion(GO:0044245)
0.0	0.1	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
1.2	7.2	GO:0061517	macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.9	2.6	GO:0000412	histone peptidyl-prolyl isomerization(GO:0000412)
0.6	2.4	GO:0051541	elastin metabolic process(GO:0051541) negative regulation of blood vessel remodeling(GO:0060313)
0.6	1.8	GO:0046947	hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
0.5	1.5	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.3	0.7	GO:1990523	bone regeneration(GO:1990523)
0.3	1.0	GO:1904395	retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397)
0.3	1.6	GO:0016998	cell wall macromolecule catabolic process(GO:0016998)
0.3	1.6	GO:0030070	insulin processing(GO:0030070)
0.3	2.6	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.3	2.1	GO:2000467	positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.3	0.8	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.2	3.3	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.2	0.6	GO:1901594	detection of temperature stimulus involved in thermoception(GO:0050960) response to capsazepine(GO:1901594)
0.2	0.6	GO:0090427	activation of meiosis(GO:0090427)
0.2	1.0	GO:0061143	alveolar primary septum development(GO:0061143)
0.2	1.8	GO:0051791	medium-chain fatty acid metabolic process(GO:0051791)
0.2	1.1	GO:0042426	choline catabolic process(GO:0042426)
0.1	1.8	GO:1900028	negative regulation of ruffle assembly(GO:1900028)
0.1	0.6	GO:0071393	cellular response to progesterone stimulus(GO:0071393)
0.1	0.4	GO:1904647	response to rotenone(GO:1904647)
0.1	0.8	GO:2000158	positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.1	0.7	GO:2001181	positive regulation of interleukin-10 secretion(GO:2001181)
0.1	1.3	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1	0.4	GO:1903224	regulation of endodermal cell differentiation(GO:1903224)
0.1	0.2	GO:0043585	nose morphogenesis(GO:0043585)
0.1	0.9	GO:0034356	NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.1	4.3	GO:0030212	hyaluronan metabolic process(GO:0030212)
0.1	0.7	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1	0.5	GO:0070294	renal sodium ion absorption(GO:0070294)
0.1	0.3	GO:0015891	iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.1	0.5	GO:0051610	negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0	0.5	GO:0015865	purine nucleotide transport(GO:0015865) purine ribonucleotide transport(GO:0015868)
0.0	0.6	GO:0035372	protein localization to microtubule(GO:0035372)
0.0	0.2	GO:1903976	negative regulation of glial cell migration(GO:1903976)
0.0	0.3	GO:0055059	asymmetric neuroblast division(GO:0055059)
0.0	0.2	GO:0031022	nuclear migration along microfilament(GO:0031022)
0.0	1.9	GO:0050690	regulation of defense response to virus by virus(GO:0050690)
0.0	0.6	GO:0036148	phosphatidylglycerol acyl-chain remodeling(GO:0036148)
0.0	0.1	GO:0042320	positive regulation of circadian sleep/wake cycle, wakefulness(GO:0010841) regulation of circadian sleep/wake cycle, REM sleep(GO:0042320)
0.0	0.1	GO:0030718	germ-line stem cell population maintenance(GO:0030718)
0.0	0.2	GO:0010793	regulation of mRNA export from nucleus(GO:0010793)
0.0	0.1	GO:0050883	negative regulation of sodium:proton antiporter activity(GO:0032416) gastric motility(GO:0035482) gastric emptying(GO:0035483) musculoskeletal movement, spinal reflex action(GO:0050883)
0.0	0.3	GO:0048386	positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0	0.2	GO:0035989	tendon development(GO:0035989)
0.0	0.4	GO:0090091	positive regulation of extracellular matrix disassembly(GO:0090091)
0.0	0.1	GO:0090038	negative regulation of protein kinase C signaling(GO:0090038)
0.0	0.1	GO:0044339	canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339) Spemann organizer formation(GO:0060061)
0.0	0.3	GO:0038089	positive regulation of cell migration by vascular endothelial growth factor signaling pathway(GO:0038089)
0.0	0.1	GO:0015811	L-cystine transport(GO:0015811)
0.0	0.6	GO:0043101	purine-containing compound salvage(GO:0043101)
0.0	0.3	GO:1904322	response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.0	0.1	GO:0055064	chloride ion homeostasis(GO:0055064)
0.0	0.1	GO:0060301	vestibulocochlear nerve structural organization(GO:0021649) neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) positive regulation of cytokine activity(GO:0060301) ganglion morphogenesis(GO:0061552) endothelial tip cell fate specification(GO:0097102) positive regulation of retinal ganglion cell axon guidance(GO:1902336) VEGF-activated neuropilin signaling pathway involved in axon guidance(GO:1902378) dorsal root ganglion morphogenesis(GO:1904835) otic placode development(GO:1905040)
0.0	0.4	GO:0050812	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.0	0.2	GO:0002933	lipid hydroxylation(GO:0002933)
0.0	0.2	GO:0097116	gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.0	1.0	GO:0007029	endoplasmic reticulum organization(GO:0007029)
0.0	0.2	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.1	GO:0019509	L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0	0.6	GO:0030517	negative regulation of axon extension(GO:0030517)
0.0	0.8	GO:0030866	cortical actin cytoskeleton organization(GO:0030866)
0.0	0.0	GO:0050894	determination of affect(GO:0050894)
0.0	0.2	GO:0060628	regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.0	0.1	GO:0005986	sucrose biosynthetic process(GO:0005986)
0.0	0.0	GO:0086100	endothelin receptor signaling pathway(GO:0086100)
0.0	0.2	GO:0002021	response to dietary excess(GO:0002021)
0.0	0.1	GO:2000622	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0	0.1	GO:0036414	protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.0	0.2	GO:0008212	mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212)
0.0	0.1	GO:1902414	protein localization to cell junction(GO:1902414)
0.0	0.0	GO:0061010	gall bladder development(GO:0061010)
0.0	0.2	GO:0002192	IRES-dependent translational initiation(GO:0002192)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	4.5	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.1	1.9	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.1	0.7	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.1	1.0	REACTOME POL SWITCHING	Genes involved in Polymerase switching
0.1	1.2	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.1	1.0	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	1.0	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.0	1.5	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	0.8	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	2.8	REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS	Genes involved in Golgi Associated Vesicle Biogenesis
0.0	0.5	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.0	1.2	REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	Genes involved in Nuclear Events (kinase and transcription factor activation)
0.0	0.7	REACTOME SIGNALLING TO P38 VIA RIT AND RIN	Genes involved in Signalling to p38 via RIT and RIN
0.0	1.0	REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0	0.7	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	0.5	REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN	Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0	0.5	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.0	0.4	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	0.3	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.4	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.0	0.2	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.9	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.0	1.7	REACTOME TOLL RECEPTOR CASCADES	Genes involved in Toll Receptor Cascades
0.0	0.5	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
0.0	0.5	REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION	Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.0	0.2	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.2	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.0	0.7	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.6	1.8	GO:0033823	procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
0.5	2.6	GO:0005219	ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.4	1.8	GO:0004771	sterol esterase activity(GO:0004771) methylumbelliferyl-acetate deacetylase activity(GO:0047374)
0.4	7.2	GO:0051787	misfolded protein binding(GO:0051787)
0.3	1.6	GO:0003796	lysozyme activity(GO:0003796)
0.2	1.0	GO:0035373	chondroitin sulfate proteoglycan binding(GO:0035373)
0.2	0.6	GO:0042015	interleukin-20 binding(GO:0042015)
0.2	0.8	GO:0030760	nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.2	0.7	GO:0050509	N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509)
0.2	2.8	GO:0008179	adenylate cyclase binding(GO:0008179)
0.2	0.6	GO:0097603	temperature-gated ion channel activity(GO:0097603)
0.1	0.8	GO:0035800	deubiquitinase activator activity(GO:0035800)
0.1	1.6	GO:0042043	neurexin family protein binding(GO:0042043)
0.1	0.6	GO:0016657	GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.1	2.6	GO:0005528	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.1	0.6	GO:0071253	connexin binding(GO:0071253)
0.1	0.8	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.1	0.3	GO:0052827	inositol pentakisphosphate phosphatase activity(GO:0052827)
0.1	0.4	GO:0038062	protein tyrosine kinase collagen receptor activity(GO:0038062)
0.1	0.4	GO:0004741	[pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.1	0.6	GO:0047498	calcium-dependent phospholipase A2 activity(GO:0047498)
0.1	0.2	GO:0035033	histone deacetylase regulator activity(GO:0035033)
0.1	0.7	GO:0016413	O-acetyltransferase activity(GO:0016413)
0.1	2.1	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.1	0.7	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0	0.9	GO:0050786	RAGE receptor binding(GO:0050786)
0.0	0.3	GO:0030267	hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.0	0.5	GO:0005243	gap junction channel activity(GO:0005243)
0.0	4.3	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.0	0.1	GO:0036134	thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
0.0	1.8	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.7	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.1	GO:0034584	piRNA binding(GO:0034584)
0.0	2.4	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0	0.1	GO:0008466	glycogenin glucosyltransferase activity(GO:0008466)
0.0	0.2	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0	0.8	GO:0005521	lamin binding(GO:0005521)
0.0	0.1	GO:0015184	L-cystine transmembrane transporter activity(GO:0015184)
0.0	0.2	GO:0060072	large conductance calcium-activated potassium channel activity(GO:0060072)
0.0	0.3	GO:0031821	G-protein coupled serotonin receptor binding(GO:0031821)
0.0	0.5	GO:0005112	Notch binding(GO:0005112)
0.0	0.3	GO:0043225	anion transmembrane-transporting ATPase activity(GO:0043225)
0.0	0.7	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0	0.5	GO:0004029	aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.0	1.5	GO:0050840	extracellular matrix binding(GO:0050840)
0.0	0.3	GO:0017160	Ral GTPase binding(GO:0017160)
0.0	0.1	GO:0001591	dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591)
0.0	0.2	GO:0000990	transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0	0.1	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.5	GO:0070410	co-SMAD binding(GO:0070410)
0.0	0.2	GO:0031681	G-protein beta-subunit binding(GO:0031681)
0.0	0.0	GO:0031877	somatostatin receptor binding(GO:0031877)
0.0	0.1	GO:0030369	ICAM-3 receptor activity(GO:0030369)
0.0	0.1	GO:0038085	vascular endothelial growth factor binding(GO:0038085)
0.0	0.2	GO:0003993	acid phosphatase activity(GO:0003993) non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0034618	arginine binding(GO:0034618)
0.0	0.2	GO:0005221	intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855)
0.0	0.1	GO:0042132	fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132)
0.0	0.2	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.0	GO:0004962	endothelin receptor activity(GO:0004962)
0.0	0.5	GO:0051183	vitamin transporter activity(GO:0051183)
0.0	0.0	GO:0017098	sulfonylurea receptor binding(GO:0017098)
0.0	0.6	GO:0004364	glutathione transferase activity(GO:0004364)
0.0	0.0	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0	0.1	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0	0.1	GO:0097371	MDM2/MDM4 family protein binding(GO:0097371)
0.0	0.2	GO:0097109	neuroligin family protein binding(GO:0097109)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:1990423	RZZ complex(GO:1990423)
0.1	0.3	GO:0009330	DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
0.1	0.5	GO:0030870	Mre11 complex(GO:0030870)
0.1	0.9	GO:0033093	Weibel-Palade body(GO:0033093)
0.1	0.2	GO:0005863	striated muscle myosin thick filament(GO:0005863)
0.1	0.3	GO:0005726	perichromatin fibrils(GO:0005726)
0.1	0.7	GO:0005664	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1	0.3	GO:0044530	supraspliceosomal complex(GO:0044530)
0.1	0.5	GO:0016013	syntrophin complex(GO:0016013)
0.0	0.2	GO:0034751	aryl hydrocarbon receptor complex(GO:0034751)
0.0	0.2	GO:0000798	nuclear cohesin complex(GO:0000798)
0.0	0.0	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.0	0.4	GO:0031595	nuclear proteasome complex(GO:0031595)
0.0	0.2	GO:0045272	plasma membrane respiratory chain complex I(GO:0045272)
0.0	0.7	GO:0032591	dendritic spine membrane(GO:0032591)
0.0	0.2	GO:0071012	catalytic step 1 spliceosome(GO:0071012)
0.0	0.7	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0	0.4	GO:0000788	nuclear nucleosome(GO:0000788)
0.0	0.6	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.2	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0	0.2	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.1	GO:0097255	R2TP complex(GO:0097255)
0.0	0.1	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	0.4	GO:0005833	hemoglobin complex(GO:0005833)
0.0	0.5	GO:0033202	Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.0	0.5	GO:0000145	exocyst(GO:0000145)
0.0	0.6	GO:0032982	myosin filament(GO:0032982)
0.0	0.2	GO:1990635	proximal dendrite(GO:1990635)
0.0	0.3	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.4	GO:0043194	axon initial segment(GO:0043194)
0.0	0.4	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.2	GO:0000796	condensin complex(GO:0000796)
0.0	0.2	GO:0030688	preribosome, small subunit precursor(GO:0030688)
0.0	0.3	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.2	GO:0033588	Elongator holoenzyme complex(GO:0033588)
0.0	0.1	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	0.2	GO:0044666	MLL3/4 complex(GO:0044666)
0.0	0.5	GO:0035371	microtubule plus-end(GO:0035371)
0.0	0.1	GO:0019815	B cell receptor complex(GO:0019815)
0.0	0.2	GO:0042575	DNA polymerase complex(GO:0042575)
0.0	6.1	GO:0016323	basolateral plasma membrane(GO:0016323)
0.0	0.1	GO:0033186	CAF-1 complex(GO:0033186)
0.0	0.1	GO:0016011	dystroglycan complex(GO:0016011) sarcoglycan complex(GO:0016012)
0.0	0.3	GO:0005687	U4 snRNP(GO:0005687)
0.0	0.1	GO:0045179	apical cortex(GO:0045179)
0.0	0.1	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.1	GO:0045180	basal cortex(GO:0045180)
0.0	0.1	GO:0036513	Derlin-1 retrotranslocation complex(GO:0036513)
0.0	0.4	GO:0080008	Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0	0.2	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0	0.1	GO:0000800	lateral element(GO:0000800)
0.0	0.1	GO:0070531	BRCA1-A complex(GO:0070531)
0.0	2.2	GO:0032993	protein-DNA complex(GO:0032993)
0.0	0.2	GO:0005922	connexon complex(GO:0005922)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.9	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1	2.1	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	1.6	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.1	0.6	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	1.3	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.6	REACTOME ACYL CHAIN REMODELLING OF PG	Genes involved in Acyl chain remodelling of PG
0.0	3.5	REACTOME AMYLOIDS	Genes involved in Amyloids
0.0	1.8	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.0	0.6	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.7	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	3.9	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	1.7	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.6	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	0.4	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	0.7	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION	Genes involved in TRAF6 mediated IRF7 activation
0.0	0.6	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.2	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.0	0.7	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.5	REACTOME HS GAG BIOSYNTHESIS	Genes involved in HS-GAG biosynthesis
0.0	0.7	REACTOME TRAFFICKING OF AMPA RECEPTORS	Genes involved in Trafficking of AMPA receptors
0.0	0.2	REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	Genes involved in Adenylate cyclase inhibitory pathway
0.0	0.2	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.0	0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.7	REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES	Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.8	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1	8.6	PID MYC REPRESS PATHWAY	Validated targets of C-MYC transcriptional repression
0.0	1.6	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.0	0.6	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.0	0.7	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	1.6	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.0	1.8	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	7.8	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0	1.8	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.0	1.4	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0	1.5	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.0	0.7	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.0	0.2	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.0	1.6	PID CMYB PATHWAY	C-MYB transcription factor network
0.0	0.6	NABA COLLAGENS	Genes encoding collagen proteins
0.0	0.8	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.0	0.2	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.8	4.5	GO:1903435	positive regulation of constitutive secretory pathway(GO:1903435)
0.6	1.8	GO:0010760	negative regulation of macrophage chemotaxis(GO:0010760) negative regulation of macrophage colony-stimulating factor signaling pathway(GO:1902227) negative regulation of response to macrophage colony-stimulating factor(GO:1903970) negative regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903973)
0.4	1.9	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.4	1.1	GO:0046098	guanine metabolic process(GO:0046098)
0.4	1.4	GO:0043376	regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376) actin polymerization-dependent cell motility(GO:0070358)
0.3	1.0	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.3	0.8	GO:0007509	mesoderm migration involved in gastrulation(GO:0007509)
0.3	2.4	GO:0035799	ureter maturation(GO:0035799)
0.2	0.7	GO:0010430	fatty acid omega-oxidation(GO:0010430)
0.2	0.9	GO:1903660	negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.2	0.8	GO:0003138	primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.2	1.2	GO:0090308	regulation of methylation-dependent chromatin silencing(GO:0090308)
0.2	0.5	GO:0044205	'de novo' UMP biosynthetic process(GO:0044205)
0.2	0.5	GO:1903598	positive regulation of gap junction assembly(GO:1903598)
0.2	0.5	GO:0061010	negative regulation of transcription by transcription factor localization(GO:0010621) gall bladder development(GO:0061010)
0.1	1.0	GO:0098532	histone H3-K27 trimethylation(GO:0098532)
0.1	1.1	GO:0097116	gephyrin clustering involved in postsynaptic density assembly(GO:0097116)
0.1	0.8	GO:1903385	regulation of homophilic cell adhesion(GO:1903385)
0.1	0.8	GO:0071233	cellular response to leucine(GO:0071233)
0.1	0.6	GO:0019348	dolichol metabolic process(GO:0019348)
0.1	0.1	GO:0086092	regulation of the force of heart contraction by cardiac conduction(GO:0086092)
0.1	0.4	GO:0007499	ectoderm and mesoderm interaction(GO:0007499)
0.1	0.4	GO:0002314	germinal center B cell differentiation(GO:0002314)
0.1	0.5	GO:2000301	negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.1	0.3	GO:0050917	sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.1	0.5	GO:0070980	biphenyl catabolic process(GO:0070980)
0.1	0.3	GO:1903572	regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
0.1	0.9	GO:0043950	positive regulation of cAMP-mediated signaling(GO:0043950)
0.1	0.4	GO:0046116	queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.1	0.4	GO:1901979	regulation of inward rectifier potassium channel activity(GO:1901979) regulation of cyclic nucleotide-gated ion channel activity(GO:1902159)
0.1	0.7	GO:0033211	adiponectin-activated signaling pathway(GO:0033211)
0.1	0.4	GO:0050717	positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.1	0.9	GO:0031848	protection from non-homologous end joining at telomere(GO:0031848)
0.1	1.7	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1	0.3	GO:0001826	inner cell mass cell differentiation(GO:0001826)
0.1	0.2	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.1	0.4	GO:1904550	chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.1	0.4	GO:0006196	AMP catabolic process(GO:0006196)
0.1	0.3	GO:0060743	epithelial cell maturation involved in prostate gland development(GO:0060743)
0.1	1.4	GO:0010623	programmed cell death involved in cell development(GO:0010623)
