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ENCODE cell lines, expression (Ernst 2011)

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Results for HOXA5

Z-value: 0.51

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Transcription factors associated with HOXA5

Gene Symbol Gene ID Gene Info
HOXA5
ENSG00000106004.4 HOXA5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXA5hg19_v2_chr7_-_27183263_271832870.647.4e-03Click!

Activity profile of HOXA5 motif

Sorted Z-values of HOXA5 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXA5

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr4_+_74275057 1.63 ENST00000511370.1
 ALB
 albumin
chr12_-_91574142 1.21 ENST00000547937.1
 DCN
 decorin
chr14_+_21156915 1.00 ENST00000397990.4
ENST00000555597.1
 ANG
RNASE4
 angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr3_-_149093499 0.97 ENST00000472441.1
 TM4SF1
 transmembrane 4 L six family member 1
chr10_-_52645379 0.97 ENST00000395489.2
 A1CF
 APOBEC1 complementation factor
chr10_-_52645416 0.96 ENST00000374001.2
ENST00000373997.3
ENST00000373995.3
ENST00000282641.2
ENST00000395495.1
ENST00000414883.1
 A1CF
 APOBEC1 complementation factor
chr3_-_79068594 0.94 ENST00000436010.2
 ROBO1
 roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr17_+_19437132 0.86 ENST00000436810.2
ENST00000270570.4
ENST00000457293.1
ENST00000542886.1
ENST00000575023.1
ENST00000395585.1
 SLC47A1
 solute carrier family 47 (multidrug and toxin extrusion), member 1
chr8_-_41166953 0.82 ENST00000220772.3
 SFRP1
 secreted frizzled-related protein 1
chr11_-_115375107 0.81 ENST00000545380.1
ENST00000452722.3
ENST00000537058.1
ENST00000536727.1
ENST00000542447.2
ENST00000331581.6
 CADM1
 cell adhesion molecule 1
chr2_+_102508955 0.75 ENST00000414004.2
 FLJ20373
 FLJ20373
chr11_+_12399071 0.71 ENST00000539723.1
ENST00000550549.1
 PARVA
 parvin, alpha
chr1_+_100111479 0.69 ENST00000263174.4
 PALMD
 palmdelphin
chr1_-_149889382 0.69 ENST00000369145.1
ENST00000369146.3
 SV2A
 synaptic vesicle glycoprotein 2A
chr14_-_92413727 0.67 ENST00000267620.10
 FBLN5
 fibulin 5
chr14_-_92413353 0.64 ENST00000556154.1
 FBLN5
 fibulin 5
chr11_-_2162468 0.59 ENST00000434045.2
 IGF2
 insulin-like growth factor 2 (somatomedin A)
chr3_+_12392971 0.57 ENST00000287820.6
 PPARG
 peroxisome proliferator-activated receptor gamma
chr1_+_100111580 0.55 ENST00000605497.1
 PALMD
 palmdelphin
chrX_+_99899180 0.54 ENST00000373004.3
 SRPX2
 sushi-repeat containing protein, X-linked 2
chr4_+_71063641 0.52 ENST00000514097.1
 ODAM
 odontogenic, ameloblast asssociated
chr15_-_73925651 0.48 ENST00000545878.1
ENST00000287226.8
ENST00000345330.4
 NPTN
 neuroplastin
chr19_+_50016610 0.48 ENST00000596975.1
 FCGRT
 Fc fragment of IgG, receptor, transporter, alpha
chr6_-_116575226 0.45 ENST00000420283.1
 TSPYL4
 TSPY-like 4
chr16_-_66764119 0.41 ENST00000569320.1
 DYNC1LI2
 dynein, cytoplasmic 1, light intermediate chain 2
chrX_+_54947229 0.41 ENST00000442098.1
ENST00000430420.1
ENST00000453081.1
ENST00000173898.7
ENST00000319167.8
ENST00000375022.4
ENST00000399736.1
ENST00000440072.1
ENST00000420798.2
ENST00000431115.1
ENST00000440759.1
ENST00000375041.2
 TRO
 trophinin
chr1_-_227505289 0.37 ENST00000366765.3
 CDC42BPA
 CDC42 binding protein kinase alpha (DMPK-like)
chr11_-_46722117 0.34 ENST00000311956.4
 ARHGAP1
 Rho GTPase activating protein 1
chr16_+_14927538 0.33 ENST00000287667.7
 NOMO1
 NODAL modulator 1
chr16_-_18573396 0.30 ENST00000543392.1
ENST00000381474.3
ENST00000330537.6
 NOMO2
 NODAL modulator 2
chr8_-_122653630 0.29 ENST00000303924.4
 HAS2
 hyaluronan synthase 2
chr14_+_65878565 0.29 ENST00000556518.1
ENST00000557164.1
 FUT8
 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
chr1_+_150337100 0.27 ENST00000401000.4
 RPRD2
 regulation of nuclear pre-mRNA domain containing 2
chr1_+_84609944 0.27 ENST00000370685.3
 PRKACB
 protein kinase, cAMP-dependent, catalytic, beta
chr6_+_26365443 0.26 ENST00000527422.1
ENST00000356386.2
ENST00000396934.3
ENST00000377708.2
ENST00000396948.1
ENST00000508906.2
 BTN3A2
 butyrophilin, subfamily 3, member A2
chr1_+_150337144 0.26 ENST00000539519.1
ENST00000369067.3
ENST00000369068.4
 RPRD2
 regulation of nuclear pre-mRNA domain containing 2
chr6_-_143266297 0.23 ENST00000367603.2
 HIVEP2
 human immunodeficiency virus type I enhancer binding protein 2
chr7_+_100136811 0.23 ENST00000300176.4
ENST00000262935.4
 AGFG2
 ArfGAP with FG repeats 2
chr21_+_44073860 0.22 ENST00000335512.4
ENST00000539837.1
ENST00000291539.6
ENST00000380328.2
ENST00000398232.3
ENST00000398234.3
ENST00000398236.3
ENST00000328862.6
ENST00000335440.6
ENST00000398225.3
ENST00000398229.3
ENST00000398227.3
 PDE9A
 phosphodiesterase 9A
chr19_+_18794470 0.22 ENST00000321949.8
ENST00000338797.6
 CRTC1
 CREB regulated transcription coactivator 1
chr5_+_140723601 0.21 ENST00000253812.6
 PCDHGA3
 protocadherin gamma subfamily A, 3
chr11_+_9685604 0.21 ENST00000447399.2
ENST00000318950.6
 SWAP70
 SWAP switching B-cell complex 70kDa subunit
chr20_+_4666882 0.21 ENST00000379440.4
ENST00000430350.2
 PRNP
 prion protein
chr9_-_110251836 0.19 ENST00000374672.4
 KLF4
 Kruppel-like factor 4 (gut)
chr12_+_111051832 0.19 ENST00000550703.2
ENST00000551590.1
 TCTN1
 tectonic family member 1
chr12_+_111051902 0.17 ENST00000397655.3
ENST00000471804.2
ENST00000377654.3
ENST00000397659.4
 TCTN1
 tectonic family member 1
chr18_-_33709268 0.16 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
 SLC39A6
 solute carrier family 39 (zinc transporter), member 6
chr2_+_90259593 0.16 ENST00000471857.1
 IGKV1D-8
 immunoglobulin kappa variable 1D-8
chr1_+_221051699 0.15 ENST00000366903.6
 HLX
 H2.0-like homeobox
chr11_+_65686802 0.15 ENST00000376991.2
 DRAP1
 DR1-associated protein 1 (negative cofactor 2 alpha)
chr4_+_74606223 0.15 ENST00000307407.3
ENST00000401931.1
 IL8
 interleukin 8
chr12_+_104337515 0.14 ENST00000550595.1
 HSP90B1
 heat shock protein 90kDa beta (Grp94), member 1
chr10_+_101089107 0.14 ENST00000446890.1
ENST00000370528.3
 CNNM1
 cyclin M1
chr17_+_74733744 0.14 ENST00000586689.1
ENST00000587661.1
ENST00000593181.1
ENST00000336509.4
ENST00000355954.3
 MFSD11
 major facilitator superfamily domain containing 11
chr14_+_93389425 0.14 ENST00000216492.5
ENST00000334654.4
 CHGA
 chromogranin A (parathyroid secretory protein 1)
chr13_+_97874574 0.13 ENST00000343600.4
ENST00000345429.6
ENST00000376673.3
 MBNL2
 muscleblind-like splicing regulator 2
chr2_-_207082748 0.13 ENST00000407325.2
ENST00000411719.1
 GPR1
 G protein-coupled receptor 1
chr7_-_99717463 0.12 ENST00000437822.2
 TAF6
 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr1_+_87012753 0.12 ENST00000370563.3
 CLCA4
 chloride channel accessory 4
chr20_-_34638841 0.12 ENST00000565493.1
 LINC00657
 long intergenic non-protein coding RNA 657
chrX_+_55478538 0.11 ENST00000342972.1
 MAGEH1
 melanoma antigen family H, 1
chr17_-_33446735 0.11 ENST00000460118.2
ENST00000335858.7
 RAD51D
 RAD51 paralog D
chr1_-_244006528 0.08 ENST00000336199.5
ENST00000263826.5
 AKT3
 v-akt murine thymoma viral oncogene homolog 3
chr18_+_616672 0.08 ENST00000338387.7
 CLUL1
 clusterin-like 1 (retinal)
chr19_+_8455077 0.07 ENST00000328024.6
 RAB11B
 RAB11B, member RAS oncogene family
chr5_+_140552218 0.07 ENST00000231137.3
 PCDHB7
 protocadherin beta 7
chr14_-_20801427 0.07 ENST00000557665.1
ENST00000358932.4
ENST00000353689.4
 CCNB1IP1
 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
chr9_-_123342415 0.06 ENST00000349780.4
ENST00000360190.4
ENST00000360822.3
ENST00000359309.3
 CDK5RAP2
 CDK5 regulatory subunit associated protein 2
chr6_+_167525277 0.06 ENST00000400926.2
 CCR6
 chemokine (C-C motif) receptor 6
chr8_-_90769422 0.06 ENST00000524190.1
ENST00000523859.1
 RP11-37B2.1
 RP11-37B2.1
chr14_+_24025462 0.06 ENST00000556015.1
ENST00000554970.1
ENST00000554789.1
 THTPA
 thiamine triphosphatase
chr20_+_58515417 0.05 ENST00000360816.3
 FAM217B
 family with sequence similarity 217, member B
chr5_-_131879205 0.05 ENST00000231454.1
 IL5
 interleukin 5 (colony-stimulating factor, eosinophil)
chr10_-_7708918 0.05 ENST00000256861.6
ENST00000397146.2
ENST00000446830.2
ENST00000397145.2
 ITIH5
 inter-alpha-trypsin inhibitor heavy chain family, member 5
chr16_+_10971037 0.05 ENST00000324288.8
ENST00000381835.5
 CIITA
 class II, major histocompatibility complex, transactivator
chr7_-_99716952 0.04 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
 TAF6
 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa
chr1_+_171283331 0.04 ENST00000367749.3
 FMO4
 flavin containing monooxygenase 4
chrX_+_10124977 0.04 ENST00000380833.4
 CLCN4
 chloride channel, voltage-sensitive 4
chr18_+_616711 0.04 ENST00000579494.1
 CLUL1
 clusterin-like 1 (retinal)
chr3_-_62358690 0.03 ENST00000475839.1
 FEZF2
 FEZ family zinc finger 2
chr6_+_42896865 0.03 ENST00000372836.4
ENST00000394142.3
 CNPY3
 canopy FGF signaling regulator 3
chr17_-_33446820 0.02 ENST00000592577.1
ENST00000590016.1
ENST00000345365.6
ENST00000360276.3
ENST00000357906.3
 RAD51D
 RAD51 paralog D
chr11_-_33744256 0.02 ENST00000415002.2
ENST00000437761.2
ENST00000445143.2
 CD59
 CD59 molecule, complement regulatory protein
chr21_-_35884573 0.02 ENST00000399286.2
 KCNE1
 potassium voltage-gated channel, Isk-related family, member 1
chr2_-_160919112 0.01 ENST00000283243.7
ENST00000392771.1
 PLA2R1
 phospholipase A2 receptor 1, 180kDa
chr6_+_168418553 0.01 ENST00000354419.2
ENST00000351261.3
 KIF25
 kinesin family member 25
chr10_-_115904361 0.00 ENST00000428953.1
ENST00000543782.1
 C10orf118
 chromosome 10 open reading frame 118
chr11_+_33061543 0.00 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
 TCP11L1
 t-complex 11, testis-specific-like 1
chr3_-_62359180 0.00 ENST00000283268.3
 FEZF2
 FEZ family zinc finger 2
chr5_+_76326187 0.00 ENST00000312916.7
ENST00000506806.1
 AGGF1
 angiogenic factor with G patch and FHA domains 1
chr8_-_141774467 0.00 ENST00000520151.1
ENST00000519024.1
ENST00000519465.1
 PTK2
 protein tyrosine kinase 2

Gene Ontology Analysis

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0015307 drug:proton antiporter activity(GO:0015307)
0.2 1.0 GO:0004522 ribonuclease A activity(GO:0004522)
0.2 0.9 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.5 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.1 0.5 GO:0019770 IgG receptor activity(GO:0019770)
0.1 1.6 GO:0015643 toxic substance binding(GO:0015643)
0.1 0.3 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 0.3 GO:0008424 glycoprotein 6-alpha-L-fucosyltransferase activity(GO:0008424) alpha-(1->6)-fucosyltransferase activity(GO:0046921)
0.1 0.6 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.2 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.0 0.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.4 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.1 GO:0005137 interleukin-5 receptor binding(GO:0005137)
0.0 0.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 1.9 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 1.2 GO:0050840 extracellular matrix binding(GO:0050840)
0.0 0.6 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.2 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.1 GO:0046790 virion binding(GO:0046790)
0.0 0.1 GO:0000150 recombinase activity(GO:0000150)
0.0 0.2 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 1.9 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.2 1.0 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.1 1.3 GO:0071953 elastic fiber(GO:0071953)
0.1 1.2 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.0 0.7 GO:0030285 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0 0.5 GO:0060077 inhibitory synapse(GO:0060077)
0.0 0.3 GO:0097443 sorting endosome(GO:0097443)
0.0 0.4 GO:0036038 MKS complex(GO:0036038)
0.0 0.1 GO:0033061 DNA recombinase mediator complex(GO:0033061) Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0 2.1 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.1 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.4 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.6 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.1 0.9 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.0 1.2 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 0.8 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.7 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.6 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 0.3 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.2 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 0.2 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.0 0.2 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.9 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 1.4 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.5 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.6 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.7 PID ILK PATHWAY Integrin-linked kinase signaling

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0052331 hemolysis by symbiont of host erythrocytes(GO:0019836) hemolysis in other organism(GO:0044179) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
0.3 1.9 GO:0016554 cytidine to uridine editing(GO:0016554)
0.3 0.9 GO:0021836 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827) chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923)
0.3 0.8 GO:0090244 Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.2 0.8 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.2 1.0 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.2 0.5 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.1 0.6 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
0.1 0.5 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
0.1 0.3 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
0.1 1.3 GO:0048251 elastic fiber assembly(GO:0048251)
0.1 0.9 GO:0046618 drug export(GO:0046618)
0.1 0.3 GO:0036071 N-glycan fucosylation(GO:0036071)
0.1 0.4 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.1 1.1 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.1 0.7 GO:0014052 regulation of gamma-aminobutyric acid secretion(GO:0014052)
0.1 0.2 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.1 0.2 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.1 0.5 GO:0002414 immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.1 0.6 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.1 0.2 GO:0071409 negative regulation of muscle hyperplasia(GO:0014740) cellular response to cycloheximide(GO:0071409)
0.1 0.3 GO:1900127 renal water absorption(GO:0070295) positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.1 0.5 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1 0.3 GO:0097338 response to clozapine(GO:0097338)
0.1 0.7 GO:0071670 smooth muscle cell chemotaxis(GO:0071670)
0.0 0.1 GO:1901899 dense core granule biogenesis(GO:0061110) positive regulation of relaxation of cardiac muscle(GO:1901899) regulation of dense core granule biogenesis(GO:2000705)
0.0 0.2 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.0 0.1 GO:0000707 meiotic DNA recombinase assembly(GO:0000707)
0.0 0.1 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.0 0.1 GO:0045645 regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645)
0.0 0.2 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.1 GO:0042357 thiamine diphosphate metabolic process(GO:0042357)
0.0 0.2 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.4 GO:0051642 centrosome localization(GO:0051642)
0.0 0.3 GO:0072643 interferon-gamma secretion(GO:0072643)
0.0 0.1 GO:0036500 ATF6-mediated unfolded protein response(GO:0036500)