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ENCODE cell lines, expression (Ernst 2011)

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Results for HOXB3

Z-value: 1.13

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Transcription factors associated with HOXB3

Gene Symbol Gene ID Gene Info
HOXB3
ENSG00000120093.7 HOXB3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
HOXB3hg19_v2_chr17_-_46667594_466676190.361.7e-01Click!

Activity profile of HOXB3 motif

Sorted Z-values of HOXB3 motif

Network of associatons between targets according to the STRING database.

First level regulatory network of HOXB3

PNG image of the network

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Top targets:

Promoter Score Transcript Gene Gene Info
chr8_-_49834299 2.94 ENST00000396822.1
 SNAI2
 snail family zinc finger 2
chr8_-_49833978 2.81 ENST00000020945.1
 SNAI2
 snail family zinc finger 2
chr18_+_61554932 2.67 ENST00000299502.4
ENST00000457692.1
ENST00000413956.1
 SERPINB2
 serpin peptidase inhibitor, clade B (ovalbumin), member 2
chr11_+_121447469 2.51 ENST00000532694.1
ENST00000534286.1
 SORL1
 sortilin-related receptor, L(DLR class) A repeats containing
chr8_-_41166953 2.30 ENST00000220772.3
 SFRP1
 secreted frizzled-related protein 1
chr3_-_151034734 2.28 ENST00000260843.4
 GPR87
 G protein-coupled receptor 87
chr11_-_119991589 2.03 ENST00000526881.1
 TRIM29
 tripartite motif containing 29
chr4_+_87515454 2.02 ENST00000427191.2
ENST00000436978.1
ENST00000502971.1
 PTPN13
 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
chr12_-_123201337 1.92 ENST00000528880.2
 HCAR3
 hydroxycarboxylic acid receptor 3
chr2_+_234637754 1.81 ENST00000482026.1
ENST00000609767.1
 UGT1A3
UGT1A1
 UDP glucuronosyltransferase 1 family, polypeptide A3
UDP glucuronosyltransferase 1 family, polypeptide A8
chr1_+_156030937 1.76 ENST00000361084.5
 RAB25
 RAB25, member RAS oncogene family
chr2_+_234545092 1.70 ENST00000344644.5
 UGT1A10
 UDP glucuronosyltransferase 1 family, polypeptide A10
chr18_-_21891460 1.65 ENST00000357041.4
 OSBPL1A
 oxysterol binding protein-like 1A
chr1_+_152486950 1.62 ENST00000368790.3
 CRCT1
 cysteine-rich C-terminal 1
chr12_-_123187890 1.46 ENST00000328880.5
 HCAR2
 hydroxycarboxylic acid receptor 2
chr13_+_73632897 1.45 ENST00000377687.4
 KLF5
 Kruppel-like factor 5 (intestinal)
chr7_-_24797546 1.41 ENST00000414428.1
ENST00000419307.1
ENST00000342947.3
 DFNA5
 deafness, autosomal dominant 5
chrX_+_43515467 1.26 ENST00000338702.3
ENST00000542639.1
 MAOA
 monoamine oxidase A
chr17_-_27418537 1.23 ENST00000408971.2
 TIAF1
 TGFB1-induced anti-apoptotic factor 1
chr9_+_130911723 1.23 ENST00000277480.2
ENST00000373013.2
ENST00000540948.1
 LCN2
 lipocalin 2
chr9_+_130911770 1.22 ENST00000372998.1
 LCN2
 lipocalin 2
chr1_-_68698222 1.17 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
 WLS
 wntless Wnt ligand secretion mediator
chr11_-_104905840 1.16 ENST00000526568.1
ENST00000393136.4
ENST00000531166.1
ENST00000534497.1
ENST00000527979.1
ENST00000446369.1
ENST00000353247.5
ENST00000528974.1
ENST00000533400.1
ENST00000525825.1
ENST00000436863.3
 CASP1
 caspase 1, apoptosis-related cysteine peptidase
chr9_+_470288 1.11 ENST00000382303.1
 KANK1
 KN motif and ankyrin repeat domains 1
chr11_-_118134997 1.09 ENST00000278937.2
 MPZL2
 myelin protein zero-like 2
chr2_+_234580499 1.06 ENST00000354728.4
 UGT1A9
 UDP glucuronosyltransferase 1 family, polypeptide A9
chr2_+_234580525 1.04 ENST00000609637.1
 UGT1A1
 UDP glucuronosyltransferase 1 family, polypeptide A8
chr18_+_55888767 1.03 ENST00000431212.2
ENST00000586268.1
ENST00000587190.1
 NEDD4L
 neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr7_+_142458507 0.98 ENST00000492062.1
 PRSS1
 protease, serine, 1 (trypsin 1)
chr5_+_36608422 0.92 ENST00000381918.3
 SLC1A3
 solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr4_-_102268484 0.88 ENST00000394853.4
 PPP3CA
 protein phosphatase 3, catalytic subunit, alpha isozyme
chr3_-_185538849 0.84 ENST00000421047.2
 IGF2BP2
 insulin-like growth factor 2 mRNA binding protein 2
chr22_+_30792980 0.83 ENST00000403484.1
ENST00000405717.3
ENST00000402592.3
 SEC14L2
 SEC14-like 2 (S. cerevisiae)
chr11_-_104817919 0.82 ENST00000533252.1
 CASP4
 caspase 4, apoptosis-related cysteine peptidase
chr11_-_104827425 0.73 ENST00000393150.3
 CASP4
 caspase 4, apoptosis-related cysteine peptidase
chr17_+_48624450 0.67 ENST00000006658.6
ENST00000356488.4
ENST00000393244.3
 SPATA20
 spermatogenesis associated 20
chr11_-_107729887 0.65 ENST00000525815.1
 SLC35F2
 solute carrier family 35, member F2
chr12_-_6484376 0.64 ENST00000360168.3
ENST00000358945.3
 SCNN1A
 sodium channel, non-voltage-gated 1 alpha subunit
chr11_-_102651343 0.62 ENST00000279441.4
ENST00000539681.1
 MMP10
 matrix metallopeptidase 10 (stromelysin 2)
chr1_-_68698197 0.61 ENST00000370973.2
ENST00000370971.1
 WLS
 wntless Wnt ligand secretion mediator
chr5_+_150639360 0.58 ENST00000523004.1
 GM2A
 GM2 ganglioside activator
chr11_+_5710919 0.57 ENST00000379965.3
ENST00000425490.1
 TRIM22
 tripartite motif containing 22
chr1_+_79115503 0.55 ENST00000370747.4
ENST00000438486.1
ENST00000545124.1
 IFI44
 interferon-induced protein 44
chr2_+_234545148 0.54 ENST00000373445.1
 UGT1A10
 UDP glucuronosyltransferase 1 family, polypeptide A10
chr12_+_15699286 0.50 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
 PTPRO
 protein tyrosine phosphatase, receptor type, O
chr7_+_26331541 0.47 ENST00000416246.1
ENST00000338523.4
ENST00000412416.1
 SNX10
 sorting nexin 10
chr3_-_126327398 0.43 ENST00000383572.2
 TXNRD3NB
 thioredoxin reductase 3 neighbor
chr3_+_130745688 0.42 ENST00000510769.1
ENST00000429253.2
ENST00000356918.4
ENST00000510688.1
ENST00000511262.1
ENST00000383366.4
 NEK11
 NIMA-related kinase 11
chr1_+_144173162 0.40 ENST00000356801.6
 NBPF8
 neuroblastoma breakpoint family, member 8
chr2_+_29336855 0.40 ENST00000404424.1
 CLIP4
 CAP-GLY domain containing linker protein family, member 4
chr5_+_115177178 0.40 ENST00000316788.7
 AP3S1
 adaptor-related protein complex 3, sigma 1 subunit
chr16_-_11036300 0.38 ENST00000331808.4
 DEXI
 Dexi homolog (mouse)
chr14_-_70883708 0.37 ENST00000256366.4
 SYNJ2BP
 synaptojanin 2 binding protein
chr3_-_151047327 0.35 ENST00000325602.5
 P2RY13
 purinergic receptor P2Y, G-protein coupled, 13
chr7_-_134896234 0.34 ENST00000354475.4
ENST00000344400.5
 WDR91
 WD repeat domain 91
chr2_+_200820494 0.33 ENST00000435773.2
 C2orf47
 chromosome 2 open reading frame 47
chr1_-_146040968 0.31 ENST00000401010.3
 NBPF11
 neuroblastoma breakpoint family, member 11
chr1_+_81771806 0.30 ENST00000370721.1
ENST00000370727.1
ENST00000370725.1
ENST00000370723.1
ENST00000370728.1
ENST00000370730.1
 LPHN2
 latrophilin 2
chr2_+_113816215 0.29 ENST00000346807.3
 IL36RN
 interleukin 36 receptor antagonist
chrX_-_13835147 0.28 ENST00000493677.1
ENST00000355135.2
 GPM6B
 glycoprotein M6B
chr2_+_113816685 0.27 ENST00000393200.2
 IL36RN
 interleukin 36 receptor antagonist
chr16_+_28763108 0.25 ENST00000357796.3
ENST00000550983.1
 NPIPB9
 nuclear pore complex interacting protein family, member B9
chr6_+_160542821 0.23 ENST00000366963.4
 SLC22A1
 solute carrier family 22 (organic cation transporter), member 1
chr1_+_28261492 0.22 ENST00000373894.3
 SMPDL3B
 sphingomyelin phosphodiesterase, acid-like 3B
chrX_+_135730373 0.22 ENST00000370628.2
 CD40LG
 CD40 ligand
chrX_+_135730297 0.22 ENST00000370629.2
 CD40LG
 CD40 ligand
chr14_-_24711806 0.21 ENST00000540705.1
ENST00000538777.1
ENST00000558566.1
ENST00000559019.1
 TINF2
 TERF1 (TRF1)-interacting nuclear factor 2
chr11_-_128894053 0.21 ENST00000392657.3
 ARHGAP32
 Rho GTPase activating protein 32
chr7_-_99277610 0.21 ENST00000343703.5
ENST00000222982.4
ENST00000439761.1
ENST00000339843.2
 CYP3A5
 cytochrome P450, family 3, subfamily A, polypeptide 5
chr12_+_28410128 0.20 ENST00000381259.1
ENST00000381256.1
 CCDC91
 coiled-coil domain containing 91
chr4_+_175204818 0.20 ENST00000503780.1
 CEP44
 centrosomal protein 44kDa
chr6_+_160542870 0.20 ENST00000324965.4
ENST00000457470.2
 SLC22A1
 solute carrier family 22 (organic cation transporter), member 1
chr14_-_24711865 0.20 ENST00000399423.4
ENST00000267415.7
 TINF2
 TERF1 (TRF1)-interacting nuclear factor 2
chr11_+_94706973 0.20 ENST00000536741.1
 KDM4D
 lysine (K)-specific demethylase 4D
chr12_+_66582919 0.19 ENST00000545837.1
ENST00000457197.2
 IRAK3
 interleukin-1 receptor-associated kinase 3
chr1_+_207226574 0.19 ENST00000367080.3
ENST00000367079.2
 PFKFB2
 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2
chr11_+_3819049 0.19 ENST00000396986.2
ENST00000300730.6
ENST00000532535.1
ENST00000396993.4
ENST00000396991.2
ENST00000532523.1
ENST00000459679.1
ENST00000464261.1
ENST00000464906.2
ENST00000464441.1
 PGAP2
 post-GPI attachment to proteins 2
chr3_+_121774202 0.19 ENST00000469710.1
ENST00000493101.1
ENST00000330540.2
ENST00000264468.5
 CD86
 CD86 molecule
chr6_+_149721495 0.18 ENST00000326669.4
 SUMO4
 small ubiquitin-like modifier 4
chrX_-_24690771 0.18 ENST00000379145.1
 PCYT1B
 phosphate cytidylyltransferase 1, choline, beta
chr20_-_44600810 0.18 ENST00000322927.2
ENST00000426788.1
 ZNF335
 zinc finger protein 335
chr1_+_160160346 0.18 ENST00000368078.3
 CASQ1
 calsequestrin 1 (fast-twitch, skeletal muscle)
chr1_+_220267429 0.17 ENST00000366922.1
ENST00000302637.5
 IARS2
 isoleucyl-tRNA synthetase 2, mitochondrial
chr9_+_131062367 0.17 ENST00000601297.1
 AL359091.2
 CDNA: FLJ21673 fis, clone COL09042; HCG2036511; Uncharacterized protein
chr1_+_158978768 0.17 ENST00000447473.2
 IFI16
 interferon, gamma-inducible protein 16
chr8_-_17579726 0.16 ENST00000381861.3
 MTUS1
 microtubule associated tumor suppressor 1
chr6_+_45296391 0.16 ENST00000371436.6
ENST00000576263.1
 RUNX2
 runt-related transcription factor 2
chr4_-_120243545 0.16 ENST00000274024.3
 FABP2
 fatty acid binding protein 2, intestinal
chr17_+_46970134 0.16 ENST00000503641.1
ENST00000514808.1
 ATP5G1
 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr2_-_70780572 0.16 ENST00000450929.1
 TGFA
 transforming growth factor, alpha
chr1_-_93257951 0.16 ENST00000543509.1
ENST00000370331.1
ENST00000540033.1
 EVI5
 ecotropic viral integration site 5
chr17_+_46970178 0.15 ENST00000393366.2
ENST00000506855.1
 ATP5G1
 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr16_-_28937027 0.15 ENST00000358201.4
 RABEP2
 rabaptin, RAB GTPase binding effector protein 2
chr12_+_22778009 0.15 ENST00000266517.4
ENST00000335148.3
 ETNK1
 ethanolamine kinase 1
chr6_+_26501449 0.14 ENST00000244513.6
 BTN1A1
 butyrophilin, subfamily 1, member A1
chr7_+_129015484 0.14 ENST00000490911.1
 AHCYL2
 adenosylhomocysteinase-like 2
chr8_+_27168988 0.14 ENST00000397501.1
ENST00000338238.4
ENST00000544172.1
 PTK2B
 protein tyrosine kinase 2 beta
chr7_-_134855517 0.14 ENST00000430372.1
 C7orf49
 chromosome 7 open reading frame 49
chr14_+_69865401 0.14 ENST00000556605.1
ENST00000336643.5
ENST00000031146.4
 SLC39A9
 solute carrier family 39, member 9
chr1_+_160160283 0.14 ENST00000368079.3
 CASQ1
 calsequestrin 1 (fast-twitch, skeletal muscle)
chr8_+_22132810 0.14 ENST00000356766.6
 PIWIL2
 piwi-like RNA-mediated gene silencing 2
chr12_+_122688090 0.13 ENST00000324189.4
ENST00000546192.1
 B3GNT4
 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4
chr17_+_46970127 0.13 ENST00000355938.5
 ATP5G1
 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr2_+_138722028 0.13 ENST00000280096.5
 HNMT
 histamine N-methyltransferase
chr9_-_5339873 0.13 ENST00000223862.1
ENST00000223858.4
 RLN1
 relaxin 1
chr16_+_28648975 0.13 ENST00000529716.1
 NPIPB8
 nuclear pore complex interacting protein family, member B8
chr16_-_28374829 0.12 ENST00000532254.1
 NPIPB6
 nuclear pore complex interacting protein family, member B6
chr21_-_27423339 0.12 ENST00000415997.1
 APP
 amyloid beta (A4) precursor protein
chr11_+_94706804 0.12 ENST00000335080.5
 KDM4D
 lysine (K)-specific demethylase 4D
chr14_-_24711470 0.12 ENST00000559969.1
 TINF2
 TERF1 (TRF1)-interacting nuclear factor 2
chr14_+_22320634 0.12 ENST00000390435.1
 TRAV8-3
 T cell receptor alpha variable 8-3
chr16_-_30257122 0.12 ENST00000520915.1
 RP11-347C12.1
 Putative NPIP-like protein LOC613037
chrX_+_37208540 0.12 ENST00000466533.1
ENST00000542554.1
ENST00000543642.1
ENST00000484460.1
ENST00000449135.2
ENST00000463135.1
ENST00000465127.1
 PRRG1
TM4SF2
 proline rich Gla (G-carboxyglutamic acid) 1
Uncharacterized protein; cDNA FLJ59144, highly similar to Tetraspanin-7
chr2_+_54350316 0.12 ENST00000606865.1
 ACYP2
 acylphosphatase 2, muscle type
chr12_+_18414446 0.12 ENST00000433979.1
 PIK3C2G
 phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
chr1_+_202317815 0.12 ENST00000608999.1
ENST00000336894.4
ENST00000480184.1
 PPP1R12B
 protein phosphatase 1, regulatory subunit 12B
chr4_-_176733897 0.11 ENST00000393658.2
 GPM6A
 glycoprotein M6A
chr9_+_125132803 0.11 ENST00000540753.1
 PTGS1
 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr8_+_22132847 0.11 ENST00000521356.1
 PIWIL2
 piwi-like RNA-mediated gene silencing 2
chr9_+_125133315 0.11 ENST00000223423.4
ENST00000362012.2
 PTGS1
 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
chr6_-_133035185 0.10 ENST00000367928.4
 VNN1
 vanin 1
chr4_-_10686475 0.10 ENST00000226951.6
 CLNK
 cytokine-dependent hematopoietic cell linker
chr1_-_67266939 0.10 ENST00000304526.2
 INSL5
 insulin-like 5
chr14_-_54908043 0.10 ENST00000556113.1
ENST00000553660.1
ENST00000395573.4
ENST00000557690.1
ENST00000216416.4
 CNIH1
 cornichon family AMPA receptor auxiliary protein 1
chr2_-_10587897 0.09 ENST00000405333.1
ENST00000443218.1
 ODC1
 ornithine decarboxylase 1
chr3_+_40518599 0.09 ENST00000314686.5
ENST00000447116.2
ENST00000429348.2
ENST00000456778.1
 ZNF619
 zinc finger protein 619
chr16_-_21431078 0.09 ENST00000458643.2
 NPIPB3
 nuclear pore complex interacting protein family, member B3
chrX_+_106045891 0.09 ENST00000357242.5
ENST00000310452.2
ENST00000481617.2
ENST00000276175.3
 TBC1D8B
 TBC1 domain family, member 8B (with GRAM domain)
chr3_+_121902511 0.09 ENST00000490131.1
 CASR
 calcium-sensing receptor
chr12_-_118797475 0.09 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
 TAOK3
 TAO kinase 3
chr12_+_22778116 0.09 ENST00000538218.1
 ETNK1
 ethanolamine kinase 1
chr3_-_44519131 0.09 ENST00000425708.2
ENST00000396077.2
 ZNF445
 zinc finger protein 445
chr10_+_53806501 0.09 ENST00000373975.2
 PRKG1
 protein kinase, cGMP-dependent, type I
chr17_-_40337470 0.08 ENST00000293330.1
 HCRT
 hypocretin (orexin) neuropeptide precursor
chr12_+_56521840 0.08 ENST00000394048.5
 ESYT1
 extended synaptotagmin-like protein 1
chr16_-_21868739 0.08 ENST00000415645.2
 NPIPB4
 nuclear pore complex interacting protein family, member B4
chr6_-_42690312 0.08 ENST00000230381.5
 PRPH2
 peripherin 2 (retinal degeneration, slow)
chr5_-_22853429 0.08 ENST00000504376.2
 CDH12
 cadherin 12, type 2 (N-cadherin 2)
chr16_-_29415350 0.07 ENST00000524087.1
 NPIPB11
 nuclear pore complex interacting protein family, member B11
chr3_+_148508845 0.07 ENST00000491148.1
 CPB1
 carboxypeptidase B1 (tissue)
chr14_+_32798547 0.07 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
 AKAP6
 A kinase (PRKA) anchor protein 6
chr7_+_100860949 0.06 ENST00000305105.2
 ZNHIT1
 zinc finger, HIT-type containing 1
chr14_+_32798462 0.06 ENST00000280979.4
 AKAP6
 A kinase (PRKA) anchor protein 6
chrX_+_138612889 0.06 ENST00000218099.2
ENST00000394090.2
 F9
 coagulation factor IX
chr2_+_166095898 0.06 ENST00000424833.1
ENST00000375437.2
ENST00000357398.3
 SCN2A
 sodium channel, voltage-gated, type II, alpha subunit
chr4_-_8873531 0.06 ENST00000400677.3
 HMX1
 H6 family homeobox 1
chrX_+_144908928 0.06 ENST00000408967.2
 TMEM257
 transmembrane protein 257
chr16_-_21868978 0.05 ENST00000357370.5
ENST00000451409.1
ENST00000341400.7
ENST00000518761.4
 NPIPB4
 nuclear pore complex interacting protein family, member B4
chrX_-_48824793 0.05 ENST00000376477.1
 KCND1
 potassium voltage-gated channel, Shal-related subfamily, member 1
chr11_+_15095108 0.05 ENST00000324229.6
ENST00000533448.1
 CALCB
 calcitonin-related polypeptide beta
chr6_+_26087509 0.05 ENST00000397022.3
ENST00000353147.5
ENST00000352392.4
ENST00000349999.4
ENST00000317896.7
ENST00000357618.5
ENST00000470149.1
ENST00000336625.8
ENST00000461397.1
ENST00000488199.1
 HFE
 hemochromatosis
chr11_-_117748138 0.05 ENST00000527717.1
 FXYD6
 FXYD domain containing ion transport regulator 6
chr16_-_21436459 0.05 ENST00000448012.2
ENST00000504841.2
ENST00000419180.2
 NPIPB3
 nuclear pore complex interacting protein family, member B3
chr2_+_65215604 0.05 ENST00000531327.1
 SLC1A4
 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr6_+_29429217 0.04 ENST00000396792.2
 OR2H1
 olfactory receptor, family 2, subfamily H, member 1
chr12_-_117175819 0.04 ENST00000261318.3
ENST00000536380.1
 C12orf49
 chromosome 12 open reading frame 49
chr1_-_51796987 0.04 ENST00000262676.5
 TTC39A
 tetratricopeptide repeat domain 39A
chr7_+_5919458 0.04 ENST00000416608.1
 OCM
 oncomodulin
chr15_+_64680003 0.04 ENST00000261884.3
 TRIP4
 thyroid hormone receptor interactor 4
chr11_+_33061543 0.03 ENST00000432887.1
ENST00000528898.1
ENST00000531632.2
 TCP11L1
 t-complex 11, testis-specific-like 1
chr19_+_48949030 0.03 ENST00000253237.5
 GRWD1
 glutamate-rich WD repeat containing 1
chr2_-_120282070 0.03 ENST00000019103.5
 SCTR
 secretin receptor
chr6_-_62996066 0.03 ENST00000281156.4
 KHDRBS2
 KH domain containing, RNA binding, signal transduction associated 2
chr19_-_3985455 0.03 ENST00000309311.6
 EEF2
 eukaryotic translation elongation factor 2
chr21_+_43823983 0.03 ENST00000291535.6
ENST00000450356.1
ENST00000319294.6
ENST00000398367.1
 UBASH3A
 ubiquitin associated and SH3 domain containing A
chr12_-_91451758 0.03 ENST00000266719.3
 KERA
 keratocan
chr17_-_73258425 0.02 ENST00000578348.1
ENST00000582486.1
ENST00000582717.1
 GGA3
 golgi-associated, gamma adaptin ear containing, ARF binding protein 3
chr19_-_46088068 0.02 ENST00000263275.4
ENST00000323060.3
 OPA3
 optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia)
chr9_-_95166841 0.02 ENST00000262551.4
 OGN
 osteoglycin
chr14_-_23058063 0.02 ENST00000538631.1
ENST00000543337.1
ENST00000250498.4
 DAD1
 defender against cell death 1
chr12_-_118796910 0.02 ENST00000541186.1
ENST00000539872.1
 TAOK3
 TAO kinase 3
chr4_-_66536196 0.02 ENST00000511294.1
 EPHA5
 EPH receptor A5
chr5_-_35089722 0.02 ENST00000511486.1
ENST00000310101.5
ENST00000231423.3
ENST00000513753.1
ENST00000348262.3
ENST00000397391.3
ENST00000542609.1
 PRLR
 prolactin receptor
chr19_+_49990811 0.02 ENST00000391857.4
ENST00000467825.2
 RPL13A
 ribosomal protein L13a
chr22_-_30234218 0.02 ENST00000307790.3
ENST00000542393.1
ENST00000397771.2
 ASCC2
 activating signal cointegrator 1 complex subunit 2
chr8_-_141810634 0.01 ENST00000521986.1
ENST00000523539.1
ENST00000538769.1
 PTK2
 protein tyrosine kinase 2
chrX_-_130423200 0.01 ENST00000361420.3
 IGSF1
 immunoglobulin superfamily, member 1
chr12_+_64798095 0.01 ENST00000332707.5
 XPOT
 exportin, tRNA
chr2_-_89160770 0.01 ENST00000390240.2
 IGKJ3
 immunoglobulin kappa joining 3
chr21_-_37914898 0.01 ENST00000399136.1
 CLDN14
 claudin 14
chr2_-_73869508 0.01 ENST00000272425.3
 NAT8
 N-acetyltransferase 8 (GCN5-related, putative)
chr12_-_10959892 0.01 ENST00000240615.2
 TAS2R8
 taste receptor, type 2, member 8
chr19_+_12848299 0.01 ENST00000357332.3
 ASNA1
 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
chr2_-_20251744 0.01 ENST00000175091.4
 LAPTM4A
 lysosomal protein transmembrane 4 alpha
chr16_-_66864806 0.00 ENST00000566336.1
ENST00000394074.2
ENST00000563185.2
ENST00000359087.4
ENST00000379463.2
ENST00000565535.1
ENST00000290810.3
 NAE1
 NEDD8 activating enzyme E1 subunit 1
chr6_-_32095968 0.00 ENST00000375203.3
ENST00000375201.4
 ATF6B
 activating transcription factor 6 beta
chr12_-_10978957 0.00 ENST00000240619.2
 TAS2R10
 taste receptor, type 2, member 10
chr1_-_54356404 0.00 ENST00000539954.1
 YIPF1
 Yip1 domain family, member 1
chr2_+_28618532 0.00 ENST00000545753.1
 FOSL2
 FOS-like antigen 2

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 5.8 GO:0070563 negative regulation of vitamin D receptor signaling pathway(GO:0070563)
0.8 2.5 GO:1902948 regulation of choline O-acetyltransferase activity(GO:1902769) positive regulation of choline O-acetyltransferase activity(GO:1902771) negative regulation of tau-protein kinase activity(GO:1902948) positive regulation of early endosome to recycling endosome transport(GO:1902955) negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902960) negative regulation of neurofibrillary tangle assembly(GO:1902997) negative regulation of aspartic-type peptidase activity(GO:1905246)
0.8 2.3 GO:0090244 Wnt signaling pathway involved in somitogenesis(GO:0090244)
0.6 6.2 GO:0051552 flavone metabolic process(GO:0051552)
0.6 1.8 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
0.5 2.4 GO:0015891 iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
0.4 1.1 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.3 0.9 GO:1905205 positive regulation of connective tissue replacement(GO:1905205)
0.3 1.5 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.3 1.2 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.2 1.0 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.2 1.6 GO:1903265 positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.2 0.5 GO:0036058 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.2 1.4 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.1 0.9 GO:0006537 glutamate biosynthetic process(GO:0006537) gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.1 2.6 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1 1.8 GO:0031268 pseudopodium organization(GO:0031268)
0.1 0.6 GO:1902714 negative regulation of interferon-gamma secretion(GO:1902714)
0.1 0.5 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836)
0.1 0.2 GO:0030718 germ-line stem cell population maintenance(GO:0030718)
0.1 1.3 GO:0042420 dopamine catabolic process(GO:0042420)
0.1 2.7 GO:0042730 fibrinolysis(GO:0042730)
0.1 0.6 GO:0006689 ganglioside catabolic process(GO:0006689)
0.1 0.3 GO:2001034 positive regulation of double-strand break repair via nonhomologous end joining(GO:2001034)
0.1 0.4 GO:0048241 epinephrine transport(GO:0048241)
0.1 0.2 GO:0042109 negative regulation of tolerance induction(GO:0002644) lymphotoxin A production(GO:0032641) interleukin-4 biosynthetic process(GO:0042097) lymphotoxin A biosynthetic process(GO:0042109) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.1 0.2 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.1 0.2 GO:0009822 alkaloid catabolic process(GO:0009822)
0.0 0.1 GO:0010752 regulation of cGMP-mediated signaling(GO:0010752)
0.0 0.1 GO:0030309 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0 0.4 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.2 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.0 1.0 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 1.5 GO:0006699 bile acid biosynthetic process(GO:0006699)
0.0 0.1 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.0 0.2 GO:1903301 fructose 2,6-bisphosphate metabolic process(GO:0006003) positive regulation of glucokinase activity(GO:0033133) positive regulation of hexokinase activity(GO:1903301)
0.0 0.3 GO:0014894 response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.3 GO:0051581 negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.1 GO:0071874 response to norepinephrine(GO:0071873) cellular response to norepinephrine stimulus(GO:0071874)
0.0 0.4 GO:0048490 anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0 0.1 GO:0033387 putrescine biosynthetic process from ornithine(GO:0033387)
0.0 0.1 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.4 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 0.2 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.0 1.4 GO:0060113 inner ear receptor cell differentiation(GO:0060113)
0.0 0.5 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 0.2 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.1 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.0 1.9 GO:1900181 negative regulation of protein localization to nucleus(GO:1900181)
0.0 0.2 GO:0090160 Golgi to lysosome transport(GO:0090160)
0.0 0.0 GO:0002590 regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002589) negative regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002590) regulation of T cell antigen processing and presentation(GO:0002625) positive regulation of iron ion transport(GO:0034758) positive regulation of iron ion transmembrane transport(GO:0034761) regulation of iron ion import(GO:1900390) regulation of ferrous iron import into cell(GO:1903989) positive regulation of ferrous iron import into cell(GO:1903991) regulation of ferrous iron binding(GO:1904432) positive regulation of ferrous iron binding(GO:1904434) regulation of transferrin receptor binding(GO:1904435) positive regulation of transferrin receptor binding(GO:1904437) regulation of ferrous iron import across plasma membrane(GO:1904438) positive regulation of ferrous iron import across plasma membrane(GO:1904440) response to iron ion starvation(GO:1990641)
0.0 2.0 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.2 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.2 GO:0016925 protein sumoylation(GO:0016925)
0.0 0.1 GO:0051970 negative regulation of transmission of nerve impulse(GO:0051970)
0.0 0.2 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 0.4 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.6 GO:0070206 protein trimerization(GO:0070206)
0.0 0.2 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.2 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.0 0.8 GO:0045540 regulation of cholesterol biosynthetic process(GO:0045540)
0.0 0.6 GO:0050909 sensory perception of taste(GO:0050909)
0.0 0.0 GO:0015808 L-alanine transport(GO:0015808)
0.0 0.1 GO:0015939 pantothenate metabolic process(GO:0015939)
0.0 0.2 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
0.0 0.0 GO:0006409 tRNA export from nucleus(GO:0006409) tRNA transport(GO:0051031) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.7 GO:0072557 IPAF inflammasome complex(GO:0072557)
0.2 2.6 GO:0005641 nuclear envelope lumen(GO:0005641)
0.2 0.8 GO:0010370 perinucleolar chromocenter(GO:0010370)
0.1 0.6 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.1 2.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 0.9 GO:0005955 calcineurin complex(GO:0005955)
0.1 0.5 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 1.8 GO:0031143 pseudopodium(GO:0031143)
0.1 1.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 0.3 GO:0014802 terminal cisterna(GO:0014802)
0.0 0.4 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.0 0.7 GO:0034706 sodium channel complex(GO:0034706)
0.0 0.4 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.1 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 1.0 GO:0005771 multivesicular body(GO:0005771)
0.0 1.7 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 5.0 GO:0000790 nuclear chromatin(GO:0000790)
0.0 0.3 GO:0005721 pericentric heterochromatin(GO:0005721)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.9 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 1.3 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.1 1.3 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 1.3 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.0 1.4 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.0 0.3 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.0 0.4 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.3 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 3.6 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 0.8 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 1.3 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.2 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 0.5 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 1.7 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.0 0.2 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.7 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.8 GO:0008431 vitamin E binding(GO:0008431)
0.2 2.0 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.2 2.6 GO:0050700 CARD domain binding(GO:0050700)
0.2 6.2 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 2.5 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.2 1.3 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 0.4 GO:0005174 CD40 receptor binding(GO:0005174)
0.1 4.6 GO:0017147 Wnt-protein binding(GO:0017147)
0.1 0.9 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.1 2.6 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.1 1.0 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 0.6 GO:0005152 interleukin-1 receptor antagonist activity(GO:0005152)
0.1 0.4 GO:0005277 acetylcholine transmembrane transporter activity(GO:0005277) secondary active organic cation transmembrane transporter activity(GO:0008513) acetate ester transmembrane transporter activity(GO:1901375)
0.1 0.9 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 0.2 GO:0034584 piRNA binding(GO:0034584)
0.1 0.6 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.1 1.7 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 0.2 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.1 0.2 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.0 1.7 GO:0015248 sterol transporter activity(GO:0015248)
0.0 0.1 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.6 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 0.1 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0 0.2 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 5.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.2 GO:0003873 6-phosphofructo-2-kinase activity(GO:0003873) fructose-2,6-bisphosphate 2-phosphatase activity(GO:0004331)
0.0 0.2 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.0 2.8 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.8 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.0 0.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.0 0.5 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.1 GO:0017159 pantetheine hydrolase activity(GO:0017159)
0.0 0.1 GO:0003998 acylphosphatase activity(GO:0003998)
0.0 0.1 GO:0004692 cGMP-dependent protein kinase activity(GO:0004692)
0.0 0.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 2.3 GO:0002020 protease binding(GO:0002020)
0.0 0.2 GO:0031386 protein tag(GO:0031386)
0.0 0.2 GO:0070330 aromatase activity(GO:0070330)
0.0 0.0 GO:0022858 L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.0 0.5 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 1.1 GO:0008013 beta-catenin binding(GO:0008013)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.0 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.1 2.3 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 1.2 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.0 2.0 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 1.1 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 1.2 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 4.0 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.5 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.1 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.