0.1	0.2	GO:0002384	hepatic immune response(GO:0002384)
0.1	0.6	GO:0086024	adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.1	0.2	GO:2000296	negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.1	0.2	GO:0018283	metal incorporation into metallo-sulfur cluster(GO:0018282) iron incorporation into metallo-sulfur cluster(GO:0018283)
0.1	0.4	GO:1904381	Golgi apparatus mannose trimming(GO:1904381)
0.1	0.2	GO:2000342	negative regulation of chemokine (C-X-C motif) ligand 2 production(GO:2000342)
0.1	0.6	GO:0046784	viral mRNA export from host cell nucleus(GO:0046784)
0.1	0.2	GO:0006001	fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624)
0.1	0.2	GO:0021529	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.1	0.5	GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.1	0.4	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
0.1	0.2	GO:0097156	fasciculation of motor neuron axon(GO:0097156)
0.1	0.4	GO:0098735	positive regulation of the force of heart contraction(GO:0098735)
0.0	0.8	GO:0051531	NFAT protein import into nucleus(GO:0051531) positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103)
0.0	0.5	GO:0008612	peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.0	0.3	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.0	0.3	GO:0070537	histone H2A K63-linked deubiquitination(GO:0070537)
0.0	0.3	GO:0090336	positive regulation of brown fat cell differentiation(GO:0090336)
0.0	0.3	GO:0009441	glycolate metabolic process(GO:0009441)
0.0	0.3	GO:1902570	protein localization to nucleolus(GO:1902570)
0.0	0.1	GO:1990414	replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.0	1.0	GO:0086069	bundle of His cell to Purkinje myocyte communication(GO:0086069)
0.0	0.2	GO:0055059	asymmetric neuroblast division(GO:0055059)
0.0	0.9	GO:0048026	positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0	1.0	GO:0006825	copper ion transport(GO:0006825)
0.0	0.7	GO:0072321	chaperone-mediated protein transport(GO:0072321)
0.0	0.6	GO:0060712	spongiotrophoblast layer development(GO:0060712)
0.0	0.3	GO:0019530	taurine metabolic process(GO:0019530)
0.0	1.1	GO:0042776	mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0	0.2	GO:0051694	pointed-end actin filament capping(GO:0051694)
0.0	0.2	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0	0.2	GO:1903760	regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760)
0.0	0.2	GO:0002074	extraocular skeletal muscle development(GO:0002074)
0.0	0.1	GO:0001550	ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.0	0.3	GO:0006878	cellular copper ion homeostasis(GO:0006878)
0.0	0.3	GO:0006335	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0	3.5	GO:0031532	actin cytoskeleton reorganization(GO:0031532)
0.0	0.4	GO:0070307	lens fiber cell development(GO:0070307)
0.0	1.7	GO:0006910	phagocytosis, recognition(GO:0006910)
0.0	3.2	GO:0007338	single fertilization(GO:0007338)
0.0	1.4	GO:0046677	response to antibiotic(GO:0046677)
0.0	0.2	GO:0070072	proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0	0.1	GO:0071205	protein localization to juxtaparanode region of axon(GO:0071205)
0.0	0.1	GO:0032277	negative regulation of gonadotropin secretion(GO:0032277)
0.0	1.0	GO:0071431	tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)
0.0	0.1	GO:2000320	negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
0.0	0.7	GO:0000027	ribosomal large subunit assembly(GO:0000027)
0.0	0.2	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.1	GO:0033029	regulation of neutrophil apoptotic process(GO:0033029) common myeloid progenitor cell proliferation(GO:0035726)
0.0	0.3	GO:0033141	positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.0	0.0	GO:2000354	response to prolactin(GO:1990637) regulation of ovarian follicle development(GO:2000354)
0.0	1.8	GO:0007286	spermatid development(GO:0007286)
0.0	1.8	GO:0030183	B cell differentiation(GO:0030183)
0.0	0.1	GO:0045636	positive regulation of melanocyte differentiation(GO:0045636)
0.0	0.2	GO:0006265	DNA topological change(GO:0006265)
0.0	0.6	GO:0018149	peptide cross-linking(GO:0018149)
0.0	0.0	GO:0050720	interleukin-1 beta biosynthetic process(GO:0050720)
0.0	0.6	GO:0046949	fatty-acyl-CoA biosynthetic process(GO:0046949)
0.0	0.2	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0	0.3	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.1	GO:0001180	transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript(GO:0001180)
0.0	0.6	GO:0045616	regulation of keratinocyte differentiation(GO:0045616)
0.0	0.7	GO:0051646	establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197) mitochondrion localization(GO:0051646)
0.0	0.3	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.0	0.1	GO:0051775	response to redox state(GO:0051775)
0.0	0.4	GO:0007184	SMAD protein import into nucleus(GO:0007184)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.1	GO:0061752	telomeric repeat-containing RNA binding(GO:0061752)
0.3	1.9	GO:0032564	adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564)
0.3	1.8	GO:0005157	macrophage colony-stimulating factor receptor binding(GO:0005157)
0.2	0.6	GO:0003976	UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
0.2	2.4	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.2	1.0	GO:0016623	oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.2	0.6	GO:0004768	stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
0.2	0.9	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
0.2	4.5	GO:0031489	myosin V binding(GO:0031489)
0.2	1.2	GO:0004126	cytidine deaminase activity(GO:0004126)
0.2	0.5	GO:0004087	carbamoyl-phosphate synthase (ammonia) activity(GO:0004087) carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity(GO:0004088)
0.2	0.8	GO:0070728	leucine binding(GO:0070728)
0.1	0.4	GO:0099580	ion antiporter activity involved in regulation of postsynaptic membrane potential(GO:0099580)
0.1	1.9	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.1	3.5	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.1	0.9	GO:0035312	5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1	1.0	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1	0.4	GO:0035673	oligopeptide transmembrane transporter activity(GO:0035673)
0.1	0.8	GO:0043559	insulin binding(GO:0043559)
0.1	1.0	GO:0031013	troponin I binding(GO:0031013)
0.1	1.0	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.1	0.5	GO:0008241	peptidyl-dipeptidase activity(GO:0008241)
0.1	0.4	GO:0008479	queuine tRNA-ribosyltransferase activity(GO:0008479)
0.1	0.2	GO:0004915	interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.1	1.7	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.1	0.3	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.1	1.4	GO:0071837	HMG box domain binding(GO:0071837)
0.1	1.1	GO:0033130	acetylcholine receptor binding(GO:0033130)
0.1	0.4	GO:1990763	arrestin family protein binding(GO:1990763)
0.0	0.4	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.3	GO:0043183	vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0	0.2	GO:0004906	interferon-gamma receptor activity(GO:0004906)
0.0	0.6	GO:0030280	structural constituent of epidermis(GO:0030280)
0.0	1.1	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0	2.2	GO:0001105	RNA polymerase II transcription coactivator activity(GO:0001105)
0.0	0.3	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.7	GO:0016500	protein-hormone receptor activity(GO:0016500)
0.0	0.6	GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.0	0.2	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.0	0.4	GO:0097371	MDM2/MDM4 family protein binding(GO:0097371)
0.0	0.2	GO:0030492	hemoglobin binding(GO:0030492)
0.0	0.1	GO:0001181	transcription factor activity, core RNA polymerase I binding(GO:0001181)
0.0	0.2	GO:0008121	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0	1.7	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.0	0.7	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	0.7	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.0	0.8	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0	0.3	GO:0016290	palmitoyl-CoA hydrolase activity(GO:0016290)
0.0	0.1	GO:0042030	ATPase inhibitor activity(GO:0042030)
0.0	0.3	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.2	GO:0004705	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.1	GO:0009378	four-way junction helicase activity(GO:0009378)
0.0	0.2	GO:0089720	caspase binding(GO:0089720)
0.0	1.0	GO:0003899	DNA-directed RNA polymerase activity(GO:0003899)
0.0	1.1	GO:0004520	endodeoxyribonuclease activity(GO:0004520)
0.0	0.1	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0	0.2	GO:0005004	GPI-linked ephrin receptor activity(GO:0005004)
0.0	0.1	GO:0004882	androgen receptor activity(GO:0004882)
0.0	0.2	GO:0005132	type I interferon receptor binding(GO:0005132)
0.0	0.2	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.6	GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0	0.3	GO:0017070	U6 snRNA binding(GO:0017070)
0.0	0.4	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.1	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.1	GO:0005134	interleukin-2 receptor binding(GO:0005134)
0.0	0.3	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
0.0	0.3	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
0.0	1.4	GO:0030295	protein kinase activator activity(GO:0030295)
0.0	0.3	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.0	0.1	GO:0036402	proteasome-activating ATPase activity(GO:0036402)
0.0	0.1	GO:0016167	glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.0	0.2	GO:0008252	nucleotidase activity(GO:0008252)
0.0	0.8	GO:0001191	transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.0	0.2	GO:0016783	sulfurtransferase activity(GO:0016783)
0.0	0.1	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0	0.4	GO:0005212	structural constituent of eye lens(GO:0005212)
0.0	0.3	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0	0.2	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.0	0.5	GO:0001972	retinoic acid binding(GO:0001972)
0.0	1.0	GO:0003707	steroid hormone receptor activity(GO:0003707)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.7	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.1	2.7	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.1	4.1	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	3.1	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.6	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.0	1.0	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	1.0	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	0.9	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	4.0	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	0.3	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.0	1.8	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0	0.3	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0	0.6	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	2.4	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.0	0.5	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.4	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	0.8	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.8	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.0	0.4	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.0	0.8	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins

Gene overrepresentation in C2:CP category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	5.1	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1	3.1	NABA COLLAGENS	Genes encoding collagen proteins
0.1	3.7	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.0	2.0	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.0	0.9	PID IL3 PATHWAY	IL3-mediated signaling events
0.0	5.9	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.0	0.4	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.0	1.1	PID ERBB4 PATHWAY	ErbB4 signaling events
0.0	0.8	PID IL1 PATHWAY	IL1-mediated signaling events
0.0	0.7	PID TRAIL PATHWAY	TRAIL signaling pathway
0.0	0.3	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network

Gene overrepresentation in C2:CP category:

Total log-likelihood	Term	Description
2.8	PID AR PATHWAY	Coregulation of Androgen receptor activity
1.1	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
1.0	ST JNK MAPK PATHWAY	JNK MAPK Pathway
0.4	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.7	PID BARD1 PATHWAY	BARD1 signaling events
1.1	PID ILK PATHWAY	Integrin-linked kinase signaling
0.4	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.4	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.1	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
1.0	PID E2F PATHWAY	E2F transcription factor network
0.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.2	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.9	2.7	GO:0010645	regulation of cell communication by chemical coupling(GO:0010645) positive regulation of cell communication by chemical coupling(GO:0010652)
0.9	6.8	GO:0060414	aorta smooth muscle tissue morphogenesis(GO:0060414)
0.7	2.2	GO:0017186	peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase(GO:0017186)
0.5	1.5	GO:0023016	signal transduction by trans-phosphorylation(GO:0023016) negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.4	1.2	GO:2000525	regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525)
0.4	3.5	GO:0035583	sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.3	1.0	GO:2000393	negative regulation of lamellipodium morphogenesis(GO:2000393)
0.2	1.1	GO:0030047	actin modification(GO:0030047)
0.2	3.2	GO:0030913	paranodal junction assembly(GO:0030913)
0.2	0.7	GO:2001245	regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.2	2.7	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.2	0.8	GO:1902498	regulation of protein autoubiquitination(GO:1902498)
0.2	0.9	GO:0097338	response to clozapine(GO:0097338)
0.2	0.6	GO:0052331	hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
0.1	0.7	GO:0045617	negative regulation of keratinocyte differentiation(GO:0045617)
0.1	0.8	GO:0038172	interleukin-33-mediated signaling pathway(GO:0038172)
0.1	0.8	GO:0072564	lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
0.1	0.3	GO:0060278	regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.1	1.0	GO:1902459	positive regulation of stem cell population maintenance(GO:1902459)
0.1	0.6	GO:0044334	regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.1	0.4	GO:0035720	signal transduction downstream of smoothened(GO:0007227) intraciliary anterograde transport(GO:0035720) ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.1	0.4	GO:0010701	positive regulation of norepinephrine secretion(GO:0010701)
0.1	1.1	GO:0048251	elastic fiber assembly(GO:0048251)
0.1	0.3	GO:0061394	regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) response to manganese-induced endoplasmic reticulum stress(GO:1990737)
0.1	0.8	GO:2000622	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.1	0.5	GO:0060613	fat pad development(GO:0060613)
0.1	1.6	GO:0009312	oligosaccharide biosynthetic process(GO:0009312)
0.1	2.1	GO:0045026	plasma membrane fusion(GO:0045026)
0.1	0.8	GO:0043374	CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.0	0.1	GO:0051066	dihydrobiopterin metabolic process(GO:0051066)
0.0	0.3	GO:2000158	positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.0	0.6	GO:0060272	embryonic skeletal joint morphogenesis(GO:0060272)
0.0	0.6	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.0	1.0	GO:0043101	purine-containing compound salvage(GO:0043101)
0.0	0.1	GO:0052314	serotonin biosynthetic process(GO:0042427) phytoalexin metabolic process(GO:0052314)
0.0	0.8	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.0	0.3	GO:0003190	atrioventricular valve formation(GO:0003190)
0.0	0.4	GO:0010839	negative regulation of keratinocyte proliferation(GO:0010839)
0.0	0.6	GO:0051764	actin crosslink formation(GO:0051764)
0.0	0.3	GO:0050747	positive regulation of lipoprotein metabolic process(GO:0050747)
0.0	0.1	GO:0090467	L-arginine import(GO:0043091) arginine import(GO:0090467) L-arginine transport(GO:1902023)
0.0	0.2	GO:1903238	neutrophil mediated killing of gram-negative bacterium(GO:0070945) positive regulation of leukocyte tethering or rolling(GO:1903238)
0.0	1.3	GO:0045599	negative regulation of fat cell differentiation(GO:0045599)
0.0	0.4	GO:0006853	carnitine shuttle(GO:0006853)
0.0	0.1	GO:2001034	positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.0	0.2	GO:0002036	regulation of L-glutamate transport(GO:0002036)
0.0	0.1	GO:0034197	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0	0.3	GO:0090331	negative regulation of platelet aggregation(GO:0090331)
0.0	0.3	GO:0045116	protein neddylation(GO:0045116)
0.0	0.2	GO:0010886	positive regulation of cholesterol storage(GO:0010886)
0.0	0.6	GO:0051642	centrosome localization(GO:0051642)
0.0	0.1	GO:0042796	snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.0	0.2	GO:0006346	methylation-dependent chromatin silencing(GO:0006346)
0.0	0.4	GO:1904380	endoplasmic reticulum mannose trimming(GO:1904380)
0.0	0.0	GO:0090487	toxin catabolic process(GO:0009407) secondary metabolite catabolic process(GO:0090487)
0.0	0.1	GO:1904262	negative regulation of TORC1 signaling(GO:1904262)
0.0	0.2	GO:0031272	regulation of pseudopodium assembly(GO:0031272)
0.0	0.2	GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.0	1.7	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0	1.2	GO:0006892	post-Golgi vesicle-mediated transport(GO:0006892)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	7.2	GO:0097418	neurofibrillary tangle(GO:0097418)
0.2	0.8	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.1	0.4	GO:0005588	collagen type V trimer(GO:0005588)
0.1	0.6	GO:1902560	GMP reductase complex(GO:1902560)
0.1	1.3	GO:0098647	collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.1	0.7	GO:0045179	apical cortex(GO:0045179)
0.1	0.3	GO:0045160	myosin I complex(GO:0045160)
0.1	1.8	GO:0030867	rough endoplasmic reticulum membrane(GO:0030867)
0.1	2.8	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.0	1.9	GO:0030131	clathrin adaptor complex(GO:0030131)
0.0	2.5	GO:0005771	multivesicular body(GO:0005771)
0.0	0.7	GO:0019774	proteasome core complex, beta-subunit complex(GO:0019774)
0.0	2.7	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.0	0.6	GO:0032591	dendritic spine membrane(GO:0032591)
0.0	0.3	GO:0097470	ribbon synapse(GO:0097470)
0.0	9.2	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.0	0.1	GO:0034688	integrin alphaM-beta2 complex(GO:0034688)
0.0	0.2	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.1	GO:0071546	perinucleolar chromocenter(GO:0010370) pi-body(GO:0071546)
0.0	0.7	GO:0030173	integral component of Golgi membrane(GO:0030173)
0.0	1.6	GO:0035578	azurophil granule lumen(GO:0035578)
0.0	1.4	GO:0031594	neuromuscular junction(GO:0031594)
0.0	0.8	GO:0005791	rough endoplasmic reticulum(GO:0005791)
0.0	0.0	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.1	GO:0036157	outer dynein arm(GO:0036157)
0.0	0.1	GO:0097443	sorting endosome(GO:0097443)
0.0	2.2	GO:0030658	transport vesicle membrane(GO:0030658)
0.0	0.4	GO:1904115	axon cytoplasm(GO:1904115)
0.0	0.7	GO:0043195	terminal bouton(GO:0043195)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	5.8	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.0	2.5	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	1.1	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	1.0	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.0	0.6	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0	0.7	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0	0.6	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	0.4	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.0	0.4	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	1.0	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.0	0.3	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.0	0.3	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.7	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.0	0.1	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.0	0.4	REACTOME SIGNALLING TO P38 VIA RIT AND RIN	Genes involved in Signalling to p38 via RIT and RIN
0.0	0.5	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.0	0.4	REACTOME KINESINS	Genes involved in Kinesins
0.0	0.5	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.0	1.2	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.3	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.0	0.3	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.0	0.4	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.0	0.4	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.0	0.2	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.0	1.0	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	0.9	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.0	0.7	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.0	0.3	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	0.1	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation

Results for HOXA1

Z-value: 0.91

Motif logo

Transcription factors associated with HOXA1

Activity-expression correlation:

Activity profile of HOXA1 motif

Sorted Z-values of HOXA1 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA1

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Top targets:

Gene Ontology Analysis

Gene overrepresentation in cellular_component category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP:REACTOME category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in C2:CP:REACTOME category: