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ENCODE cell lines, expression (Ernst 2011)

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Results for HOXA4

Z-value: 0.65

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Transcription factors associated with HOXA4

Gene Symbol Gene ID Gene Info
HOXA4
ENSG00000197576.9 HOXA4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXA4hg19_v2_chr7_-_27169801_27169844-0.504.8e-02Click!

Activity profile of HOXA4 motif

Sorted Z-values of HOXA4 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA4

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr3_-_52486841 1.60 ENST00000496590.1
 TNNC1
 troponin C type 1 (slow)
chr10_-_75415825 1.23 ENST00000394810.2
 SYNPO2L
 synaptopodin 2-like
chr10_-_92681033 1.22 ENST00000371697.3
 ANKRD1
 ankyrin repeat domain 1 (cardiac muscle)
chr5_-_88179302 1.20 ENST00000504921.2
 MEF2C
 myocyte enhancer factor 2C
chr2_-_190927447 1.09 ENST00000260950.4
 MSTN
 myostatin
chr17_-_10325261 1.02 ENST00000403437.2
 MYH8
 myosin, heavy chain 8, skeletal muscle, perinatal
chr5_+_152870106 0.92 ENST00000285900.5
 GRIA1
 glutamate receptor, ionotropic, AMPA 1
chr16_+_6533380 0.86 ENST00000552089.1
 RBFOX1
 RNA binding protein, fox-1 homolog (C. elegans) 1
chr13_-_46716969 0.83 ENST00000435666.2
 LCP1
 lymphocyte cytosolic protein 1 (L-plastin)
chr17_-_10452929 0.76 ENST00000532183.2
ENST00000397183.2
ENST00000420805.1
 MYH2
 myosin, heavy chain 2, skeletal muscle, adult
chr10_+_11047259 0.71 ENST00000379261.4
ENST00000416382.2
 CELF2
 CUGBP, Elav-like family member 2
chr16_+_7382745 0.67 ENST00000436368.2
ENST00000311745.5
ENST00000355637.4
ENST00000340209.4
 RBFOX1
 RNA binding protein, fox-1 homolog (C. elegans) 1
chr17_-_10421853 0.65 ENST00000226207.5
 MYH1
 myosin, heavy chain 1, skeletal muscle, adult
chr5_+_49962495 0.60 ENST00000515175.1
 PARP8
 poly (ADP-ribose) polymerase family, member 8
chr11_+_112832133 0.56 ENST00000524665.1
 NCAM1
 neural cell adhesion molecule 1
chr22_+_22930626 0.54 ENST00000390302.2
 IGLV2-33
 immunoglobulin lambda variable 2-33 (non-functional)
chr4_-_41884620 0.53 ENST00000504870.1
 LINC00682
 long intergenic non-protein coding RNA 682
chr12_+_54447637 0.48 ENST00000609810.1
ENST00000430889.2
 HOXC4
HOXC4
 homeobox C4
Homeobox protein Hox-C4
chr1_-_204329013 0.45 ENST00000272203.3
ENST00000414478.1
 PLEKHA6
 pleckstrin homology domain containing, family A member 6
chr8_+_77593448 0.44 ENST00000521891.2
 ZFHX4
 zinc finger homeobox 4
chr11_+_22688150 0.41 ENST00000454584.2
 GAS2
 growth arrest-specific 2
chr2_-_145278475 0.38 ENST00000558170.2
 ZEB2
 zinc finger E-box binding homeobox 2
chr8_+_77593474 0.35 ENST00000455469.2
ENST00000050961.6
 ZFHX4
 zinc finger homeobox 4
chrX_+_37639264 0.35 ENST00000378588.4
 CYBB
 cytochrome b-245, beta polypeptide
chr2_+_54683419 0.33 ENST00000356805.4
 SPTBN1
 spectrin, beta, non-erythrocytic 1
chr8_-_95449155 0.30 ENST00000481490.2
 FSBP
 fibrinogen silencer binding protein
chr15_+_80351910 0.30 ENST00000261749.6
ENST00000561060.1
 ZFAND6
 zinc finger, AN1-type domain 6
chr3_+_88188254 0.30 ENST00000309495.5
 ZNF654
 zinc finger protein 654
chr17_-_39538550 0.28 ENST00000394001.1
 KRT34
 keratin 34
chr1_-_42384343 0.26 ENST00000372584.1
 HIVEP3
 human immunodeficiency virus type I enhancer binding protein 3
chr1_+_167298281 0.25 ENST00000367862.5
 POU2F1
 POU class 2 homeobox 1
chr15_+_80351977 0.25 ENST00000559157.1
ENST00000561012.1
ENST00000564367.1
ENST00000558494.1
 ZFAND6
 zinc finger, AN1-type domain 6
chr5_+_152870734 0.24 ENST00000521843.2
 GRIA1
 glutamate receptor, ionotropic, AMPA 1
chr20_-_45035223 0.23 ENST00000450812.1
ENST00000290246.6
ENST00000439931.2
ENST00000396391.1
 ELMO2
 engulfment and cell motility 2
chrX_+_129473859 0.23 ENST00000424447.1
 SLC25A14
 solute carrier family 25 (mitochondrial carrier, brain), member 14
chrX_+_37639302 0.23 ENST00000545017.1
ENST00000536160.1
 CYBB
 cytochrome b-245, beta polypeptide
chrX_-_119445306 0.22 ENST00000371369.4
ENST00000440464.1
ENST00000519908.1
 TMEM255A
 transmembrane protein 255A
chrX_-_119445263 0.21 ENST00000309720.5
 TMEM255A
 transmembrane protein 255A
chr5_+_152870287 0.18 ENST00000340592.5
 GRIA1
 glutamate receptor, ionotropic, AMPA 1
chr13_-_41593425 0.18 ENST00000239882.3
 ELF1
 E74-like factor 1 (ets domain transcription factor)
chr3_+_122103014 0.18 ENST00000232125.5
ENST00000477892.1
ENST00000469967.1
 FAM162A
 family with sequence similarity 162, member A
chr6_-_26235206 0.17 ENST00000244534.5
 HIST1H1D
 histone cluster 1, H1d
chr14_-_38064198 0.15 ENST00000250448.2
 FOXA1
 forkhead box A1
chr5_+_49962772 0.15 ENST00000281631.5
ENST00000513738.1
ENST00000503665.1
ENST00000514067.2
ENST00000503046.1
 PARP8
 poly (ADP-ribose) polymerase family, member 8
chr1_+_155658849 0.15 ENST00000368336.5
ENST00000343043.3
ENST00000421487.2
ENST00000535183.1
ENST00000465375.1
ENST00000470830.1
 DAP3
 death associated protein 3
chr6_+_31514622 0.15 ENST00000376146.4
 NFKBIL1
 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr19_+_45409011 0.14 ENST00000252486.4
ENST00000446996.1
ENST00000434152.1
 APOE
 apolipoprotein E
chr15_+_89631381 0.14 ENST00000352732.5
 ABHD2
 abhydrolase domain containing 2
chr14_-_36988882 0.14 ENST00000498187.2
 NKX2-1
 NK2 homeobox 1
chrX_+_129473916 0.13 ENST00000545805.1
ENST00000543953.1
ENST00000218197.5
 SLC25A14
 solute carrier family 25 (mitochondrial carrier, brain), member 14
chr5_+_69321074 0.13 ENST00000380751.5
ENST00000380750.3
ENST00000503931.1
ENST00000506542.1
 SERF1B
 small EDRK-rich factor 1B (centromeric)
chr9_+_87284675 0.12 ENST00000376208.1
ENST00000304053.6
ENST00000277120.3
 NTRK2
 neurotrophic tyrosine kinase, receptor, type 2
chr15_+_89631647 0.12 ENST00000569550.1
ENST00000565066.1
ENST00000565973.1
 ABHD2
 abhydrolase domain containing 2
chr2_-_163100045 0.12 ENST00000188790.4
 FAP
 fibroblast activation protein, alpha
chr12_-_57037284 0.12 ENST00000551570.1
 ATP5B
 ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr17_+_37894570 0.12 ENST00000394211.3
 GRB7
 growth factor receptor-bound protein 7
chr6_-_116447283 0.11 ENST00000452729.1
ENST00000243222.4
 COL10A1
 collagen, type X, alpha 1
chr2_-_163099885 0.11 ENST00000443424.1
 FAP
 fibroblast activation protein, alpha
chr10_+_118305435 0.10 ENST00000369221.2
 PNLIP
 pancreatic lipase
chr5_+_67586465 0.10 ENST00000336483.5
 PIK3R1
 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr17_-_56082455 0.10 ENST00000578794.1
 RP11-159D12.5
 Uncharacterized protein
chr13_-_28545276 0.10 ENST00000381020.7
 CDX2
 caudal type homeobox 2
chr20_+_32150140 0.09 ENST00000344201.3
ENST00000346541.3
ENST00000397800.1
ENST00000397798.2
ENST00000492345.1
 CBFA2T2
 core-binding factor, runt domain, alpha subunit 2; translocated to, 2
chr1_+_214161272 0.09 ENST00000498508.2
ENST00000366958.4
 PROX1
 prospero homeobox 1
chr15_+_75080883 0.09 ENST00000567571.1
 CSK
 c-src tyrosine kinase
chr9_+_87284622 0.09 ENST00000395882.1
 NTRK2
 neurotrophic tyrosine kinase, receptor, type 2
chr14_-_36989336 0.07 ENST00000522719.2
 NKX2-1
 NK2 homeobox 1
chr14_+_39734482 0.07 ENST00000554392.1
ENST00000555716.1
ENST00000341749.3
ENST00000557038.1
 CTAGE5
 CTAGE family, member 5
chr3_+_69134080 0.07 ENST00000273258.3
 ARL6IP5
 ADP-ribosylation-like factor 6 interacting protein 5
chr7_-_140714430 0.07 ENST00000393008.3
 MRPS33
 mitochondrial ribosomal protein S33
chr12_-_10959892 0.07 ENST00000240615.2
 TAS2R8
 taste receptor, type 2, member 8
chr10_-_101825151 0.07 ENST00000441382.1
 CPN1
 carboxypeptidase N, polypeptide 1
chr4_-_66536196 0.06 ENST00000511294.1
 EPHA5
 EPH receptor A5
chr12_+_27677085 0.05 ENST00000545334.1
ENST00000540114.1
ENST00000537927.1
ENST00000318304.8
ENST00000535047.1
ENST00000542629.1
ENST00000228425.6
 PPFIBP1
 PTPRF interacting protein, binding protein 1 (liprin beta 1)
chrX_-_55024967 0.05 ENST00000545676.1
 PFKFB1
 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
chr5_+_40909354 0.05 ENST00000313164.9
 C7
 complement component 7
chr6_+_50786414 0.05 ENST00000344788.3
ENST00000393655.3
ENST00000263046.4
 TFAP2B
 transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr17_+_73452545 0.05 ENST00000314256.7
 KIAA0195
 KIAA0195
chr6_+_152011628 0.05 ENST00000404742.1
ENST00000440973.1
 ESR1
 estrogen receptor 1
chr8_+_71383312 0.05 ENST00000520259.1
 RP11-333A23.4
 RP11-333A23.4
chr14_-_80697396 0.04 ENST00000557010.1
 DIO2
 deiodinase, iodothyronine, type II
chr8_+_22424551 0.04 ENST00000523348.1
 SORBS3
 sorbin and SH3 domain containing 3
chr12_+_53818855 0.04 ENST00000550839.1
 AMHR2
 anti-Mullerian hormone receptor, type II
chr18_+_13612613 0.04 ENST00000586765.1
 LDLRAD4
 low density lipoprotein receptor class A domain containing 4
chr4_-_66536057 0.03 ENST00000273854.3
 EPHA5
 EPH receptor A5
chr18_-_28742813 0.03 ENST00000257197.3
ENST00000257198.5
 DSC1
 desmocollin 1
chr17_-_10372875 0.03 ENST00000255381.2
 MYH4
 myosin, heavy chain 4, skeletal muscle
chr11_-_62313090 0.03 ENST00000528508.1
ENST00000533365.1
 AHNAK
 AHNAK nucleoprotein
chr3_-_188665428 0.03 ENST00000444488.1
 TPRG1-AS1
 TPRG1 antisense RNA 1
chr11_+_12766583 0.03 ENST00000361985.2
 TEAD1
 TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr1_+_245318279 0.02 ENST00000407071.2
 KIF26B
 kinesin family member 26B
chr3_-_57233966 0.02 ENST00000473921.1
ENST00000295934.3
 HESX1
 HESX homeobox 1
chr7_+_129015484 0.02 ENST00000490911.1
 AHCYL2
 adenosylhomocysteinase-like 2
chr6_-_31514516 0.02 ENST00000303892.5
ENST00000483251.1
 ATP6V1G2
 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr7_-_29234802 0.01 ENST00000449801.1
ENST00000409850.1
 CPVL
 carboxypeptidase, vitellogenic-like
chr5_+_140535577 0.01 ENST00000539533.1
 PCDHB17
 Protocadherin-psi1; Uncharacterized protein
chr6_-_55740352 0.01 ENST00000370830.3
 BMP5
 bone morphogenetic protein 5
chr11_+_120971882 0.01 ENST00000392793.1
 TECTA
 tectorin alpha
chr5_+_159343688 0.00 ENST00000306675.3
 ADRA1B
 adrenoceptor alpha 1B
chr6_-_31514333 0.00 ENST00000376151.4
 ATP6V1G2
 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2
chr2_+_87135076 0.00 ENST00000409776.2
 RGPD1
 RANBP2-like and GRIP domain containing 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0032972 diaphragm contraction(GO:0002086) regulation of muscle filament sliding speed(GO:0032972)
0.3 1.2 GO:0003138 primary heart field specification(GO:0003138) sinoatrial valve development(GO:0003172) sinoatrial valve morphogenesis(GO:0003185)
0.3 1.1 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816) negative regulation of skeletal muscle cell proliferation(GO:0014859) regulation of skeletal muscle tissue growth(GO:0048631) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.2 1.3 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 0.6 GO:1904845 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
0.1 0.4 GO:1902748 positive regulation of lens fiber cell differentiation(GO:1902748)
0.1 0.3 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.1 1.2 GO:0043517 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.1 0.8 GO:0001778 plasma membrane repair(GO:0001778)
0.1 0.2 GO:0097325 melanocyte proliferation(GO:0097325)
0.1 0.8 GO:0051639 actin filament network formation(GO:0051639)
0.0 0.1 GO:1902994 regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995)
0.0 0.2 GO:0021759 globus pallidus development(GO:0021759)
0.0 0.2 GO:0099538 synaptic signaling via neuropeptide(GO:0099538) trans-synaptic signaling by neuropeptide(GO:0099540) trans-synaptic signaling by neuropeptide, modulating synaptic transmission(GO:0099551)
0.0 0.2 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.1 GO:0046619 optic placode formation involved in camera-type eye formation(GO:0046619)
0.0 1.5 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.1 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 0.2 GO:0098532 histone H3-K27 trimethylation(GO:0098532)
0.0 0.5 GO:0006625 protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
0.0 0.7 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.1 GO:0042997 negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0 0.1 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0 0.8 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 0.1 GO:0030070 insulin processing(GO:0030070)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.0 2.6 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 1.2 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.4 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.4 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0 0.6 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.3 GO:0044308 axonal spine(GO:0044308)
0.3 1.6 GO:1990584 cardiac Troponin complex(GO:1990584)
0.3 0.8 GO:0005826 actomyosin contractile ring(GO:0005826)
0.1 1.7 GO:0032982 myosin filament(GO:0032982)
0.0 0.1 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.0 0.3 GO:0032437 cuticular plate(GO:0032437)
0.0 0.8 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.6 GO:0043020 NADPH oxidase complex(GO:0043020)
0.0 0.1 GO:1990578 perinuclear endoplasmic reticulum membrane(GO:1990578)
0.0 0.2 GO:0071438 invadopodium membrane(GO:0071438)
0.0 0.3 GO:0097524 sperm plasma membrane(GO:0097524)
0.0 0.1 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0061629 RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.2 1.0 GO:0017018 myosin phosphatase activity(GO:0017018)
0.2 1.3 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 1.6 GO:0031013 troponin I binding(GO:0031013)
0.1 1.2 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0 0.2 GO:0060175 brain-derived neurotrophic factor-activated receptor activity(GO:0060175)
0.0 0.6 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 0.5 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.8 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.8 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 0.1 GO:0043532 angiostatin binding(GO:0043532)
0.0 0.7 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 0.2 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 0.1 GO:0043559 insulin binding(GO:0043559)
0.0 0.5 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 0.3 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.1 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.1 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.2 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.2 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 1.4 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.8 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton